ライフサイエンスコーパス: neuropathologic

1 causative factor of AD and other associated neuropathologic abnormalities are of secondary consequen

2 ginal G93A mice, but they developed the same neuropathologic abnormalities seen in the original G93A

3 The resemblance of these functional and neuropathologic abnormalities to human neurodevelopmenta

4 In addition, quantitative neuropathologic analyses were performed.

5 NCE STATEMENT This study provides a detailed neuropathologic analysis of hippocampal Lewy pathology i

6 Neuropathologic analysis of the mice with end-stage dise

7 Neuropathologic analysis revealed abundant PrP amyloid p

8 Progress has been made in clinical, neuropathologic and biochemical characterization of the

9 disease and reconcile apparently conflicting neuropathologic and biomarker data.

10 Neuropathologic and genetics studies as well as transgen

11 was used to determine substantial changes in neuropathologic and MR spectroscopic markers.

12 yet there is a remarkable convergence in the neuropathologic and neurologic phenotype.

13 ere calculated between plasma viral load and neuropathologic and spectroscopic markers.

14 To date, MPS IIIB neuropathologic and therapeutic studies have focused pre

15 Biochemical, neuropathologic, and cell culture analyses were used to

16 nstitute of Ageing - Alzheimer's Association neuropathologic assessment guidelines.

17 demonstrate neuritic plaques, we performed a neuropathologic assessment of the frontal, occipital, an

18 Neuropathologic assessments were performed with investig

19 earning and memory features of PPA and their neuropathologic associations have not been characterized

20 This study identified neuropathologic associations of learning and memory in a

21 Evidence from neuropathologic, biomarker, genetic and cellular/mouse s

22 oss-sectional study examined a single-center neuropathologic CAA cohort of eligible patients from the

23 This neuropathologic case-control study investigated whether

24 roup that remained MCI until death, mixed AD neuropathologic changes (ADNC; >/=1 comorbid pathology)

25 entia with high-level Alzheimer disease (AD) neuropathologic changes (NCs) but without Lewy body dise

26 overy of the conduction defect and corrected neuropathologic changes characteristic of 4-mo diabetic

27 lyzed by mutant CuZnSOD enzymes initiate the neuropathologic changes in FALS.

28 1,3-dinitrobenzene (DNB) is associated with neuropathologic changes in specific brainstem nuclei, me

29 reduce cerebral Abeta burden and consequent neuropathologic changes in the brains of mice transgenic

30 ta-form of the peptide failed to develop any neuropathologic changes more than 600 days after the pep

31 ne (MPTP) produces clinical, biochemical and neuropathologic changes reminiscent of those which occur

32 Neither PrP(Sc) nor neuropathologic changes were found.

33 These neuropathologic changes were reversed following portal v

34 andardized histopathologic assessments of AD neuropathologic changes were the primary measures of int

35 on of spatial learning/memory and diminished neuropathologic changes.

36 f 19 elderly subjects with Alzheimer-related neuropathologic changes.

37 ementia highlights the need to determine the neuropathologic characteristics of individuals whose cog

38 lude neurodevelopmentally induced structural neuropathologic characteristics, sensitization of nigros

39 rdless of ante-mortem clinical diagnosis and neuropathologic co-morbidities, and all assigned Thal am

40 the severity of an underlying and developing neuropathologic condition that does not manifest itself

41 specific type of molecular Alzheimer disease neuropathologic condition with clinically significant ne

42 Four of six brains from non-MS neuropathologic conditions associated with inflammation

43 had complete autopsy data and were free from neuropathologic conditions other than Alzheimer's diseas

44 gnitive decline after controlling for common neuropathologic conditions.

45 ve decline even after controlling for common neuropathologic conditions.

46 ath in many experimental paradigms and human neuropathologic conditions.

47 ine above and beyond the influence of common neuropathologic conditions.

48 dy was designed to investigate, in rats, the neuropathologic consequences of heightened leukocyte tra

49 tion of the Ub-proteasome system, leading to neuropathologic consequences.

50 xicity of alpha-synuclein and its downstream neuropathologic consequences.

51 However, understanding the neuropathologic correlates of early cognitive decline, a

52 This study aims to clarify the neuropathologic correlates of longitudinal brain atrophy

53 e research to uncover them, the anatomic and neuropathologic correlates of memory impairment in demen

54 ording to National Institute on Aging-Reagan neuropathologic criteria at autopsy.

55 troscopy metabolite measurements against the neuropathologic criteria for AD, and when combined with

56 , among 41 participants who did not meet the neuropathologic criteria for AD, brain infarcts were onl

57 Among 61 participants who met the neuropathologic criteria for AD, those with brain infarc

58 neocortex were classified as having met the neuropathologic criteria for AD.

59 VI ratings, and 15 of the others (75.0%) met neuropathologic criteria for other dementia-related dise

60 ) had Braak stages III to VI ratings and met neuropathologic criteria for other dementia-related dise

61 Pooled clinical and neuropathologic data from 3 prospective cohort studies i

62 y, we analyzed the clinical, radiologic, and neuropathologic data of 174 patients (77 women and 97 me

63 th results that agree with known trends from neuropathologic data showing increased axon diameter and

64 he Cognitive Function and Ageing Study) with neuropathologic data; mean (SD) age at death was 90 (6.4

65 he NAWM of SPMS patients is in line with the neuropathologic demonstration that activated microglial

66 In the 87 cases lacking a neuropathologic diagnosis of AD or other dementing disor

67 from families with affected individuals with neuropathologic diagnosis of dementia with Lewy bodies (

68 that affect autonomic function, a coexisting neuropathologic diagnosis, or insufficient clinical info

69 on of sEH was observed previously in various neuropathologic disorders including vascular dementia an

70 ptor CD11b/CD18 protects from all immune and neuropathologic effects.

71 aphasia (PPA) can be caused by 1 of several neuropathologic entities, including forms of frontotempo

72 Those who died underwent a uniform neuropathologic evaluation from which previously establi

73 within the ensuing 24 months, and underwent neuropathologic evaluation on autopsy.

74 Neuropathologic evaluation revealed extensive limbic and

75 Neuropathologic evaluation reveals a striking spongiform

76 n evaluations during old age, and postmortem neuropathologic evaluations of the participants' brains.

77 ta) assembly is hypothesized to be a seminal neuropathologic event in Alzheimer's disease (AD).

78 Rating Scale scores lacked correlation with neuropathologic evidence of dementing disorders.

79 er 30 years' disease duration, the proband's neuropathologic examination demonstrated abundant intran

80 We also report the human neuropathologic examination of SIK1-related developmenta

81 Upon the proband's death at age 63, neuropathologic examination revealed frontotemporal loba

82 A neuropathologic examination was performed on 100 consecu

83 e past few years, however, studies comparing neuropathologic examination with PET have established re

84 On neuropathologic examination, we collected semiquantitati

85 Neuropathologic examinations provided quantitative measu

86 up to 21 years, died, and underwent detailed neuropathologic examinations to identify Alzheimer's dis

87 yloid peptide (Abeta) plaques are a cardinal neuropathologic feature of Alzheimer disease (AD), yet m

88 Although the major neuropathologic feature of PD is the degeneration of dop

89 es composed of hyperphosphorylated tau are a neuropathologic feature of these closely related disorde

90 at these disorders share common clinical and neuropathologic features and that overlap between the tw

91 glycosylated PrP showed strikingly different neuropathologic features compared to those expressing di

92 r disease (AD) display well-recognized early neuropathologic features in the endolysosomal and autoph

93 We report the clinical and neuropathologic features of a family carrying a 6.4 Mb d

94 een these AD risk genes and the cellular and neuropathologic features of AD.

95 amyloid fibrils is one of the most prominent neuropathologic features of Alzheimer's disease.

96 ism does not strongly impact the clinical or neuropathologic features of Alzheimer's disease.

97 We report the clinical, neuroimaging, and neuropathologic features of progressive nonfluent aphasi

98 utopsy many AD patients not only exhibit the neuropathologic features of that disorder but also exhib

99 ata set by weighting results by clinical and neuropathologic features, sibship size, and APOE genotyp

100 The neuropathologic features, taxonomy, history, role of bio

101 severe and accelerated disease with atypical neuropathologic features.

102 hanges and alterations resulting from non-AD neuropathologic features.

103 ffuse Lewy-body dementia (DLBD) have diverse neuropathologic features.

104 We have also assessed the detailed neuropathologic findings in 18 autopsies from these fami

105 techniques, which is in dramatic contrast to neuropathologic findings in comparably hyperglycemic 6-m

106 ANTS: We describe the clinical, genetic, and neuropathologic findings of 5 unrelated cases of parkin

107 has occurred to validate the AD8 against the neuropathologic findings of Alzheimer's disease, we inve

108 re needed to help explain the variability in neuropathologic findings seen in individuals whose cogni

109 patient with progressive neurologic decline, neuropathologic findings, and final diagnosis are discus

110 rkers of synaptic plasticity and exaggerated neuropathologic findings, before such changes were found

111 ynuclein aggregation, are the most prominent neuropathologic findings.

112 This neuropathologic form of alpha-Syn plays a central role i

113 eta-Amyloid protein (betaAP) deposition is a neuropathologic hallmark of Alzheimer's disease (AD).

114 Amyloid Abeta deposition is a neuropathologic hallmark of Alzheimer's disease.

115 tep in amyloid-beta (Abeta) production and a neuropathologic hallmark of Alzheimer's disease; thus, p

116 ng distal axons and synapses, represents the neuropathologic hallmark of diabetic sympathetic autonom

117 ted microglia and brain macrophages, are the neuropathologic hallmark of HIV dementia.

118 gregation of alpha-synuclein (alphaSyn) is a neuropathologic hallmark of Parkinson's disease and othe

119 junction with neurofibrillary lesions is the neuropathologic hallmark of the dementia associated with

120 Neuropathologic hallmarks include nuclear and cytosolic

121 th DS will eventually show both clinical and neuropathologic hallmarks of Alzheimer's disease (AD).

122 variety of neurologic, neuropsychologic, and neuropathologic impairments.

123 whether the effects of demographics and each neuropathologic index on cognition changed over time.

124 At autopsy, several neuropathologic indicators of Alzheimer disease were det

125 ed to 11 typical PSP cases with quantitative neuropathologic indices and assessment of demographics,

126 vitro and in-vivo models supports a role for neuropathologic injury and neurobehavioral deficits at o

127 nstitutions; however, previous autopsy-based neuropathologic investigations have provided conflicting

128 al applications in experimental and clinical neuropathologic investigations.

129 Fewer neuropathologic lesions of AD appeared to result in deme

130 home residents who had either no significant neuropathologic lesions or lesions associated only with

131 by several reports associating the cardinal neuropathologic lesions with markers of free radical-ind

132 atistically significant correlation with any neuropathologic marker.

133 rative processes associated with the classic neuropathologic markers of senile plaques and neurofibri

134 chiatric ratings and densities of any of the neuropathologic markers.

135 derived standardized uptake value ratios to neuropathologic measures of amyloid.

136 autopsy, conscientiousness was unrelated to neuropathologic measures, but it modified the associatio

137 did not differ on several Alzheimer disease neuropathologic measures; however, high CLS men had less

138 at anti-DNA antibodies may promote important neuropathologic mechanisms in chronic inflammatory disor

139 Neuropathologic outcomes included neurofibrillary tangle

140 impacts that induces the neurobehavioral and neuropathologic outcomes seen in humans with a history o

141 r and that intrauterine infection results in neuropathologic outcomes similar to those observed in hu

142 gregation-induced apoptosis and improves the neuropathologic phenotype in an animal model of human ne

143 This study describes the neuropathologic phenotype of PrP(d) accumulation in shee

144 otype resembles Alzheimer's disease, and the neuropathologic phenotype resembles progressive supranuc

145 TTR gene accelerated the development of the neuropathologic phenotype.

146 condary inflammation that contributes to the neuropathologic process.

147 t cognitive profile that differed from other neuropathologic processes (related to decline in episodi

148 ltimodal neuroimaging measures of underlying neuropathologic processes account for over a third of th

149 th the symptomatology of ADC, as well as the neuropathologic profile of post-mortem HIV brains sugges

150 with unusual clinical features and a unique neuropathologic profile was reported in the United Kingd

151 ction may be explained by early HTLV-related neuropathologic progression.

152 mechanism by which alpha-synuclein becomes a neuropathologic protein through Nox1-mediated oxidative

153 analyzed using Aperio software, which allows neuropathologic quantification in the posterior cingulat

154 The few available detailed neuropathologic reports suggest that homozygous and comp

155 gic analysis was still available, additional neuropathologic review led to a more specific categoriza

156 A retrospective neuropathologic review of 30 SIV-infected pigtailed maca

157 Despite a comprehensive neuropathologic review with additional studies and infor

158 stic oligodendroglioma on subsequent central neuropathologic review.

159 ain regions and analyzed to compute a summed neuropathologic score.

160 ened lesions in both fentanyl groups' summed neuropathologic scores (P=0.002) in protocol 1 and speci

161 In addition to analysis of specific regions, neuropathologic scores were also summated over all brain

162 oglia could be contributing to the secondary neuropathologic sequelae after a diffuse TBI.

163 Bcl-2 protein may play a protective role in neuropathologic sequelae after TBI.

164 Clinical and neuropathologic similarities suggest that the disease in

165 harmacologic, and, most recently, postmortem neuropathologic studies have confirmed.

166 Recent neuroimaging, clinical and molecular neuropathologic studies have provided new insights into

167 Neuropathologic studies indicate that these disorders ma

168 Neuropathologic studies of nine affected individuals sho

169 Neuropathologic studies provide consistent evidence of a

170 RECENT FINDINGS: Although neuropathologic studies show that limbic system tau dise

171 We report the results of a comprehensive neuropathologic study performed to identify AD and other

172 Alzheimer type (AD/SDAT) is the most common neuropathologic substrate of dementia.

173 RG1 provides beneficial effects in candidate neuropathologic substrates of AD and, therefore, is a po

174 er's neurofibrillary pathology is one of the neuropathologic substrates of mild cognitive impairments

175 Heterogeneity was driven by neuropathologic subtype and DKI technique.

176 RP deficiency and provide insight into their neuropathologic underpinnings.