ライフサイエンスコーパス: neuropilin

1 e C-terminus of Sema3F with the b1 domain of neuropilin.

2 al domain of semaphorin and the b1 domain of neuropilin.

3 hat potently inhibits the binding of VEGF to neuropilin.

4 that acts through a mechanism distinct from neuropilins.

5 nteraction with their receptors, plexins and neuropilins.

6 However, invertebrates lack neuropilins.

7 ropose possible models for ligand binding to neuropilins.

8 tC signal independently of the Robos and the Neuropilins.

9 e known primarily as ligands for plexins and neuropilins.

10 L1) and the semaphorin 3A (Sema3A) receptor, neuropilin 1 (Npn1), important for establishment of area

11 We provide evidence that Neuropilin 1 (Nrp-1), highly expressed by Foxp3(+) T reg

12 Here we show that Neuropilin 1 (Nrp1) and Nrp2, transmembrane proteins wit

13 BMA nucleus, owing to reduced expression of neuropilin 1 (Nrp1) and Nrp2, two semaphorin receptors t

14 VEGF165 binds the transmembrane protein neuropilin 1 (NRP1) and promotes the migration, survival

15 mall molecule ligand for the VEGF-A receptor neuropilin 1 (NRP1) and the structural characterization

16 demonstrate that beta8 integrin (Itgb8) and neuropilin 1 (Nrp1) cooperatively promote CNS angiogenes

17 Moreover, high expression of PlGF receptor neuropilin 1 (Nrp1) correlates with poor overall surviva

18 Here we show that neuropilin 1 (NRP1) directly interacts with EBV gB(23-43

19 tion, bevacizumab decreased Ang1 and induced neuropilin 1 (NRP1) expression in tumor-associated macro

20 semaphorin SEMA3C, and their shared receptor neuropilin 1 (NRP1) in OFT development, the precise mech

21 Neuropilin 1 (NRP1) is a receptor for class 3 semaphorin

22 Neuropilin 1 (NRP1) is a transmembrane glycoprotein that

23 We report here that Neuropilin 1 (Nrp1) is expressed at high levels by most

24 Neuropilin 1 (NRP1) plays an important but ill-defined r

25 analyses with in vitro assays, we show that neuropilin 1 (NRP1) promotes contralateral RGC projectio

26 of GlyRS, enabling GlyRS(CMT2D) to bind the neuropilin 1 (Nrp1) receptor.

27 by endothelial cells where it partners with neuropilin 1 (Nrp1) to form a functional receptor for th

28 The transmembrane receptor protein neuropilin 1 (Nrp1) was recently identified as an aberra

29 Neuropilin 1 (Nrp1), a coreceptor for class 3 semaphorin

30 Moreover, TAOK2 interacts with Neuropilin 1 (Nrp1), a receptor protein that binds the s

31 Emerging evidence suggests that neuropilin 1 (Nrp1), an originally defined coreceptor fo

32 ssel growth, endothelial cells (ECs) express neuropilin 1 (NRP1), and NRP1 associates with the recept

33 f these targets is the guidance cue receptor Neuropilin 1 (Nrp1), which is sensitive to the repellent

34 However, the addition of neuropilin 1 (Nrp1)-blocking antibody or siRNA knockdown

35 e identified the LD22-4 membrane receptor as neuropilin 1 (NRP1).

36 r involved signaling through VEGF receptor 2-neuropilin 1 (VEGFR2-NP1) receptors on endometrial strom

37 Syb2 associated with Neuropilin 1 and Plexin A1, two essential components of

38 izes the extrinsic pathway and requires both neuropilin 1 and plexin A3.

39 aging, as well as suggest miR-208a, AT2R and neuropilin 1 as potential therapeutic targets and mechan

40 study highlights the proangiogenic receptor neuropilin 1 in macrophages and microglial cells in glio

41 A novel role for myeloid cell-specific neuropilin 1 in mitigating sepsis.

42 Importantly, deletion of either neuropilin 1 or plexin A3 significantly reduces developm

43 L1 and modulating the endocytosis of the L1/neuropilin 1 Sema3A receptor complex.

44 betic female rats have reduced expression of neuropilin 1 that attenuates cardiomyopathy compared to

45 iple combination of selection markers--CD34, neuropilin 1, and human kinase insert domain-containing

46 ls of multiple genes and proteins (including Neuropilin 1, glucocorticoid-induced tumor necrosis fact

47 actor (VEGF), VEGF receptors, semaphorin 3F, neuropilin 1, neuropilin 2, podoplanin, and LYVE-1 by qu

48 evels of known A10 elevated genes, including neuropilin 1, neuropilin 2, slit2 and adenylyl cyclase-a

49 egulate axonal levels of the Sema3A receptor neuropilin 1.

50 moral M1, acting through the SEMA3A receptor neuropilin 1.

51 Further, we show that neuropilin-1 (NP-1) mediates both PS-dependent and PS-in

52 Neuropilin-1 (Np-1), a receptor for semaphorin 3A and va

53 t and are linked to tumor cell expression of neuropilin-1 (Np-1).

54 Interestingly, neuropilin-1 (Npn-1) is expressed by periocular neural c

55 ding of Sema3A to its high-affinity receptor Neuropilin-1 (Npn-1).

56 ssed in the lens epithelium and its receptor Neuropilin-1 (Npn1) is expressed in the trigeminal gangl

57 RPPR peptide, with affinity for the receptor neuropilin-1 (NRP), which is expressed on both endotheli

58 that must be C-terminally exposed to trigger neuropilin-1 (NRP-1) binding, cellular internalization a

59 Instead, VEGF-A acts via the neuropilin-1 (NRP-1) co-receptor.

60 eport that expression of the VEGF coreceptor neuropilin-1 (NRP-1) coincides with expression of Brachy

61 Expression of neuropilin-1 (NRP-1) has been shown in many cancer cells

62 tosis transport pathway that is regulated by neuropilin-1 (NRP-1) has recently been reported.

63 Heparin/heparan sulfate proteoglycans and neuropilin-1 (NRP-1) have been identified as co-receptor

64 gated the role of semaphorin 3A (Sema3A) and neuropilin-1 (Nrp-1) in lymphatic vessel maturation and

65 that trafficking of the angiogenic receptor neuropilin-1 (NRP-1) is abrogated by the liver kinase B1

66 raphy showed that the CendR peptides bind to neuropilin-1 (NRP-1) on the target cells.

67 essing a conditional deletion of endothelial neuropilin-1 (Nrp-1) or in wild-type mice systemically t

68 Here, we report that neuropilin-1 (NRP-1) orchestrates communications between

69 One targets the neuropilin-1 (NRP-1) receptors of cancer cells through t

70 Recently, neuropilin-1 (NRP-1) was reported to bind and activate t

71 liver fibrosis, the axonal guidance molecule neuropilin-1 (NRP-1) was upregulated in activated HSCs,

72 , heparan sulfate proteoglycans (HSPGs), and neuropilin-1 (NRP-1) were demonstrated to facilitate HTL

73 and conditional knockout mice, we show that neuropilin-1 (NRP-1), a known receptor of VEGF, is neces

74 As a model, we have targeted neuropilin-1 (NRP-1), a membrane-bound receptor expresse

75 we demonstrate that a cell surface molecule, neuropilin-1 (Nrp-1), is expressed at high levels on nT

76 th heparan sulfate proteoglycans (HSPGs) and neuropilin-1 (NRP-1), two molecules important for HTLV-1

77 s mediated through a molecular cross-talk of neuropilin-1 (NRP-1), VEGFR1 (Flt-1), and phosphoinositi

78 We found that Neuropilin-1 (Nrp-1), which is expressed by most Treg ce

79 We identify Neuropilin-1 (NRP-1)-mediated activation of KDR signalin

80 emma vesicle-associated protein-1 (PV-1) and neuropilin-1 (NRP-1).

81 h through interaction with the VEGF receptor neuropilin-1 (NRP-1).

82 g receptor as the transmembrane glycoprotein neuropilin-1 (NRP-1).

83 actions with alphavbeta3/beta5 integrins and neuropilin-1 (NRP-1).

84 n exposed site within the b1 domain of human neuropilin-1 (NRP-1).

85 progression by binding with its co-receptor, neuropilin-1 (NRP-1).

86 Neuropilin-1 (NRP1) and NRP2 are cell surface receptors

87 ein binds to lymphatic valves expressing the Neuropilin-1 (Nrp1) and PlexinA1 receptors.

88 VEGF receptors VEGFR1, VEGFR2 and Neuropilin-1 (NRP1) are mostly in 'Free State'.

89 ass spectrometry-based approach, we identify neuropilin-1 (NRP1) as a NE receptor that mediates uptak

90 n part, on signaling through the VEGF-VEGFR2-Neuropilin-1 (NRP1) axis.

91 In endothelial cells, neuropilin-1 (NRP1) binds vascular endothelial growth fa

92 Neuropilin-1 (NRP1) functions as a coreceptor through in

93 Neuropilin-1 (Nrp1) guides the development of the nervou

94 has implicated the transmembrane co-receptor neuropilin-1 (NRP1) in cancer progression.

95 Sema4a) and the Treg-cell-expressed receptor neuropilin-1 (Nrp1) interact both in vitro, to potentiat

96 Neuropilin-1 (Nrp1) is a cell surface molecule originall

97 Neuropilin-1 (NRP1) is a coreceptor for multiple extrace

98 Neuropilin-1 (Nrp1) is an essential receptor for angioge

99 Neuropilin-1 (Nrp1) is required to maintain intratumoral

100 tion of circulating monocytes expressing the neuropilin-1 (Nrp1) receptor (Nrp1-expressing monocytes;

101 onset of Sema3A sensitivity and concomitant neuropilin-1 (NRP1) receptor expression and caused cell-

102 Neuropilin-1 (NRP1) was first described as a receptor fo

103 Neuropilin-1 (NRP1), a cell-surface receptor for both va

104 Neuropilin-1 (NRP1), a non-tyrosine kinase receptor, is

105 ligo G) reduce endothelial levels of surface neuropilin-1 (NRP1), a receptor shared by semaphorin 3A

106 Here, we demonstrate that neuropilin-1 (NRP1), a Semaphorin receptor expressed in

107 disrupts the developmental downregulation of Neuropilin-1 (Nrp1), the receptor for Sema3A, in sensory

108 Neuropilin-1 (NRP1), which is a critical receptor implic

109 Mice that lack the transmembrane receptor neuropilin-1 (Nrp1), which modulates GAM immune polariza

110 e show this is a key endothelial function of neuropilin-1 (Nrp1), which suppresses the stalk-cell phe

111 Semaphorin3A (Sema3A) which both signal via neuropilin-1 (Nrp1).

112 dritic cell (pDC) marker, BDCA4, identifying neuropilin-1 (NRP1); and the helper T cell marker, CD4.

113 microenvironment by increasing the levels of neuropilin-1 (NRP1, a co-receptor of vascular endothelia

114 ration of siRNAs against the Sema3A receptor neuropilin-1 also resulted in polarization defects in vi

115 Patients with low baseline expression of neuropilin-1 also showed a trend toward improved overall

116 ded to associated cues of axon guidance like neuropilin-1 and F-actin.

117 First, aged Tregs had high expression of neuropilin-1 and Helios, and had a broad Vbeta repertoir

118 pecific genes including VEGFR-3, FGFR-3, and neuropilin-1 and is required along with Prox1 to maintai

119 PDC secretion of IFN-alpha and expression of Neuropilin-1 and MHC I.

120 1 involves heparan sulfate proteoglycans and neuropilin-1 and results in long-term productive infecti

121 A and Slit2, and their respective receptors, Neuropilin-1 and Robo2.

122 ng of VEGF to low-affinity binding sites and neuropilin-1 and stimulates further growth factor recept

123 also upregulated VEGFR2 and its co-receptor neuropilin-1 and suppressed the expression of semaphorin

124 th factor A (VEGF-A) isoforms, expression of neuropilin-1 and VEGF receptor 1 in tumors or plasma, an

125 The arterial marker neuropilin-1 and venous marker EphB4 are ectopically exp

126 Plasma VEGF-A and tumor neuropilin-1 are strong biomarker candidates for predict

127 We identified neuropilin-1 as a mediator of cancer cell invasion by a

128 Investigation of PlGF/Neuropilin-1 binding and function suggests a critical ro

129 The model predicts that Neuropilin-1 can induce differences in the surface-to-in

130 CI, 0.59 to 0.97) versus patients with high neuropilin-1 expression (HR, 1.07; 95% CI, 0.81 to 1.40;

131 Neuropilin-1 expression in anergic conventional CD4(+) T

132 Although neuropilin-1 expression in GBMs was previously shown, it

133 Baseline plasma VEGF-A levels and tumor neuropilin-1 expression were identified as potential pre

134 tract region that are attenuated by blocking neuropilin-1 function.

135 the translation of the guidance cue receptor Neuropilin-1 in RGCs, with Hermes knock-down resulting i

136 hosphorylation status and down-regulation of neuropilin-1 in the HemSCs demonstrate that VEGFR-2 and

137 e transfer experiments and the expression of neuropilin-1 indicate that these cells are predominantly

138 s a critical role for heparin-binding domain/Neuropilin-1 interaction and its regulation by plasmin p

139 Neuropilin-1 is a receptor for semaphorin3A (Sema3A), a

140 The cAMP-dependent guidance receptor neuropilin-1 is also lost from beta3GnT2(-/-) OSNs and a

141 surprise, we found that membrane-associated neuropilin-1 is polysialylated at approximately 50% of t

142 vation and RNA interference , we showed that neuropilin-1 is required for GBM cell migration.

143 MAOA-dependent activation of neuropilin-1 promoted AKT/FOXO1/TWIST1 signaling, allowi

144 e adhesion and suggest that targeting Sema3A-neuropilin-1 signaling may limit GBM infiltration.

145 ar tumor areas is regulated by Semaphorin 3A/Neuropilin-1 signaling; interference with this pathway e

146 Specific inhibition of neuropilin-1 significantly reduced CNS vascular permeabi

147 Specifically, pDCs upregulate neuropilin-1 to enable the long term interactions of pDC

148 implicate Sema3A as an autocrine signal for neuropilin-1 to promote GBM dispersal by modulating subs

149 stemmed from a failure to expand functional neuropilin-1(+) regulatory T (T reg) cells in the absenc

150 th, portal vessels undergo a transition from Neuropilin-1(+)Ephrin-B2(+) artery to EphB4(+) vein phen

151 crease in the pTreg to CD4(+)CD25(+)Foxp3(+) neuropilin-1(high) thymic Treg ratio by day 10.

152 ound was driven by the CD4(+)CD25(+)Foxp3(+) neuropilin-1(low) peripheral Treg (pTreg), resulting in

153 giogenic receptors (alphavbeta3 integrin and neuropilin-1) in vitro as well as in vivo.

154 owed slightly decreased binding to the NRP1 (neuropilin-1) receptor, and analyses suggested the hepar

155 of domain swap chimeras with sequences from neuropilin-1, a protein for which polysialylation had no

156 r to those of others following inhibition of neuropilin-1, a receptor previously implicated in TGFbet

157 finity for its primary receptor and binds to neuropilin-1, activating a tissue penetration pathway th

158 ication of sialoglycoproteins such as CD105, neuropilin-1, and CLEC14A, which have already been descr

159 (VEGF) and three of its receptors, VEGFR-2, neuropilin-1, and neuropilin-2, in paraffin-embedded sam

160 ate the role of a potential guidance factor, neuropilin-1, and use functional knockdown assays, tissu

161 wth factor-A (VEGF-A), protein expression of neuropilin-1, and VEGF receptors-1 and -2 (VEGFR-1 and V

162 express similar levels of Sema3A receptors (neuropilin-1, cell adhesion molecule L1, and plexinA4),

163 rent iNKT subsets defined by CD4, NK1.1, and neuropilin-1, indicating that distinct functional subpop

164 that VEGF immobilization, interactions with Neuropilin-1, perturbations of VEGFR2 trafficking, and c

165 dipocytes, probably through up-regulation of neuropilin-1, the OB-mediated enhanced hematopoiesis fun

166 rnalized into cultured tumor cells through a neuropilin-1-activated pathway and triggered cell death.

167 nd tLyP-1 internalize into cells through the neuropilin-1-dependent CendR internalization pathway.

168 tissue permeability in a tumor-specific and neuropilin-1-dependent manner, allowing coadministered d

169 ema3A decreases cell-substrate adhesion in a neuropilin-1-dependent manner.

170 istic insights into the regulation of PlGF-2/Neuropilin-1-mediated tissue vascularization and growth.

171 that SEMA3A acts as a potent attractant for neuropilin-1-positive (NRP-1-positive) MPs.

172 pment and is not required for maintenance of neuropilin-1-positive natural Tregs in the periphery, it

173 h 2 (ba2), is due to chemoattraction through neuropilin-1-vascular endothelial growth factor (VEGF) i

174 pendent on chemoattractive signaling through neuropilin-1-VEGF interactions.

175 hrough activation of VEGF and its coreceptor neuropilin-1.

176 increased binding of VEGF to its coreceptor neuropilin-1.

177 pecific phosphorylation in vivo, mediated by Neuropilin-1.

178 lar endothelial growth factor receptor-2 and neuropilin-1.

179 otif Arg-Pro-Leu targets VEGF receptor-1 and neuropilin-1.

180 olysialylation process than those regions of neuropilin-1.

181 n into cancer cells via the interaction with neuropilin-1.

182 its impaired binding to the VEGF co-receptor neuropilin-1.

183 esults support that Farp1 interacts with the Neuropilin-1/PlexinA1 complex and colocalizes with Plexi

184 The neuropilins-1 and -2 (NRP1 and NRP2) function as recepto

185 screen identified the transmembrane protein neuropilin 2 (NRP2) and tetraspanin CD63 as factors for

186 a3f, but not Sema3b, phenocopies the loss of neuropilin 2 (Nrp2) for axonal wiring of GC-D+ neurons.

187 and protein expression analysis showed that neuropilin 2 (NRP2), a key factor for vascular developme

188 An axon guidance molecule, Neuropilin 2 (Nrp2), is known to mediate targeting of ol

189 islet cells produced the semaphorin receptor neuropilin 2 (Nrp2).

190 We previously showed that neuropilin 2 (Nrp2)/semaphorin 3F (Sema3F) signaling is

191 We show that deficiency of one of the neuropilin 2 ligands of the class III semaphorin family,

192 VEGF receptors, semaphorin 3F, neuropilin 1, neuropilin 2, podoplanin, and LYVE-1 by quantitative (re

193 A10 elevated genes, including neuropilin 1, neuropilin 2, slit2 and adenylyl cyclase-activating pept

194 d in neural and vascular patterning, such as neuropilin-2 (NETO2), a plexin domain containing recepto

195 mplex in brain with Sema3F receptor subunits Neuropilin-2 (Npn-2) and PlexinA3 (PlexA3) through an Np

196 Here we show that NrCAM interaction with neuropilin-2 (Npn-2) is critical for semaphorin 3F (Sema

197 guidance cue semaphorin 3F (Sema3F) and its neuropilin-2 (Npn-2)/plexinA3 (PlexA3) holoreceptor medi

198 ding Sema3F, and its holoreceptor components neuropilin-2 (Npn-2, also known as Nrp2) and plexin A3 (

199 Here, we show that neuropilin-2 (NRP-2), a multifunctional nonkinase recept

200 We show here that neuropilin-2 (NRP-2), a receptor for the semaphorin and

201 ared the PBR sequence requirements for NCAM, neuropilin-2 (NRP-2), and synaptic cell adhesion molecul

202 surface receptors transduce VEGF-C signals: neuropilin-2 (Nrp2) and VEGF-receptor (VEGFR)-2/3.

203 Here, we show that the expression of Neuropilin-2 (NRP2) controls EGFR protein levels, thereb

204 Neuropilin-2 (NRP2) is a non-tyrosine kinase receptor fr

205 eptors, plexins and neuropilins, among which neuropilin-2 (NRP2) is highly expressed in lymphatic end

206 Neuropilin-2 (NRP2) is well known as a co-receptor for c

207 ell surface and secreted proteins, including Neuropilin-2 (NRP2).

208 Moreover, we show that neuropilin-2 also binds tLyP-1 and that this binding equ

209 the ability of ST8SiaIV/PST to polysialylate neuropilin-2 and SynCAM 1, suggesting that Arg(82) plays

210 and the O-glycan-containing linker region of neuropilin-2 are necessary and sufficient for its polysi

211 lylated at approximately 50% of the level of neuropilin-2 but not polysialylated when it lacks its cy

212 Our results show that floor plate-derived neuropilin-2 is developmentally regulated, functioning a

213 f floor plate-derived, but not axon-derived, neuropilin-2 is required for precrossing axon pathfindin

214 gnizes and docks on an acidic surface of the neuropilin-2 MAM domain to polysialylate O-glycans on th

215 overshooting after crossing, reminiscent of Neuropilin-2 mutant embryos.

216 To understand the biochemical basis of neuropilin-2 polysialylation, we created a series of dom

217 e surface of the MAM domain are critical for neuropilin-2 polysialylation.

218 s type I SGN process extension by activating Neuropilin-2 receptors expressed on SGNs.

219 The Sema3F receptor neuropilin-2 selectively binds beta2Chn, and ligand enga

220 Floor plate-specific deletion of neuropilin-2 significantly reduces the presence of precr

221 he transmembrane nontyrosine kinase receptor neuropilin-2 was found to be essential for the VEGF-C-me

222 owed that SEMA3F formed a complex with NRP2 (neuropilin-2) and plexin A1.

223 n part by directly stimulating expression of neuropilin-2, a coreceptor for VEGF-C.

224 of its receptors, VEGFR-2, neuropilin-1, and neuropilin-2, in paraffin-embedded samples from 21 vesti

225 One of these substrates, neuropilin-2, is a VEGF and semaphorin co-receptor that

226 This was not the case for neuropilin-2, which is polysialylated when either membra

227 on of lymphatic endothelial cells (LEC) in a neuropilin-2-, plexin-D1-, and plexin-A1-dependent manne

228 ing the expression of the guidance receptor, Neuropilin-2.

229 aterals depends on plexin-A3, plexin-A4, and neuropilin-2.

230 Here, we show that neuropilin-2/plexin-A1 are also coexpressed on commissur

231 Secreted semaphorins signal through neuropilin-2/plexin-A1 receptor complexes on post-crossi

232 SEMA3F acts on its coreceptors, plexins and neuropilins, among which neuropilin-2 (NRP2) is highly e

233 has been confirmed through interactions with neuropilin and heparin.

234 in dimerization and binding to their cognate neuropilin and plexin receptors.

235 We recently identified Neuropilin and Tolloid like-2 (Neto2) as a novel accesso

236 ted by the single-pass transmembrane protein neuropilin and tolloid like-2 (Neto2).

237 The neuropilin and tolloid-like 1 and 2 proteins (Neto1 and

238 The neuropilin and tolloid-like proteins (NETO) 1 and NETO2,

239 y, we found that the intracellular region of neuropilin and tolloid-like proteins (Neto) 1 and Neto2,

240 ified and characterized the Drosophila neto (neuropilin and tolloid-like) as an essential gene requir

241 semaphorin complex by combining the roles of neuropilins and L1CAMs.

242 receptor(s), we evaluated gene expression of neuropilins and plexins.

243 KARs associate with the auxiliary proteins neuropilin- and tolloid-like 1 and 2 (Neto1 and Neto2),

244 The putative KAR auxiliary subunit Neuropilin- and tolloid-like 2 (Neto2) is also expressed

245 s well as the putative KAR auxiliary subunit Neuropilin- and tolloid-like 2 (Neto2).

246 Neuropilins are a class of cell surface proteins implica

247 class 3 semaphorin family, but VEGF164, the neuropilin-binding isoform of the classical vascular gro

248 circulation-independent, and mediated by the neuropilin-binding RXXK tissue-penetration peptide motif

249 By reconstituting all possible plexin and neuropilin combinations, we found that SEMA3F acts throu

250 er semaphorin and VEGF competitively bind to neuropilin conflict.

251 of signaling via a plexin receptor without a neuropilin coreceptor.

252 nce molecules that signal through plexin and neuropilin coreceptors and since then have been establis

253 signaling without altering VEGF receptor or neuropilin expression.

254 We also analyzed the expression of neuropilins in synovial tissue and SF, as they may inter

255 ted that all known ligands and inhibitors of neuropilin interact with the b1 domain of neuropilin via

256 Neuropilin is an essential cell surface receptor that fu

257 The Neuropilin ligand Semaphorin3 enhances this interaction,

258 ro models, we show here that the alternative neuropilin ligand VEGF164 promotes the survival of migra

259 of retinal axons to Sema3D, Sema3E, or other neuropilin ligands at the midline, and consequently faci

260 Thus, the loss of both neuropilin ligands leads to an almost complete failure t

261 physical interaction and competition between neuropilin ligands.

262 Here, we determined that the discoidina neuropilin-like membrane protein DCBLD2 is upregulated i

263 Endothelial and smooth muscle cell-derived neuropilin-like protein (ESDN) is a neuropilin-related t

264 Endothelial and smooth muscle cell-derived neuropilin-like protein (ESDN) is up-regulated in the ne

265 phogenic proteins, Hedgehog, Notch, ephrins, neuropilins, neurotrophins and netrins.

266 ndantly through both its classical receptors neuropilin (NRP) 1 and, unconventionally, NRP2, while th

267 Neuropilin (NRP) 1 is a receptor for the vascular endoth

268 in the class 3 semaphorin (SEMA3) receptors neuropilin (NRP) 1 or 2 raised the possibility that each

269 composed of a ligand binding subunit termed neuropilin (NRP) and a signal transduction subunit of th

270 The neuropilin (Nrp) family consists of essential multifunct

271 Neuropilin (Nrp) is a cell surface receptor with essenti

272 Neuropilin (NRP) receptors and their class 3 semaphorin

273 igeminal ganglia and for VEGFR1, VEGFR2, and neuropilin (NRP)-1 in the cornea.

274 transcription of VEGF receptor (VEGFR)-2 and neuropilin (NRP)-1, the primary receptors regulating end

275 e mediated by the VEGFR2 and its coreceptor, neuropilin (NRP)-1.

276 ost & Microbe, Raaben et al. (2017) identify neuropilin (NRP)-2 as cell surface receptor and the tetr

277 Here, we report that neuropilin (NRP)-2, the high-affinity receptor for SEMA3

278 The neuropilin (Nrp)1 receptor is essential for both nervous

279 Neuropilins (Nrp) are type I transmembrane proteins that

280 Neuropilins (NRPs) are 130-kDa receptors that bind and r

281 The Neuropilins (Nrps) are a family of essential cell surfac

282 Neuropilins (Nrps) are co-receptors for class 3 semaphor

283 Neuropilins (NRPs) are trans-membrane receptors involved

284 Neuropilins (NRPs) are transmembrane receptors that bind

285 Neuropilins (NRPs), which have well-defined roles in Sem

286 al growth factor (VEGF) receptors, including neuropilins (NRPs), which regulate interstitial fluid fl

287 Neuropilins (NRPs; NRP1 and NRP2) are the cell surface r

288 We conclude that neuropilins play multiple roles in the sensory nervous s

289 fically through binding of soluble Sema3A to Neuropilin/PlexinA coreceptors.

290 PDE4D interacts directly with Neuropilins, positive regulators of Hh pathway.

291 ibodies for VEGF receptor (VEGFR) 1 and 2 or neuropilin receptor 1 or by VEGFR2 inhibitors (SU 1498 a

292 lass 3 semaphorin SEMA3A signals through its neuropilin receptors, NRP1 and NRP2, to organise the axo

293 s, and tumor progression, through Plexin and neuropilin receptors.

294 he developing cerebellum, genetic removal of Neuropilins reduces Hh signaling activity and suppresses

295 -derived neuropilin-like protein (ESDN) is a neuropilin-related transmembrane protein expressed in EC

296 o examine which A-type plexin conveyed SEMA3/neuropilin signals during facial nerve development, we c

297 sphodiesterase 4D (PDE4D) acts downstream of Neuropilins to control Hh transduction and medulloblasto

298 of neuropilin interact with the b1 domain of neuropilin via a C-terminal arginine.

299 Although the neuropilins were characterized as semaphorin receptors t

300 Here we demonstrate that select plexins and neuropilins, which serve as coreceptors for semaphorins,