ライフサイエンスコーパス: neuron-specific

1 The effect is neuron specific.

2 cyclodextrin had no effect on transcripts of neuron-specific 24-hydroxylase, and its product 24(S)-hy

3 ssociative memories is elicited by inducible neuron-specific ablation of Nptn gene expression in adul

4 we generated and compared Schwann cell- and neuron-specific ablation of Perk in S63del nerves.

5 mice with pan-neuron-specific or cholinergic neuron-specific ablation of the cpeb2 gene.

6 Here we show that global and sensory neuron-specific ablation of the mechanically activated i

7 d putrescine increase expression of p35, the neuron-specific activator of Cdk5, and rat DRG neurons t

8 inct set of transcription factors, including neuron-specific activity-dependent factors.

9 The discovery of a neuron-specific adhesion molecule as an EV-D68 receptor

10 ally-directed sparse labeling with a sensory neuron-specific alkaline phosphatase reporter.

11 the past few years, mutations in a number of neuron-specific alpha- and beta-tubulin genes have been

12 encodes aPKC-zeta and PKM-zeta, a truncated, neuron-specific alternative transcript, and Prkcl encode

13 described a unique neuroprotective role for neuron-specific alternatively spliced isoforms of endoph

14 Together, neuron-specific and canonical IIS/FOXO-regulated targets

15 While the constitutive/neuron-specific and conditional/ubiquitous overexpressio

16 Both neuron-specific and GABA-specific recombination of the P

17 expression, yielded large sets of predicted neuron-specific and non-neuron-specific genes.

18 type-specific expression of circular RNAs-a neuron-specific and nuclear-enriched RNA arising from th

19 uirement for HSF-1 in this phenotype was IL2 neuron-specific and required the downstream expression o

20 icating that neuronal aging is an intrinsic, neuron-specific, and genetically regulated process.

21 s to glial-specific (antikeratin) as well as neuron-specific (anti-Hu) antigens, indicating that both

22 ether, these data identify OXR1 as the first neuron-specific antioxidant modulator of pathogenesis an

23 These human NSC-derived neurons express the neuron-specific APP(695) splice variant, BACE1, and all

24 Using neuron-specific approaches to measure and manipulate kin

25 Neuron-specific AR signaling was required for the develo

26 These effects are neuron specific, as PS1 affects the EGFR of neither glia

27 Postmitotic neurons express a neuron-specific assembly, nBAF, characterized by the neu

28 Neuron-specific associations of the ArPIKfyve-Sac3 heter

29 We have defined the kinetics of neuron-specific BAF complex assembly in the formation of

30 We generated ubiquitous and neuron-specific Bcl7a and Bcl7b single and double knocko

31 In addition, protein levels of class III neuron-specific beta-tubulin and microtubule-associated

32 re/LoxP technology was used to generate GnRH neuron-specific beta1-integrin conditional KO (GnRH-Itgb

33 -140 during rat neurosphere differentiation, neuron-specific beta3-tubulin and enolase expression was

34 Using neuron-specific betaarr2-KO mice, we show that the antip

35 ctions may relate to the presence of longer, neuron-specific Bif-1 isoforms, because only these forms

36 s, confirming Arc-dVenus to be an excitatory neuron-specific but non-layer-specific activity reporter

37 promoter, and two versions of the excitatory neuron-specific Ca(2+) /calmodulin-dependent kinase subu

38 t dynamin-1 (Dyn1), previously assumed to be neuron-specific, can be selectively activated in cancer

39 a neuron-derived exosomes (NDEs), containing neuron-specific cargo, has permitted characterization of

40 The neuron-specific cation chloride cotransporter KCC2 plays

41 Neuron-specific caveolin-1 overexpression improves motor

42 nd others showed that mutations in the major neuron-specific CerS1, which synthesizes 18-carbon fatty

43 ar chaperones; however, our understanding of neuron-specific chaperones and their involvement in the

44 regulate cell survival, differentiation, and neuron-specific characteristics.

45 f cells of neuronal phenotype, identified by neuron-specific class III beta-tubulin (TUJ-1) labeling,

46 In contrast to Drp1, the neuron-specific classical dynamin dynamin-1 (Dyn1) has b

47 d an adult forebrain-specific and excitatory neuron-specific conditional knock-out mouse line, and de

48 Our results show neuron-specific conditional plasticity for actively firi

49 Ubiquitin C-terminal hydrolase-L1 (UCHL1), a neuron-specific de-ubiquitinating enzyme, is one of the

50 In addition, contrary to expectations, its neuron-specific deletion in mice resulted in development

51 imals with GABA-neuron-specific or glutamate-neuron-specific deletion of Esr1.

52 Using genetic strategies enabling neuron-specific deletion of estrogen receptor alpha (Esr

53 but molecular and cellular phenotypes after neuron-specific deletion of H3K4 methyl-regulators remai

54 l deletion of Kiss1r (Kiss1r(-/-)) or a GnRH neuron-specific deletion of Kiss1r (Kiss1r(d/d)) display

55 Mice with neuron-specific deletion of LPL have increases in food i

56 Neuron-specific deletion of Notch genes decreased these

57 Arcuate proopiomelanocortin (POMC) neuron-specific deletion of Ptpn1 causes a similar, but

58 ith a neurogenic origin of these phenotypes, neuron-specific deletion of Scyl2 also caused perinatal

59 However, loss of AIS proteins by the neuron-specific deletion of the master AIS scaffold Anky

60 e enhanced following global, but not sensory neuron-specific, deletion of maternal Ube3a in mice.

61 in the ubiquitously expressed DYNC1H1 cause neuron-specific disease.

62 er's disease and observed that expression of neuron-specific endophilin-B1 isoforms declined with dis

63 cortical neuron cultures, overexpression of neuron-specific endophilin-B1 isoforms protected against

64 Additionally, protein and mRNA levels of neuron-specific endophilin-B1 isoforms were also selecti

65 ease pathogenesis where amyloid-beta reduces neuron-specific endophilin-B1, which in turn enhances am

66 We found that rs31746 mapped to a long-range neuron-specific enhancer element shown previously to reg

67 ption factors (TFs), Isl1 and Lhx3, to motor-neuron-specific enhancers.

68 rs progastrin releasing peptide (ProGRP) and neuron specific enolase (NSE) is presented, which involv

69 cularly imprinted electrochemical sensor for neuron specific enolase (NSE) was developed by electroch

70 lpropyl)imidazolium bromine ionic liquid and neuron specific enolase (NSE).

71 duced increases in serum S100beta, GFAP, and neuron specific enolase.

72 urden, plasma chromogranin A (>/=600 mug/L), neuron-specific enolase (>/=25 mug/L), and classic gradi

73 tio, 5.58; 95% CI, 2.56-12.16), and elevated neuron-specific enolase (false-positive rate, 0.12; 95%

74 Serum levels of neuron-specific enolase (NSE) and neuron-enriched S100 b

75 Neuron-specific enolase (NSE) is a biomarker for neurona

76 Neuron-specific enolase (NSE) is a widely-used biomarker

77 has been successfully used for detection of neuron-specific enolase (NSE), a traumatic brain injury

78 ks were analyzed for the neuromarkers S100B, neuron-specific enolase (NSE), and glial fibrillary acid

79 Tau had higher accuracy than serum neuron-specific enolase (NSE; the area under the receive

80 /chemokine (C-C motif) ligand 2 (p = 0.030), neuron-specific enolase (p = 0.006), and S100b (p = 0.01

81 tivariate analysis, markedly elevated plasma neuron-specific enolase (P = 0.016; hazard ratio, 2.9; 9

82 orrelated with 1- and 4-hr postresuscitation neuron-specific enolase (r = -.86, p < .001 and r = -.87

83 uantitative PLR correlated with higher serum neuron-specific enolase (Spearman r = -0.52, p < 0.0001)

84 concentrations peaked earliest, followed by neuron-specific enolase and finally myelin basic protein

85 Finally we identified two TMs (neuron-specific enolase and pro-gastrin-releasing peptid

86 Serum neuron-specific enolase and S100b concentrations were in

87 eviously characterized biomarkers, including neuron-specific enolase and S100B protein.

88 al tau, S-100 calcium-binding protein B, and neuron-specific enolase concentrations in plasma and ser

89 Serum S100 beta (S100B) and neuron-specific enolase concentrations rise after brain

90 acy, defined as the geometric area under the neuron-specific enolase curve from 24 to 72 hours after

91 ignificant differences in the area under the neuron-specific enolase curve, or a composite end point

92 Confounders of neuron-specific enolase elevation should be actively con

93 Performance Category 1-2 had confounders for neuron-specific enolase elevation.

94 icant changes were detected in the levels of neuron-specific enolase from preseason values (median, 6

95 corneal reflexes, presence of myoclonus, and neuron-specific enolase greater than 75 microg/L; accura

96 All three patients with neuron-specific enolase greater than 90 mug/L and Cerebr

97 d case reviews of good outcome patients with neuron-specific enolase greater than 90 mug/L and poor o

98 Using best specificity, serum S100b and neuron-specific enolase had optimal positive and negativ

99 em reflexes in normothermia (p = 0.013), and neuron-specific enolase higher than 33 mug/L (p = 0.029)

100 Neuron-specific enolase is an easily available, observer

101 than 90 mug/L and poor outcome patients with neuron-specific enolase less than or equal to 17 mug/L (

102 The majority of 14 patients with neuron-specific enolase less than or equal to 17 mug/L w

103 e score), the tumor burden, and the baseline neuron-specific enolase level.

104 Exenatide did not reduce neuron-specific enolase levels and did not significantly

105 er S100B levels at all time points and lower neuron-specific enolase levels on days 1 and 3 compared

106 (a total of 137 lactate dehydrogenase and 77 neuron-specific enolase observations), the statistical f

107 equal to 25%, and a baseline plasma level of neuron-specific enolase of greater than 15 ng/mL indepen

108 electroencephalography reactivity, and serum neuron-specific enolase offers the best outcome predicti

109 inal cultures, subsequently characterized by neuron-specific enolase or glial fibrillary acidic prote

110 e overexpressing CatB under the control of a neuron-specific enolase promoter.

111 A neuron-specific enolase serum concentration greater than

112 An neuron-specific enolase serum concentration less than or

113 We analyzed neuron-specific enolase serum concentrations 3 days afte

114 Neuron-specific enolase serum concentrations less than o

115 High neuron-specific enolase serum concentrations reliably pr

116 Receiver operator curves for serum S100b and neuron-specific enolase to classify favorable versus unf

117 added value of the serum biomarkers S100 and neuron-specific enolase to clinical characteristics for

118 osensory evoked potentials (SSEP), and serum neuron-specific enolase were performed in parallel, as p

119 tion, electroencephalography reactivity, and neuron-specific enolase yielded the best predictive perf

120 y can potentially measure injury to neurons (neuron-specific enolase), astrocytes (S100b), and axons

121 Enrollment leptin, neuron-specific enolase, and intracellular cell adhesion

122 The baseline levels of chromogranin A, neuron-specific enolase, and multiple soluble angiogenic

123 Preliminary data show that serum S100b, neuron-specific enolase, and myelin basic protein may ai

124 serum biomarkers (matrix metallopeptidase-9, neuron-specific enolase, and vascular cellular adhesion

125 As compared to neuron-specific enolase, circulating microRNAs are modes

126 also measured fasting serum chromogranin A, neuron-specific enolase, gastrin, glucagon, vasoactive i

127 , somatosensory-evoked potentials, and serum neuron-specific enolase, is recommended; however, no stu

128 illary acidic protein, CD11b), and neuronal (neuron-specific enolase, neuronal nitric oxide synthase)

129 Elevated baseline chromogranin A, neuron-specific enolase, placental growth factor, and so

130 We measured serum neuron-specific enolase, S100b, and myelin basic protein

131 nt protein 1/chemokine (C-C motif) ligand 2, neuron-specific enolase, S100b, intercellular adhesion m

132 le outcome were 2.89 (95% CI, 1.09-7.73) for neuron-specific enolase, using a cutoff of 62.0 ng/mL, a

133 ase elevation should be actively considered: neuron-specific enolase-producing tumors, acute brain di

134 , somatosensory-evoked potentials, and serum neuron-specific enolase.

135 for the determination of microRNA levels and neuron-specific enolase.

136 fibrovascular tissue that did not stain for neuron-specific enolase.

137 previously reported biomarkers of acute IS (neuron-specific enolase: area under the curve=0.69; inte

138 However, neuron-specific Et2 knockout mice displayed a normal cor

139 ent that associate with DNA methylation of a neuron-specific exon 17 promoter of the glucocorticoid r

140 e alternative splicing of activity-dependent neuron-specific exons, and attenuation of normal differe

141 n the NPC-to-neuron transition by regulating neuron-specific exons.

142 eveloped a promoter that supports long-term, neuron-specific expression by fusing the chicken ss-glob

143 diversity is specified during development by neuron-specific expression of key transcription factors,

144 requires UBE3A-ATS expression, and no other neuron-specific factors.

145 Neuron-specific FMRP mutants revealed a requirement for

146 on and gentle touch, less is known about the neurons specific for mechanical pain.

147 er RNA (mRNA) and ribosomes are in a masked, neuron-specific form.

148 Unlike other neuron-specific Foxo1 knockout mice, Foxo1KO(Nkx2.1) mic

149 Combining primary sensory neuron-specific GCaMP3 imaging with a trigeminal neuropa

150 We used constitutive and neuron-specific gene ablation models targeting an integr

151 -compacted promoter/proximal enhancer of the neuron-specific gene doublecortin (Dcx) Once differentia

152 se neuronal regulators include the family of Neuron-Specific Gene family members (Nsg), NEEP21 (Nsg1)

153 t food abundance is encoded by combinatorial neuron-specific gene-expression of conserved TGFbeta and

154 , is required to maintain full repression of neuron-specific genes and for occupancy of the LSD1-CoRE

155 l recognized in ctenophores, many bilaterian neuron-specific genes and genes of 'classical' neurotran

156 Clusters of Hcrt-neuron-specific genes are predicted to be regulated by s

157 Products from some of these neuron-specific genes are present in peripheral blood, r

158 1 binding to known regulatory regions of the neuron-specific genes Dcx and Th days or even weeks befo

159 resses a large array of coding and noncoding neuron-specific genes important to synaptic plasticity i

160 s revealed lower expression of multiple 5-HT neuron-specific genes in BN compared to control Dahl sal

161 The neuron-specific genes Syt2, Cplx1, and Nefh were develop

162 is suggested that region-based clustering of neuron-specific genes was related to (i) a combination o

163 ge sets of predicted neuron-specific and non-neuron-specific genes.

164 ing to the identification of new STP and STN neuron-specific genes.

165 H3K27 acetylation and a robust activation of neuron-specific genes.

166 Sensory-neuron-specific genetic deletion/silencing or local or s

167 These results indicate a role for neuron-specific glutamate transporters in AMPAR synaptic

168 These studies reveal a neuron-specific glutathione defense mechanism that is es

169 s study, we generated and characterized AgRP neuron-specific Gpr17 knockout mice (Agrp-Gpr17(-/-)) to

170 In summary, AgRP neuron-specific Gpr17 knockouts phenocopy FOXO1 knockout

171 r CNG subunits, TAX-2 and TAX-4, a gustatory neuron-specific heteromeric CNG channel complex.

172 patients, is substituted by AP3beta3B in the neuron-specific heterotetramer.

173 We expressed neuron-specific (hSyn promoter) DREADDs that were either

174 Thus, we suggest that chkINA is a neuron-specific IF protein that may be a useful marker f

175 ilt a novel mouse model, combining inducible neuron-specific IGF-1R knock-out with AD transgenics.

176 age, in both mammals and C. elegans, but the neuron-specific IIS/FOXO targets that regulate these fun

177 ic, in keeping with observations that US9 is neuron specific.IMPORTANCE Herpes simplex virus (HSV) an

178 Although neuron-specific imprinting is thought to limit the disea

179 Due to neuron-specific imprinting, the paternal UBE3A copy is s

180 virus particles were novel because they were neuron specific, in keeping with observations that US9 i

181 Furthermore, using neuron-specific infusion of pharmacological agents and m

182 These mutant phenotypes cannot be rescued by neuron-specific inhibition of caspases, suggesting that

183 cific effects on anterograde run parameters, neuron-specific inhibition of mitochondrial transport by

184 We describe a new neuron-specific inhibitor of viral infections in the cen

185 alitis, yet little is known about the innate neuron-specific inhibitors of viral infections in the CN

186 Here we identify neuron-specific intercellular adhesion molecule 5 (ICAM-

187 By contrast, the expression of neuron-specific ion channels was considered to be highly

188 Dynamin-1, which was thought to be neuron specific, is activated by the Akt/GSK3beta signal

189 The neuron-specific isoform JNK3 is required for neuron dege

190 However, the role of the neuron-specific isoform JNK3 is unclear.

191 We found that a neuron-specific isoform of LSD1, LSD1n, which results fr

192 t studies suggest that dynamin-1, a presumed neuron-specific isoform of the large, membrane fission G

193 egulatory pathway allows the production of a neuron-specific isoform of unc-44 and an inhibitory isof

194 KCC2 is a neuron specific K(+)-Cl(-) co-transporter that controls

195 ne gradient of chloride, which is set by the neuron-specific K(+)-Cl(-) co-transporter KCC2.

196 KCC2 is a neuron-specific K(+)-Cl(-) cotransporter essential for e

197 The neuron-specific K(+)-Cl(-) cotransporter SLC12A5, also k

198 KCC2 is a neuron-specific K(+)-Cl(-) cotransporter that is essenti

199 Here we demonstrate that neuron-specific K(+)-Cl(-) cotransporter2 (KCC2) is a cr

200 ro functional assays, we establish that the "neuron-specific" K(+)Cl(-) co-transporter 2 (KCC2, Slc12

201 We propose that the long-time considered "neuron-specific" KCC2 co-transporter is expressed in pan

202 Sensory neuron-specific knock-out of OGT results in behavioral h

203 -of-function studies of Chrono including Avp neuron-specific knockout (KO) mice display a longer circ

204 To assess this idea, we generated Sirt1 neuron-specific knockout (SINKO) mice.

205 In behavior analyses, granule neuron-specific knockout of RNF8 or UBC13 impairs cerebe

206 The GABA neuron-specific LEPR knock-out females and males showed

207 In contrast, glutamate neuron-specific LEPR knock-out mice displayed normal fer

208 Active transcription of the neuron-specific long non-coding RNA (lncRNA), UBE3A-ATS,

209 Here we examined the effect of the DA neuron-specific loss of GIRK channels on D2R-dependent r

210 der of postnatal brain development caused by neuron-specific loss of the HECT (homologous to E6AP car

211 Using neuron-specific manipulations combined with immunocytoch

212 techniques influence synaptic responses in a neuron-specific manner.

213 Neuron-specific mapping of the genome-wide distribution

214 pressed in neurons, including the well-known neuron-specific markers ELAV and NeuN and the disease an

215 te of DCX-labeled cells by using mitotic and neuron-specific markers, retrograde tracings, and immedi

216 ssential homeostatic process in neurons, but neuron-specific mechanisms are poorly understood.

217 l-color live-cell imaging to investigate the neuron-specific mechanisms of constitutive autophagosome

218 Calcium-binding protein 1 (CaBP1) is a neuron-specific member of the calmodulin superfamily tha

219 KCC2 is the neuron-specific member of the of K(+)-Cl(-) cotransporte

220 Auxilin-1 is a neuron-specific membrane-binding protein involved in a l

221 cular level, we demonstrated that REEP1 is a neuron-specific, membrane-binding, and membrane curvatur

222 miR-132 is a neuron-specific microRNA and plays a pivotal role in syn

223 We find that a neuron-specific microRNA, miR-138, represses expression

224 We hypothesized that motor neuron-specific miRNA expression changes are involved in

225 e investigated the role of a brain-enriched, neuron-specific miRNA, miR-124-3p, whose expression is h

226 We find that neuron-specific misexpression of TRP-4, the pore-forming

227 hiverer and then genetically deleted a major neuron-specific mitochondrial anchoring protein Syntaphi

228 In this study, we generated neuron-specific Mkk7 knockout mice (MKK7 cKO), which imp

229 We have created two neuron-specific mouse models of mitochondrial electron t

230 ptor DCC and DSCAM with polymerized TUBB3, a neuron-specific MT subunit in the brain, is required for

231 genitor Brg/Brm-associated factor (npBAF) to neuron-specific nBAF complexes that is in part driven by

232 omplete CB(1)(-/-) mice and in glutamatergic neuron-specific Nex-CB(1)(-/-) mice induced overt altera

233 vation and neuronal demise is due to severe, neuron-specific, nicotinamide adenine dinucleotide (NAD(

234 pyramidal neurons using forebrain pyramidal neuron specific NMDA receptor 1 knockout mice.

235 itous protein-coding Snrpn gene and multiple neuron-specific noncoding RNAs, including the PWS-relate

236 phogenesis in model vertebrates, and DNER, a neuron-specific Notch ligand required for cerebellar dev

237 mice with genetic manipulations targeting a neuron-specific nucleosome remodelling complex subunit,

238 ects could be recapitulated in mice with pan-neuron-specific or cholinergic neuron-specific ablation

239 d by genetically manipulated mice with D2(+) neuron-specific or global deletion of p11.

240 (lox/lox) line to generate animals with GABA-neuron-specific or glutamate-neuron-specific deletion of

241 Using sensory neuron-specific overexpression of GRK2 or its kinase-dea

242 the constitutive/ubiquitous and conditional/neuron-specific overexpression of Hus1, mnk, mei-9, mus2

243 of neuronal structure and function, yet the neuron-specific pathways within which they act are poorl

244 ing protein, which makes the primarily motor neuron-specific phenotype rather unexpected.

245 -Enriched protein tyrosine Phosphatase) is a neuron-specific phosphatase that regulates N-methyl-D-as

246 Synapsin III (SynIII) is a neuron-specific phosphoprotein that plays a unique role

247 in mature neurons is largely mediated by the neuron-specific potassium-chloride cotransporter KCC2.

248 that this protein may normally control some neuron-specific process.

249 are not required for gene expression and/or neuron-specific processing in the SNURF/SNRPN-UBE3A regi

250 that while RBFOX1 and RBFOX2 do not mediate neuron-specific processing of UBE3A-ATS, these proteins

251 P under the control of this putative sensory neuron specific promoter was generated and characterized

252 t within cis-regulatory sequences, including neuron-specific promoters and superenhancers, affected b

253 The use of neuron-specific promoters can direct staining to mammali

254 ein-associated protein B (VAPB) protein with neuron-specific promoters have provided some insight int

255 This network enabled the discovery of the neuron-specific protein CRMP1 that targets aggregation-p

256 Here we examine the role of this neuron-specific protein in hippocampal plasticity and co

257 nal hydrolase L1 (UCH-L1) is an example of a neuron-specific protein which displays two different dim

258 The induced neurons express neuron-specific proteins, generate action potentials and

259 The induced neuronal cells expressed various neuron-specific proteins, their mRNA expression during n

260 synGAP is a neuron-specific Ras and Rap GTPase-activating protein (G

261 Using 5-HT neuron-specific reduction of 5-HT1A autoreceptor gene ex

262 ith AgRP-Cre mice to generate mice with AgRP neuron-specific rescue of LepR.

263 The neuron specific RNA-binding proteins NOVA1 and NOVA2 are

264 rologic disorders target several families of neuron-specific RNA binding proteins (RNABPs), revealing

265 Here, we focus on a neuron-specific RNA-binding protein, Rbfox3, recently id

266 trocytes and microglia, regulated in part by neuron-specific RNA-binding proteins NOVA2 and PTBP2.

267 tributed model of SMN function with distinct neuron-specific roles that are likely to be compromised

268 Functional inhibition and neuron-specific silencing of PKCdelta attenuated spontan

269 Forebrain neuron-specific Sirt1 knock-out closely recapitulated th

270 Here we generated global and sensory neuron-specific Slack mutant mice and analyzed their beh

271 supporting previous demonstrations of motor neuron-specific SMN function in mice.

272 ge, LH surges could be induced in almost all neuron-specific SOCS3 knock-out mice on this diet.

273 We used neuron-specific SOCS3 knock-out mice to elucidate this a

274 As expected, male and female neuron-specific SOCS3 knock-out mice were protected from

275 adiol-induced GnRH/LH surge were overcome by neuron-specific SOCS3 knock-out.

276 ) was expressed under control of the sensory neuron-specific sodium channel (sns) gene to selectively

277 Vertebrates have evolved a neuron-specific splice variant of C-Src, N1-Src, which d

278 is located within the RBFOX1 gene which is a neuron-specific splicing factor regulating a wide range

279 pecific assembly, nBAF, characterized by the neuron-specific subunit BAF53b.

280 AP3B2 encodes the neuron-specific subunit of the AP-3 complex.

281 mice expressing the Cre recombinase from the neuron-specific synapsin promoter.

282 Excitatory neuron-specific targeting was promoter-dependent, with a

283 To test if BoNT/C1 ad retains neuron-specific targeting without concomitant toxic host

284 ial to eliminate toxicity without disrupting neuron-specific targeting, thereby creating a molecular

285 IIS/FOXO neuron-specific targets are distinct from canonical IIS/

286 V)-GFP-Syntaxin1, all under the control of a neuron-specific Thy-1 promoter.

287 L) and PSEN1(L166P) under the control of the neuron-specific Thy-1 promoter; referred to here as 'APP

288 ellular accumulation, which was indicated by neuron-specific transcript analysis.

289 ibroblasts to neurons, we found that the pan neuron-specific transcription factor Myt1-like (Myt1l) e

290 eurons directly from dermal fibroblasts with neuron-specific transcription factors, which does not re

291 Neuron-specific transcriptional progression through Ube3

292 We also studied the role of neuron-specific transcripts in the blood of healthy adul

293 combined spatial expression patterns of 170 neuron-specific transcripts revealed strikingly clear an

294 Dozens of Hcrt-neuron-specific transcripts were identified and comprehe

295 site-specific modification found in several neuron-specific transcripts.

296 d in Tsc2-deficient neurons, as well as in a neuron-specific Tsc1 conditional knock-out mouse model,

297 We find that neuron-specific Tsc1 deletion results in an increase in

298 rs is dependent on chloride extrusion by the neuron-specific type 2K(+)-Cl(-) cotransporter (KCC2).

299 Here, we show that ubiquitous or neuron-specific up-regulation of Parkin, in adult Drosop

300 nal is genetically controlled and determines neuron-specific variation in peptidergic function.