ライフサイエンスコーパス: neuroticism

1 Personality Questionnaire was used to assess neuroticism.

2 lotype or diplotype-predicted expression and neuroticism.

3 in amygdala or subgenual AC activation with neuroticism.

4 appeared when we controlled for the level of neuroticism.

5 tic vulnerability to MD are not reflected in neuroticism.

6 version-extroversion and emotional stability-neuroticism.

7 that contribute to an individual's level of neuroticism.

8 nxiety disorder and the personality trait of neuroticism.

9 hip of panic attacks, cigarette smoking, and neuroticism.

10 o longer evident after analyses adjusted for neuroticism.

11 related traits, including harm avoidance and neuroticism.

12 on and that this association is moderated by neuroticism.

13 ked to an anxiety-related personality trait, Neuroticism.

14 ce of pleiotropy with cognitive function and neuroticism.

15 s identified nine novel loci associated with neuroticism.

16 IL-1ra was identified in females with lower neuroticism.

17 enge increased IL-1beta in females with high neuroticism.

18 This study identifies a novel locus for neuroticism.

19 etic variants explain 15% of the variance in neuroticism.

20 ders that are phenotypically correlated with neuroticism.

21 sm but there is no established connection to neuroticism.

22 nancial risk taking through its influence on neuroticism.

23 eft BA44 reflected individual differences in neuroticism.

24 grees of optimism and extraversion, and less neuroticism.

25 D, P < .001), they reported little change on neuroticism (-0.18 SD, P = .08) or extraversion (0.08 SD

26 ticism in 27 cohorts significantly predicted neuroticism (1.09 x 10-12 < P < .05) and MDD (4.02 x 10-

27 childhood sexual abuse, cluster C features, neuroticism, a history of anxiety and eating disorders,

28 Genetic factors shared with neuroticism accounted for between one-third and one-half

29 aits of the five-factor model (extraversion, neuroticism, agreeableness, conscientiousness, and openn

30 oxetine reported 6.8 times as much change on neuroticism and 3.5 times as much change on extraversion

31 An interaction was seen between neuroticism and adversity such that individuals with hig

32 Neuroticism and affective instability manifested varied

33 The findings suggest that neuroticism and affective instability--which are conside

34 constructs related to affective experience: neuroticism and affective instability.

35 s combined with major depression, increasing neuroticism and age, less education, and an interaction

36 ial phobia and agoraphobia, and that between neuroticism and animal phobia was moderate.

37 vided a neural correlate of the link between neuroticism and anxiety and mood disorders.

38 correlations were high and positive between neuroticism and both social phobia and agoraphobia, and

39 ssociation between individual differences in neuroticism and brain activity in response to threat of

40 , and helping to elucidate the links between neuroticism and complex diseases from a genetic perspect

41 tial genetic correlations were found between neuroticism and depressive symptoms (r g = 0.82, standar

42 tial genetic correlations were found between neuroticism and depressive symptoms (r g = 0.82, standar

43 the models, the genetic correlations between neuroticism and each disorder were high, while individua

44 Neuroticism and extraversion are personality traits asso

45 pleted a self-report questionnaire assessing neuroticism and extroversion in 1972 and 1973 and were p

46 udies suggest that the personality traits of neuroticism and extroversion may be related to the liabi

47 ould confirm the role of the MAGI1 locus for neuroticism and further investigate the association of M

48 eries significantly advance understanding of neuroticism and its association with MDD.

49 Regarding personality factors, high neuroticism and low conscientiousness are most widely as

50 individuals, males, and AAs scored higher on Neuroticism and lower on other personality factors.

51 elative to the depressive characteristics of neuroticism and may constitute vulnerability markers for

52 eling indicated that the association between neuroticism and MD resulted largely from shared genetic

53 ntified a strong genetic correlation between neuroticism and MDD and a less strong but significant ge

54 in phobic twins, was found between levels of neuroticism and mode of acquisition.

55 raits and psychiatric disorders, except that neuroticism and openness to experience were clustered wi

56 s been associated with several dimensions of neuroticism and psychopathology, especially anxiety trai

57 f E effects, we also examined the effects of neuroticism and psychoticism (P) scores.

58 e forward future work on the neurobiology of neuroticism and related phenotypes.

59 loci and identified two loci shared between neuroticism and schizophrenia and six loci shared betwee

60 Controlling for neuroticism and self efficacy, affective disorder histor

61 onal Assessment of Fatigue and indicators of neuroticism and self efficacy.

62 ntal factors shared by the personality trait neuroticism and seven internalizing disorders may help e

63 Stage of cancer, trait extroversion/neuroticism and spiritual support were significantly dif

64 ctors that influence individual variation in neuroticism and those that increase liability across the

65 ctors that influence individual variation in neuroticism and those that increase liability for genera

66 Because women have higher levels of neuroticism and twice the risk of lifetime generalized a

67 Psychosocial adversity interacts both with neuroticism and with sex in the etiology of major depres

68 ment, has examined dimensional traits (e.g., neuroticism) and anxious temperament (e.g., behavioral i

69 aseline depressive symptom score, and higher neuroticism) and during internship (increased work hours

70 ong genetic correlations between loneliness, neuroticism, and a scale of 'depressive symptoms.' We al

71 ion are female sex, the personality trait of neuroticism, and adversity resulting from exposure to st

72 compose the correlations among extraversion, neuroticism, and each phobia.

73 an anxious cluster personality disorder, low neuroticism, and high agreeableness.

74 rsonality dispositions such as extraversion, neuroticism, and self-esteem can markedly influence leve

75 rment, and help seeking; (3) lower levels of neuroticism; and (4) an increased risk of MD in cotwins-

76 the genetically related emotional domains of neuroticism, anxiety and depression.

77 rvation that some responses to threat (i.e., neuroticism/anxiety) are associated with a more left-win

78 nce individual variation in extraversion and neuroticism appear to account entirely for the genetic l

79 The personality domains of extraversion and neuroticism are regarded as being stable individual psyc

80 Two personality traits, extraversion and neuroticism, are strongly associated with emotional expe

81 support for a role of either extraversion or neuroticism as determinants of long-term mortality risk.

82 gistry, we assessed the personality trait of neuroticism--as an index of phobia-proneness--and the li

83 The identification of nine novel neuroticism-associated loci will drive forward future wo

84 positively with measures of cyclothymia and neuroticism at baseline, but not with measures of depres

85 manifested varied concurrent relations, with neuroticism being strongly related to an anxious, avoida

86 howed that individuals with a higher risk of neuroticism (beta = 1.01; 95% CI, 0.50-1.52) or depressi

87 uals who developed dementia scored higher on neuroticism (beta = 2.83; 95% CI, 1.44 to 4.22; P < .001

88 paired and the Alzheimer disease groups (eg, neuroticism: beta = 0.00; 95% CI, -0.08 to 0.08; P = .91

89 who developed mild cognitive impairment (eg, neuroticism: beta = 0.00; 95% CI, -0.12 to 0.12; P = .98

90 o 0.05; P = .18) and all-cause dementia (eg, neuroticism: beta = 0.02; 95% CI, -0.06 to 0.10; P = .49

91 aist-hip ratio, childhood cognitive ability, neuroticism, bipolar disorder, major depressive disorder

92 three emerging endophenotypes of depression: neuroticism, blunted reward learning, and cognitive cont

93 rences in the common allelic architecture of neuroticism by sex.

94 ing on this and other (eg, personality trait neuroticism) core phenotypes to identify risk loci.

95 Neuroticism correlated positively with amygdala and subg

96 The results revealed that neuroticism correlated positively with the ratings of fe

97 n, emotional stability (i.e., the inverse of neuroticism) correlated with increased activation in the

98 To determine whether increases in neuroticism, declines in conscientiousness, and changes

99 howed higher levels of the personality trait neuroticism, despite not differing from others with resp

100 Although neuroticism did not positively correlate with any whole-

101 ble personality dimensions, extroversion and neuroticism, differentially influence emotional reactivi

102 a greater impact in women: parental warmth, neuroticism, divorce, social support, and marital satisf

103 ing closely tied to the personality trait of neuroticism, does not fit with the established personali

104 itive correlation between brain activity and neuroticism during anticipation was found in regions ass

105 e regions showed a negative correlation with neuroticism during pain (P < .001).

106 between anorexia nervosa and schizophrenia, neuroticism, educational attainment, and high-density li

107 esources (e.g., a good marriage, a low level neuroticism, enjoyment of vacations, and a capacity for

108 ng of pain in subjects with higher levels of neuroticism, especially the anxiety component of this tr

109 the personality factors termed the "big 5" (neuroticism, extraversion, openness to experience, agree

110 of the "Big Five" personality factors (i.e., neuroticism, extraversion, openness to experience, agree

111 The Big Five personality traits neuroticism, extraversion, openness, agreeableness and c

112 acets, 6 for each of the 5 major dimensions: neuroticism, extraversion, openness, agreeableness, and

113 st), and personality traits (measured by the Neuroticism-Extraversion-Openness Personality Inventory)

114 st), and personality traits (measured by the Neuroticism-Extraversion-Openness Personality Inventory)

115 inistered the Beck Depression Inventory, the Neuroticism-Extraversion-Openness Personality Inventory,

116 was administered consisting of the NEO-FFI (Neuroticism-Extroversion-Openness-Five Factor Inventory)

117 x model for prediction of depressive onsets, neuroticism, female sex, and greater adversity all stron

118 le in those vulnerable for depression due to neuroticism, genetic risk, or previous depressive illnes

119 Genome-wide association studies (GWAS) of neuroticism have identified up to 11 associated genetic

120 (hypothesis-driven scales) of perfectionism, neuroticism, highly sensitive person, ego resiliency, ne

121 contagion is related to trait differences in neuroticism (i.e., the tendency to experience negative e

122 Sex and neuroticism impacted IL-1 family cytokines; higher basel

123 lygenic scores based on the meta-analysis of neuroticism in 27 cohorts significantly predicted neurot

124 significant independent loci from a GWAS of neuroticism in 329,821 UK Biobank participants; 15 of th

125 ion, using the personality phenotype of high neuroticism in a double-blind, between-groups design.

126 rkers were tested for their association with neuroticism in a genomewide association study (GWAS).

127 gdala and subgenual AC associated with trait neuroticism in a nonclinical sample of 36 volunteers dur

128 stimuli are correlated with extraversion and neuroticism in healthy women.

129 At the same time, the role of neuroticism in later-life depression warrants further st

130 of both introversion (low extraversion) and neuroticism in some psychiatric disorders.

131 captured approximately 1% of the variance in neuroticism in the GS:SFHS and QIMR samples, although mo

132 d with those that influence extraversion and neuroticism; in contrast, only a small proportion of the

133 ve symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms.

134 In addition, the authors could identify a neuroticism-independent genetic factor that significantl

135 Neuroticism independently predicted the co-occurrence of

136 jor personality dimensions (extraversion and neuroticism) index the genetic and environmental risk fo

137 This association arises largely because neuroticism indexes the genetic risk for depressive illn

138 nutritional status) decreases with a woman's neuroticism, indicating a reproductive trade-off between

139 mplitude was greater in patients with higher neuroticism, indicating that error processing is moderat

140 ll participants were assessed using the same neuroticism instrument, the Eysenck Personality Question

141 ons between generalized anxiety disorder and neuroticism into genetic and environmental components, i

142 of certain personality traits, particularly neuroticism, introversion, and interpersonal dependency.

143 Neuroticism involves a tendency for enhanced emotional a

144 High neuroticism is a personality risk factor that reflects m

145 Neuroticism is a personality trait of fundamental import

146 Neuroticism is a pervasive risk factor for psychiatric c

147 Neuroticism is a relatively stable personality trait cha

148 anxiety and mood disorders, for which trait neuroticism is a risk factor.

149 Neuroticism is a trait that reflects a tendency toward n

150 study provides novel data suggesting higher neuroticism is associated with engagement of brain regio

151 Increased neuroticism is associated with poorer mental and physica

152 Although neuroticism is heritable, attempts to identify the allel

153 In addition, the study shows that neuroticism is influenced by many genetic variants of sm

154 expression is correlated with trait anxiety (neuroticism) is not replicated in a data set consisting

155 ness is achieved by women at an intermediate neuroticism level.

156 nts have been associated with depression and neuroticism, likely because of limitations on sample siz

157 arette smoking but provide new evidence that neuroticism may play an essential role in this relations

158 preliminary but, if replicated, suggest that neuroticism may reflect a shared vulnerability for the c

159 The coheritability between loneliness and neuroticism may reflect the role of negative affectivity

160 Neuroticism measured about 3 decades before the diagnost

161 Anxiety and neuroticism measures were completed by 385 monozygotic a

162 420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911).

163 dimensions: Extraversion (E), Openness (O), Neuroticism (N), and Agreeableness (A).

164 uroticism that reflected the anxious form of neuroticism (N1) explained a greater proportion of varia

165 ticism that reflected the depressive form of neuroticism (N3).

166 Moreover, neither neuroticism nor extraversion was shown to have a moderat

167 polymorphism-based heritability estimate for neuroticism of approximately 15% (s.e.=0.7%).

168 known to influence the experience of pain is neuroticism, of which little is known about in visceral

169 The impact of neuroticism on illness risk is greater at high than at l

170 ism scores (range, 0-22) but no influence of neuroticism on skin conductance level and pain tolerance

171 o moderate its correlation with openness and neuroticism (OR = 1.39, 95%CI = 1.18-1.63, p = 7.64e-04

172 9), somatization (OR, 4.1; 95% CI, 2.7-6.0), neuroticism (OR, 3.3; 95% CI, 1.6-6.5), and clinical ind

173 significant after controlling for change in neuroticism (P = .46) or extraversion (P = .14).

174 .04]), personality (extroversion [P = .03], neuroticism [P = .01]), pruritus characteristics (severi

175 fter controlling for depression improvement (neuroticism, P < .001; extraversion, P = .002).

176 ed to consolidation of fear associations and neuroticism points to underlying mechanisms of the enhan

177 In women, neuroticism positively predicts the number of children,

178 Prospectively, neuroticism predicted later symptoms, occupational impai

179 ur aim was to study the relationship between neuroticism, psychophysiologic response, and brain proce

180 blood pressure, cholesterol, hostility, and neuroticism (rate ratio=0.76, p=0.002).

181 Neuroticism reduction during treatment predicted lower r

182 Neuroticism reflects emotional instability, and is relat

183 majority of genetic variants associated with neuroticism remain unclear.

184 Questionnaire-Revised (EPQ-R-S) Short Form's Neuroticism scale.

185 bipolar disorder, major depressive disorder, neuroticism, schizophrenia and verbal-numerical reasonin

186 There was a wide spread of neuroticism scores (range, 0-22) but no influence of neu

187 Neuroticism scores harmonized across all 29 discovery co

188 was compared in volunteers with high vs low neuroticism scores on the Eysenck Personality Questionna

189 diagnoses had effects on harm avoidance and neuroticism scores, there was no main effect of genotype

190 group, and genotype with harm avoidance and neuroticism scores.

191 trait level, G carriers reported higher NEO-Neuroticism scores; a personality trait previously assoc

192 ldhood parental loss), 2) early adolescence (neuroticism, self-esteem, and early-onset anxiety and co

193 terviews on the basis of previously assessed neuroticism, sex, and adversity during the past year; ad

194 e addition of terms for depressive symptoms, neuroticism, social network size, and number of chronic

195 Levels of neuroticism strongly predicted the risks for both lifeti

196 genetic analyses support the hypothesis that neuroticism strongly reflects the liability to MD.

197 s of genome-wide association study (GWAS) of neuroticism that includes 91 370 participants from the U

198 a maladaptive mechanism in those with higher neuroticism that promotes overarousal during anticipatio

199 The subscale of neuroticism that reflected the anxious form of neurotici

200 n the observed clusters than the subscale of neuroticism that reflected the depressive form of neurot

201 For both anxiety and neuroticism, the models provide support for significant

202 ess, and openness to more engagement coping; neuroticism to more disengagement coping; and optimism,

203 measures assessing anxiety proneness (e.g., neuroticism, trait anxiety, and anxiety sensitivity) wer

204 likely to be female, and had lower levels of neuroticism, treatment-seeking, and guilt and higher lev

205 performed on G and the personality scale of neuroticism using the regression-based linkage program M

206 s perceived stress, depressive symptoms, and neuroticism; using formal genetic twin models and molecu

207 d cigarette smoking and to determine whether neuroticism was an independent predictor of the co-occur

208 The effect of neuroticism was assessed using correlation analysis.

209 Neuroticism was associated with increased resting gamma

210 Prospectively assessed neuroticism was associated with the subsequent developme

211 tive stimuli in localized brain regions, and neuroticism was correlated with brain reactivity to nega

212 ion between generalized anxiety disorder and neuroticism was estimated at 0.20 for both genders.

213 rsonality Questionnaire in all subjects, and neuroticism was measured by the NEO Five-Factor Inventor

214 an placebo (P </= .01); but its advantage on neuroticism was no longer significant after controlling

215 atios for the 75th versus 25th percentile of neuroticism were 1.38 (95% CI: 1.10, 1.73) and 0.63 (95%

216 Lifetime generalized anxiety disorder and neuroticism were assessed in more than 8,000 twins from

217 obia, animal phobia, situational phobia, and neuroticism were assessed in over 9,000 twins from male-

218 on (CS+/- differentiation), higher levels of neuroticism were associated with a stronger interaction

219 nd adversity such that individuals with high neuroticism were at greater overall risk for major depre

220 s for plasma cortisol, major depression, and neuroticism were calculated using data from large genome

221 ons between generalized anxiety disorder and neuroticism were estimated at 0.80 (95% confidence inter

222 ons between generalized anxiety disorder and neuroticism were high and differed (nonsignificantly) be

223 Medical burden and neuroticism were independently associated with major dep

224 identified within a UK Biobank-only GWAS of neuroticism were not independently replicated within the

225 uring which their levels of extraversion and neuroticism were quantified.

226 In Study 2, volunteers with high neuroticism were randomized in a double-blind design to

227 dependent associations of medical burden and neuroticism with depression in a group of 196 subjects,

228 d with extraversion-introversion and grouped neuroticism with internalizing psychopathology (e.g., de

229 with variants in WSCD2 and near PCDH15, and neuroticism with variants on chromosome 8p23.1 and in L3