ライフサイエンスコーパス: neuron

1 vely the multisensory transform used by each neuron.

2 s in clusters and the same nearby excitatory neurons.

3 and depletion of GABAergic and glutamatergic neurons.

4 tated by optogenetically activating dopamine neurons.

5 n ventral tegmental area (VTA) dopamine (DA) neurons.

6 kinase in the epigenic activation of MOR in neurons.

7 ow these two modalities converge in the same neurons.

8 anding of this functionally complex group of neurons.

9 s comprised of a heterogeneous population of neurons.

10 eliminates the burst firing potential of Re neurons.

11 oss of approximately 60% of layer VI A1-MGBv neurons.

12 reliably evoked spiking in SNc dopaminergic neurons.

13 artners shapes the responses of postsynaptic neurons.

14 omatin histone modification H3K4me2 in mouse neurons.

15 ransient outward currents in developing MNTB neurons.

16 in axonal reinnervation of the lumbar motor neurons.

17 e in retinal ganglion cells (RGCs) and other neurons.

18 ure and increased spontaneous firing of 5-HT neurons.

19 ce in gamma-aminobutyric acidergic forebrain neurons.

20 ctional analyses of this important system of neurons.

21 ave reduced glutamatergic innervation of OLM neurons.

22 cally mimicking the communication among real neurons.

23 occurs in dorsal root ganglia (DRG) sensory neurons.

24 restoration of Zfp106 specifically in motor neurons.

25 ns, but not 5-HT2CR expressing dopamine (DA) neurons.

26 ritic spines of mouse dorsal hippocampal CA1 neurons.

27 higher, respectively, than those of adapting neurons.

28 ose but similar numbers of catecholaminergic neurons.

29 lation that control the activity of dopamine neurons.

30 n microscopy to target fluorescently labeled neurons.

31 cord and oxidative DNA damage in dorsal horn neurons.

32 the basal spike firing in olfactory sensory neurons.

33 ing late indirect (I) waves in corticospinal neurons (4.3 ms; I-wave protocol) or at an interstimulus

34 Silencing CYLD in hippocampal neurons abolishes NMDA-induced chemical long-term depres

35 e capable of recording from large numbers of neurons across multiple local circuits and, importantly,

36 at Atg7 and Atg16L1 were up-regulated in the neurons after SE, together with an increase in autophago

37 f cells located in the brain, the AVM001b/2b neurons, also rescued the locomotion and motor defects,

38 enerated by calpain cleavage, in the sensory neuron and L7 are required to maintain each form of LTF.

39 rvation of myelinated white matter and motor neurons and an increase in axonal reinnervation of the l

40 ability to periodically reactivate in those neurons and be transported back to the body surface.

41 required for robust axon regeneration of DRG neurons and behavioral recovery.

42 mical heterogeneity of midbrain dopaminergic neurons and contribute to a better understanding of this

43 re, we examined Drosophila olfactory sensory neurons and found that inhibitory odors triggered outwar

44 suggest that cell autonomous changes in both neurons and glia may contribute to C9orf72-mediated dise

45 as the tight relationship between activated neurons and hemodynamic responses, is a fundamental brai

46 ith validation in additional mouse and human neurons and multiple learning tests from 1486 rats ident

47 vated (BK) channels are broadly expressed in neurons and muscle where they modulate cellular activity

48 te-1 phosphorylated at serine residue 312 in neurons and oligodendrocytes in the putamen of patients

49 ively labeled noxious-stimulus-activated PBL neurons and performed comprehensive anatomical input-out

50 rus establishes latent reservoirs in sensory neurons and persists for life.

51 nd whole cell transcriptomes in mouse single neurons and provided a normalization strategy to reduce

52 therapy by expressing DAT selectively in DA neurons and terminals, resulting in the rescue of aberra

53 ha-syn conformers in human midbrain dopamine neurons and tested their contribution to the aggregation

54 l role in neuronal morphogenesis in placodal neurons and that early defects are associated with ASD-a

55 and axon compartments of peripheral sensory neurons and the 3' untranslated region (3'UTR) landscape

56 ction electron microscopy to reconstruct PNS neurons and their hitherto unknown synaptic networks in

57 palette of histological methods we describe neurons and their neuropils most immediately associated

58 the function of individual subpopulations of neurons and ultimately brain circuits is largely unknown

59 ropagation of action potential within single neurons, and validate the imaging technique with the tra

60 ubstantia nigra pars compacta (SNc) dopamine neurons are a key node in the circuitry that drives addi

61 Not all catecholaminergic neurons are activated and other neurochemical content is

62 the hypothesis that SST-immunoreactive (IR) neurons are decreased in the amygdala of subjects with S

63 ffects of anti-epileptic drugs on individual neurons are difficult to separate from their network-lev

64 gamma activity (HGA) in cortical areas where neurons are heterogeneous in selectivity and temporal re

65 These neurons are heterogeneous, and distinct subsets are thou

66 show that thirst-promoting subfornical organ neurons are negatively reinforcing and that this negativ

67 ed in PD patients, which suggests that these neurons are not involved in the pathogenesis or the gast

68 r to those we found experimentally, model RT neurons are predisposed to an activity-dependent switch

69 how that brief optogenetic inhibition of BLA neurons around moments of aversive reinforcement or nonr

70 a defect in repetitive firing of lower motor neurons as a novel contributor to intensive care unit ac

71 nd neuropeptidergic signaling in hippocampal neurons as a novel substrate of importance in the higher

72 NTS: Intracellular pH regulation is vital to neurons as nerve activity produces large and rapid acid

73 x (mPFC), particularly deep-layer projection neurons, as a potential locus for autism pathology.

74 These findings suggest a new type of neuron-astrocyte communication, based on the expression

75 In association with prominent Purkinje neuron atrophy, repetitive spiking is restored, although

76 d to underlie the transient inhibition of DA neurons attributed to activation of the LHb.

77 In cultured dorsal spinal neurons, blockade of Kv3.4 by blood depressing substance

78 ed that TBPH mutants displayed reduced motor neuron bursting and coordination during crawling and res

79 atrophy (SMA) is caused by the loss of motor neurons, but astrocyte dysfunction also contributes to t

80 rmed RNA-seq on purified peripheral afferent neurons, but found no striking differences in gene expre

81 CR expressing gamma-aminobutyric acid (GABA) neurons, but not 5-HT2CR expressing dopamine (DA) neuron

82 Restraint stress or optogenetic C1 neuron (C1) stimulation (10 min) protected mice from isc

83 a marine worm reveals how simple networks of neurons can control behavior.

84 old, age-associated, aggregated proteins in neurons can induce inflammation, resulting in multiple f

85 We demonstrate that individual modulatory neurons can integrate neuron class-specific input from t

86 Neurons can last a lifetime, but proteins turn over rapi

87 motor commands, but how a network of spiking neurons can learn non-linear body dynamics using local,

88 aging in humans, as linear sums of groups of neurons (channels) tuned for visual stimulus properties.

89 individual modulatory neurons can integrate neuron class-specific input from their target network, w

90 The anatomically defined neuron classes connecting the AOTU, BU, and EB represent

91 ystem organization is the diversification of neuron classes into subclasses that share large sets of

92 in distant neurons superimposed upon that of neurons close to the recording electrode.

93 Neurons co-storing glutamate and dopamine were found to

94 eurological disorders.SIGNIFICANCE STATEMENT Neurons communicate with multiple targets by forming axo

95 nly in dopamine release but also in dopamine neuron connectivity, cotransmission, modulation, and act

96 ockout-layer 5 subcortically projecting (SC) neurons consistently exhibit reduced input resistance an

97 upregulation in mouse prefrontal projection neurons consistently resulted in enhanced cognitive perf

98 nificant proportion of Lewy bodies in nigral neurons containing SUMO1 and PIAS2.

99 mprove their derivation and predict dopamine neuron content after engraftment.

100 ticulospinal neurons project to spinal motor neurons controlling hand muscles and extensively sprout

101 gap, we asked whether activation of PZ(Vgat) neurons could attenuate or block the wake-promoting effe

102 Motion-induced neuron deformation and damage are associated with severa

103 at Zfp106 knockout mice develop severe motor neuron degeneration, which can be suppressed by transgen

104 Together, these data indicate that neuron-derived E2 modulates synaptic plasticity in roden

105 Noting that DMV neurons display extensive alpha-synucleinopathies earlie

106 hippocampal cornu ammonis 1 and granule cell neurons, effects that were also observed in aged mice, a

107 Neurons electroporated with a shRNA targeting IGF-1 rece

108 at have been associated with increased motor neuron excitability and decreased inhibition.

109 a result, loss of GIRK function can enhance neuron excitability, whereas gain of GIRK function can r

110 llectively, these findings suggest that 5-HT neurons exert a frequency-dependent, cell-type-specific

111 Neocortical inhibitory neurons exhibit remarkably diverse morphology, physiolog

112 Mice lacking GIRK channels in DA neurons exhibited increased locomotor activation in resp

113 We found that sensory neurons express major proteins necessary for GABA synthe

114 -stimulating fasting-responsive hypothalamic neurons expressing agouti-related peptide (AgRP) and neu

115 to selectively activate or inhibit ArcN NPY neurons expressing agouti-related peptide (AgRP) in mice

116 hanisms by which distinct populations of RVM neurons facilitate or diminish pain remain elusive.

117 e mice, and induction of Cadm1 in excitatory neurons facilitated weight gain while exacerbating energ

118 Current-clamp revealed GnRH neurons fired more action potentials in response to curr

119 These neurons form an anterior neurosecretory center expressin

120 n experiments that Kenyon cells and dopamine neurons from axoaxonic reciprocal synapses.

121 se inhibitor, enables adult mice to generate neurons from MG after retinal injury.

122 activation of cultured dorsal root ganglion neurons from mice.

123 In cerebellar Purkinje neurons from postnatal day 30 Snord116p-/m+ mice the red

124 an expression system, and protected cortical neurons from slow excitotoxic injury in vitro, without i

125 ssium current observed in cortical pyramidal neurons from wild type mice was conspicuously reduced in

126 aken together, synaptic recruitment of young neurons generates sparse and orthogonal AP firing, which

127 Neurons have adapted their endosomal system to meet thei

128 Its neurons have bipolar extension of dendrites, which recei

129 hese results imply that electrically coupled neurons have distinct sets of mechanisms for adjusting c

130 tudies of multisensory integration by single neurons have traditionally emphasized empirical principl

131 ced increase in Rac1 activity in hippocampal neurons; however, the identity of an antagonistic GAP re

132 lated emission depletion (STED) nanoscopy in neurons, human fibroblasts, U2OS, and HeLa cells.

133 In contrast, the number of inputs per neuron in cerebral cortex is more uniform and large.

134 Glutamatergic inputs to neurones in the inferior olive generate bidirectional po

135 e the electrophysiological properties of DMV neurons in A53T-SNCA mice.

136 Spiking patterns of single neurons in both core and shell subregions during singing

137 asal firing rate and the excitability of LHb neurons in brain slices was higher, whereas the amplitud

138 lex, and tools for characterizing early-born neurons in central complex function.

139 Many of the neurons in early visual cortex are selective for the ori

140 by measuring electrical activity from single neurons in experimental sessions.

141 human disease-with progressive loss of motor neurons in heterozygous animals.

142 aimed to understand the cell-source for new neurons in infectious and inflammatory colitis.

143 (PVN) are mediated via actions on local OXT neurons in male Wistar rats.

144 le-cell patch clamp recordings from auditory neurons in mature (2-4 months) and aged (20-26 months) m

145 ker, Neuromedin B mRNA (Nmb), identifies RTN neurons in rodents.

146 Decreased SST-IR neurons in the amygdala of patients with SZ and BD, inte

147 re we investigate functional diversity among neurons in the anterior fundus (AF) face patch, combinin

148 serve to amplify and sharpen the response of neurons in the barrel cortex to incoming sensory input s

149 useful for imaging other structures, such as neurons in the brain.

150 e dismutase (SOD1) selectively affects motor neurons in the central nervous system (CNS), causing the

151 ard excitation in liver-related hypothalamic neurons in the diabetic condition.

152 e used simultaneous recordings from multiple neurons in the hippocampus and neocortex of rats with ch

153 ionary changes in the size and the number of neurons in the human nervous system, as well as the cell

154 ion in a small subpopulation of FOS-positive neurons in the NAc.

155 PV1 expression and excitation of laryngeal C neurons in the nodose/jugular (N/J) ganglia.

156 ses of breathing are controlled by brainstem neurons in the preBotzinger complex (preBotC) and the re

157 s (alpha4beta2-nAChR) enhanced the firing of neurons in the primate prefrontal cortex that subserve t

158 tional saliency model with the activation of neurons in the primate superior colliculus (SC), a midbr

159 Activation of GABAergic neurons in the rostromedial tegmental nucleus (RMTg), a

160 ropathological hallmark of HD is the loss of neurons in the striatum and, to a lesser extent, in the

161 Dopamine neurons in the substantia nigra pars compacta and ventra

162 can shape the receptive field properties of neurons in the ventral division of the medial geniculate

163 Dopaminergic (DA) neurons in the ventral tegmental area (VTA) mediate the

164 Here we recorded neurons in three color patches, middle color patch CLC (

165 "Utah" arrays to record from populations of neurons in V1 and V2.

166 out the functional development of individual neurons in vivo.

167 Most neurons in VPM respond to touch and also show an increas

168 brain region that is rich in neurosecretory neurons, including those that secrete some of the Drosop

169 inhibition of rostral raphe pallidus (rRPa) neurons influences thermogenesis of brown adipose tissue

170 ns of the RMTg reduced both the number of DA neurons inhibited by, and the duration of inhibition res

171 In some contrast, activation of PZ(Vgat) neurons inhibited the behavioral, but not electrocortica

172 cortical connectivity, prefrontal projection neurons innervate subcortical structures that contribute

173 recruits negatively reinforcing dopaminergic neurons innervating the same compartment and re-engages

174 Our results support the view that striatal neurons integrate medial frontal activity and are consis

175 how that the differentiation into such a hub neuron involves the sex-specific scaling of several comp

176 TRPV1 is blocked, glutamatergic input to OLM neurons is dramatically reduced.

177 we show that the transcriptional response in neurons is exquisitely sensitive to the temporal nature

178 CTCF deficiency in embryonic neurons is lethal in mice, but mice with postnatal CTCF

179 Neurons lacking FMRP show aberrant mRNA translation and

180 tation had a pathogenic impact on projection neuron laminar allocation by reducing protein expression

181 consistent with the distribution of cortical neuron latencies and that temporal motion integration fo

182 sis of conscious volition down to the single-neuron level.

183 GDF15 activates GFRAL-expressing neurons localized exclusively in the area postrema and n

184 stinct subtypes of mesodiencephalic dopamine neurons located in the substantia nigra pars compacta an

185 mice have an ovoid core of medium-sized Bar neurons located medial to the locus coeruleus (LC).

186 and release of miR-21 contribute to sensory neuron-macrophage communication after damage to the peri

187 We show that patient-derived placodal neurons make fewer synapses than control cells.

188 vealing that developmentally defined sets of neurons may differentially participate in hedonic aspect

189 y affected by the states of primary afferent neuron mechanics.

190 junction (NMJ) dysfunction and spinal motor neuron (MN) loss.

191 s (FPs) may reflect the synaptic currents of neurons near the recording electrode, due to the use of

192 We further show that neuron numbers impact overall interconnectivity as the p

193 brane mechanics of cultured primary afferent neurons of the dorsal root ganglia (DRG).

194 and GABA (gamma-aminobutyric-acid)-releasing neurons of the lateral hypothalamus, which promote the t

195 ojections from reward-sensitive dopaminergic neurons of the midbrain ventral tegmental areas.

196 ate chemoarchitectural differences in ERbeta neurons of the mouse PVN that are different from that pr

197 rize angiotensin type-1a receptor-containing neurons of the paraventricular nucleus of the hypothalam

198 Neurons of the rostral ventromedial medulla (RVM) are th

199 gment dispersing factor (PDF) cell-pacemaker neurons; only mir-92a peaks during the night.

200 l connections, after injury to clear damaged neurons, or pathologically during disease.

201 Cilia on dendritic endings of sensory neurons organize distinct types of sensory machinery [1]

202 To phenotype OT-receptor (OTR) expressing neurons originating within the VTA, we delivered Cre-ind

203 ensor since its peripheral olfactory sensory neurons (OSNs) respond to the external stimuli and trans

204 ural coding of odorants by olfactory sensory neurons (OSNs), primary sensory neurons that physically

205 ow stable tracking of the evolution of these neurons over the entire course of study.

206 In this issue of Neuron, Padamsey et al. (2017) demonstrate that neuronal

207 ke regulation of daf-7 expression in the ASJ neuron pair reveals a hierarchy of regulation among mult

208 ceptors on the membrane of olfactory sensory neurons, plays a vital role in their host seeking and ri

209 densely innervated glutamatergic projection neurons (PNs) with apparently random connectivity.

210 were unable to form an axon and, therefore, neuron polarity was absent.

211 The new neurons predominantly express calretinin, thus appear to

212 Non-adapting neurons presented frequencies of spontaneous inhibitory

213 Finally, in a cortical neuron primary culture, both Nanobodies were able to inh

214 lation of glutamatergic median preoptic area neurons produced a profound hypothermia due to cutaneous

215 Reticulospinal neurons project to spinal motor neurons controlling hand

216 eriments, we found that a proportion of vCA1 neurons projected to both the mPFC and amygdala and were

217 LHb neurons projecting to the ventral tegmental area (VTA)/r

218 Neurons promote the growth of cancers of the brain, skin

219 e increased firing of active dentate granule neurons rapidly and robustly.

220 Although both types of neurons receive direct input from entorhinal cortex onto

221 R neurons recruit both GABA and GABA-A receptors to their

222 GABA synthesis and release and that sensory neurons released GABA in response to depolarization.

223 7 or overexpression of PERK-K618A in primary neurons rescues the loss of dendritic outgrowth and numb

224 rode recordings to investigate how single GC neurons respond to intraorally delivered tastants and ta

225 re combined to modulate how strongly sensory neurons respond to mechanical force.

226 r RE1-silencing transcription (also known as neuron-restrictive silencer factor) to position 509 of t

227 g is sensitive to inactivation of adult-born neurons, revealing that developmentally defined sets of

228 role of the JNK pathway in VZV infection of neurons reveals potential avenues for the development of

229 spiking and the frequency dependence of the neuron's transfer function determine whether synchronous

230 , a decrease in inhibitory afferents to MNTB neurons should lead to greater inhibitory output to the

231 Based on this mapping, neighboring neurons showed markedly different affiliation with dista

232 y in the Class IV multidendritic nociceptive neuron, significantly attenuated ultraviolet injury-indu

233 A) is caused by diminished Survival of Motor Neuron (SMN) protein, leading to neuromuscular junction

234 However, the protracted timing of human neuron specification and functional maturation remains a

235 receptor-containing; D1R-) spiny projection neurons (SPNs) co-release the opioid neuropeptide dynorp

236 edes dendritic arborization of primary motor neurons, suggesting that the structured neuropil could p

237 collection of brain targets of Galphat-S-ir neurons, suggesting they might mediate non-visual modula

238 panying reduction in untransfected GABAergic neurons suggests hampered intercellular communication.

239 duction, FPs may reflect activity in distant neurons superimposed upon that of neurons close to the r

240 the associated protomer was also observed in neurons, supporting the physiological relevance of 5-HT2

241 on reduces axonal TrkA levels and attenuates neuron survival and target innervation under limiting NG

242 Dopamine neuron synaptic actions vary across the striatum, involv

243 Hydralazine activated more neurons than 2-deoxyglucose but similar numbers of catec

244 ing to identify a class of cutaneous sensory neurons that are selectively activated by high-threshold

245 ntly function better than similarly stressed neurons that did not produce exophers.

246 Proteotoxically stressed neurons that generate exophers subsequently function bet

247 rom stem cells have the potential to replace neurons that have already been lost and thereby to resto

248 ein kinase A dopamine signaling in pyramidal neurons that in turn pathologically recruits l-type Ca(2

249 tory sensory neurons (OSNs), primary sensory neurons that physically contact odor molecules in the no

250 Because many of the PBel neurons that respond to CO2 express calcitonin gene-rela

251 BK and SK channels in inferior olivary (IO) neurons that send climbing fibers to innervate cerebella

252 ed that neurite outgrowth from adult sensory neurons that were maintained under subsaturating neurotr

253 travel time by comparing for individual MSO neurons the best difference in arrival times, as predict

254 icity, and survival of midbrain dopaminergic neurons, the dysfunction of which contributes to various

255 nics which adopt the fractal geometry of the neurons they interface with.

256 ld coherence of a rat primary motor cortical neuron to the LFP theta rhythm.

257 These findings highlight the capacity of DA neurons to act as metabolic sensors by responding not on

258 Thus, we identified the sublateral SIA neurons to control the three-dimensional movements of fl

259 ability abolished the spacing effect and led neurons to decode distinct stimulation patterns as masse

260 notype, suggesting that Myt1l allows newborn neurons to escape Notch activation during normal develop

261 se cytokines regulate central nervous system neurons to induce sleep.

262 ecifically allows dendrites of space-filling neurons to innervate all target tissues in Drosophila.

263 Here we analyse responses of V2 neurons to natural stimuli and find three organizing pri

264 -engages positively reinforcing dopaminergic neurons to reconsolidate the original reward memory.

265 rine signals act on receptors in hippocampal neurons to reduce (leptin, glucagon-like peptide-1) or i

266 s two opposing actions in cortical pyramidal neurons: transient inhibition and longer-lasting excitat

267 Inferior olivary neurons transmit their signals via climbing fibres, whic

268 ously reported that embryonic motor cortical neurons transplanted immediately after lesions in the ad

269 lobulin (Ig) domain, instructs the distinct, neuron-type-specific elaboration of ciliated endings of

270 Using calcium imaging, we found that these neuron types are not directionally selective and that se

271 n of ciliated endings of different olfactory neuron types in the nematode C. elegans.

272 revealed Cadm1-positive innervation of POMC neurons via afferent projections originating from beyond

273 contributes to neuronal death in hippocampal neurons via diverse effects on NADPH oxidase activity an

274 eased excitability of layer II/III pyramidal neurons was accompanied by consistent reductions in volt

275 king monkeys, evoked firing of OFC pyramidal neurons was reduced, whereas the amplitude and frequency

276 sistent activity of hippocampal and amygdala neurons was stimulus-specific, formed stable attractors

277 mmature interneurons to those of more mature neurons, we identified genes important for human interne

278 of the GLP-1 receptor in the single-minded 1 neurons, we show dependence of paraventricular nucleus G

279 Using two-photon imaging of large groups of neurons, we show that multisensory modulation of V1 popu

280 Cholinergic ChAT-ir neurons were also found within transitional cortical are

281 We found that submucous neurons were not affected in PD patients, which suggests

282 Firing rates of some neurons were phasically selective for conditioned stimul

283 o probes, more than 700 well-isolated single neurons were recorded simultaneously from five brain str

284 In addition, action potentials in fmr1(-/y) neurons were significantly larger, faster and narrower.

285 ded on which room the rat was in; nearly all neurons were tonically selective for environments in a w

286 This ability is particularly critical in neurons, which comprise vast, highly differentiated doma

287 unication, based on the expression of AE3 in neurons, which could explain how AE3 reduces seizure sus

288 omposed of fast-spiking, putative inhibitory neurons, which displayed unusually strong coupling to lo

289 transcription in dorsal root ganglion (DRG) neurons, which may contribute to nerve injury-induced ne

290 nto immature rat lamina I spino-parabrachial neurons, which serve as a major source of nociceptive tr

291 a-synucleinopathies earlier than SN dopamine neurons while exhibiting milder cell loss in PD, we aime

292 en excitation and inhibition in VTA dopamine neurons, while PDE4 inhibition reestablishes the balance

293 How an adult-born neuron with initially simple spindle-like morphology dev

294 ng in vivo Ca(2+) imaging of dentate granule neurons with a novel, unrestrained virtual reality syste

295 av-1 on structural plasticity of hippocampal neurons with age.

296 l working memory that employs populations of neurons with conjunction responses.

297 hts the suitability of iPSC-derived cortical neurons with SGCE mutations for myoclonus-dystonia resea

298 gene expression regulation, particularly in neurons with unique spatial constraints.

299 atch-clamp recordings from 6068 pairs of rat neurons with validation in additional mouse and human ne

300 to investigate the involvement of individual neurons within each neuronal class.

301 eriod of fluid delivery and are generated by neurons within the MFC.