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1 opulation or reduced cell density within the neurosphere.
2 itions for inducing differentiation in human neurospheres.
3 ne, Gpr17, resulted in a decreased number of neurospheres.
4 the male-specific Sry gene, and cultured as neurospheres.
5 ts of forced differentiation in glioblastoma neurospheres.
6 to form pluripotent, long-term self-renewing neurospheres.
7 id not induce neuronal differentiation in WT neurospheres.
8 ly higher in Cx43-null than in WT littermate neurospheres.
9 ease in differentiation in etoposide-treated neurospheres.
10 ion of GABAergic cells derived from passaged neurospheres.
11 mouse models of GBM and in primary human GBM neurospheres.
12 inhibited IGF2-induced growth of GBM-derived neurospheres.
13 for EGF to support the growth of GBM-derived neurospheres.
14 maintained as free-floating undifferentiated neurospheres.
15 ssed by neural progenitors grown as cultured neurospheres.
16 elomerase activity in cultured eNOS(-/-) SVZ neurospheres.
17 cell sorting and can generate multipotential neurospheres.
18 tiation into differentiated embryoid body or neurospheres.
19 lizes flow and microstructures to dissociate neurospheres.
20 Inhibition of OPN blocked the formation of neurospheres, affected the proliferative capacity of tra
21 Average diameters of individual cells and neurospheres after 1 week in culture were similar in mic
25 grafts derived from EphB2-overexpressing GBM neurospheres also showed decreased cellular proliferatio
26 y properties of RA activation in the SVZ; in neurospheres, altered retinoid signaling elicits neither
29 potential; and as few as six cells will form neurospheres and 20-30 cells will grow tumor in mice.
30 fied prominin+ lin- cells form self-renewing neurospheres and can differentiate into astrocytes, olig
32 Moreover, a fraction of GFP+ cells formed neurospheres and differentiated into neurons, astrocytes
34 ay analysis on control and shMCT4-expressing neurospheres and found a dramatic reduction in the expre
36 hermore, GD3 synthase (GD3S) is increased in neurospheres and human GBM tissues, but not in normal br
37 inished the proliferation of patient-derived neurospheres and increased survival in mouse models of e
39 n of Musashi-Notch signaling by TRIM3 in GBM neurospheres and neural stem cells that may better expla
41 B proliferation in vitro compared to control neurospheres and substantially inhibited G3 MB prolifera
42 ZIKV infection of human organoids and mouse neurospheres and TLR3 inhibition reduced the phenotypic
43 nglioside D3 (GD3) is overexpressed on eight neurospheres and tumor cells; in combination with CD133,
44 in gene expression of patient-derived glioma neurospheres and uncover subpopulations similar to those
45 tion of embryonic and adult NPCs cultured as neurospheres and, in vivo, in the subventricular zone of
47 aged IDH wild-type glioblastomas, derivative neurospheres, and single-cell gene expression profiles t
49 eration and differentiation both in cultured neurospheres as well as in vivo mouse and fly models of
50 Hh-pathway in TMZ-response on additional GBM neurospheres as well as on GBM patients, by extracting R
52 greater differentiation of hair cells in the neurosphere assay showed that Lgr5-positive cells had th
53 istochemistry (IHC), electron microscopy and neurosphere assay the morphology, cytoarchitecture and n
57 Neural precursor responses were evaluated by neurosphere assays as well as by stereological analyses.
59 ar movement in cortical slice assays, and in neurosphere assays, the percentage of migrating neurons
60 his study explores the use of a simple human neurosphere-based in vitro model to characterise the pha
61 ma cells and glioma-initiating cell-enriched neurospheres both in vitro and in vivo, and we show that
63 ells had the ability to proliferate and form neurospheres but had an impaired response to mitogen sti
64 plantation of a clonally derived spinal cord neurosphere can result in reconstitution of all examined
66 from the murine spinal cord and organized as neurospheres, can be triggered to migrate out in respons
70 ion with this, we confirmed that both normal neurosphere cells and ENU-im-mortalized subventricular z
71 rtib exerted similar effects on glioblastoma neurosphere cells in vivo and resulted in markedly reduc
74 se in PrP(Sc) levels with time in the Tg4053 neurosphere cells, whereas the level of PrP(Sc) decayed
77 -deficient embryos formed greater numbers of neurospheres compared with neurospheres from wild-type e
78 ote that an intact tumor microenvironment or neurosphere conditions in vitro are required for Gli act
81 radial glial morphology) expressed YFP; YFP+ neurospheres could be generated in vitro after recombina
84 eshly isolated human glioblastoma multiforme neurosphere cultures (containing "stem cell-like cells")
86 micked those seen in mice, validating use of neurosphere cultures as models for studying tau phosphor
87 binant murine TIMP-1 (rmTIMP-1) to TIMP-1 KO neurosphere cultures evoked a dose-dependent increase in
88 ry and qRT-PCR to screen fetal mouse-derived neurosphere cultures for ethanol-sensitive neural stem c
89 e central nervous system (CNS) SC-containing neurosphere cultures for studying heritable neurodegener
91 table neurodegenerative disease, we compared neurosphere cultures from transgenic mice that express h
92 iments on bulk GBM cell line cultures and on neurosphere cultures of a human-origin GBM xenograft tum
96 ansient exposure of embryonic day 14.5 mouse neurosphere cultures to dexamethasone (DEX) limits proli
100 sic fibroblast growth factor (bFGF)-expanded neurosphere cultures with the EGF-like domain of neuregu
101 on is markedly reduced in human GBM samples, neurosphere cultures, and cell lines and its reconstitut
102 netically engineered mice and derivative NSC neurosphere cultures, we show that this brain region-spe
103 By using a conditional deletion system and neurosphere cultures, we showed that FoxM1 is important
108 of differentiation in CNS progenitor cells (neurosphere) cultures from TIMP-1 KO mice revealed a spe
109 sion levels in undifferentiated, SVZ-derived neurospheres decline markedly with differentiation.
110 ties (80-85%) and the ability to regrow into neurospheres, demonstrating the applicability of this de
111 A activation in similar cells in SVZ-derived neurospheres depends on retinoid synthesis from the prem
113 These changes can be preserved in vitro, as neurospheres derived from Gdf11(-/-) and wild-type litte
114 hat relatively mature neurons generated from neurospheres derived from postnatal subependymal zone or
116 logy, the degree of neuronal maturation from neurospheres derived from wild-type (WT) and Cx43-null m
117 this, LY364947 treatment in irradiated GL261 neurosphere-derived cells decreased DNA damage responses
118 However, when ectopically transplanted, neurosphere-derived cells from either region are largely
119 investigate cell cycle dynamics in olfactory neurosphere-derived cells from nine male schizophrenia p
121 s study was to investigate whether olfactory neurosphere-derived cells from schizophrenia patients ha
124 ition, neural stem/progenitor cell cultures (neurosphere-derived cells) from nasal biopsies from indi
126 e of the B2BkR antagonist HOE-140 during rat neurosphere differentiation, neuron-specific beta3-tubul
127 The Met(high) subpopulation within Met-pos neurospheres displayed clonogenic potential and long-ter
129 ment of variant allele frequencies (VAFs) in neurospheres displaying contrasting phenotypes of sustai
131 We show that this microfluidic-chip-based neurosphere-dissociation method can generate high yields
132 enitor cells in vivo, yet in vitro generated neurospheres, divided in response to bFGF (basic fibrobl
133 tivated and functional in glioblastoma (GBM) neurospheres enriched for glioblastoma tumor-initiating
137 sion of the MET oncogene was associated with neurospheres expressing the gene signature of mesenchyma
139 evidence that TRBP is required for efficient neurosphere formation and for the expression of neural s
140 38 significantly reduced the cell viability, neurosphere formation and induced apoptosis of GSCs with
141 We show that TMZ + GSI treatment decreased neurosphere formation and inhibited neurosphere recovery
142 t to induce the stem cell characteristics of neurosphere formation and neurosphere cell self-renewal.
143 qualities of primary GBM cultures, including neurosphere formation and the expression of stem cell ma
147 364947 treatment before IR decreased primary neurosphere formation by 75% and secondary neurosphere f
148 ut not control IgG, dramatically reduced the neurosphere formation frequency in mice that had exercis
150 activity and blocked cell proliferation and neurosphere formation in cultures of glioma stem cells,
151 layed an enhanced capacity for self-renewing neurosphere formation in response to Wnt and were conver
152 duced proliferating (BrdU-labeled) cells and neurosphere formation in wild type but not TLR3(-/-)-der
154 equence of vascular regression, since YFP(+) neurosphere formation over serial passage was unaffected
155 k attenuated stem cell marker expression and neurosphere formation while having minimal effects on tu
156 t by analyzing cell viability via MTT assay, neurosphere formation, and endoplasmic reticulum stress/
157 on of miR-124 and knockdown of SNAI2 reduced neurosphere formation, CD133(+) cell subpopulation, and
158 in CD133(+) glioma cells potently disrupted neurosphere formation, induced apoptosis, and inhibited
159 ved from eNOS-/- mice restored the decreased neurosphere formation, proliferation, neurite outgrowth,
161 increasing cell proliferation and stem cell neurosphere formation, with its ectopic overexpression s
166 tures, TMZ treatment significantly decreases neurosphere formation; however, a small percentage of ce
167 e retinal integration and differentiation of neurospheres formed by stem cells and mouse neural proge
172 at allows the purification to homogeneity of neurosphere-forming neural precursors from the adult mou
173 uorescence-activated cell sorting to isolate neurosphere-forming neural stem cells (NSCs) from embryo
175 population, which comprises the majority of neurosphere-forming precursors, there are two distinct s
176 show that Shh regulates the self-renewal of neurosphere-forming stem cells and that it modulates pro
177 l glia in the GEs where ActN1 increases FGF2 neurosphere frequency, but not in the septum where it do
179 nockdown diminishes) the ability to generate neurospheres from MNPs, indicating a function in self-re
181 compared FTD-hallmark tau phosphorylation in neurospheres from rTg(tau(P301L))4510 mice and from rTg(
182 pon differentiation, more than twice as many neurospheres from the damaged brain were tripotential, s
183 h the Notch intracellular domain rescued GBM neurospheres from the RA-induced differentiation and ste
185 ntiated cells (GBMDC) grown in serum and GBM neurospheres (GBMNS) grown as neurospheres in vitro.
188 cells represent <2% of the cells present in neurospheres generated from postnatal rat brain but >95%
190 phenotype defined by glioblastoma invasion, neurosphere growth, and endothelial tube formation was m
192 led that rats transplanted with CNTF-treated neurospheres had a 22% greater striatal volume on the le
193 vely isolated, human CNS stem cells grown as neurospheres (hCNS-SCns) survive, migrate, and express d
194 ted TMZ-sensitization of a TMZ non-responder neurosphere in vitro by treating them with the FDA-appro
197 k genes important in hypoxia, we treated GBM neurospheres in hypoxia and identified monocarboxylate t
199 adherent in serum-containing media and forms neurospheres in supplemented serum-free media was develo
201 but not proliferation or differentiation, in neurospheres in vitro and in newly born SGZ cells in viv
202 ne in three EGFR(+) astrocytes gives rise to neurospheres in vitro, a 20-fold enrichment over unsorte
203 forebrain in vivo, and in adult multipotent neurospheres in vitro, derived from progenitors that exp
204 Using enteric neurons differentiated from neurospheres in vitro, we show that enteric axon growth
207 apitulated all of these findings in cultured neurospheres, in which overexpression and depletion of B
208 each gene in LGE or MGE cells propagated as neurospheres, indicating that these newly identified mol
210 (NSC) function but the relationship between neurosphere-initiating cells (NICs) and NSCs remains unc
211 The effect of sera on differentiation of NPC neurospheres into neuronal colonies was tested in 72-h-l
217 tative PCR analysis showed that treatment of neurosphere-like ReN cell aggregate cultures with gamma-
218 ensitive in vitro bioassay for mouse prions; neurosphere lines from other Tg mice overexpressing PrP
220 lf-renewal potential of several glioblastoma neurosphere lines in vitro, and this activity was furthe
222 osphorylation patterns, the observation that neurosphere lines maintained their cell line-specific-di
223 anti-proliferative actions in GBM stem-like neurospheres mediated, in part, by interactions between
224 not observed in mature hematopoietic cells, neurospheres, mesenchymal stem cells, or hepatocytes.
227 enotype-specific phosphorylation patterns in neurospheres mimicked those seen in mice, validating use
231 onditioning also modulated alteration in the neurosphere morphology in response to oxidative stress.
232 logical disorders, on the cell viability and neurosphere morphology of NPCs derived from the perivent
233 cells isolated from Sox1 null embryos formed neurospheres normally, but were specifically deficient i
234 ristics of groups of progenitor cells called neurosphere (NS) cells, including individual cell diamet
236 for the detection of spikes recorded from 3D neurospheres (NS) with a very low signal-to-noise ratio.
238 r cell viability and neurosphere morphology (neurosphere number, size and chain migration) were asses
239 ration and neurosphere size while decreasing neurosphere numbers, specially in the cultures that were
240 me, on development of neuronal colonies from neurospheres of HNPCs in the presence of Abeta1-40.
241 high yields of single cells from dissociated neurospheres of mouse KT98 and DC115 cell models (passag
244 ith those receiving transplants of untreated neurospheres (P = 0.0003) and a 26% greater striatal vol
245 PCs, namely the chain migration of NPCs from neurospheres, perhaps as a result of its effect on cell
250 Similarly, the number and size of primary neurospheres produced from the injured SVZ increased app
253 fferences between neuron differentiation and neurosphere proliferation: adhesion dependence and the d
254 elial cells (hBMEC) or NOTCH ligand with GBM neurospheres promoted GBM cell growth and increased CSLC
259 ation of gliomas from Sulf2(-/-) tumorigenic neurospheres resulted in decreased growth in vivo in mic
260 idative stress increased chain migration and neurosphere size while decreasing neurosphere numbers, s
263 sistant cancer cells as well as glioblastoma neurosphere stemlike cell cultures derived from patients
264 Thus, transplanted human CNS (hCNS)-derived neurospheres survived robustly in naive and ischemic bra
266 tely 1,400-fold more efficient in generating neurospheres than are GFP-negative cells and, despite th
267 with a lower frequency and produced smaller neurospheres than control cells in vitro, indicating red
269 eir small number, give rise to 70 times more neurospheres than does the GFP-negative population.
270 cohort yielded significantly lower number of neurospheres than the WKY cohort (by 69+/-7%; p<0.05).
271 cytes, some of which, when cultured, produce neurospheres that differentiate into neurons and glia.
273 ferate late into embryogenesis, can generate neurospheres that passage extensively, and differentiate
274 hat these iMuSCs have the capability to form neurospheres that represent multiple neural phenotypes.
275 lastoma cell lines and patient-derived tumor neurospheres, the E3 ligase is confined to the nucleus a
277 e-forming capacity, inhibited the ability of neurospheres to form colonies in soft agar and inhibited
278 n in vitro model of neural cell development (neurospheres) to evaluate, through immunocytochemistry,
279 rom postnatal rat brain but >95% of cells in neurospheres treated with the anti-mitotic agent Ara C.
280 xhibits potent efficacy against glioblastoma neurosphere tumor stem-like cells in vitro and in vivo.
282 he reduced Notch1 and Hes1 expression in LBW neurosphere, under both basal and stimulated conditions,
283 antation of spinal cord tissue and nonclonal neurospheres, we show that the central spinal cord repre
286 th following early CVB3 infection, surviving neurospheres were readily observed and continued to expr
288 -positive and NG2(+) progenitor cells within neurospheres were shown to preferentially express high l
290 roliferation of patient-derived glioblastoma neurospheres, whereas a STAT3 inhibitor reversed this ef
291 Here, we demonstrate that cultured murine neurospheres, which comprise neural stem cells and their
292 f function in glioblastoma-derived stem-like neurospheres, whose in vivo growth pattern closely repli
294 nsduced neural progenitor cells gave rise to neurospheres with a lower frequency and produced smaller
295 Treatment of cultured embryonic cortical neurospheres with a TLR3 ligand (polyIC) significantly r
299 requirement for MCT4 in vitro, we transduced neurospheres with lentiviruses encoding short-hairpin RN
300 n central nervous system stem cells grown as neurospheres with magnetic nanoparticles does not advers
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