ライフサイエンスコーパス: neuromuscular transmission

1 esponse, thus reducing the safety margin for neuromuscular transmission.

2 e of MEPCs, preserving the safety factor for neuromuscular transmission.

3 d/or to concomitant use of drugs that affect neuromuscular transmission.

4 g presynaptic cytosolic [Ca2+] during normal neuromuscular transmission.

5 acilitate action potential generation during neuromuscular transmission.

6 udies, and has advanced our understanding of neuromuscular transmission.

7 nce of slow AChR ion channels, and defective neuromuscular transmission.

8 up of rare genetic disorders that compromise neuromuscular transmission.

9 likely to be crucial for ensuring effective neuromuscular transmission.

10 e group of heterogeneous disorders affecting neuromuscular transmission.

11 sorders that compromise the safety margin of neuromuscular transmission.

12 loroquine may worsen or provoke disorders of neuromuscular transmission.

13 ptic facilitation, and attenuated inhibitory neuromuscular transmission.

14 oup of rare diseases resulting from impaired neuromuscular transmission.

15 ding proteins essential for the integrity of neuromuscular transmission.

16 e action potentials (CMAPs), and compromised neuromuscular transmission.

17 g frog, use the P/Q-type calcium channel for neuromuscular transmission.

18 ymptoms, including reduced CMAP and impaired neuromuscular transmission.

19 n pathway and that manifest through impaired neuromuscular transmission.

20 to delay or reverse BoNT-induced blockade of neuromuscular transmission.

21 lly induced blockade of action potentials or neuromuscular transmission.

22 rtance of glycosylation for the integrity of neuromuscular transmission.

23 importantly to the reduced safety margin of neuromuscular transmission.

24 ispersed synaptic AChR clusters and impaired neuromuscular transmission.

25 astatin (CS) transgene improved strength and neuromuscular transmission.

26 y SFEMG, confirming the presence of impaired neuromuscular transmission.

27 c currents in the unc-9 mutant showed normal neuromuscular transmission.

28 m any abnormality in the immediate events of neuromuscular transmission.

29 r se is not a reliable indicator of impaired neuromuscular transmission.

30 ndicate that the defect is not manifested in neuromuscular transmission.

31 lpha(2)betadelta(2) pentamers cannot sustain neuromuscular transmission.

32 elease of acetylcholine and eventually block neuromuscular transmission.

33 receptor (AChR) on muscle and interfere with neuromuscular transmission.

34 rget the ion channels that are essential for neuromuscular transmission.

35 eterogeneous group of inherited disorders of neuromuscular transmission.

36 hallmark of LEMS is a large potentiation of neuromuscular transmission after high-frequency stimulat

37 NA could generate sufficient AChR to support neuromuscular transmission, albeit at a reduced level.

38 age at subsynaptic nuclei, and improved both neuromuscular transmission and clinical measures of moto

39 on excitability produced by manipulations of neuromuscular transmission and compared these with the e

40 , but significant changes in NMJ morphology, neuromuscular transmission and EMG data were found only

41 verified that these evoked twitches involved neuromuscular transmission and faithfully reported muscl

42 Neuromuscular transmission and muscle activity during ea

43 cetylcholine receptor, reduced efficiency of neuromuscular transmission and muscle weakness and fatig

44 potentials were reduced, indicating impaired neuromuscular transmission and providing cellular mechan

45 sies for in vitro microelectrode analysis of neuromuscular transmission and quantitative electron mic

46 d our understanding of genes associated with neuromuscular transmission and resistance to the antinem

47 at sit atop the neuromuscular junction sense neuromuscular transmission and respond to perturbations

48 study, we examined the relationship between neuromuscular transmission and skeletal muscle hyperexci

49 observations with regard to toxic effects on neuromuscular transmission and toxic myopathies.

50 oss brain development, muscle contractility, neuromuscular transmission, and lung development were ru

51 opment of the NMJ, homeostatic regulation of neuromuscular transmission, and synaptic gene expression

52 remodelling is associated with impairment of neuromuscular transmission, and that this contributes to

53 annel mediates fast inhibitory glutamatergic neuromuscular transmission; and (ii) a nematocidal prope

54 Genetic disorders of neuromuscular transmission are due mainly to mutations i

55 congenital myasthenic syndromes or impaired neuromuscular transmission as part of a more severe mult

56 n synaptic gene expression, development, and neuromuscular transmission, as well as mediating degener

57 both presynaptic and postsynaptic aspects of neuromuscular transmission at concentrations close to th

58 It is suggested that this is due to weak neuromuscular transmission at synapses in the process of

59 nd function of individual NMJs, we show that neuromuscular transmission at the most highly fragmented

60 re reviewed: a) the developmental changes in neuromuscular transmission; b) the pharmacokinetics and

61 we use paired patch clamp recording to study neuromuscular transmission between the caudal primary mo

62 dTC, which rescues motoneurons and blocks neuromuscular transmission, blocked neither spontaneous

63 onal view that 4-AP facilitates synaptic and neuromuscular transmission by blocking Kv channels.

64 dy, we investigate effects of these drugs on neuromuscular transmission by conventional microelectrod

65 ynaptic actions of K+ channels in Drosophila neuromuscular transmission by using electrophysiological

66 igable muscle weakness results from impaired neuromuscular transmission caused by reduced AChR number

67 nherited disorders that result from impaired neuromuscular transmission, caused by mutations in genes

68 that in zebrafish twister mutants, prolonged neuromuscular transmission causes motor axonal extension

69 SCCMS) is a dominantly inherited disorder of neuromuscular transmission characterized by delayed clos

70 (CMSs) are a group of inherited disorders of neuromuscular transmission characterized by fatigable mu

71 sthenic syndromes are inherited disorders of neuromuscular transmission characterized by fatigable mu

72 This is a disorder of neuromuscular transmission characterized by non-progress

73 muscle degeneration and dystrophy, impaired neuromuscular transmission contributes to muscle weaknes

74 otility indicating that decreased purinergic neuromuscular transmission could contribute to the infla

75 petitive nerve stimulation pointed towards a neuromuscular transmission defect.

76 NMJ maturation, led to NMJ fragmentation and neuromuscular transmission deficits.

77 patients with apparent distal myopathy for a neuromuscular transmission disorder and agrin mutations.

78 Myasthenia gravis (MG) is an autoimmune neuromuscular transmission disorder characterized by los

79 Myasthenia gravis (MG) is a neuromuscular transmission disorder in which damage to a

80 ectable autoantibodies and confirmation of a neuromuscular transmission disorder relies on specialize

81 tial for sustaining phasic release, and thus neuromuscular transmission, during and following tetanic

82 avis (MG), an autoimmune disease that causes neuromuscular transmission dysfunction.

83 Neuromuscular transmission, electromyography (EMG), and

84 Cholinergic overactivity in diseases of neuromuscular transmission elicits a retrograde signal r

85 ve evidence of any significant impairment in neuromuscular transmission, even when animals were maint

86 Neuromuscular transmission failure increased and the EMG

87 Neuromuscular transmission failure significantly increas

88 tibody positive myasthenia gravis results in neuromuscular transmission failure since MuSK antibodies

89 nd AChR function as well as those that cause neuromuscular transmission failure upon Ab binding.

90 Maximal specific force and neuromuscular transmission failure were assessed at 6, 1

91 TrkB kinase activity had similar effects on neuromuscular transmission failure, supporting a critica

92 ysiological methods revealed that functional neuromuscular transmission first occurs quite early duri

93 of the CSP gene causes impaired presynaptic neuromuscular transmission in Drosophila melanogaster, i

94 confers a marked temperature-sensitivity to neuromuscular transmission in postnatal day 14 (P14)-P21

95 The depressed neuromuscular transmission in R6/2 muscle may help compe

96 This study was undertaken to investigate neuromuscular transmission in regions of the inflamed co

97 We conclude that impaired neuromuscular transmission in these LGM patients results

98 Our examination of neuromuscular transmission in this study reveals defects

99 single-fibre EMG studies indicated unstable neuromuscular transmission in two patients.

100 Chemical signaling in autonomic neuromuscular transmission involves agents that function

101 We conclude that the temperature-sensitive neuromuscular transmission is accounted for solely by a

102 Our studies show that zebrafish neuromuscular transmission is also sensitive to omega-co

103 Thus, neuromuscular transmission is compromised because cation

104 Thus, neuromuscular transmission is compromised by AChR defici

105 The safety margin of neuromuscular transmission is compromised by AChR loss f

106 We show that this TS inhibition of neuromuscular transmission is correlated with a block of

107 the normal situation, the safety factor for neuromuscular transmission is ensured by the large INa a

108 These mice, in which neuromuscular transmission is mediated by fetal AChR, li

109 hich muscle weakness resulting from impaired neuromuscular transmission is often present from infancy

110 A long-held tenet of neuromuscular transmission is that calcium-dependent neu

111 ectrum of clinical features where deficit in neuromuscular transmission is the major component in a s

112 henia gravis (MG), an autoimmune disorder of neuromuscular transmission, is treated by an array of im

113 In either case, it is thought that neuromuscular transmission may be provided partly or ent

114 s contributes to the reduction in purinergic neuromuscular transmission measured in animal models of

115 polypeptide (VIP) participates in inhibitory neuromuscular transmission (NMT) in the internal anal sp

116 neurophysiological studies suggest abnormal neuromuscular transmission occurs in some cases of Mille

117 mutating gap junction proteins and blocking neuromuscular transmission on the synchrony of action po

118 Neurophysiology showed abnormal neuromuscular transmission only in the affected muscles

119 slow MyHC gene expression did not occur when neuromuscular transmission or depolarization was blocked

120 a clinical hallmark of LES, facilitation of neuromuscular transmission produced by vigorous voluntar

121 in guinea pig, leads to decreased purinergic neuromuscular transmission resulting in a reduction in i

122 agnostic studies evaluating for disorders of neuromuscular transmission should focus on proximal limb

123 Inherited disorders of neuromuscular transmission, termed congenital myasthenic

124 gravis (MG) is a well-recognised disorder of neuromuscular transmission that can be diagnosed by the

125 tion of this effect to the safety factor for neuromuscular transmission, the ratio of the normal quan

126 acetylcholine receptors (AChRs) that impair neuromuscular transmission, thereby causing muscle weakn

127 ity of roscovitine, known to potentiate frog neuromuscular transmission, to mediate behavioral and fu

128 Sympathetic neuromuscular transmission was achieved by electrical fi

129 Neuromuscular transmission was improved following BDNF a

130 Low frequency (0.4 Hz) neuromuscular transmission was measured as well as the o

131 Neuromuscular transmission was significantly impaired in

132 Purinergic neuromuscular transmission was significantly restored in

133 further insight into how these drugs affect neuromuscular transmission, we investigated their effect

134 r, although deficits in nerve conduction and neuromuscular transmission were observed in myd animals,

135 autoimmune syndrome caused by the failure of neuromuscular transmission, which results from the bindi

136 ividual as progressive weakness and impaired neuromuscular transmission without overt degeneration of