ライフサイエンスコーパス: neuropilin-2

1 ing the expression of the guidance receptor, Neuropilin-2.

2 aterals depends on plexin-A3, plexin-A4, and neuropilin-2.

3 omomultimerize and form heteromultimers with neuropilin-2.

4 Here, we show that neuropilin-2, a coreceptor for some of the class 3 semap

5 n part by directly stimulating expression of neuropilin-2, a coreceptor for VEGF-C.

6 Neuropilin-2, a receptor for secreted semaphorins, is ex

7 We also describe the identification of neuropilin-2, a related neuropilin family member, and sh

8 uidance defects are observed in mice lacking neuropilin-2, a Semaphorin receptor.

9 Moreover, we show that neuropilin-2 also binds tLyP-1 and that this binding equ

10 The axon-guidance-associated proteins neuropilin-2 and dehydropyriminidase-related protein-2 w

11 neuropilin-2 and semaIV are expressed in strikingly comp

12 the ability of ST8SiaIV/PST to polysialylate neuropilin-2 and SynCAM 1, suggesting that Arg(82) plays

13 owed that SEMA3F formed a complex with NRP2 (neuropilin-2) and plexin A1.

14 family member, and show that neuropilin and neuropilin-2 are expressed in overlapping, yet distinct,

15 and the O-glycan-containing linker region of neuropilin-2 are necessary and sufficient for its polysi

16 Neuropilin-1 and neuropilin-2 bind differentially to different class 3 se

17 lylated at approximately 50% of the level of neuropilin-2 but not polysialylated when it lacks its cy

18 VEGFR-3(+) DC in normal corneas are VEGF-C(-)neuropilin-2(-), but express VEGF-C in inflammation.

19 ding (CUB) and coagulation factor domains of neuropilin-2 confer specificity to the Sema IV repulsive

20 hippocampus in establishing specific Npn-2 (neuropilin-2)-expressing limbic tracts.

21 We generated a knock-out mutation in the neuropilin-2 gene by gene targeting in embryonic stem ce

22 e Sema3F receptor and identify key roles for neuropilin-2 in axon guidance in the PNS and CNS.

23 GFR-3, its ligand VEGF-C and the co-receptor neuropilin-2, in normal and inflamed corneas and charact

24 of its receptors, VEGFR-2, neuropilin-1, and neuropilin-2, in paraffin-embedded samples from 21 vesti

25 Here, we show that neuropilin-2 is a receptor for the secreted semaphorin S

26 Our results show that neuropilin-2 is an essential component of the Sema3F rec

27 Our results show that floor plate-derived neuropilin-2 is developmentally regulated, functioning a

28 ncipally by Plexin-A4, whereas signaling via Neuropilin-2 is mediated principally by Plexin-A3.

29 f floor plate-derived, but not axon-derived, neuropilin-2 is required for precrossing axon pathfindin

30 One of these substrates, neuropilin-2, is a VEGF and semaphorin co-receptor that

31 We show that deficiency of one of the neuropilin 2 ligands of the class III semaphorin family,

32 gnizes and docks on an acidic surface of the neuropilin-2 MAM domain to polysialylate O-glycans on th

33 overshooting after crossing, reminiscent of Neuropilin-2 mutant embryos.

34 Neuropilin-2 mutant mice exhibit profound and distinct e

35 nction of neuropilin-2 through analysis of a neuropilin-2 mutant mouse, which is viable and fertile.

36 d in neural and vascular patterning, such as neuropilin-2 (NETO2), a plexin domain containing recepto

37 mplex in brain with Sema3F receptor subunits Neuropilin-2 (Npn-2) and PlexinA3 (PlexA3) through an Np

38 Here we show that NrCAM interaction with neuropilin-2 (Npn-2) is critical for semaphorin 3F (Sema

39 nerated mice with a targeted deletion in the neuropilin-2 (Npn-2) locus.

40 Analysis of the vomeronasal nerve in neuropilin-2 (npn-2) mutant mice reveals pathfinding def

41 guidance cue semaphorin 3F (Sema3F) and its neuropilin-2 (Npn-2)/plexinA3 (PlexA3) holoreceptor medi

42 ding Sema3F, and its holoreceptor components neuropilin-2 (Npn-2, also known as Nrp2) and plexin A3 (

43 that neural crest cells express the receptor neuropilin 2 (Npn2), while its repulsive ligand semaphor

44 Here, we show that neuropilin-2 (NRP-2), a multifunctional nonkinase recept

45 We show here that neuropilin-2 (NRP-2), a receptor for the semaphorin and

46 ared the PBR sequence requirements for NCAM, neuropilin-2 (NRP-2), and synaptic cell adhesion molecul

47 screen identified the transmembrane protein neuropilin 2 (NRP2) and tetraspanin CD63 as factors for

48 a3f, but not Sema3b, phenocopies the loss of neuropilin 2 (Nrp2) for axonal wiring of GC-D+ neurons.

49 and protein expression analysis showed that neuropilin 2 (NRP2), a key factor for vascular developme

50 An axon guidance molecule, Neuropilin 2 (Nrp2), is known to mediate targeting of ol

51 islet cells produced the semaphorin receptor neuropilin 2 (Nrp2).

52 We previously showed that neuropilin 2 (Nrp2)/semaphorin 3F (Sema3F) signaling is

53 surface receptors transduce VEGF-C signals: neuropilin-2 (Nrp2) and VEGF-receptor (VEGFR)-2/3.

54 Neuropilin-1 (NRP1) and neuropilin-2 (NRP2) are both receptors for semaphorins,

55 Here, we show that the expression of Neuropilin-2 (NRP2) controls EGFR protein levels, thereb

56 Neuropilin-2 (NRP2) is a non-tyrosine kinase receptor fr

57 eptors, plexins and neuropilins, among which neuropilin-2 (NRP2) is highly expressed in lymphatic end

58 Neuropilin-2 (NRP2) is well known as a co-receptor for c

59 r and lymphatic endothelial cells expressing neuropilin-2 (NRP2), a novel mechanism for a tumor angio

60 ell surface and secreted proteins, including Neuropilin-2 (NRP2).

61 europilin-1 oligomers, the Sema IV signal by neuropilin-2 oligomers, and the Sema E signal by neuropi

62 Cytokeratin 20, neuropilin-2, p21, and p33ING1 were selected among the t

63 on of lymphatic endothelial cells (LEC) in a neuropilin-2-, plexin-D1-, and plexin-A1-dependent manne

64 Here, we show that neuropilin-2/plexin-A1 are also coexpressed on commissur

65 Secreted semaphorins signal through neuropilin-2/plexin-A1 receptor complexes on post-crossi

66 VEGF receptors, semaphorin 3F, neuropilin 1, neuropilin 2, podoplanin, and LYVE-1 by quantitative (re

67 To understand the biochemical basis of neuropilin-2 polysialylation, we created a series of dom

68 e surface of the MAM domain are critical for neuropilin-2 polysialylation.

69 reted semaphorins, whereas 82% expressed the neuropilin-2 receptor.

70 s type I SGN process extension by activating Neuropilin-2 receptors expressed on SGNs.

71 cause repulsion by binding Neuropilin-1 and Neuropilin-2, respectively.

72 The Sema3F receptor neuropilin-2 selectively binds beta2Chn, and ligand enga

73 Neuropilin-1 and neuropilin-2 show specificity in binding to different cl

74 d semaphorins Sema III, Sema E, and Sema IV, neuropilin-2 shows high affinity binding only to Sema E

75 Floor plate-specific deletion of neuropilin-2 significantly reduces the presence of precr

76 A10 elevated genes, including neuropilin 1, neuropilin 2, slit2 and adenylyl cyclase-activating pept

77 Sema K1 does not bind to neuropilin-1 or neuropilin-2, the two receptors implicated in mediating

78 four genes, Ctla4, Icos, Als2cr19, and Nrp2 (neuropilin-2), thereby excluding a major candidate gene,

79 Here, we have studied the function of neuropilin-2 through analysis of a neuropilin-2 mutant m

80 semaphorin 3F (Sema3F) bind to the receptor neuropilin-2 to confer chemorepulsive responses in vitro

81 he transmembrane nontyrosine kinase receptor neuropilin-2 was found to be essential for the VEGF-C-me

82 This was not the case for neuropilin-2, which is polysialylated when either membra

83 ort the identification of a related protein, neuropilin-2, whose mRNA is expressed by developing neur