ライフサイエンスコーパス: neuronal migration

1 nctions, such as hypoxic preconditioning and neuronal migration.

2 cerebral cortex, a consequence of defective neuronal migration.

3 neural progenitors in vivo is detrimental to neuronal migration.

4 ar brush cells (UBCs), indirectly disrupting neuronal migration.

5 the centrosome and the nucleus, and disrupts neuronal migration.

6 embryos, cilia appear to be dispensable for neuronal migration.

7 downstream target of PHF6 in the control of neuronal migration.

8 merase 2, and Integrator similarly regulates neuronal migration.

9 onarily conserved role for this cell type in neuronal migration.

10 gely in floor plate cells to regulate caudal neuronal migration.

11 thin the bounds of the nuclear lamina during neuronal migration.

12 e cerebral cortex and allow for the study of neuronal migration.

13 ecreted and short-range guidance cues direct neuronal migration.

14 ired for normal progenitor proliferation and neuronal migration.

15 ers focal adhesion size and number to effect neuronal migration.

16 and GRD domains of Dab2ip are important for neuronal migration.

17 ssion of phosphomimetic Ser2512 FLNA impairs neuronal migration.

18 ed calcium permeability, thereby fine-tuning neuronal migration.

19 tein Reelin is an important factor directing neuronal migration.

20 adhesions, thereby disrupting cell intrinsic neuronal migration.

21 ctor known to guide axon/dendrite growth and neuronal migration.

22 tubule organization during cell division and neuronal migration.

23 reased BDNF may mediate cocaine's effects on neuronal migration.

24 sion is critical for proper neurogenesis and neuronal migration.

25 Thus, eyeless links neurogenesis and neuronal migration.

26 ng the cortical infrastructure necessary for neuronal migration.

27 us function for these proteins in regulating neuronal migration.

28 ion with DISC1/Ndel1 in vivo is required for neuronal migration.

29 mutations in tubulin-encoding genes disrupt neuronal migration.

30 mpairs critical developmental events such as neuronal migration.

31 ne or more MAPs that are essential to proper neuronal migration.

32 ed for their effect on CAMK2 function and on neuronal migration.

33 the vertebrate brain depends on glial-guided neuronal migration.

34 ression levels of EphAs and ephrin-As during neuronal migration.

35 aly, which is believed to reflect failure of neuronal migration.

36 tors are known to guide axon pathfinding and neuronal migration.

37 ing and neuronal-branching regulation during neuronal migration.

38 how Reelin controls the cytoskeleton during neuronal migration.

39 s to brain malformation and abnormalities of neuronal migration.

40 dyslexia (DD) owing to its important role in neuronal migration.

41 ndent of normal neocortical neurogenesis and neuronal migration.

42 /3 complex is a cell-autonomous regulator of neuronal migration.

43 RNAi have comparable effects on postmitotic neuronal migration.

44 leading process during the terminal phase of neuronal migration.

45 nic brain, including progenitor division and neuronal migration.

46 nstream targets involved in neurogenesis and neuronal migration.

47 demonstrate that cytoplasmic FBXO41 promotes neuronal migration.

48 ted proteins that regulate axon guidance and neuronal migration.

49 d no evidence for overt radial or tangential neuronal migrations.

50 neuronal abnormalities indicative of altered neuronal migration [4].

51 Neuronal migration, a key event during brain development

52 nal layering abnormality is due to defective neuronal migration, a process that is dependent on the o

53 ases stable microtubules and leads to slower neuronal migration, abnormal centrosome position and abe

54 nd its dysfunction in PDE is associated with neuronal migration abnormalities and other structural br

55 ese mice before the onset of seizures reveal neuronal migration abnormalities, reduced number of inte

56 ore complex environment for neurogenesis and neuronal migration, adding new arenas in which neurodeve

57 Dab2ip down-regulation severely disrupts neuronal migration, affecting preferentially late-born p

58 otubule-associated protein, is essential for neuronal migration, although a clear mechanistic underst

59 Mutations in human LIS1 cause abnormal neuronal migration and a smooth brain phenotype known as

60 rsectin 1 (ITSN1) in mice leads to defective neuronal migration and ablates Reelin stimulation of hip

61 In the developing CNS, TSP-1 is involved in neuronal migration and adhesion, neurite outgrowth, and

62 e cerebral cortex that results from impaired neuronal migration and although several genes have been

63 eoglycans (HSPGs), are essential to regulate neuronal migration and axon development.

64 s essential roles in neuronal proliferation, neuronal migration and axon guidance and has been implic

65 neurodevelopmental disorder with defects in neuronal migration and axon outgrowth.

66 CDC2 in ciliary function, which affects both neuronal migration and axonal outgrowth.

67 proteins with overlapping functions in both neuronal migration and axonal outgrowth.

68 e a variety of cellular functions, including neuronal migration and axonal pathfinding in the brain.

69 e have reported that Big2 inhibition impairs neuronal migration and binds to FlnA, and its loss promo

70 ablish an essential function for lamin B2 in neuronal migration and brain development.

71 Loss of Arf1 activity disrupts neuronal migration and cell adhesion.

72 lin dependent kinase 5 (Cdk5) contributes to neuronal migration and cell cycle control during embryog

73 l insights and fresh perspectives concerning neuronal migration and connectivity in the mesencephalon

74 individuals revealed that genes critical for neuronal migration and cortex organization (TUBG1, FLNA,

75 omologous to mechanisms that regulate radial neuronal migration and cortical lamination in the develo

76 n important transcription factor controlling neuronal migration and corticofugal axon projections.

77 ) axons, whereas EphA7 affects both cortical neuronal migration and CT axon guidance.

78 we identify a novel cytoplasmic regulator of neuronal migration and demonstrate that its inactivation

79 eelin signaling pathway, and is critical for neuronal migration and dendrite outgrowth during develop

80 e dominant-negative form of ARF6 rescues the neuronal migration and dendritic outgrowth defects induc

81 ral development, such as cell proliferation, neuronal migration and differentiation, providing a reli

82 rs for upper layer neurons leads to impaired neuronal migration and inappropriate branching, sponge-m

83 e we report that srGAP2 negatively regulates neuronal migration and induces neurite outgrowth and bra

84 ngation of cilia is not essential for proper neuronal migration and laminar organization or establish

85 osome 7q11.23, including genes important for neuronal migration and maturation (LIMK1 and CLIP2), is

86 rotein-2 (MeCP2) dysfunction on iPSC-derived neuronal migration and maturation (reduced neurite outgr

87 demonstrate an essential role of TBC1D24 in neuronal migration and maturation and highlight the phys

88 in is an extracellular protein essential for neuronal migration and maturation during development, an

89 The Reelin signaling pathway controls radial neuronal migration and maturation in the developing brai

90 The DYX1C1 has also been shown to affect neuronal migration and modulate estrogen receptor signal

91 Similar, albeit less striking, neuronal migration and morphological defects were observ

92 Defects in early neuronal migration and morphology, electrophysiological

93 s morphological abnormalities and defects in neuronal migration and morphology.

94 (Mkl1) and MRTF-B (Mkl2) redundantly control neuronal migration and neurite outgrowth during mouse br

95 onment plays a critical role in coordinating neuronal migration and neurite outgrowth during neural c

96 development, with each having roles in both neuronal migration and neurite outgrowth.

97 y of membrane protein complexes required for neuronal migration and neuroependymal integrity.

98 tive evidence for a critical role for Dcx in neuronal migration and neurogenesis, as well as for the

99 protein, and demonstrate a role for VRK1 in neuronal migration and neuronal stem cell proliferation.

100 its orthologs regulate conserved aspects of neuronal migration and outgrowth in the nervous system b

101 that eliminating UNC-34 function results in neuronal migration and polarity phenotypes that are enha

102 Reelin pathway that plays a critical role in neuronal migration and positioning during brain developm

103 n-5 regulates the rate and directionality of neuronal migration and possibly the cessation of migrati

104 (MT)-associated proteins (MAPs) involved in neuronal migration and process outgrowth.

105 Here, we uncovered novel neuronal migration and proliferation defects in the Dcx

106 ncy and Dcx knock-out leading to more severe neuronal migration and proliferation phenotypes in the L

107 lin receptors, as evidenced by the prominent neuronal migration and radial glial defects in hippocamp

108 Here, we document severe defects in neuronal migration and reduced numbers of neurons in lam

109 ent is associated with extensive deficits in neuronal migration and substantial hypertrophy of neuron

110 cently emerged as a molecular determinant of neuronal migration and synapse formation during cortical

111 pression of MIG-10 isoforms rescued both the neuronal migration and the canal outgrowth defects, show

112 nnectivity in the cerebral cortex; defective neuronal migration and the resultant connectivity change

113 neurons is already established during their neuronal migration and well before significant synapse f

114 at is disrupted in MKS and causes defects in neuronal migration and Wnt signalling.

115 1 in C. elegans, where they are required for neuronal migrations and during vulval development.

116 egulates the expression of genes involved in neuronal migration, and a functional assay showed that C

117 rk1 knockdown significantly impairs cortical neuronal migration, and affects the cell cycle of neuron

118 developmental events such as cell division, neuronal migration, and axon guidance are still prominen

119 ve been previously associated with dyslexia, neuronal migration, and ciliary function.

120 vestigated defects in cortical neurogenesis, neuronal migration, and differentiation in NfiB(-/-) bra

121 the KIF20B minimal binding domain inhibited neuronal migration, and in vivo migration assays suggest

122 ant increase in cell and head size, aberrant neuronal migration, and induction of seizures, concordan

123 ges of cell proliferation and specification, neuronal migration, and late cortical organisation.

124 precursor proliferation and differentiation, neuronal migration, and neurite outgrowth.

125 neuronal function during cell proliferation, neuronal migration, and postmigrational development: the

126 of RG cells to provide a stable scaffold for neuronal migration, and suggest that the transition in m

127 transients that determine neuronal polarity, neuronal migration, and synapse assembly in the developi

128 animals that have defects in axon guidance, neuronal migration, and the outgrowth of the processes o

129 rted genetic perturbations to disrupt normal neuronal migration-and thus positioning-in a population

130 Contemporary models for neuronal migration are grounded in the view that virtual

131 We find that adult neurogenesis and neuronal migration are not unusual in naked mole rat bra

132 h serve as both stem cells and scaffolds for neuronal migration, are crucial for cortical development

133 primates, with implications for patterns of neuronal migration, area patterning, and cortical foldin

134 that cocaine can alter tangential and radial neuronal migration as well as BDNF expression in the emb

135 , displacement of mitotic NPCs, and impaired neuronal migration, as assessed both ex vivo and in vivo

136 e stress (MSR3B), ubiquitination (FBXW8) and neuronal migration (ASTN2), as well as enzymes targeted

137 that radial glia function as a scaffold for neuronal migration at early stages of tectal development

138 ding neural progenitor cell differentiation, neuronal migration, axon extension and the folding of th

139 tors and neurotrophic factors that influence neuronal migration, axon guidance pathways, and neurite

140 formation requires the precise regulation of neuronal migration, axon guidance, and dendritic arboriz

141 re recently, including in the later steps of neuronal migration, axon navigation, and synaptogenesis.

142 t the NOVA family of RBPs play a key role in neuronal migration, axon outgrowth, and axon guidance.

143 hypothyroxinemia in rodents induces cortical neuronal migration brain lesions resembling those of aut

144 lar critical roles for LIS1 and NDEL1 during neuronal migration, but neuronal migration has not been

145 ning defects preclude analysis of cerebellar neuronal migration, but we have found that Met signaling

146 tablish that IP6K1 physiologically regulates neuronal migration by binding to alpha-actinin and influ

147 n to activate signalling cascades regulating neuronal migration by binding to lipoprotein receptors.

148 Both Rnd2 and Rnd3 promote neuronal migration by inhibiting RhoA signaling, but the

149 fic RNA binding protein Nova2 contributes to neuronal migration by regulating alternative splicing of

150 Finally, Zac1 controlled neuronal migration by regulating Pac1 transcription, a r

151 lamina in neurons, perhaps through abnormal neuronal migration, causes the epilepsy and early ataxia

152 nd NDEL1 proteins suggest that they regulate neuronal migration cell autonomously.

153 utcome compared to those related to abnormal neuronal migration (class II) or abnormal cortical organ

154 pendymal disruption, but the extent to which neuronal migration contributes to this phenotype is unkn

155 gulates several biological processes such as neuronal migration, cytoskeletal dynamics, axonal guidan

156 This syndrome may arise from a neuronal migration defect during development caused by d

157 craniofacial features, ocular colobomata and neuronal migration defect.

158 the X-linked DCX result in lissencephaly, a neuronal migration defect.

159 rated that Dab1.7bc was sufficient to induce neuronal migration defects in wild-type mice and exacerb

160 of SDCCAG8 carrying a human mutation causes neuronal migration defects.

161 genital muscular dystrophies associated with neuronal migration defects.

162 e central nervous system, characteristics of neuronal migration defects.

163 he two genes most commonly involved in human neuronal migration defects.

164 asymmetric centrosome inheritance leading to neuronal migration delays, and altered neuronal differen

165 Type I lissencephaly, a neuronal migration disorder characterized by cognitive d

166 Cobblestone brain malformation (COB) is a neuronal migration disorder characterized by protrusions

167 ht into how cortactin and DCX, a known human neuronal migration disorder gene, participate in this pr

168 Neuronal migration disorders are often identified in pat

169 y linking DYX1C1 with many genes involved in neuronal migration disorders.

170 ging from mild cognitive impairment (MCI) to neuronal migration disorders.

171 r using nonrodent model systems for studying neuronal migration disorders.

172 logue Lis1, which is crucial for nuclear and neuronal migration during brain development.

173 insic polarity and extracellular cues guides neuronal migration during cerebellar development.

174 are usually single-gene disorders affecting neuronal migration during cerebral cortical development.

175 , a MT-associated protein (MAP) required for neuronal migration during cortical development [4, 5], b

176 me, where it plays a key role in controlling neuronal migration during cortical development.

177 The best studied defects are in neuronal migration during corticogenesis and in the hipp

178 quence from progenitor cell proliferation to neuronal migration during corticogenesis are poorly unde

179 , Lpd contributes to neuronal morphogenesis, neuronal migration during development and its C. elegans

180 ortance of cytoskeletal function for correct neuronal migration during development of the cerebral co

181 es a number of targeted proteins involved in neuronal migration during development to synaptic activi

182 n-binding protein filamin A (FLNa) regulates neuronal migration during development, yet its roles in

183 compartments that play an important role in neuronal migration during development.

184 ration in a wound assay, as well as cortical neuronal migration during embryonic development was impa

185 of adhesion proteins plays a crucial role in neuronal migration during neocortical development.

186 w here that NudC, like Lis1, is required for neuronal migration during neocorticogenesis and we ident

187 Cone packing and neuronal migration during pit formation combined to form

188 overed crucial roles for lamins B1 and B2 in neuronal migration during the development of the brain.

189 Elucidating neuronal migration dynamics in the gyrencephalic, or fol

190 y associated with dyslexia and implicated in neuronal migration (DYX1C1, DCDC2, KIAA0319) and white m

191 THBS2), tissue differentiation (e.g., CHN2), neuronal migration (e.g., NDE1), myelination (e.g., UGT8

192 Lis1 regulates neuronal migration efficiency in a dose-dependent manner

193 ic, previously uncharacterized, late step of neuronal migration: entry into the target lamina.

194 ts suggest that RGP-guided inside-out radial neuronal migration facilitates the initial assembly of l

195 Neuronal migration from a germinal zone to a final lamin

196 ate from rhombic lips, the first analysis of neuronal migrations from these lips was performed with m

197 These results identify a novel neuronal migration gene with a specific role in interkin

198 myloid-beta precursor protein (APP), a known neuronal migration gene.

199 expression of nervous system development and neuronal migration genes such as RELN and associate with

200 l aspects of neuronal development, including neuronal migration, growth cone collapse, dendrite branc

201 opmental processes, such as neurogenesis and neuronal migration, guide precise circuit assembly.

202 IS1 and NDEL1 during neuronal migration, but neuronal migration has not been studied in genetic mutan

203 affecting auto-phosphorylation also affected neuronal migration, highlighting the importance of tight

204 s was sufficient to disturb neurogenesis and neuronal migration in a similar manner to Mecp2 knockdow

205 hydrolase 1B1 (LIS1), a critical mediator of neuronal migration in developing brain, is expressed thr

206 rthermore, knockdown of vasohibins disrupted neuronal migration in developing mouse neocortex.

207 specific RNA-binding protein Nova2 regulates neuronal migration in late-generated cortical and Purkin

208 interneuron leading process dynamics during neuronal migration in mice and provides insight into how

209 FBM neurons in zebrafish, but their roles in neuronal migration in mouse have not been investigated i

210 Moreover, we observed aberrant Tuj1(+) neuronal migration in RB-KO organoids and upregulation o

211 Although much less is known about neuronal migration in species with a gyrencephalic corte

212 Together, these results provide insight into neuronal migration in the adult mammalian nervous system

213 ic transcriptional pathway that orchestrates neuronal migration in the brain, with important implicat

214 at FBXO41 is a critical factor, not only for neuronal migration in the cerebellum, but also for its l

215 nal proliferation in the embryonic brain and neuronal migration in the cerebellum.

216 y facilitating the VLDLR-Dab1 axis to direct neuronal migration in the cortex and hippocampus and to

217 at another proneural factor, Ascl1, promotes neuronal migration in the cortex through direct regulati

218 role for B-type lamins (lamins B1 and B2) in neuronal migration in the developing brain.

219 nd its transmembrane receptor, Robo-1, repel neuronal migration in the developing central nervous sys

220 ctrum of brain malformations due to impaired neuronal migration in the developing cerebral cortex.

221 During neuronal migration in the developing cortex, however, th

222 DYX1C1 has been associated with dyslexia and neuronal migration in the developing neocortex.

223 e initial discovery that loss of p35 impairs neuronal migration in the embryonic brain prompted inten

224 ty supported callosal projections and radial neuronal migration in the embryonic neocortex.

225 d a viral labeling technique for visualizing neuronal migration in the ferret, a gyrencephalic carniv

226 e also adapted a well characterized assay of neuronal migration in the hawkmoth Manduca to show that

227 e also adapted a well characterized assay of neuronal migration in the hawkmoth, Manduca sexta, to sh

228 onserved LIS1/NDEL1 complex is essential for neuronal migration in the mammalian cerebral cortex.

229 rt that knockdown of PHF6 profoundly impairs neuronal migration in the mouse cerebral cortex in vivo,

230 a developmental role for CCM3 in regulating neuronal migration in the neocortex.

231 Disabled (Dab), which is a key regulator of neuronal migration in the vertebrate brain, might be a c

232 Our findings underscore that aberrant neuronal migration, inhibitory/excitatory imbalance, and

233 ct, in vivo evidence for a wandering form of neuronal migration involved in the addition of new neuro

234 Glial-guided neuronal migration is a key step in the development of l

235 rotrusions and synapses of young brain after neuronal migration is complete.

236 Neuronal migration is critical for establishing neocorti

237 at the formation of parallel axon fibers and neuronal migration is disrupted in Nav2 mutants.

238 Neuronal migration is essential for proper development o

239 Precise control of neuronal migration is essential for proper function of t

240 Neuronal migration is essential for the development of t

241 n impairment, suggesting the role of VRK1 in neuronal migration is partly noncatalytic.

242 , suggesting that Disc1's role in regulating neuronal migration is spatially restricted within the hi

243 fied more than a decade ago, its function on neuronal migration is still poorly understood.

244 Neuronal migration leads to a highly organized laminar s

245 DNF positively influences various aspects of neuronal migration, maturation, and survival in the deve

246 During neuronal migration, MgcRacGap also concentrates in the p

247 ole assembly and that the observed defect in neuronal migration might derive from a defect in this pr

248 ucturing of MTs facilitate distinct modes of neuronal migration necessary for laminar organization of

249 on what we have learned from zebrafish about neuronal migration, network formation and behavioral con

250 and Ndel1 are essential for normal cortical neuronal migration, neurite outgrowth, and function of t

251 them to function in cell-cell communication, neuronal migration, neurite outgrowth, neuronal pathfind

252 in particular neural progenitor development, neuronal migration, neuronal differentiation and early n

253 n vitro and in vivo, including neurogenesis, neuronal migration, neuronal survival and axon guidance.

254 rely ataxic gait in mice, which show delayed neuronal migration of granule neurons in the developing

255 Developmental defects such as impaired neuronal migration or neurodegeneration are thus detrime

256 teracts the deleterious effect of miR-128 on neuronal migration, outgrowth and intrinsic physiologica

257 D-1, which compromises the inside-out radial neuronal migration pattern in the developing neocortex.

258 ockdown but not knockout shows a neocortical neuronal migration phenotype.

259 embryos did not exacerbate the Vangl2(Lp/+) neuronal migration phenotype.

260 xpression of Pac1 rescued the Zac1 knockdown neuronal migration phenotype.

261 y is not required for cortical neurogenesis, neuronal migration, polarization, or survival.

262 ignificance of this well-established orderly neuronal migration remains largely unclear.

263 al development typically caused by deficient neuronal migration resulting in cortical thickening and

264 NOS1AP overexpression disrupts neuronal migration, resulting in increased cells in inte

265 This impairs late neuronal migration, resulting in the formation of perive

266 ce RG are also neural progenitors as well as neuronal migration scaffolds, these findings suggest tha

267 Neuronal migration segregates motor neurons into distinc

268 n with this disorder suffer from deficits in neuronal migration, severe intellectual disability, intr

269 Neuronal migration speed was reduced and neurite lengths

270 f RhoA signaling and differential control of neuronal migration stages.

271 ronal responsiveness to reelin signaling and neuronal migration, suggesting new links between splicin

272 fying factor contributing to disturbances of neuronal migration, synaptic connectivity, and GABAergic

273 The 50 genes in the network function in neuronal migration, synaptic transmission, signaling, tr

274 s system development and function, including neuronal migration, synaptogenesis, synaptic plasticity,

275 dk5) and its activator p35 are important for neuronal migration that is regulated by basic helix-loop

276 ment is crucial for further neurogenesis and neuronal migration, the underlying mechanisms are still

277 GTPases, have been implicated in regulating neuronal migration, their respective roles in the tangen

278 Vrk1 knockdown, suggesting that VRK1 affects neuronal migration through an APP-dependent mechanism.

279 mbryonic neural progenitor proliferation and neuronal migration through an interaction with DIX domai

280 We report that Hem regulates neuronal migration through stabilizing WAVE.

281 Basal structures influence neuronal migration, tissue integrity, and proliferation

282 Neurogenesis is integrated with neuronal migration to ensure proper development of the c

283 Reelin choreographs neuronal migration to establish laminar structures durin

284 nding the genetic regulation of cell number, neuronal migration to proper layers, columns, and region

285 s neural stem cell maintenance in the VZ and neuronal migration to the CP.

286 t that pre-existing DA neurons modulate GABA neuronal migration to their final destination, providing

287 of neuronal precursor cells, facilitates the neuronal migration toward injured areas, and shows survi

288 ervation has been the dependence of cortical neuronal migration upon acetylation of alpha-tubulin at

289 te the role and mechanisms of Fat-PCP during neuronal migration using the murine facial branchiomotor

290 We conclude that neuronal migration utilizes a cytoskeletal pathway analo

291 te that laminin regulates neurite growth and neuronal migration via integrin signaling through the AK

292 Postmitotic neuronal migration was independently disrupted at the mu

293 Similar to the rodent, we found that neuronal migration was predominantly radial at early pos

294 Since BDNF can influence tangential neuronal migration, we added BDNF to the culture medium

295 During neuronal migration, we discovered that phosphorylation o

296 ogenitor cells and impairment of postmitotic neuronal migration, were also observed.

297 e is known about the mechanisms of axophilic neuronal migration, whereby neurons travel along axon pa

298 on of Rnd proteins, integrate the process of neuronal migration with other events in the neurogenic p

299 thalamic nuclei; EphA4 affects only cortical neuronal migration, with no visible effects on the guida

300 Zac1 misexpression also blocked neuronal migration, with Zac1-overexpressing neurons pau