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1 s and often do not survive control for other neuropeptides).
2 ful application to prepare an (18) F-labeled neuropeptide.
3 much attention as a prosocial and anxiolytic neuropeptide.
4 ts and quantify 133 peptides belonging to 18 neuropeptides.
5 amine, acetylcholine, serotonin, and several neuropeptides.
6 functional characterization ArPPLNP2-derived neuropeptides.
7 action yield (up to 72%) for most lipophilic neuropeptides.
8 utive expression of orexigenic receptors and neuropeptides.
9 ronal-specific gene set, notably nociceptive neuropeptides.
10 ehavior are directly modulated by inhibitory neuropeptides.
18 or specifying AgRP-neurons, the anorexigenic neuropeptide alphaMSH for POMC-neurons, and two growth-s
19 e sequence data has revealed that PP/OK-type neuropeptides also occur in a deuterostomian phylum-the
20 ctors and matrix metalloprotease substrates, neuropeptides, amyloid peptides, antioxidant peptides, p
29 tain classical transmitters plus an array of neuropeptides and enzymes known to regulate diverse proc
31 udied, relatively little is known about most neuropeptides and only a few model insects have been inv
32 and (i.e., adenohypophysis) known to secrete neuropeptides and other small metabolites related to dev
35 vation of abundant copy number variations on neuropeptides and receptors, which will be valuable for
36 nd may mediate the spatiotemporal release of neuropeptides and their interactions in modulating aggre
37 ing decisions NPR-1 and TYRA-3, for NPY-like neuropeptides and tyramine respectively, do not appear t
38 receptors, ion channels, signaling proteins, neuropeptides and vesicular release components, and tran
39 While the ability for neurotransmitters, neuropeptides, and cytokines to initiate and maintain pa
40 Neuromodulators, including biogenic amines, neuropeptides, and hormones, are released to signal chan
43 and the recognition of the crucial role for neuropeptides are among the advances that have led to no
49 re, our data provide the first evidence that neuropeptides are present in the lateral motor nerves an
50 mass spectrometry was used to identify five neuropeptides (ArPPLN1a-e) derived from the SMP precurso
51 P2 revealed that it comprises eleven related neuropeptides (ArPPLN2a-k), the structures of several of
52 rmacology revealed that the ArPPLNP2-derived neuropeptide ArPPLN2h has no effect on the contractility
53 This highlights a novel role for sensory neuropeptides as acute and local mediators of pathogen-d
55 ew role for Otp in controlling developmental neuropeptide balance in a discrete OXT circuit whose dis
57 ips, and social networks) to show that three neuropeptides (beta-endorphin, oxytocin, and dopamine) p
58 ently deorphanized receptor for the abundant neuropeptide BigLEN, is expressed in the BLA, we investi
61 cesses, including oxidative phosphorylation, neuropeptide biogenesis, and connective tissue maturatio
62 cause of variability in patients' underlying neuropeptide biology, but this hypothesis has not been t
63 markers are lacking, and the frequently used neuropeptide/CaBP signatures are subject to regulation b
66 ditionally, NADA reduces blood levels of the neuropeptide calcitonin gene-related peptide but increas
67 d one peptide-receptor pair and found that a neuropeptide can couple neurosecretory and synaptic brai
69 ion of the ALA neuron, which releases FLP-13 neuropeptides characterized by an amidated arginine-phen
71 solute levels, which suggests formation of a neuropeptide cloud that covers the receptor-expressed ci
72 onoamine connections, as well as a subset of neuropeptide connections, in C. elegans based on new and
74 esults indicate that variation in an ancient neuropeptide contributes to interspecific differences in
77 , vasoactive intestinal polypeptide (VIP), a neuropeptide critical for synchrony in the adult SCN, an
78 h classical spike-dependent and nonclassical neuropeptide-dependent mechanisms.SIGNIFICANCE STATEMENT
79 mical and pharmacological data indicate that neuropeptides derived from ArPPLNP1 act as inhibitory ne
80 also indicate specialization in the roles of neuropeptides derived from these two PP/OK-type precurso
81 Analysis of the expression of ArPPLNP1 and neuropeptides derived from this precursor in A. rubens u
82 Analysis of the expression of ArPPLNP2 and neuropeptides derived from this precursor using mRNA in
83 rgeted and low-abundance analytes, including neuropeptides deriving from the pro-opiomelanocortin pre
85 omotor activity are unclear, but involve the neuropeptide diuretic hormone 44 (DH44), an ortholog of
86 sults suggest that an increase in the opioid neuropeptide dynorphin is responsible for reduced TBS LT
87 of the direct pathway co-release the opioid neuropeptide dynorphin which can inhibit dopamine releas
88 jection neurons (SPNs) co-release the opioid neuropeptide dynorphin, which acts at presynaptic kappa-
89 study shows that the neuron releases several neuropeptides - each with distinct sleep behavioral effe
93 neuropeptide precursors for all known insect neuropeptides except for arginine-vasopressin-like pepti
98 ever, little is known about the variation of neuropeptide expression patterns across closely related
100 tamate transporter eat-4/VGLUT, induction of neuropeptide expression, changes in axonal projection mo
103 atostatin A (AstA), allatotropin (AT), short neuropeptide F (sNPF), and tachykinin (TK) as potential
104 rimary nociceptive output by releasing short neuropeptide F, the Drosophila neuropeptide Y homolog.
105 the isolation of mutants in which inhibitory neuropeptides fail to properly modulate serotonin neuron
107 d peptides with their receptors, the largest neuropeptide family, and by characterizing coexpression
108 rminal pentapeptide of neuropeptide Y, and a neuropeptide FF analogue) were subject of this proof-of-
109 ME-SIMS for de novo sequencing of endogenous neuropeptides from tissue in situ (i.e., rat pituitary g
113 elated genes, with special relevance for the neuropeptide galanin that also revealed DNA methylation
114 ctivating transcription factor 3 (ATF3), the neuropeptides galanin and neuropeptide Y (NPY), brain-de
116 er, we manually curated a total of 127 human neuropeptide genes by integrating information from the l
123 detailed description, the hypocretin/orexin neuropeptides have since been studied in many different
124 ggests that TRH is an evolutionarily ancient neuropeptide, having its origin before the divergence of
125 ing the transition reveals that corazonin, a neuropeptide homologous to the vertebrate gonadotropin-r
127 ent research indicates that the hypothalamic neuropeptide hormone oxytocin is a key central nervous s
128 intergroup conflicts in humans involves the neuropeptide hormone oxytocin, known to influence trust,
131 ministration of oxytocin has implicated this neuropeptide in face perception and social memory, no pr
132 ne-related peptide (CGRP), the most abundant neuropeptide in primary afferent sensory neurons, is str
135 peptide (SMP) was identified as a PP/OK-type neuropeptide in the starfish Patiria pectinifera (phylum
137 hypothesis that packing of peptide hormones/neuropeptides in dense-core vesicles do not necessarily
140 l studies showing the importance of multiple neuropeptides in reinstatement of drug use, we formulate
141 the receptor genes for six well-known social neuropeptides in relation to three separate domains of s
142 hese observations support a regional role of neuropeptides in the brain after a long withdrawal inter
143 ysis, we discovered similar up-regulation of neuropeptides in the dauer-like infective juveniles of d
144 compare the immunoreactivity patterns of 14 neuropeptides in three closely related microscopic dinop
145 obial communities in other organisms.Certain neuropeptides, in addition to their neuromodulatory func
147 terior neurosecretory center expressing many neuropeptides, including hypothalamic peptide orthologs
148 he SCN expresses many functionally important neuropeptides, including vasoactive intestinal peptide (
149 eral distribution and age-related changes in neuropeptides indicate a modulatory role in sensory inpu
151 important gap in our understanding of brain neuropeptide interactions in the context of regulation o
152 ight with associated changes in hypothalamic neuropeptides involved in growth and feeding after 24 hr
154 transmission, especially via monoamines and neuropeptides, is also critical to brain function and oc
156 e-vasopressin-like peptide (AVLP), CNMamide, neuropeptide-like precursors 2-4 (NPLP2-4), and proctoli
157 imately 400 mum or more, including potential neuropeptide markers involved in many diseases such as n
158 The non-overlapping expression of different neuropeptides may indicate that the regionalization in t
159 formation and rewiring of neural circuits by neuropeptides may require coordinated production of thes
162 l how integration of somatosensory input and neuropeptide-mediated modulation can produce robust moda
165 is eliminated in mutants lacking oxytocin, a neuropeptide modulating social behaviors in many species
172 and general principles for understanding how neuropeptides organize neuronal activity and behaviors.
176 e in psychosocial behavior, the hypothalamic neuropeptide oxytocin contributes to metabolic control b
180 A large body of evidence has implicated the neuropeptides oxytocin and vasopressin in the modulation
182 ocytochemistry for SST and neuropeptide Y, a neuropeptide partially coexpressed in SST-IR neurons.
183 ep-promoting system and suggest that RFamide neuropeptides participate in an ancient and central aspe
187 d genetic manipulations demonstrate that the neuropeptide pigment-dispersing factor (PDF) amplifies t
188 ure today attests that the hypocretin/orexin neuropeptides play important roles in multiple physiolog
190 Ap and Chi in the neurons expressing PDF, a neuropeptide, play important roles in proper sleep/wake
191 rs: an SMP-type precursor (A. rubens PP-like neuropeptide precursor 1; ArPPLNP1) and a second precurs
192 a-e) derived from the SMP precursor (PP-like neuropeptide precursor 1; ArPPLNP1) in the starfish Aste
193 g frequencies increased in mice lacking TAC1 neuropeptide precursor and decreased in capsaicin-diet f
195 ree candidate genes were found to encode the neuropeptide precursors for all known insect neuropeptid
198 that both overexpression and mutation of the neuropeptide prokineticin 2 (Prok2) affect sleep and wak
205 es a particle-embedded monolith to condition neuropeptide releasates collected from several Aplysia n
206 UNC-18, which regulates neurotransmitter and neuropeptide release from synaptic vesicles, is a critic
208 MENT Given the rising scientific interest in neuropeptide research in the context of emotional and st
209 ion toolkit available for parasitic nematode neuropeptide research, and assess the scope and limitati
210 e and others described the same hypothalamic neuropeptides, respectively called the hypocretins or or
215 Thereby, oxytocin neurons seem essential for neuropeptide S-induced anxiolysis, as this effect was bl
217 ngs warrant further research to test whether neuropeptides secreted by nerve cells contribute to the
219 ion potentials and dendritic integration, to neuropeptide signaling and processing of signals from mu
220 indings reveal that, under stress, increased neuropeptide signaling in C. elegans enhances their deci
221 s in a complex network with serotonergic and neuropeptide signaling pathways to control food-regulate
222 ing using sbt-1 mutants and demonstrate that neuropeptide signaling promotes the decision to enter da
224 d that bursts of action potentials and local neuropeptide signals are both capable of evoking large i
233 neuroendocrine PanIN cells that express the neuropeptide substance P (SP) receptor neurokinin 1-R (N
238 Thus, otpa and otpb differentially regulate neuropeptide switching in a newly identified subset of O
239 eleasing hormone (TRH) is a highly conserved neuropeptide that exerts the hormonal control of thyroid
240 e-releasing hormone (GHRH) is a hypothalamic neuropeptide that has been shown to act as paracrine/aut
241 Gonadotropin-inhibitory hormone (GnIH) is a neuropeptide that suppresses reproduction in birds and m
242 mmune mediators to produce pain, and release neuropeptides that act on the immune system to regulate
243 n language of cytokines, growth factors, and neuropeptides that enables bidirectional communication.
244 cokinins (OKs) are prototypes of a family of neuropeptides that have been identified in several phyla
245 peptide (PP) and orcokinin (OK) are related neuropeptides that were discovered in protostomian inver
246 t these outcomes are mediated by a number of neuropeptides, the roles these play remain debated.
247 RNAi reverse genetics, we show that TRH-like neuropeptides, through the activation of their receptor
251 ne related peptide (CGRP), substance P (SP), neuropeptide tyrosine (NPY), and the nitric oxide synthe
259 ort that the vertebrate hypothalamic RFamide neuropeptide VF (NPVF) regulates sleep in the zebrafish,
260 nct from AMP functions, including endogenous neuropeptides, viral fusion proteins, topogenic peptides
262 that impair the somnogenic effects of FLP-13 neuropeptides, we identified the gene dmsr-1, which enco
263 s, neurotransmitter-synthesizing enzymes and neuropeptides, were selected according to their expressi
265 excitatory (NKB) and inhibitory (dynorphin) neuropeptides, which were found to synchronize the Kiss1
266 ember of the animal phylum Cnidaria) secrete neuropeptides with antibacterial activity that may shape
267 mouse vagina, effecting the distribution of neuropeptides with diverse roles in function of the fema
270 e truncated cleaved form of neurotransmitter neuropeptide Y (NPY) actively promotes a breach of BM va
272 sh, and here we report the identification of neuropeptide Y (NPY) as both necessary for normal daytim
275 ic inputs to the two populations of striatal neuropeptide Y (NPY) interneurons, plateau low threshold
279 In birds, CART inhibits food intake, whereas neuropeptide Y (NPY), a well-known orexigenic peptide, s
280 ctor 3 (ATF3), the neuropeptides galanin and neuropeptide Y (NPY), brain-derived neurotrophic factor
281 ent with PEDF + DHA induced transcription of neuropeptide y (npy), small proline-rich protein 1a (spr
285 s that synthesize agouti-related peptide and neuropeptide Y but inhibited anorexigenic neurons that s
288 used immunohistochemistry for calretinin and neuropeptide Y in 24 age- and gender-matched patients wi
292 lly significant difference in the density of neuropeptide Y+ neurons between subjects with autism and
293 rocessed for immunocytochemistry for SST and neuropeptide Y, a neuropeptide partially coexpressed in
294 n analogue of the C-terminal pentapeptide of neuropeptide Y, and a neuropeptide FF analogue) were sub
295 ridization to localize appetite-stimulating (neuropeptide Y, NPY; agouti-related protein, AGRP) and a
300 f sympathetic nerves and tissue abundance of neuropeptide-Y, an indicator of sympathetic nerve activi
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