ライフサイエンスコーパス: neuronal differentiation

1 duces Pax6 expression, whereas Ebf1 promotes neuronal differentiation.

2 crease of Cdk5 activity during rat and mouse neuronal differentiation.

3 l as cellular structure changes accompanying neuronal differentiation.

4 ulates synaptic gene expression and inhibits neuronal differentiation.

5 ne expression which is essential for correct neuronal differentiation.

6 ion of genes pertaining to proliferation and neuronal differentiation.

7 spensable for their maintenance and controls neuronal differentiation.

8 ing exclusively and redundantly in promoting neuronal differentiation.

9 nelle fusion and promoted the early phase of neuronal differentiation.

10 der endogenous conditions in a cell model of neuronal differentiation.

11 itive and negative role on proliferation and neuronal differentiation.

12 ed EZCs without altering oligodendroglial or neuronal differentiation.

13 tion in this context is essential for proper neuronal differentiation.

14 vels at its target promoters and compromises neuronal differentiation.

15 uction is only responsible for astrocyte and neuronal differentiation.

16 e networks of HVC of singing males concerned neuronal differentiation.

17 pe of poised genes activated at the onset of neuronal differentiation.

18 al glia proliferation and prevents premature neuronal differentiation.

19 s regulate the initiation and progression of neuronal differentiation.

20 ntral to neural progenitor proliferation and neuronal differentiation.

21 hanism underlies the Hox control of terminal neuronal differentiation.

22 behind the morphogenetic furrow to allow for neuronal differentiation.

23 gets by controlling target proliferation and neuronal differentiation.

24 in Cdo-deficient cells, leading to impaired neuronal differentiation.

25 disrupted wild type NSCs demonstrate delayed neuronal differentiation.

26 /864 in neural progenitors inhibits terminal neuronal differentiation.

27 ration and concurrent increase in cerebellar neuronal differentiation.

28 concomitant reduction in forebrain size and neuronal differentiation.

29 profiles indicative of inhibited sympathetic neuronal differentiation.

30 Ngn2 expression in wild-type NSPCs decreased neuronal differentiation.

31 by Ezh2 in stem cells and derepressed during neuronal differentiation.

32 activation and results in markedly impaired neuronal differentiation.

33 or, Ptch1, in control of cell signalling and neuronal differentiation.

34 embryogenesis and plays a strategic role in neuronal differentiation.

35 is bHLH transcription factor is critical for neuronal differentiation.

36 inases, neurotrophin signaling, and possibly neuronal differentiation.

37 enance of cell proliferation and blockade to neuronal differentiation.

38 mental to neuron stem cell proliferation and neuronal differentiation.

39 al stem cells to significantly enhance their neuronal differentiation.

40 s reduces FGFR3 levels, leading to premature neuronal differentiation.

41 ributes to the cortisol-induced reduction in neuronal differentiation.

42 factor-induced Ser(779) phosphorylation and neuronal differentiation.

43 l function, such as subtype specification in neuronal differentiation.

44 horizontal basal cells (HBCs) and subsequent neuronal differentiation.

45 enes involved in both cell cycle control and neuronal differentiation.

46 inhibits neuron stem cell proliferation and neuronal differentiation.

47 serine 133, which is a critical pathway for neuronal differentiation.

48 s elevated expression in neural cells blocks neuronal differentiation.

49 gible links between Zn(2+), neurulation, and neuronal differentiation.

50 ies of Zeb2 are required for EDN3 to prevent neuronal differentiation.

51 isions while in markedly disparate stages of neuronal differentiation.

52 hand, resulted in only partial inhibition of neuronal differentiation.

53 pression of glycolytic enzymes and decreased neuronal differentiation.

54 and ameliorated the observed alterations in neuronal differentiation.

55 d expression of ZEB2 but did not undergo any neuronal differentiation.

56 stem cells (aNSCs) affects proliferation and neuronal differentiation.

57 the microtubule-actomyosin interfaces during neuronal differentiation.

58 x2 and Nestin, and lacks markers of glial or neuronal differentiation.

59 ng to neuronal migration delays, and altered neuronal differentiation.

60 t can trigger signaling pathways involved in neuronal differentiation.

61 tional requirement of Cdk5 activation during neuronal differentiation.

62 nal regulator of FKBP5 and can contribute to neuronal differentiation.

63 e insulin-like peptides, which induce lamina neuronal differentiation.

64 to Eurl impair progenitor proliferation and neuronal differentiation.

65 progenitor pool, and subsequently increased neuronal differentiation.

66 group binding at the MNX1 locus during early neuronal differentiation.

67 xidation state of cytosolic glutathione upon neuronal differentiation.

68 l neurogenesis, neural plate patterning, and neuronal differentiation.

69 l progenitors and, subsequently, postmitotic neuronal differentiation, a relatively poorly understood

70 Upon neuronal differentiation, active Ras levels are high in

71 on the stability of Ngn2 protein and on its neuronal differentiation activity in vivo in the develop

72 ine-Proline (SP) sites for regulation of its neuronal differentiation activity, although the potentia

73 on of the progenitor population, and delayed neuronal differentiation, all key features of the develo

74 Genes up-regulated during in vitro neuronal differentiation also displayed a tendency for u

75 cells reduced cell proliferation and induced neuronal differentiation, an effect phenocopied by miR-1

76 Fbxo45 ablation results in defective neuronal differentiation and abnormal formation of neura

77 ETH on rat multipotent NSC proliferation and neuronal differentiation and adult hippocampal neurogene

78 n the migratory route accompanied by ectopic neuronal differentiation and altered direction and speed

79 NCCs is sufficient to recapitulate premature neuronal differentiation and apoptotic death of neural p

80 n vivo experiments showed that the premature neuronal differentiation and changes in cell cycle param

81 The knockdown of SOX9 enhanced the neuronal differentiation and decreased the glial differe

82 yonic mouse cortex, Pnky knockdown increases neuronal differentiation and depletes the NSC population

83 regulated by microRNA that can be linked to neuronal differentiation and dopaminergic gene expressio

84 progenitor development, neuronal migration, neuronal differentiation and early neuronal connectivity

85 Localized isoforms were induced during neuronal differentiation and enriched for motifs associa

86 3) as a gene required for the maintenance of neuronal differentiation and for neuroblast proliferatio

87 y, we demonstrate that ATXN3 is required for neuronal differentiation and for normal cell morphology,

88 e the gene expression patterns necessary for neuronal differentiation and function.

89 DIPG proliferative potential, by repressing neuronal differentiation and function.

90 cellular processes including cell division, neuronal differentiation and growth, and centriole assem

91 yses we found that (1) MYT1L is required for neuronal differentiation and identified ID1, a HLH inhib

92 tein-activated kinase Pak3, known to control neuronal differentiation and implicated in X-linked inte

93 pigenetic changes, consistent with increased neuronal differentiation and in correlation with changes

94 results shed light on the role of Lin28a in neuronal differentiation and increase our understanding

95 c features while at the same time increasing neuronal differentiation and integration.

96 the multifunctional co-receptor Cdo promotes neuronal differentiation and is important for the functi

97 ranscription factor (REST) is a repressor of neuronal differentiation and its elevated expression in

98 sitive non-invasive, real-time monitoring of neuronal differentiation and maturation are highly deman

99 beta-catenin-cyclin D1 pathway and promoted neuronal differentiation and maturation by inducing the

100 und that two different domains of APP impair neuronal differentiation and maturation in trisomic NPCs

101 l regulator of the ability of Ascl1 to drive neuronal differentiation and maturation in vivo in the d

102 The number of cells co-localized with neuronal differentiation and maturation labels with each

103 canonical roles of developmental cues during neuronal differentiation and maturation.

104 E) and is a transcription factor involved in neuronal differentiation and maturation.

105 icated in many important functions including neuronal differentiation and memory formation.

106 results reveal unexpected parallels between neuronal differentiation and mesenchymal-to-epithelial t

107 ssion of genes that regulate the cell cycle, neuronal differentiation and migration in NfiB(-/-) brai

108 monstrated that sumoylation of Foxp1 affects neuronal differentiation and migration in the developing

109 loss leads to aberrations in proliferation, neuronal differentiation and migration in the embryonic

110 ell proliferation and reversed the premature neuronal differentiation and migration.

111 be a very useful tool for quality control of neuronal differentiation and moreover, for neurogenic co

112 Taken together, our results reveal that the neuronal differentiation and neuritogenesis of neuroblas

113 idating the influences of mechanical cues on neuronal differentiation and neuritogenesis.

114 st an important role for tPA in the abnormal neuronal differentiation and plasticity in FXS.

115 and signaling pathways play crucial roles in neuronal differentiation and plasticity.

116 in like growth factor-1 receptor (IGF-1R) on neuronal differentiation and polarization in vivo in mam

117 sults demonstrate a novel role for ARID1B in neuronal differentiation and provide new insights into t

118 In conclusion, UCBMC promote neuronal differentiation and reduce glial differentiatio

119 ETH enhanced NSC proliferation and neuronal differentiation and reduced Abeta toxin-mediate

120 g the untimely activation of genes promoting neuronal differentiation and stem cell quiescence.

121 APC expression, thereby driving neocortical neuronal differentiation and suppressing oligodendrocyte

122 neurotrophic factor (BDNF) is essential for neuronal differentiation and survival.

123 f microglia, and cell autonomously regulates neuronal differentiation and survival.

124 Rho family GTPases play integral roles in neuronal differentiation and survival.

125 K1A is a serine/threonine kinase involved in neuronal differentiation and synaptic plasticity and a m

126 sette formation, which involves induction of neuronal differentiation and the utilization of embryoid

127 eam of precocious cell cycle exit, premature neuronal differentiation, and abnormal mitosis patterns.

128 deficient IGF-1-dependent Akt signaling and neuronal differentiation, and accordingly, Sox2-dependen

129 reduction in N-cadherin expression, impaired neuronal differentiation, and diminished formation of ne

130 cts in gene expression programs required for neuronal differentiation, and fail to differentiate and

131 deficits in cell-autonomous and cue-directed neuronal differentiation, and following orthotopic trans

132 r cell proliferation, induction of premature neuronal differentiation, and interruption of neural tis

133 n factors, neurogenesis, the cell cycle, and neuronal differentiation, and m(6)A tagging promotes the

134 -derived cell (ENCC) proliferation, promoted neuronal differentiation, and reduced expression of Gdnf

135 ding proliferation of neural progenitors and neuronal differentiation, and stimulated neurite outgrow

136 ion of genes involved in cell proliferation, neuronal differentiation, and synaptic assembly.

137 rochromatin replication is indispensible for neuronal differentiation, and that the loss of NDE1 func

138 that the majority of genes activated during neuronal differentiation are silent in neural stem cells

139 lation of layer formation and layer-specific neuronal differentiation at prenatal developmental stage

140 ay in cortical progenitors induces premature neuronal differentiation at the expense of proliferation

141 Neural connectivity requires neuronal differentiation, axon growth, and precise targe

142 urogenic program, including Notch signaling, neuronal differentiation, axon guidance and synapse form

143 receptor TrkC play crucial trophic roles in neuronal differentiation, axon outgrowth, and synapse de

144 lling in neural stem cells and promote their neuronal differentiation both in culture and within the

145 rbofuran-altered TGF-beta signaling impaired neuronal differentiation (BrdU/DCX(+) and BrdU/NeuN(+) c

146 es in conjunction with retinoic acid-induced neuronal differentiation brings about progeny virus prop

147 erized the effects on human neurogenesis and neuronal differentiation brought about by MeCP2 deficien

148 naling by Ser(779) was critical not only for neuronal differentiation but also for cell survival unde

149 developmental process, with a requirement in neuronal differentiation but not cell survival.

150 Nup210 as a critical regulator of muscle and neuronal differentiation, but how this nucleoporin exert

151 at carbofuran inhibits NSC proliferation and neuronal differentiation by altering TGF-beta signaling.

152 bution of FlnA/AR complex and PI3-K delta to neuronal differentiation by androgens and NGF is also no

153 we show that Ezh2 levels are dampened during neuronal differentiation by brain-enriched microRNA miR-

154 NGF induces neuronal differentiation by modulating [Ca(2+)]i.

155 Retinoic acid (RA) is required for neuronal differentiation by promoting expression of pron

156 hanistically, we found that Fezf2 stimulates neuronal differentiation by promoting Wnt/beta-catenin s

157 ous system cell fates with Shh, Cdo promotes neuronal differentiation by suppression of Wnt signallin

158 exon of Flna in NPCs, Rbfox proteins promote neuronal differentiation by switching Ninein from a cent

159 vidual BMPs promote progenitor patterning or neuronal differentiation by their activation of differen

160 r regulator of epithelial polarity, controls neuronal differentiation by transcriptionally repressing

161 Early replacement of PTBP1 by PTBP2 during neuronal differentiation causes a concerted set of splic

162 We demonstrate that upon neuronal differentiation, cellular demand for copper inc

163 more severe enteric anomalies and increased neuronal differentiation compared to mice with mutations

164 Zeb2(Delta/+) EPCs had increased neuronal differentiation compared to Zeb2(+/+) cells.

165 expression exhibited higher NPC numbers and neuronal differentiation compared with aged WT animals.

166 Upon neuronal differentiation, complex I specifically was seq

167 actor (REST), a master negative regulator of neuronal differentiation, controls neurogenesis by preve

168 -124 in embryonic carcinoma cells undergoing neuronal differentiation correlated with down-regulation

169 cific Numb splice isoform reproduced similar neuronal differentiation defects.

170 t WIP1 controls DKK3-dependent inhibition of neuronal differentiation during aging and suggest that r

171 iptional regulator is known to contribute to neuronal differentiation during development and to progr

172 rowth factors and their receptors coordinate neuronal differentiation during development, yet their r

173 s-mediated control of NPCs' self-renewal and neuronal differentiation during mammalian corticogenesis

174 equirement for Geminin for NT patterning and neuronal differentiation during mammalian neurulation in

175 lays an important role in the progression of neuronal differentiation during vertebrate development.

176 t activate the G protein Galphas and promote neuronal differentiation evoke Galphas internalization i

177 at enhancement of miR-34a expression impairs neuronal differentiation, expression of synaptic protein

178 er show that N-cadherin levels, regulated by neuronal-differentiation factor Neurog2, determine ciliu

179 ls of FTLD-Tau by Neurogenin2-induced direct neuronal differentiation from FTLD-Tau patient iPSCs.

180 at the neural-specific lncRNA Pnky regulates neuronal differentiation from neural stem cells and medi

181 , significantly correlate with expression of neuronal differentiation genes and better prognosis but

182 n also induced the expression of REST-target neuronal differentiation genes even though REST levels w

183 The presence and role of UNC-45A in neuronal differentiation have been largely unknown.

184 (aNSCs) and MBD1 deficiency leads to reduced neuronal differentiation, impaired neurogenesis, learnin

185 y retracting expression of her5 that directs neuronal differentiation in a precise spatiotemporal man

186 rm Pax6(5a) could potentially play a role in neuronal differentiation in brain development.

187 Accordingly, miR-511 increased neuronal differentiation in cells and enhanced neuronal

188 elated to synapse formation, maintenance and neuronal differentiation in CSB neurons using unbiased R

189 This suggested that delays in neuronal differentiation in epb41l5-deficient embryos ar

190 ZEB2 and EWS, which regulates metastasis and neuronal differentiation in ES, respectively.

191 s between multiple regulatory factors during neuronal differentiation in mice, we characterised genom

192 leading to cell cycle arrest, apoptosis, and neuronal differentiation in MYCN-amplified neuroblastoma

193 ue experiments, revealed that EZH2 represses neuronal differentiation in neuroblastoma in a PRC2-depe

194 sion of full-length Etv4 or Etv5 potentiated neuronal differentiation in response to this neurotrophi

195 , we demonstrate that ARID1B is required for neuronal differentiation in the developing brain, such a

196 ETH potently induced NSC proliferation and neuronal differentiation in the hippocampus-derived NSC

197 ising the possibility that RNF113A regulates neuronal differentiation in the human CNS.

198 iatal development, also supported by reduced neuronal differentiation in the LGE of Meis1(-/-) embryo

199 F1A loss-of-function was sufficient to drive neuronal differentiation in vitro and in vivo.

200 8 was sufficient to affect cell survival and neuronal differentiation in vitro and in vivo.

201 nscript abundance across postnatal stages of neuronal differentiation in vivo and in culture.

202 ion of proneural proteins directly regulates neuronal differentiation in vivo during development, and

203 ple sites acts to limit its ability to drive neuronal differentiation in vivo.

204 Activated Notch signaling interferes with neuronal differentiation, in part because neurite and ax

205 RhoGEFs are implicated in various aspects of neuronal differentiation, including dendritogenesis and

206 (100 muM) decreased proliferation (-17%) and neuronal differentiation into MAP2-positive neurons (-22

207 Therefore, neuronal differentiation is associated with upregulation

208 progenitors are not maintained normally and neuronal differentiation is compromised: rx3-derived ff1

209 little evidence that cortical lamination or neuronal differentiation is influenced by extrinsic acti

210 Thus, TrkB-dependent neuronal differentiation is involved in the sustained an

211 Neuronal differentiation is largely under the control of

212 sults suggest that the apparent hierarchy of neuronal differentiation is not irreversible and that li

213 t whether and how they relate to TF-directed neuronal differentiation is poorly investigated.

214 ously proposed that the timing of vertebrate neuronal differentiation is regulated by molecular oscil

215 How metabolism is reprogrammed during neuronal differentiation is unknown.

216 The role of Hb9 in directing neuronal differentiation is well documented, but the lin

217 igodendrocyte marker gene PPP1R14a and other neuronal differentiation marker genes.

218 Expression of neuronal differentiation markers is ablated in both KIF1

219 companied by premature ectopic expression of neuronal differentiation markers.

220 r that regulates chromatin and expression of neuronal differentiation markers.

221 When tested in vitro, morphine inhibited neuronal differentiation, neurite outgrowth, and surviva

222 essential role in controlling when and where neuronal differentiation occurs within the developing fo

223 eficiency could reduce the proliferation and neuronal differentiation of adult neural stem cells in v

224 Focusing on the first hours of neuronal differentiation of adult subventricular zone-de

225 Pretreatment with METH also decreased neuronal differentiation of HIV-infected NPCs in both in

226 the first time, that SGSMs do not affect the neuronal differentiation of hNPCs while selectively decr

227 several genes simultaneously and stimulating neuronal differentiation of human induced pluripotent st

228 strongly suppressed Rap2a, thereby promoting neuronal differentiation of neural stem cells (NSCs) and

229 ed that APP stimulates the proliferation and neuronal differentiation of neural stem/progenitor cells

230 und FGF2 and exogenous FGFR1, which promoted neuronal differentiation of neuroblastoma cells.

231 in some neuroblastoma cell lines and induced neuronal differentiation of NGP cells.

232 Nonetheless, the neuronal differentiation of NPCs that proliferated durin

233 y group box-1 protein (HMGB-1) could promote neuronal differentiation of NPCs via activation of the R

234 overexpression of Mbd3 significantly blocked neuronal differentiation of NPCs, and Mbd3 depletion res

235 ex plays a critical role in self-renewal and neuronal differentiation of NPCs.

236 factor (CNTF) receptor signaling may inhibit neuronal differentiation of NSP cells.

237 The results demonstrate that APP-stimulated neuronal differentiation of NSPCs is mediated by Ngn2.

238 eased to regulate MOR gene expression during neuronal differentiation of P19 cells, suggesting a cons

239 tional as it displayed the ability to induce neuronal differentiation of PC12 cells.

240 revealed that Rbfox3 is required to promote neuronal differentiation of postmitotic neurons.

241 differentially promote the proliferation and neuronal differentiation of qNSCs, aNSCs, and TACs.

242 Thus, we studied the impact of SGSMs on the neuronal differentiation of ReNcell VM (ReN) human neura

243 iptionally and post-transcriptionally during neuronal differentiation of the embryonic carcinoma cell

244 lying nanoparticle monolayer causes enhanced neuronal differentiation of the hNSCs, thus having great

245 rs involved in the induction, patterning and neuronal differentiation of the hypothalamus, highlighti

246 crest emigration, and subsequent precocious neuronal differentiation of the trigeminal ganglion.

247 the precocious and transient acceleration of neuronal differentiation of these cells.

248 ects of each single therapy, and facilitated neuronal differentiation of transplanted cells and matur

249 abnormal blood vessel networks and advanced neuronal differentiation of tumor cells.

250 ) medium conditioned by TgCRND8 NPC promoted neuronal differentiation of WT NPCs; and (3) the proneur

251 d find the seasonal gene networks related to neuronal differentiation only in the HVC.

252 er release in human neurons without changing neuronal differentiation or synapse formation.

253 lar model sensitive to small perturbation of neuronal differentiation pathways.

254 , a transcriptional regulator of sympathetic neuronal differentiation, predispose to diseases of the

255 In the zebrafish retina, neuronal differentiation proceeds in two stages with emb

256 for sensitive and quantitative monitoring of neuronal differentiation processes.

257 e transdifferentiation is closely related to neuronal differentiation processes.

258 NPCs, thus enabling proper activation of the neuronal differentiation program under neurogenic cue.

259 ate neural progenitor cell proliferation and neuronal differentiation programs observed in vivo remai

260 Overexpression of activated aPKC blocks the neuronal differentiation-promoting activity of p27Xic1.

261 a hypomorphic Gpc4 allele, in a single-step neuronal differentiation protocol, show increased differ

262 Mdlc plays an essential role in maintaining neuronal differentiation, raising the possibility that R

263 cific proteins, their mRNA expression during neuronal differentiation recapitulated embryonic neuroge

264 that function in cellular morphogenesis and neuronal differentiation, reflecting cardinal features o

265 The role of NCAM2 in neuronal differentiation remains, however, poorly unders

266 Here, we show that this all-or-nothing neuronal differentiation results from Hippo pathway posi

267 in Zeb2(Delta/+) EPCs restored inhibition of neuronal differentiation, similar to incubation of Zeb2(

268 hannel anchoring mechanisms depending on the neuronal differentiation state.

269 applying compounds that are known to promote neuronal differentiation such as the gamma-secretase inh

270 terferes with neurodegeneration but promotes neuronal differentiation, suggesting that stabilization

271 TbetaRIII-mediated neuronal differentiation suppressed cell proliferation i

272 relevance of this inhibitory mechanism in a neuronal differentiation system using human SH-SY5Y cell

273 ST is a master regulator of neurogenesis and neuronal differentiation that has not been previously im

274 ired for nerve growth factor (NGF)-dependent neuronal differentiation through anterograde transport o

275 Our data indicate a role of AR in neuronal differentiation through regulation of APC/C(Cdh

276 lutionary-conserved protein important during neuronal differentiation through several mechanisms, inc

277 NCX3 isoforms could play a relevant role in neuronal differentiation through the modulation of [Ca(2

278 y, these data show that NCX1 participates in neuronal differentiation through the modulation of ER Ca

279 vate identity-specific effector genes during neuronal differentiation to define the structural and fu

280 pha and ERRgamma increase significantly upon neuronal differentiation to sustain the transcription of

281 Coupling retinoic acid (R), an inducer of neuronal differentiation, to VP pulse stimulation attenu

282 utgrowth and in nerve growth factor-mediated neuronal differentiation, together with reduced miniatur

283 vailing model suggests that N1-Src regulates neuronal differentiation via cytoskeletal dynamics in th

284 To identify chromatin mechanisms of neuronal differentiation, we characterized chromatin acc

285 To elucidate the role of DNA methylation in neuronal differentiation, we developed a new protocol fo

286 to single pluripotent stem cells undergoing neuronal differentiation, we discover that up to 20% of

287 cells as models for growth factor-regulated neuronal differentiation, we show that Ser(779) in the c

288 These proteins, which play ancient roles in neuronal differentiation were first recruited to the dor

289 associated with the progress and quality of neuronal differentiation were identified.

290 that neurogenesis, neuronal development, and neuronal differentiation were likely controlled by these

291 inhibitory effects on NSC proliferation and neuronal differentiations were also mitigated by Drp-1 i

292 ranscription factor) and NeuN (biomarker for neuronal differentiation) were investigated together wit

293 APP expression remained stable during neuronal differentiation, whereas APP processing changed

294 Ngn2 overexpression in APPKO NSPCs promoted neuronal differentiation, whereas siRNA knockdown of Ngn

295 the robustly increased Cdk5 activity during neuronal differentiation, which activator is responsible

296 g MGPCs in damaged retinas, and enhances the neuronal differentiation while diminishing glial differe

297 mbryonic RGCs by stimulating their premature neuronal differentiation while preventing quiescence in

298 ptor function for TbetaRIII in FGF2-mediated neuronal differentiation, while identifying potential th

299 gest that prenatal exposure to nPM can alter neuronal differentiation with gender-specific behavioral

300 activity acts as a sensor to directly couple neuronal differentiation with redox environments in the