ライフサイエンスコーパス: neuropathology

1 ular development, neurovascular coupling and neuropathology.

2 to AIDS-related central nervous system (CNS) neuropathology.

3 perience of the patient and their underlying neuropathology.

4 tal neural stem cells are vulnerable to ZIKV neuropathology.

5 th normal aging and can elicit or exacerbate neuropathology.

6 was correlated with lesser Alzheimer disease neuropathology.

7 ly correlated with increased levels of brain neuropathology.

8 nset of AD and greater burden of Alzheimer's neuropathology.

9 these levels were not correlated with brain neuropathology.

10 vivo (18) F-flortaucipir and postmortem tau neuropathology.

11 models characterized by progressive/chronic neuropathology.

12 function that is associated with significant neuropathology.

13 r it affects AAO and severity of Alzheimer's neuropathology.

14 n ATP13A2 activity may be driving PD-related neuropathology.

15 critically regulates alpha-synuclein-induced neuropathology.

16 epsins B, H and L, on the development of NPC neuropathology.

17 causes myelin outfoldings as a very specific neuropathology.

18 of BDNF in HD mice is protective against HD neuropathology.

19 s unknown, as is the locus of any associated neuropathology.

20 SD from the standpoint of human genetics and neuropathology.

21 rst description of diencephalic and striatal neuropathology.

22 sed in neurons-would be capable of eliciting neuropathology.

23 are points at which intervention may reduce neuropathology.

24 spinal cord and skeletal muscle before overt neuropathology.

25 ical variables in the study of developmental neuropathology.

26 ase both in regards to clinical symptoms and neuropathology.

27 hance macrophage migration, resulting in HIV neuropathology.

28 hat has been shown to reduce NPC1-associated neuropathology.

29 entation of therapies to slow progression of neuropathology.

30 henotype: memory deficits, and Abeta and tau neuropathology.

31 g both peripheral metabolic disorders and AD neuropathology.

32 etailed longitudinal clinical evaluation and neuropathology.

33 fects to variations in amount of age-related neuropathology.

34 sentation reminiscent of LRRK2-associated PD neuropathology.

35 63 (30%) with high-level Alzheimer's disease neuropathology.

36 on, in the absence of detectable progressive neuropathology.

37 ssociated with a characteristic 4-repeat tau neuropathology.

38 get(s) of FTP in cases of suspected FTLD-TDP neuropathology.

39 hich endogenous single-strand breaks trigger neuropathology.

40 tratify them by level of Alzheimer's disease neuropathology.

41 tent with the zebrafish findings and patient neuropathology.

42 estigating the development of stress-induced neuropathology.

43 rupt synaptic endosomal signaling and induce neuropathology.

44 ch correlates with lupus disease and limited neuropathology.

45 ttent hypoxia, are ineffective in preventing neuropathology.

46 ectivity in sea lion brains, with or without neuropathology.

47 otential therapeutic target for galactosemia neuropathology.

48 es to myelodysplastic syndromes, cancer, and neuropathologies.

49 line analgesics were scarce across sites and neuropathologies.

50 ty, damages to oligodendrocytes, or other WM neuropathologies.

51 ing drugs for treatment of AD and/or similar neuropathologies.

52 maging and therapy of solid malignancies and neuropathologies.

53 function, and its disruption underlies many neuropathologies.

54 n-amyloid-plaque, non-neurofibrillary-tangle neuropathologies.

55 chaperone downregulation mediates different neuropathologies.

56 a mouse model of genetically induced AD-like neuropathology (3xTg-AD).

57 56 (26%) with low-level Alzheimer's disease neuropathology, 45 (21%) with intermediate-level Alzheim

58 9 (23%) patients with no Alzheimer's disease neuropathology, 56 (26%) with low-level Alzheimer's dise

59 sruption causes previously undescribed novel neuropathology accompanying abnormal ubiquitin/p62 accum

60 er TBI, post-mortem studies on the long-term neuropathology after injury have identified complex pers

61 encing recovery of neurological function and neuropathology after SCI.

62 based on studies demonstrating prevention of neuropathology after trauma-induced nerve injury.

63 n the lifespan) and how (gene expression and neuropathology) Alzheimer's risk genes impact the brain.

64 sample (n=269, age 0-92) and (3) Alzheimer's neuropathology (amyloid plaques and tau tangles) using a

65 DNA damage are a common cause of both these neuropathologies and are associated with a growing numbe

66 assessed for the effect of the treatment on neuropathologies and behavioral impairments.

67 provide a novel model for studying human GAN neuropathologies and for the development and testing of

68 ts of neurons resulted in cell type-specific neuropathologies and gene downregulation in mouse CNS.

69 s extremely helpful in understanding various neuropathologies and neurodegenerative disorders.

70 nd (1) AAO of AD (2) severity of Alzheimer's neuropathology and (3) fibrillar brain amyloid depositio

71 sess brain function and to investigate early neuropathology and aging effects in translational resear

72 nhibition of GSK3 signaling can reduce Abeta neuropathology and alleviate memory deficits in AD model

73 (MIA) alone is sufficient to impart lifelong neuropathology and altered behaviors in offspring.

74 y reported that severe lysosomal and amyloid neuropathology and associated cognitive deficits in the

75 ding enzyme, synj1, improves amyloid-induced neuropathology and behavior deficits through acceleratin

76 ties: they may be cascade effects of earlier neuropathology and behavioral abnormalities.

77 clinical studies have assessed the long-term neuropathology and behavioral deficits after sustaining

78 er, whether targeting this pathway after the neuropathology and behavioral impairments have been esta

79 after injury, attenuates the development of neuropathology and brain dysfunction during acute and ch

80 Similarities in the neuropathology and clinical presentation shared by FBD a

81 isorder that is characterized by progressive neuropathology and cognitive decline.

82 imental lesions to the LC exacerbate AD-like neuropathology and cognitive deficits in several transge

83 m (EEG) activity in addition to the expected neuropathology and cognitive deficits.

84 imer's disease cerebrovascular degeneration, neuropathology and cognitive function, suggesting that G

85 s link neuroinflammation as a contributor to neuropathology and cognitive impairment in traumatic bra

86 Pcmt1 knock-out mice exhibit a profound neuropathology and die 30-60 days postnatal from an epil

87 vation of complement is a key determinant of neuropathology and disability after traumatic brain inju

88 However, the genetic frequency, neuropathology and downstream consequences of riboflavin

89 bnormalities were associated with HD-related neuropathology and dysfunction of the cortical-basal gan

90 s emphasize the relevance of white matter to neuropathology and familiality of bipolar disorder and e

91 als with DS develop Alzheimer's disease (AD) neuropathology and have elevated risk for dementia start

92 l role of BDNF-dependent GR signaling in tau neuropathology and indicate that DUSP1 is a potential ta

93 The role of amyloid-beta (Abeta) neuropathology and its significant changes in biofluids

94 velopment of amyloid-beta (Abeta)-associated neuropathology and learning/memory impairments in APPPS1

95 tity, characterized by the presence of mixed neuropathology and only different by the time course.

96 Concordant patterns of neuropathology and prion deposition in susceptible mice

97 clearance of proteolipid aggregates, reduces neuropathology and prolongs survival of diseased mice.

98 erwise complement-sufficient animals reduces neuropathology and promotes neurologic recovery after TB

99 rophylactic by providing both attenuation of neuropathology and stimulation of repair.

100 cture of ASD and integrate genetic evidence, neuropathology and studies in model systems with how the

101 with intermediate-level Alzheimer's disease neuropathology, and 63 (30%) with high-level Alzheimer's

102 ed BACE1 inhibitors on brain amyloid burden, neuropathology, and behavioral function in aged preclini

103 ional outcomes, postmortem analyses assessed neuropathology, and brain atrophy was detected by ex viv

104 es in the biophysical properties of PrP(Sc), neuropathology, and clinical prion disease.

105 anges in neuroinflammation, virus clearance, neuropathology, and development of brain atrophy via T2-

106 al, body weight, body temperature, behavior, neuropathology, and disease biomarkers in a genetic mous

107 y was performed; the differential diagnosis, neuropathology, and final diagnosis are discussed here.

108 Animal behavior, molecular phenotypes, neuropathology, and magnetic resonance spectroscopy were

109 tonias, DYT6 patients have no characteristic neuropathology, and mechanisms by which mutations in THA

110 g c-Abl reduced alpha-synuclein aggregation, neuropathology, and neurobehavioral deficits.

111 ice accelerated alpha-synuclein aggregation, neuropathology, and neurobehavioral deficits.

112 reduces cognitive impairments, the degree of neuropathology, and seizure susceptibility, after pediat

113 mong patients with clinical PPA syndrome, AD neuropathology appeared to interfere with effortless lea

114 wildtype mice and in a mouse model of Abeta neuropathology (APPSWE /PS1dE9 ) from 6 months of age.

115 stry of autopsy-acquired brain tissue from a neuropathology archive.

116 These results suggest that age-related neuropathologies are differentially related to late life

117 chanism by which the repeat expansion drives neuropathology are unknown.

118 in motility, and consequently their links to neuropathology, are not understood.

119 -brain barrier breakdown and T-cell-mediated neuropathology as potential underpinnings of ZIKV-associ

120 tored the mice for clinical signs of EAE and neuropathology, as well as effector T-cell responses usi

121 can promote lifelong changes in symptoms and neuropathology associated with human PTSD, even if there

122 ogical and neuroimaging evidence implicating neuropathology associated with psychosis is consistent w

123 Neuropathology-associated ANK1 hypermethylation was subs

124 Following neuropathology, astrocytes become reactive and many of t

125 YMAD), i.e., individuals with significant AD neuropathology at death but without evidence for cogniti

126 pared with ataxin-3-23Q and develop ataxin-3 neuropathology, ataxin-3 cleavage fragments and motor im

127 ting globally coherent phenomena, such as in neuropathologies, bacterial cell colonies, social system

128 nd that even before the development of overt neuropathology, both animals manifested significant memo

129 Parkinson's disease have distinct underlying neuropathology, but both diseases affect cognitive funct

130 ells via beta2 m deficiency does not reverse neuropathology, but exacerbates disease both in the brai

131 retation of its relationship with underlying neuropathology can be complex.

132 To determine whether AD neuropathology can cause peripheral metabolic impairment

133 t alpha7 nAChR may play an important role in neuropathology caused by gp120, METH and NT, which are t

134 ing a possible explanation for the selective neuropathology caused by mutations in a widely expressed

135 ients include failure to thrive and a severe neuropathology characterized by microcephaly, hypomyelin

136 demonstrated a very significant reduction in neuropathology compared to wild-type VSIV and the protot

137 One affected expansion carrier had neuropathology compatible with AD.

138 (24-month-old, aged male mice with advanced neuropathology) conditions.

139 The Stanley Neuropathology Consortium Integrative Database is a data

140 llosum, i.e., forceps minor (CCFM), and this neuropathology correlated with higher relapse-like drink

141 Neuropathology data are available for the subset of part

142 We analyzed the neuropathology data from the hippocampus to identify tho

143 base is a data-mining tool that includes 379 neuropathology data sets from hippocampus, as well as RN

144 of Bmal1 in neurons and glia caused similar neuropathology, despite the retention of intact circadia

145 hile considerable interanimal variability in neuropathology, disease onset, and tau prion formation i

146 re phenotypically normal without evidence of neuropathology, displayed an exacerbated response to EAE

147 [F-18]FDDNP PET to detect brain patterns of neuropathology distribution in retired professional Amer

148 n brain imaging, non-imaging biomarkers, and neuropathology during the past 15 years have required re

149 Recent advances in neuroimaging, neuropathology, epidemiology, and genetics have led to a

150 h lifestyle and potential chronic changes in neuropathology explain these findings is unclear.

151 The present results suggest that AD-like neuropathology extends to the pancreas in the 3xTg-AD mo

152 gress has been made toward understanding the neuropathology, genetic origins, and epidemiology of neu

153 nt of a set of vascular cognitive impairment neuropathology guidelines (VCING), representing a valida

154 the molecular and cellular underpinnings of neuropathology has been assessed via gene expression ana

155 d demyelination are not factors in long-term neuropathology.-Huseby Kelcher, A.

156 algesic variability appeared to be driven by neuropathology; ibuprofen was preferred for traumatic br

157 moting viral clearance yet may contribute to neuropathology if not rigorously regulated.

158 Neuropathology, immunohistochemistry, and immunoreactivi

159 h the lack of a membrane phospholipid causes neuropathology, implicating plasmalogens as regulators o

160 investigated for trait and state progressive neuropathologies in MDD using both unbiased approaches a

161 teins, potentially ameliorating the observed neuropathology in [A30P]alphaSyn and SynCAST(+) mice.

162 ting tau hyperphosphorylation and subsequent neuropathology in AD and related tauopathies.

163 and vascular disease also contribute to the neuropathology in AGS.

164 gnaling may influence cognitive function and neuropathology in Alzheimer's disease (AD).

165 al role in the dissociation of cognition and neuropathology in an aging population, and we expanded o

166 nal structural stability as a major cellular neuropathology in ASD.

167 In addition, I address the role of neuropathology in characterizing the sequelae of new AD/

168 on within the neuron, defining the causes of neuropathology in DCTN1 mutants has been difficult.

169 wy bodies in Parkinson's disease, is causing neuropathology in dopamine neurons remains unclear.

170 To define the mechanisms underlying neuropathology in ETC disorders, we have modeled the mos

171 od intake (dietary restriction, DR) prevents neuropathology in experimental cerebral malaria (ECM).

172 EAE severity and neuropathology in H2RKO mice expressing H2R exclusively

173 rescue this deficient BDNF release and early neuropathology in HD knock-in mouse brain.

174 alleviate the deficient exosome release and neuropathology in HD mice.

175 ecule p75NTR ligand, LM11A-31, on HD-related neuropathology in HD mouse models (R6/2, BACHD).

176 inclusions, recapitulating the diversity of neuropathology in human tauopathies.

177 gradative enzyme in lysosome contributing to neuropathology in INCL and suggest that lysosomal CD def

178 ) restored BBB integrity and also abated the neuropathology in infected mice.

179 e CNS at early stage of infection and causes neuropathology in infected rhesus macaques at a high fre

180 Prions are responsible for neuropathology in mammals, but they can also be function

181 Characterising neuropathology in mouse models of HD is commonly restric

182 Zika virus (ZIKV) is associated with severe neuropathology in neonates as well as Guillain-Barre syn

183 emerged as a pandemic associated with severe neuropathology in newborns and adults.

184 rent types and cellular distributions of tau neuropathology in our model that recapitulate the hetero

185 uggested to contribute to the progression of neuropathology in Parkinson's disease (PD).

186 increase of TPP1 activity and attenuation of neuropathology in patient iPSC-derived neural progenitor

187 ties may be important to reverse CIH-induced neuropathology in patients with sleep disordered breathi

188 logy in three brain regions found to exhibit neuropathology in postmortem ASD brains.

189 otection in vivo in a lentiviral model of HD neuropathology in rat striatum.

190 ed to obtain a viral isolate that can induce neuropathology in rhesus macaques.

191 own to rescue synaptic plasticity and reduce neuropathology in rodent models of cognitive disorders.

192 reliable biomarkers for Alzheimer's disease neuropathology in synucleinopathies should help to ident

193 red multiple motor functions and exacerbated neuropathology in tau-transgenic mice in a manner depend

194 icient (Ppt1(-/-) ) mice before the onset of neuropathology in the brain.

195 d which is also associated with the abnormal neuropathology in the disorders.

196 e results provide potential insight into how neuropathology in the entorhinal cortex could contribute

197 kyrin 1 (ANK1) gene that was associated with neuropathology in the entorhinal cortex, a primary site

198 efore age 5 weeks, and significant (P < .05) neuropathology in the hindbrain of 24-week-old mice was

199 greater clinical disease severity with more neuropathology in the spinal cord, cerebellum, and cereb

200 eficits, as well as late-onset and selective neuropathology in the striatum, which was markedly ameli

201 he 1990s and 2008, we examined behavior, and neuropathology in three brain regions found to exhibit n

202 incoordination, imbalance and the associated neuropathology in transgenic MJD mice.

203 ne response in the brain as a major cause of neuropathology in various neurodegenerative conditions,

204 may help stratify clinical cohorts with pure neuropathology in which low CSF phosphorylated-tau level

205 /PS1dE9 mice markedly ameliorated AD-related neuropathology including Abeta deposition, neuroinflamma

206 ilia dysfunction is associated with numerous neuropathologies, including hyperphagia-induced obesity,

207 c mitochondrial defects but develop specific neuropathology, including alpha-synuclein aggregation an

208 igand on neurosteroidogenesis and AD-related neuropathology, including beta-amyloid accumulation, gli

209 As levels of Alzheimer's disease neuropathology increased, cerebral alpha-synuclein score

210 amyloid beta levels and deposition, less tau neuropathology, increased synaptic integrity, and autoph

211 strains (22L and RML), which have dissimilar neuropathologies, indicated that the inflammatory respon

212 tress and an activated immune system have in neuropathology, innate immune training has important imp

213 The mechanism appears to be independent of neuropathology, instead involving an extended period of

214 o not support its use for neuroprotection in neuropathologies involving oxygen deprivation.

215 Zika virus (ZIKV)-related neuropathology is an important global health concern.

216 INTERPRETATION: Alzheimer's disease neuropathology is common in synucleinopathies and confer

217 and strain rate are greatest in sulci, where neuropathology is prominently seen in chronic traumatic

218 ctioning of white matter, but the underlying neuropathology is unclear.

219 which also causes HFMD, EV71 induces severe neuropathology leading to high fatalities, especially am

220 agnosis usually was associated with comorbid neuropathologies; less than one-quarter of MCI cases sho

221 lization in macaques with SIV-associated CNS neuropathology likely results from late viral entry of v

222 ppoptosin in neurological disorders with tau neuropathology, linking caspase-3-mediated tau cleavage

223 Consistent with the neuropathology literature, the presence of elevated neoc

224 gCRND8 mice that exhibit moderately advanced neuropathology markedly diminished the sizes of enlarged

225 Therefore, a critical aspect of ZIKV-induced neuropathology may be defined by death of uninfected cel

226 Pick disease tau neuropathology may originate in limbic/paralimbic cortic

227 This neuropathology may result from alcohol exposure or refle

228 ese behavioral changes, which precede severe neuropathology, may stem from non-pathological functions

229 cerbated leukocyte and humoral infiltration, neuropathology, motor disability, and mortality.

230 (n = 266), and controls with no significant neuropathology (n = 368).

231 ation from Machado-Joseph disease-associated neuropathology, namely reduction of Purkinje cell loss,

232 to as Non-Demented with Alzheimer's disease Neuropathology (NDAN).

233 ansgenic mice and assessed the effect on the neuropathology, neuroinflammation mediators and neurotro

234 t, p = 1.5 x 10-10), and was associated with neuropathology (NIA ADC, Braak stage of neurofibrillary

235 stem as an important research target for the neuropathology of adolescent-onset mental health disorde

236 Nearly all adults with Down syndrome show neuropathology of Alzheimer's disease, including amyloid

237 Thus, hippocampal neuropathology of chronic DA sea lions is similar to tha

238 We highlight the neuropathology of congenital syndromes that result from

239 e, we investigate the connection between the neuropathology of CS and dysregulation of gene expressio

240 ults, which could be due to heterogeneity in neuropathology of depression.

241 genesis have been shown to contribute to the neuropathology of depression.

242 The neuropathology of different neurodegenerative diseases b

243 Postmortem neuropathology of five TIA1 mutations carriers showed a

244 uit hyperexcitability has been implicated in neuropathology of fragile X syndrome, the most common in

245 sed levels ameliorate behavioral defects and neuropathology of Huntington's disease, Parkinson's dise

246 ate improvements in the understanding of the neuropathology of intellectual disability and dementia i

247 eview, we aim to describe recent advances in neuropathology of MSA from a review of the literature an

248 merous miRNAs are dysregulated in postmortem neuropathology of neuropsychiatric disorders, and there

249 gate whether RGMa might model aspects of the neuropathology of Parkinson's disease in mouse, we targe

250 ranscript (GAD67) has been implicated in the neuropathology of schizophrenia, the transcript structur

251 ing to elevate Top1cc levels phenocopied the neuropathology of the mouse models described above.

252 Furthermore, the neuropathology of the neurodegeneration that occurs afte

253 ovide unique insight into the early regional neuropathology of this symptom dimension in schizophreni

254 Neuropathology of two affected family members showed cer

255 o examine whether the effects of age-related neuropathologies on cognition change over time.

256 Brain neuropathology on 14 CLIPPERS cases demonstrated marked

257 e, not easily generalizable across different neuropathologies or inflammatory conditions.

258 own concerning their direct contributions to neuropathology or the cellular mechanisms regulating the

259 ls, no immune activation and no induction of neuropathology out to 6 weeks post injection.

260 ly different from the progressive pattern of neuropathology [paired helical filament (PHF)-tau and am

261 evels were identified as the cause of severe neuropathology present in the human microcephaly with se

262 Widespread neuropathology prior to symptom onset is consistent with

263 delivery approach, significantly ameliorates neuropathology, reducing neuroinflammation and activatin

264 ns in local hospitals (41%) or at the German Neuropathology Reference Center for Epilepsy Surgery (59

265 e independent and have distinct roles in FXS neuropathology remain poorly understood.

266 ms by which microglia alter the course of AD neuropathology remain poorly understood.

267 ch NPCT may be involved in Alzheimer disease neuropathology remain unknown.

268 oss the blood-brain barrier (BBB) and induce neuropathology remain unresolved.

269 gh the exact role of the immunoproteasome in neuropathology remains poorly defined.

270 In neuropathology research, induced pluripotent stem cell (

271 involved in the development of Abeta and tau neuropathology, respectively.

272 Neuropathology showed loss of motoneurons and motor axon

273 Neuropathology showed neuronal loss and extensive deposi

274 A (chronic DA sea lions) display hippocampal neuropathology similar to that of human patients with te

275 e network-based degeneration framework where neuropathology spreads across connectivity networks.

276 Genetics and neuropathology strongly link alpha-synuclein aggregation

277 g of brain energy metabolism and its role in neuropathologies such as diabetes, ischemia, and epileps

278 ain and help the diagnosis of early signs of neuropathologies such as multiple sclerosis, Alzheimer's

279 lops in a common mouse model of beta-amyloid neuropathology - Tg2576 mice.

280 earlier onset of phenotypes and more severe neuropathology than that in younger mice.

281 tify common pathways that influence multiple neuropathologies that coexist with NFT and found suggest

282 Ventriculomegaly is a neuropathology that has been associated with poor neurod

283 is Editorial introduces this month's special Neuropathology Theme Issue, a series of Reviews on advan

284 enes that mediate the development of AD-like neuropathologies, thereby providing new mechanistic insi

285 ity and suggest a strategy for linking focal neuropathology to remote neurophysiological changes.

286 ical pattern was pathognomonic of a specific neuropathology type, highlighting the critical role of b

287 n cognitively intact despite the presence of neuropathology usually associated with fully symptomatic

288 of HD cases, including those with low-level neuropathology (Vonsattel grade 0/1).

289 Neuropathology was also significantly ameliorated.

290 Neuropathology was measured by determining the percentag

291 stand transcriptional changes that accompany neuropathology, we acutely purify neurons, astrocytes an

292 microglial activation is a hallmark of HIV-1 neuropathology, we have investigated the role of LRRK2 a

293 microinfarcts and arteriolar sclerosis, all neuropathologies were associated with the cognitive traj

294 Neuroimaging and neuropathology were reviewed by experienced neuroradiolo

295 is a movement disorder characterized by tau neuropathology where the underlying mechanism is unknown

296 previously shown to trigger Alzheimer's-like neuropathology, which is characterized by Tau hyperphosp

297 ysiology in a rodent model of HIV-1-mediated neuropathology with and without cocaine self-administrat

298 ebral atherosclerosis and arteriolosclerosis neuropathology with probable and possible Alzheimer's di

299 at different brain regions was evaluated by neuropathology with silver staining.

300 oring high viral loads and displaying marked neuropathology, with motor impairment a frequent manifes