ライフサイエンスコーパス: neuroprotective

1 uclear accumulation of phospho-HDAC1 and was neuroprotective.

2 nhances calcium export from mitochondria was neuroprotective.

3 n and NO release, because iNOS inhibition is neuroprotective.

4 es that selective inhibition of c-Abl may be neuroprotective.

5 ed or excess soluble AS can be significantly neuroprotective.

6 and WT Abeta1-42 (Alphabeta42) is also found neuroprotective.

7 export of calcium from mitochondria was also neuroprotective.

8 astrocytic CREB is also activity-driven and neuroprotective.

9 h in H2O2-exposed astrocytes, boosting their neuroprotective action in co-cultured neurons.

10 vitro characterization of 4c showed that its neuroprotective action is partially attributable to the

11 n the development of novel therapeutics with neuroprotective action.

12 ditioning with volatile anesthetics provides neuroprotective actions that depend, in part, on activat

13 to test if TASK channels contribute to their neuroprotective actions.

14 nd, contrary to previous assumptions, exerts neuroprotective activities in vitro and in vivo Our resu

15 0 (Hsp70), a chaperone that has demonstrated neuroprotective activity against several intracellular a

16 ng the NMDAR component of the EPSC and shows neuroprotective activity in vivo without inducing psycho

17 oral tests, pregnanolone hemipimelate showed neuroprotective activity without psychomimetic symptoms.

18 the isolates were evaluated for the in vitro neuroprotective activity, both compounds 11 and 12 displ

19 ermine a structure-activity relationship for neuroprotective activity.

20 caffold are not responsible for the observed neuroprotective activity.

21 However, GM1 is known to be neuroprotective against Abeta-induced toxicity.

22 ether inhibition of mitochondrial fission is neuroprotective against alpha-syn overexpression in vivo

23 ingly, astrocytic alphaBc overexpression was neuroprotective against neuronal cell loss in BACHD brai

24 STN DBS is neuroprotective against neurotoxicants in animal models

25 Moreover, we found that 24(S)-HC is neuroprotective against pressure mediated retinal degene

26 b behaves as a water-soluble, brain-permeant neuroprotective agent against oxidative insults without

27 Animal model studies suggest nicotine as a neuroprotective agent and nicotinic acetylcholine (ACh)

28 or isradipine is currently being tested as a neuroprotective agent for PD in a phase III clinical tri

29 d thrombolysis; and 2) could be an efficient neuroprotective agent if given after tissue plasminogen

30 our findings demonstrate that NR is a better neuroprotective agent than NAD(+) in excitotoxicity-indu

31 detail through advanced imaging modalities, neuroprotective agents can and should be re-examined as

32 The use of neuroprotective agents in stroke has been a notable fail

33 nvestigating the distribution and effects of neuroprotective agents in the brain.

34 research, and focus on a few key examples of neuroprotective agents that are showing newfound promise

35 gonists and inverse agonists have emerged as neuroprotective agents, and CB2R agonists have entered s

36 hus, EphA2 targeted antagonists may serve as neuroprotective agents.

37 lbenzo[b]furan derivatives and report on the neuroprotective and anti-inflammatory effects of these p

38 crylate group on 2-arylbenzo[b]furan confers neuroprotective and anti-inflammatory effects.

39 The total mRNA analysis revealed that neuroprotective and anti-inflammatory genes were elevate

40 ment of neurodegeneration, being involved in neuroprotective and anti-inflammatory processes.

41 Estrogens have neuroprotective and antidepressive effects; however, ass

42 Moreover, the neuroprotective and antiinflammatory effects of A1-exoso

43 ments using one compound from each category (neuroprotective and antiviral) further increased protect

44 We examined whether their neuroprotective and axonal regeneration potentials can b

45 NTERPRETATION: Our data support the putative neuroprotective and disease-modifying effect of STN-DBS

46 an experimental model for the assessment of neuroprotective and disease-modifying strategies.

47 hat isoform-D is also expressed selectively, neuroprotective and downregulated in HD mice and patient

48 lectively, these data suggest that OECs have neuroprotective and immunomodulatory mechanisms that cre

49 active protein 1 (MCP1) has been shown to be neuroprotective and is released by astrocytes.

50 y whether preventing alpha-Syn expression is neuroprotective and leads to better physiological and fu

51 ophic factor (BDNF) in particular can confer neuroprotective and neuro-regenerative effects in precli

52 Our work has identified both neuroprotective and neurodegenerative roles for a previo

53 Li) is a potent mood stabilizer and displays neuroprotective and neurogenic properties.

54 K3 inhibition, and specifically VP3.15, as a neuroprotective and neuroreparative disease-modifying tr

55 glucagon-like peptide (GLP-1) receptor exert neuroprotective and neurorestorative effects across a ra

56 The prion protein (PrP) seems to exert both neuroprotective and neurotoxic activities.

57 General anesthetics are both neuroprotective and neurotoxic with unclear mechanisms.

58 The combined neuroprotective and symptomatic effects of BRF110 identi

59 ses BDNF-trkB signaling to contribute to the neuroprotective and symptomatic efficacy of STN DBS.SIGN

60 therapeutic potential for PD, offering both neuroprotective and symptomatic improvement.

61 t some of the negative risk factors might be neuroprotective and thus beneficial in individuals with

62 Such neuroprotective architectural strategies may be conserve

63 Herein, we demonstrate that neuroprotective aromatic carbamates function to increase

64 or source of endogenous neural stem cells or neuroprotective astrocytes after SCI.

65 rly neuronal help-me signal that activates a neuroprotective astrocytic response, which fails in ALS,

66 inal cord reactive astrocytes is potentially neuroprotective at an early onset of reactive astroglios

67 eved that the highest likelihood of securing neuroprotective benefit from drugs will be in these subj

68 It displays a wide range of neuroprotective benefits associated with anti-aging.

69 as prevention targets based on evidence of "neuroprotective" benefits in observational studies.

70 led previously to the discovery of our first neuroprotective brain penetrant hit compound MPAQ (5c).

71 ing to Abeta42 through its holdase domain is neuroprotective, but its ATPase activity is not required

72 In this study, we investigate the neuroprotective capabilities of an analogous peptide SAL

73 Furthermore, this neuroprotective capacity was independent of intracellula

74 at exosomes secreted from astrocytes contain neuroprotective cargoes that could support the survival

75 n at Ser-1303 by Dapk1, that is blocked by a neuroprotective cell-permeable peptide mimetic of the re

76 Ethoxyquin was recently identified as a neuroprotective compound against toxic neuropathies and

77 c acid (4486.2+/-165.6mug/kgd.w), which is a neuroprotective compound.

78 To discover druggable neuroprotective compounds for dopamine neurons, we have

79 nisms of retinal degeneration and screen for neuroprotective compounds, and provide the basis for cel

80 re remains significant uncertainty about the neuroprotective/degenerative role of these cells due to

81 /GluN2B NMDA receptors are fully occupied at neuroprotective doses of eliprodil.

82 Thus, AUTEN-99 serves as a potent neuroprotective drug candidate for preventing and treati

83 ted imaging evaluation) and therapeutic (eg, neuroprotective drugs and treatments for haemorrhagic st

84 on the potential targets for development of neuroprotective drugs in Parkinson's disease and suggest

85 cell-based models for their cytotoxicity and neuroprotective effect against oxidative toxins (H2O2, r

86 cotinic drugs that might exert this apparent neuroprotective effect are asking whether agonists, anta

87 e A1 receptor (A1R) is a key mediator of the neuroprotective effect by endogenous adenosine.

88 indicated that yolkin displayed a potential neuroprotective effect by the ability to stimulate cells

89 non-ionotropic activity of GluN2ARs and the neuroprotective effect is attenuated by Akt inhibition.

90 onnectivity analyses crucially supported the neuroprotective effect of bilingualism by showing an inc

91 arently safe, but is unlikely to enhance the neuroprotective effect of cooling after birth asphyxia.

92 These results implied that the neuroprotective effect of ethoxyquin is mediated through

93 trogen isoflavone intervention to engage the neuroprotective effect of glutamate oxaloacetate transam

94 The neuroprotective effect of NR could not be explained by g

95 rate that this alteration contributes to the neuroprotective effect of pair bonding against drug rewa

96 ies generated in SH-SY5Y cells, suggesting a neuroprotective effect of the hydroethanolic extracts fr

97 this study was to explore the signaling and neuroprotective effect of transactivator of transcriptio

98 We have found a similar neuroprotective effect using topical administration of n

99 croglia in the irradiated brain would have a neuroprotective effect.

100 ce, demonstrating that ghrelin mediates CR's neuroprotective effect.

101 tion of CSD does not underlie PEA's profound neuroprotective effect.

102 10), a vesicular Ca(2+) sensor, as the first neuroprotective effector protein downstream of the TF NP

103 However, the neuroprotective effector proteins induced by RBM3 and th

104 s a powerful CR proxy in dementia and exerts neuroprotective effects against neurodegeneration.

105 sults demonstrate that chrysophanol provided neuroprotective effects and inhibited glial activation,

106 ggests that mechanisms underlying riluzole's neuroprotective effects are insufficient for clinical re

107 tional in vitro studies showed antioxidative neuroprotective effects as well as the ability to penetr

108 findings suggest that pridopidine may exert neuroprotective effects beyond its role in alleviating s

109 Finally, VX-765 showed neuroprotective effects by preserving tyrosine hydroxyla

110 have been shown to exert both neurotoxic and neuroprotective effects during development and in models

111 These studies reveal neuroprotective effects for PDE4 inhibitors in Cln3(Delt

112 studied whether, and how, nicotine produces neuroprotective effects in cultured dopaminergic neurons

113 , sphingosine-1-phosphate lyase 1 (SPL), has neuroprotective effects in Huntington's disease models.

114 se data demonstrate that modulating Ryrs has neuroprotective effects in nGD through mechanisms that p

115 like peptide-1 (GLP-1) receptor agonist, has neuroprotective effects in preclinical models of Parkins

116 Since glucagon-like peptide 1 (GLP-1) exerts neuroprotective effects in the central nervous system an

117 ecific cell targeting or to enhance the drug neuroprotective effects in the CNS.

118 rolyl hydroxylase domain proteins (PHDs) has neuroprotective effects in various in vitro and in vivo

119 offers cytoprotective, cardioprotective, and neuroprotective effects in vivo and in vitro.

120 of a pyrazoline derivative that demonstrated neuroprotective effects in vivo, we synthesized a series

121 Neuroprotective effects involved oxidative stress reduct

122 hancing glucose uptake in neurons has strong neuroprotective effects involving improved proteostasis.

123 ng AMPK in dopamine neurons may recapitulate neuroprotective effects of CR without requiring dietary

124 BDNF signaling in the SN participates in the neuroprotective effects of DBS remains unknown.

125 Neuroprotective effects of fingolimod in mouse models of

126 1PR1-selective antagonist, W146, blocked the neuroprotective effects of FTY720.

127 We determined that the neuroprotective effects of IL-21R arose from signaling t

128 After 2 weeks of LIP ultrasound, neuroprotective effects of LIP ultrasound were evaluated

129 Here, we investigate the neuroprotective effects of Liraglutide along with the si

130 Purpose To investigate the neuroprotective effects of low-intensity pulsed (LIP) ul

131 henothiazines, we significantly enhanced the neuroprotective effects of mild hypothermia.

132 db mice retinas; 2) to determine the retinal neuroprotective effects of systemic and topical administ

133 eta1-42, providing a molecular basis for the neuroprotective effects of the chaperone.

134 We studied the neuroprotective effects of the cytokines, granulocyte-co

135 The aim of this trial was to investigate the neuroprotective effects of the glucagon-like peptide-1 a

136 med to evaluate the antioxidant activity and neuroprotective effects of the hydroethanolic extracts f

137 Our findings suggest that the neuroprotective effects of TubA likely involve HDAC6 inh

138 fying anti-Alzheimer's drugs, based on their neuroprotective effects on neuron cells, their antineuro

139 CA appears to exert its neuroprotective effects through inhibition of oxidative

140 These prominent neuroprotective effects warrant the consideration of tam

141 Finally, the treatment's neuroprotective effects were blocked by a p-Akt inhibito

142 Their potential neuroprotective effects were examined in mouse focal isc

143 The neuroprotective effects were secondary to a reduction in

144 EM2 exhibited strong neuroprotective effects, including reduced brain infarct

145 t 1 mg/kg of eliprodil, a dose with reported neuroprotective effects, more than 99.5% of binding site

146 though it has been suggested that it confers neuroprotective effects, the exact genomic mechanism has

147 te microglia-mediated inflammation and exert neuroprotective effects, with potential for alleviation

148 dies against CCL4, respectively, abolish the neuroprotective effects.

149 elated kinase A (TrkA), and to thereby exert neuroprotective effects.

150 ketimine (LK), which has been shown to have neuroprotective effects.

151 inal toxicity, paradoxically provided potent neuroprotective effects.

152 ischemia reperfusion injury and did not show neuroprotective effects.

153 and more detailed evidence of its potential neuroprotective effects.

154 gh AMPK in SN dopamine neurons mediates CR's neuroprotective effects.

155 s the issue of bilingualism and its putative neuroprotective effects.

156 by which HN exerts its cardioprotective and neuroprotective effects.

157 CNS injury that involve either neurotoxic or neuroprotective effects.

158 (secreted phosphoprotein 1), which has known neuroprotective effects.

159 idative and anti-inflammatory activities and neuroprotective effects.

160 ite, and produce anticancer, anxiolytic, and neuroprotective efficacies via cannabinoid receptor type

161 xypeptidase II which has demonstrated robust neuroprotective efficacy in many neurological disease mo

162 ely, our data demonstrate that Bok acts as a neuroprotective factor rather than a pro-death effector

163 , our results suggest exogenous IFNbeta as a neuroprotective factor that has potential to ameliorate

164 on in microglia, functioning as an important neuroprotective factor.

165 to investigate potential non-cell autonomous neuroprotective factors influencing AbetaO toxicity.

166 matory markers, and diminished expression of neuroprotective factors.

167 In all cases, the key neuroprotective function of these kinases is uncertain.

168 rough ARALAR-MAS pathway is required for its neuroprotective function.

169 og to human FPR2/lipoxin A4 receptor) evoked neuroprotective functions after cerebral ischemia/reperf

170 Here we discuss current evidence of the neuroprotective functions of microglia with a focus on o

171 ation, and that it has both neurotrophic and neuroprotective functions.

172 The identification of neuroprotective genes based on naturally occurring allel

173 Induction of neuroprotective heat-shock proteins via pharmacological

174 em, and exogenous EPO therapy is potentially neuroprotective, however the epigenetic and transcriptio

175 sulfide-rich spider venom peptide, is highly neuroprotective in a focal model of ischemic stroke.

176 tivation by a Drp1 peptide inhibitor P110 is neuroprotective in a MPTP animal model.

177 concentrations approved for therapy were not neuroprotective in a PD mouse model.

178 Erythropoietin treatment is neuroprotective in animal experimental and human clinica

179 nous Insulin-Like Growth Factor-1 (IGF-1) is neuroprotective in animal models of brain injury, and ha

180 n peptide, a calpain inhibitor, was strongly neuroprotective in mice lacking Rho while photoreceptor

181 activation of regenerative signaling is not neuroprotective in motor neurons undergoing C9orf72 toxi

182 LTCC blockers were neuroprotective in mouse neurotoxin models of PD, and is

183 Inhibition of miR-142-3p could be neuroprotective in MS.

184 ucleotide adenylyl transferase 2 (NMNAT2) is neuroprotective in numerous preclinical models of neurod

185 sodium-channel inhibition with phenytoin is neuroprotective in patient with acute optic neuritis.

186 organ injury in other disease states and are neuroprotective in preclinical models of critical illnes

187 hibition of voltage-gated sodium channels is neuroprotective in preclinical models.

188 Estriol treatment is anti-inflammatory and neuroprotective in preclinical studies.

189 Helium proved neuroprotective in rodents and cardioprotective in rabbi

190 ndogenous antioxidant enzymes and has proven neuroprotective in studies of neurodegenerative models a

191 Both drugs were markedly neuroprotective in two mouse models of neurodegeneration

192 r cobalamin, a vitamin B12 vitamer, would be neuroprotective in vitro and in vivo.

193 Treatment with EVP4593, a neuroprotective inhibitor of neuronal SOC channels, resc

194 babies, 5 trials, NNT to benefit 46) and the neuroprotective intent analysis (RR 0.68, 95% CI 0.53 to

195 isease in its prodromal phase and to promote neuroprotective interventions before the onset of motor

196 V1.2 are identified as potential targets for neuroprotective interventions.

197 trocytes, as well as in evaluating potential neuroprotective interventions.

198 athletes with lower levels of the putatively neuroprotective KYNA/QUIN ratio reported significantly w

199 nurenine (3-HK); quinolinic acid (QUIN)] and neuroprotective [kynurenic acid (KYNA)] KP metabolites.

200 However, in T1D, this neuroprotective mechanism is insufficient to prevent neu

201 of how cholesterol metabolism can modulate a neuroprotective mechanism that attenuates alpha-synuclei

202 gets for neuroprotection, but the underlying neuroprotective mechanism(s) are unknown.

203 act as a critical component of an endogenous neuroprotective mechanism.

204 db/db mice; and 3) to examine the underlying neuroprotective mechanisms.

205 Cooling and hypothermia are profoundly neuroprotective, mediated, at least in part, by the cold

206 kynurenine metabolites and reduced levels of neuroprotective metabolites relative to healthy football

207 M2 deficiency may disrupt the formation of a neuroprotective microglia barrier that regulates amyloid

208 al disorders, and there is an unmet need for neuroprotective modalities to improve photoreceptor surv

209 he activity of nicotinamide riboside (NR) in neuroprotective models and the recent description of ext

210 A combination of the known neuroprotective molecule, pigment epithelium-derived fac

211 tion of the immune response and induction of neuroprotective molecules in the central nervous system

212 We highlight the neuroprotective nature of certain myeloid cells by empha

213 critical importance of the time at which the neuroprotective noble gases xenon and argon should be ad

214 armacological analysis of the aforementioned neuroprotective peptide revealed that it acts in a seque

215 Neuroprotective pharmacological strategies are needed to

216 showed that specific tau phosphorylation is neuroprotective, phenocopying tau ablation, thus highlig

217 ovesicles secreted from hNSC affords similar neuroprotective phenotypes after head-only irradiation.

218 wards inflammatory suppression, resulting in neuroprotective phenotypes and improved functional recov

219 results identify a paradigm for compensatory neuroprotective PK2 signalling in nigral dopaminergic ne

220 ed as promising drug candidates endowed with neuroprotective potential and brain permeability.

221 ch is accompanied by impairment of astrocyte neuroprotective potential in vitro We further show that

222 The neuroprotective potential of astrocytes was itself sensi

223 t that CK2 inhibitors could release the full neuroprotective potential of HSJ1, and deserve future in

224 aim of the current study was to evaluate the neuroprotective potential of mesenchymal stem cells (MSC

225 tnatal treatment strategies exist to enhance neuroprotective potential of microglia.

226 The direct neuroprotective potential of pharmacological NOX4 inhibi

227 alterations in astrocytes, and impair their neuroprotective potential.

228 compounds were synthesized, and mostly their neuroprotective profile exceeded that offered by the hea

229 nti-inflammatory ability with an interesting neuroprotective profile on in vitro models of neuronal d

230 we go on to demonstrate that hydralazine has neuroprotective properties against endogenous and exogen

231 iluzole is a glutamate-modulating agent with neuroprotective properties approved for use in amyotroph

232 ike conditions in rat brain slices suggested neuroprotective properties for these imidazo[1,5-a]quino

233 c brain injury but, thus far, these putative neuroprotective properties have not been reported in hum

234 ecently, meclizine has been assessed for its neuroprotective properties in ischemic stroke and Huntin

235 SPO ligands have shown anti-inflammatory and neuroprotective properties in models of CNS injury.

236 proteins, investigating their expression and neuroprotective properties in parallel.

237 DM1 myoblasts, while compounds 1 and 53 have neuroprotective properties in SMA-derived cells.

238 Here, we evaluate the neuroprotective properties of argon after experimental s

239 Recent reports have highlighted the neuroprotective properties of Cu((II))ATSM, yet there ar

240 These data suggest that the neuroprotective properties of microvesicles act through

241 The neuroprotective properties of our compounds were further

242 Lithium may have neuroprotective properties that require further investig

243 Caffeine, one component of coffee, has neuroprotective properties, and has been shown to suppre

244 inal polypeptide (VIP) is known to have many neuroprotective properties, but in the avian brain, alth

245 ed that elevated ghrelin, a gut hormone with neuroprotective properties, during CR prevents neurodege

246 imental work shows that heparinoids may have neuroprotective properties.

247 To test this potential neuroprotective property, neurons were pretreated with G

248 SC transplantation improves recovery through neuroprotective, regenerative, and cell replacement mech

249 njury after alkali burn and explored a novel neuroprotective regimen suitable for prompt administrati

250 s suggest that Nos and Pum provide a crucial neuroprotective regulatory layer to ensure that neurons

251 rontotemporal dementia mice, both drugs were neuroprotective, rescued memory deficits and reduced hip

252 s, possibly indicating a potential intrinsic neuroprotective response.

253 Muller survival pathways might underlie the neuroprotective response.

254 f this process in these models is strikingly neuroprotective, resulting in the discovery of the first

255 , suggesting that TRPC channels might play a neuroprotective role during mechanical stress.

256 Together, our results suggest a neuroprotective role for Shh signaling in the context of

257 S active products due to its anti-stress and neuroprotective role in dementias particularly in retrog

258 ere, we argue that microglia play an overall neuroprotective role in prion pathogenesis.

259 n striatal and cortical neurons that plays a neuroprotective role in these cells.

260 In particular, we consider the neuroprotective role of astrocyte gap junction coupling.

261 imental models of ischemia, we demonstrate a neuroprotective role of GluN2C, suggesting a mechanism b

262 Altogether, these findings validate neuroprotective role of Shh signaling and highlight the

263 Here, we describe a neuroprotective role of the protein in acute hypoxia.

264 facilitated by elevated pressure and plays a neuroprotective role under glaucomatous conditions, whil

265 s have well-documented anti-inflammatory and neuroprotective roles in the central nervous system.

266 (sAPPalpha) play important physiological and neuroprotective roles.

267 (RGCs) in the eye to characterize a secreted neuroprotective signal present in retinal astrocyte cond

268 dentified a prominent lipid component of the neuroprotective signal through metabolomics screening.

269 Here, we identify a new neuroprotective signaling cascade involving the activity

270 Intranasal delivery of neuroprotective ST266 is a potential novel, noninvasive

271 seful tool for modeling disease-modifying or neuroprotective strategies for disease processes before

272 mine and DMV neurons in PD and could promote neuroprotective strategies that emulate endogenous homeo

273 osis (MS) research, there is still a lack of neuroprotective strategies, because the main focus has r

274 ng these mechanisms is vital to help develop neuroprotective strategies.

275 ovascular ischemia and is a target for novel neuroprotective strategies.

276 ue has potential in the future assessment of neuroprotective strategies.

277 n favor of early limitation of care or novel neuroprotective strategies.

278 anism of pUL37 x 1 may be considered a novel neuroprotective strategy in diseases where mitochondrial

279 challenge in stroke is finding an effective neuroprotective strategy to treat cerebral ischemic inju

280 arly evidence that TNS could be an effective neuroprotective strategy.

281 f Kv2.1 is an effective and highly promising neuroprotective strategy.SIGNIFICANCE STATEMENT Kv2.1 is

282 e identification of novel anticonvulsive and neuroprotective targets.

283 s monitoring effects of neuroregenerative or neuroprotective therapeutics.

284 mptoms but induce dyskinesias over time, and neuroprotective therapies are nonexistent.

285 or the development of disease biomarkers and neuroprotective therapies.

286 ility of targeting the JAK/STAT pathway as a neuroprotective therapy for neurodegenerative diseases.

287 nAChR) in fetal microglia will augment their neuroprotective transcriptome profile, while the antagon

288 rapidly translatable, disease-modifying, and neuroprotective treatment for Friedreich's ataxia.

289 thermia has long been considered a promising neuroprotective treatment of ischemic stroke, but the tr

290 , thus constituting a promising agent for HD neuroprotective treatment.

291 he early stages of the disease when putative neuroprotective treatments could stop neurodegeneration.

292 k may need to be considered in the design of neuroprotective treatments for brain injury.

293 markers for use in future clinical trials of neuroprotective treatments in MS.

294 se model, identifying a potential target for neuroprotective treatments in MS.

295 d GP+RAP/alpha-syn, is capable of triggering neuroprotective Treg responses in synucleinopathy models

296 ures, with important implications for future neuroprotective trials in rapid eye movement sleep behav

297 urrently diagnosed may be an ideal group for neuroprotective trials.

298 a new class of fluorinated analogues of the neuroprotective tripeptide glycine-proline-glutamate (GP

299 bolism might address glycemic control and be neuroprotective, we treated prediabetic and T2D mice wit

300 ong-term potentiation (LTP) and is generally neuroprotective, while calpain-2 activation limits the e