ライフサイエンスコーパス: neurotrophin

1 -term enhancement of presynaptic function by neurotrophin.

2 in the biological responses induced by this neurotrophin.

3 neuronal differentiation in response to this neurotrophin.

4 s to release anti-inflammatory cytokines and neurotrophins.

5 ithelia are the key endogenous source of the neurotrophins.

6 ear factor-kappaB (NF-kappaB) pathway by the neurotrophins.

7 DCVs for future release of neuropeptides and neurotrophins.

8 a orthologue of BDNF is the highly conserved Neurotrophin 1 (DNT1).

9 ), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and neurotrophin 4 (NT4), is impli

10 ey also express neurotrophins NGF, BDNF, and neurotrophin 3 (NT3).

11 thelial growth factor A, angiopoietin 1, and neurotrophin 3 in the ischemic muscle.

12 (NGF, brain-derived neurotrophic factor, and neurotrophin 3) and secrete NGF.

13 nfusion also increased hippocampal levels of neurotrophin 3, insulin-like growth factor 1, and nerve

14 ons of brain-derived neurotrophic factor and neurotrophin 3, which stimulated neurite outgrowth from

15 eurotrophic factor, nerve growth factor, and neurotrophin 3.

16 Neurotrophin-3 (NT-3) and its high-affinity receptor Trk

17 Removal of the TrkC ligand neurotrophin-3 (NT-3) from cerebellar granule cells, whi

18 Interestingly, neurotrophin-3 (NT-3) is upregulated in the brains of wi

19 ent receptor potential channel M5 (TrpM5) or neurotrophin-3 (NT-3) project to defined clusters of glo

20 in noise-exposed mice that local delivery of neurotrophin-3 (NT-3) to the round window niche, 24 hour

21 IYIY-I2-BODIPY binds TrkC similar to neurotrophin-3 (NT-3), and NT-3 has been reported to mod

22 ntitative PCR (qPCR) to assay NTF expression-neurotrophin-3 (NT-3), BDNF, GDNF, neurturin, artemin, a

23 from the brain metastatic protein signature, neurotrophin-3 (NT-3), has a dual function of regulating

24 nar release of nerve growth factor (NGF) and neurotrophin-3 (NT-3), respectively.

25 in resting membrane potential (RMP) or added neurotrophin-3 (NT-3).

26 We show here that intramuscular delivery of neurotrophin-3 (NT3, encoded by NTF3) can induce sensori

27 Neurotrophin-3 (Ntf3) and brain derived neurotrophic fac

28 Neurotrophin-3 also enhanced locomotor recovery.

29 t that brain-derived neurotrophic factor and neurotrophin-3 are anterogradely transported from midbra

30 Our findings pave the way for Neurotrophin-3 as a therapy that treats the underlying c

31 associated viral vector (AAV) encoding human Neurotrophin-3 at a clinically-feasible time-point after

32 Here, we demonstrate a novel role of neurotrophin-3 in synaptic assembly and function as a po

33 Neurotrophin-3 normalized the short latency Hoffmann ref

34 PTK (protein-tyrosine kinase) domain of the neurotrophin-3 receptor NTRK3.

35 cers, we identified in ACC expression of the neurotrophin-3 receptor TrkC/NTRK3, neural crest marker

36 demonstrate that axonal growth triggered by neurotrophin-3 remotely inhibits neurite outgrowth throu

37 Here, we discover that neurotrophin 4 (NT4) plays an essential role in mucus ov

38 hic factor (BDNF), neurotrophin 3 (NT3), and neurotrophin 4 (NT4), is implicated in the physiology of

39 roblast growth factor-4, CX3CL1/fractalkine, neurotrophin 4 oncostatin-M, pulmonary and activation-re

40 ration of the endogenous TrkB agonist ligand neurotrophin-4 (NT-4) profoundly decreases food intake a

41 brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4) have different developmental roles

42 ived neurotrophic factor (BDNF) is an active neurotrophin abundantly expressed throughout the nervous

43 ndocytosis are potential mechanisms by which neurotrophins achieve diverse neuronal functions.

44 Huh7 human hepatocyte cells showed that the neurotrophins activate the sterol regulatory element-bin

45 development of small molecule modulators of neurotrophin activity.

46 roteasome activator IU1, suggesting that the neurotrophin acts by decreasing proteasome activity.

47 roles, how BDNF, or more generally speaking, neurotrophins affect synapses, particularly nerve termin

48 bination therapy with both a neuroprotective neurotrophin and an anti-inflammatory agent.

49 , long-term potentiation and depression, and neurotrophin and retrograde endocannabinoid signaling.

50 aling an unforeseen relationship between the neurotrophin and Toll protein families.

51 Neurotrophins and glucocorticoids are robust synaptic mo

52 hese findings reveal a non-neuronal role for neurotrophins and identify a new regulatory pathway in i

53 used by altered expression of genes encoding neurotrophins and ion channels, and altered activity of

54 serum markers of inflammation, and levels of neurotrophins and neurotransmitters, but the BL group ha

55 ittermates, notably in the downregulation of neurotrophins and their cognate neurotrophin receptors a

56 Neurotrophins and their receptors are directly responsib

57 Neurotrophins and their receptors are frequently express

58 f HNE were not associated with production of neurotrophins and were unaffected by pretreatment with a

59 found that a few hours of treatment with the neurotrophin (and to a lower extent with basic FGF and E

60 t in Drosophila melanogaster pro- and mature neurotrophins are capable of inducing death and survival

61 Nervous system growth factors, that is, neurotrophins, are a potential solution to these disorde

62 e kinase on mouse neuroblastoma cells by the neurotrophin artemin (ART) is quantitatively coupled to

63 Both neurotrophin-based therapy and neural stem cell (NSC)-ba

64 or a given reward and that expression of the neurotrophin BDNF in the mOFC is both necessary and suff

65 The neurotrophin BDNF plays a prominent role in cognitive fu

66 Intriguingly, plasma levels of the neurotrophin BDNF were increased in patients treated wit

67 -Pep5) and in mice lacking the extracellular neurotrophin binding site of p75 neurotrophin receptor.

68 The neurotrophin brain-derived neurotrophic factor (BDNF) is

69 The neurotrophin brain-derived neurotrophic factor (BDNF) me

70 A major player in this process is the neurotrophin brain-derived neurotrophic factor (BDNF).

71 , we silenced the neuroplasticity-associated neurotrophin brain-derived neurotrophic factor (BDNF).

72 ent with a key protective role played by the neurotrophin brain-derived neurotrophic factor.

73 ell survival, and signaling responses to the neurotrophin brain-derived neurotrophic factor.

74 s ideal for examining this issue because the neurotrophins brain-derived neurotrophic factor (BDNF) a

75 on's disease (HD), controls transport of the neurotrophin, brain-derived neurotrophic factor (BDNF),

76 ic ligands (i.e., proneurotrophins or mature neurotrophins), but several of the intracellular adaptor

77 Neurons release neuropeptides, enzymes, and neurotrophins by exocytosis of dense-core vesicles (DCVs

78 Here we report that target-derived neurotrophins coordinate transcription of the antiapopto

79 Although several growth factors and neurotrophins delay degeneration and promote regrowth of

80 o, calcineurin regulates levels of STAT3 and neurotrophin dependence.

81 anglion sensory neurons and thereby promotes neurotrophin-dependent axonal viability.

82 ologic inhibition of Trk signaling decreases neurotrophin-dependent ERK activation and BTIC growth.

83 CR (qRT-PCR) for expression of apoptotic and neurotrophin-dependent signalling pathways.

84 Synaptic release of neuropeptides and neurotrophins depends on presynaptic accumulation of den

85 ivating insults ranging from nerve injury to neurotrophin deprivation result in both c-Jun N-terminal

86 Two Drosophila neurotrophins, DNT1 and DNT2, have nervous system functi

87 ious neurological conditions associated with neurotrophin dysfunction.

88 or tissue-based stem cells, cell fusion, and neurotrophin elaboration--offer renewed hope for develop

89 ion efficacy was improved when combined with neurotrophins, elevation of cyclic AMP levels, olfactory

90 Then, we asked whether or not these two neurotrophins exert their unique roles on the gustatory

91 oreceptor apoptosis, gliosis, and changes in neurotrophin expression, and it preserved the photorespo

92 nstroke mice did not alter motor behavior or neurotrophin expression, suggesting that the prorecovery

93 A for neurotrophins, including brain-derived neurotrophin factor (BNDF), was decreased following ION

94 families and some GFs from the TGF-beta and neurotrophin families.

95 ived neurotrophic factor) is a member of the neurotrophin family and it is implicated in regulating b

96 brain-derived neurotrophic factor (BDNF), a neurotrophin family member which is known to promote tum

97 The neurotrophin family of growth factors, comprised of nerv

98 neurotrophic factor (BDNF), a member of the neurotrophin family, regulates both survival and differe

99 rived neurotrophic factor (BDNF), a critical neurotrophin for brain repair and plasticity.

100 During this period, neurons depend on neurotrophins for their survival.

101 fects of adeno-associated virus vectors with neurotrophin gene inserts, AAV.BDNF and AAV.Ntf3, on gui

102 th in healthy immature brains by unbalancing neurotrophin homeostasis via p75 neurotrophin receptor s

103 Neurotrophin hypothesis of schizophrenia (SCZ) postulate

104 evidence supporting a critical role for this neurotrophin in physiological mechanisms regulating nutr

105 d provide evidence for a global role of this neurotrophin in the homeostasis of the organism by signa

106 ions per year attests to the significance of neurotrophins in biomedical sciences and underlines thei

107 Cochlear delivery of neurotrophins in humans is likely achievable as an offic

108 property of NaPB that may be used to augment neurotrophins in the CNS and improve synaptic function i

109 s increased expression of activity-dependent neurotrophins in the contralesional cortex, including br

110 vailability make exogenous administration of neurotrophins in vivo problematic; therefore, alternativ

111 Several studies have shown that neurotrophins including brain-derived neurotrophic facto

112 The production of mRNA for neurotrophins, including brain-derived neurotrophin fact

113 Neurotrophins, including nerve growth factor (NGF), incr

114 a feedforward loop, whereby upregulation of neurotrophins increases sympathetic innervation and loca

115 rally occurring death period, neurons become neurotrophin-independent and, further, that this develop

116 etary salt can affect blood pressure through neurotrophin-induced plasticity in a central homeostatic

117 for limiting neurotrophic support, and local neurotrophin insufficiency triggers caspase-dependent ax

118 Another very abundant neurotrophin is BDNF.

119 However, pharmacological modulation of this neurotrophin is challenging because BDNF is generated by

120 In the present work, the model neurotrophin is glial cell line-derived neurotrophic fac

121 el a new role for BDNF, suggesting that this neurotrophin is necessary and sufficient to maintain the

122 Upregulation of neurotrophins is accompanied by the increase of N-Methyl

123 epends on a functional nerve, application of neurotrophins is being investigated.

124 euregulin 1 (NRG1), a critical developmental neurotrophin, is associated with schizophrenia.

125 ts demonstrate that a transient elevation in neurotrophin levels can sustain the cochlear neural subs

126 kers of inflammation, neurotransmitters, and neurotrophin levels.

127 At that time, neurotrophins levels were not significantly elevated in

128 Overall our results identify a neurotrophin-mediated mechanism by which tau induces neu

129 accharides exhibited increased activation of neurotrophin-mediated signaling pathways and enhanced ax

130 The neurotrophin nerve growth factor (NGF) has been implicat

131 kB and TrkC, not TrkA, and they also express neurotrophins NGF, BDNF, and neurotrophin 3 (NT3).

132 nsulin, insulin-like growth factor-1, or the neurotrophins (NGF and BDNF).

133 In mammals, this is achieved by neurotrophin (NT) ligands, which promote cell survival v

134 ast in part to a reduction in the endogenous neurotrophin (NT) supply, normally provided by hair cell

135 ound that postnatal ASM innervation required neurotrophin (NT)-4 signaling through the TrkB receptor

136 titively reduced by the natural TrkC ligand, neurotrophin NT3.

137 It is well known that neurotrophins (NTs) are major regulators of such changes

138 Neurotrophins (NTs) have been shown to promote different

139 mental insight into the effects of exogenous neurotrophins on a degenerating neural system, and for t

140 Previous studies on the effect of neurotrophins on inositol signaling were limited to the

141 Here, we report that in response to neurotrophin or cAMP stimulation the RING ligase praja2

142 s amyloid-beta (Abeta) and the precursors of neurotrophins, outbalance neurotrophic signals, causing

143 at supporting cells influence the outcome of neurotrophin over-expression aimed at enhancing the coch

144 Neurotrophins particularly brain-derived neurotrophic fa

145 Data indicate that precuneus neurotrophin pathways are resilient to amyloid toxicity

146 These results indicate that glial-derived neurotrophins play critical roles in inner ear synapse d

147 ntial loss of cochlear hair cells, exogenous neurotrophins prevent degeneration of the auditory nerve

148 lausible therapeutic target because neuronal neurotrophin production is aberrant in AD and other neur

149 thening the clinical evidence of an abnormal neurotrophin profile in the patients with SCZ.

150 r regions that include genes associated with neurotrophins, programmed cell death, synaptic function,

151 gulated intramembrane proteolysis of the p75 neurotrophin receptor (also known as p75 cleavage).

152 is and recent evidence suggests that the p75 neurotrophin receptor (NTR) contributes significantly to

153 while down-regulating the expression of p75 neurotrophin receptor (NTR), phospho-JNK, and Bcl-2-asso

154 for choline acetyltransferase (ChAT) or p75-neurotrophin receptor (p75(NTR) ).

155 TAp73 is a transcriptional activator of p75 neurotrophin receptor (p75(NTR)) and that p75(NTR) mRNA

156 trophic factor (BDNF)-activated TrkB and p75 neurotrophin receptor (p75(NTR)) by disrupting the endos

157 The role of the p75 neurotrophin receptor (p75(NTR)) in adult cholinergic ba

158 We show that cleaved p75 neurotrophin receptor (p75(NTR)) is a component of the n

159 The p75 neurotrophin receptor (p75(NTR)) is a member of the tumo

160 The p75 neurotrophin receptor (p75(NTR)) is a multifunctional re

161 rve growth factor (NGF) signaling by the p75 neurotrophin receptor (p75(NTR)) is critical for neurona

162 distinct structural determinants in the p75 neurotrophin receptor (p75(NTR)) is crucial for the iden

163 The p75 neurotrophin receptor (p75(NTR)) is highly expressed in

164 The p75 neurotrophin receptor (p75(NTR)) mediates neuronal death

165 The p75 neurotrophin receptor (p75(NTR)) mediates the death of s

166 The p75 neurotrophin receptor (p75(NTR)) regulates a wide range

167 uctures of complexes formed by the DD of p75 neurotrophin receptor (p75(NTR)) with RhoGDI, for activa

168 This produced a substantial loss of both p75 neurotrophin receptor (p75(NTR))-positive and choline ac

169 ed synapse elimination via activation of p75 neurotrophin receptor (p75(NTR)).

170 prevented by blocking antibodies against p75 neurotrophin receptor (p75(NTR)).

171 binding to a receptor complex of the common neurotrophin receptor (p75NTR) and sortilin.

172 ur goal was to determine the role of the p75 neurotrophin receptor (p75NTR) in the loss of islet symp

173 myelin-associated glycoprotein recruited p75 neurotrophin receptor (p75NTR) into a complex with LRP1

174 Previously, we have shown that p75 neurotrophin receptor (p75NTR) is a novel mediator of in

175 Plasticity was rescued by inhibiting p75 neurotrophin receptor (p75NTR) signaling or its downstre

176 drinking produces a mobilization of DLS p75 neurotrophin receptor (p75NTR), whose activities oppose

177 s in G1H mice that re-express the common p75 neurotrophin receptor (p75NTR).

178 e with and without the expression of the p75 neurotrophin receptor (p75NTR).

179 GF increased LDLR expression through the p75 neurotrophin receptor (p75NTR).

180 ed a mouse model with a mutation in the TrkA neurotrophin receptor (P782S) that results in reduced ub

181 hibition of the cell death domain of the p75 neurotrophin receptor (TAT-Pep5) and in mice lacking the

182 udies provide a new reagent for altering p75 neurotrophin receptor actions after injury and suggest t

183 In adulthood, p75 neurotrophin receptor becomes down-regulated and propofo

184 The TrkC neurotrophin receptor belongs to the functional dependen

185 growth factor (NGF) in complex with the p75 neurotrophin receptor but is distinct from that of micro

186 lus propofol applications at the peak of p75 neurotrophin receptor expression after experimental trau

187 ricted to the developing nervous system when neurotrophin receptor expression peaks, indicate that BI

188 Neurotrophin receptor expression was confirmed in a pane

189 developmental-like programs and increase p75 neurotrophin receptor expression, probably to foster rep

190 S-HGGs, with recurrent fusions involving the neurotrophin receptor genes NTRK1, NTRK2 and NTRK3 in 40

191 eres with oligomerization of full-length p75 neurotrophin receptor in a dose-dependent manner.

192 Ubiquitination of the TrkA neurotrophin receptor in response to NGF is critical in

193 p75 neurotrophin receptor is highly expressed during early n

194 The p75 neurotrophin receptor is important in multiple physiolog

195 aline residue at position 264 in the rat p75 neurotrophin receptor is necessary for the ability of p7

196 Previously, we have shown that p75 neurotrophin receptor is required for glioma invasion an

197 compound, EVT901, which interferes with p75 neurotrophin receptor oligomerization through direct int

198 unctionally blocking antibody toward the pan-neurotrophin receptor p75 (p75(NTR) ).

199 The neurotrophin receptor p75 (p75NTR) is a receptor of Abet

200 ceptors (tropomyosin-related kinase A [TrkA]/neurotrophin receptor p75 [p75(NTR)]).

201 Efficient apical sorting of the neurotrophin receptor p75 is dependent on its O-glycosyl

202 The neurotrophin receptor p75(NTR) has been implicated in me

203 The neurotrophin receptor p75(NTR) negatively regulates spin

204 kinase TrkA (also called NTRK1), the common neurotrophin receptor p75(NTR), and the proneurotrophin

205 ability of SorCS2 to form complexes with the neurotrophin receptor p75(NTR), required for pro-brain-d

206 n and induce their death via cleavage of the neurotrophin receptor p75.

207 he pro-brain-derived neurotrophic factor-p75 neurotrophin receptor pathway.

208 same set of transcription factors from a p75 neurotrophin receptor peptide (p75NTRp)-tagged adenoviru

209 indicate that the ubiquitination of the TrkA neurotrophin receptor plays a critical role in NGF-media

210 p75 neurotrophin receptor plays an important role in the ner

211 sults revealed new functions for proBDNF-p75 neurotrophin receptor signaling pathway in the control o

212 unbalancing neurotrophin homeostasis via p75 neurotrophin receptor signaling.

213 re, we demonstrate that EVT901 abrogates p75 neurotrophin receptor signalling by other ligands, such

214 a and other neurological disorders where p75 neurotrophin receptor signalling is affected.

215 Here, we identified the pro-neurotrophin receptor sortilin as major endocytic pathwa

216 cate that UCH-L1 is important for regulating neurotrophin receptor sorting to signaling endosomes and

217 that LRP1 activation could phosphorylate the neurotrophin receptor TrkA in PC12 cells and increase ne

218 rs of the neural crest and expression of the neurotrophin receptor TrkB and its ligand, brain-derived

219 -ERK-CREB-BDNF pathway as pre-treatment with neurotrophin receptor TrkB inhibitor ANA-12 and MEK inhi

220 In mice in which the neurotrophin receptor trkB is knocked out selectively in

221 The neurotrophin receptor tropomyosin-related kinase B (TrkB

222 We show that the neurotrophin receptor tropomyosin-related kinase C (TrkC

223 Trk neurotrophin receptor ubiquitination in response to liga

224 e, nicotinic acetylcholine receptor, and p75 neurotrophin receptor), thus demonstrating that pseudoty

225 The p75 neurotrophin receptor, a member of the tumor necrosis fa

226 or induced apoptosis in cells expressing p75 neurotrophin receptor, and enhances neurite outgrowth in

227 es binding of pro-nerve growth factor to p75 neurotrophin receptor, blocks pro-nerve growth factor in

228 ceptor B (trkB) and a truncated form of this neurotrophin receptor, favoring the inactive form throug

229 cetyltransferase (ChAT) and the low-affinity neurotrophin receptor, p75(NTR) .

230 rats by the recruitment of the low-affinity neurotrophin receptor, p75NTR, whose activities opposes

231 The neurotrophin receptor, TrkB receptor tyrosine kinase, is

232 ncoded by Csf1, Nt3, and the tyrosine kinase neurotrophin receptor, TrkB.

233 assays with cysteine-rich domains-fused p75 neurotrophin receptor, we confirmed that EVT901 interfer

234 library for genes affecting the dynamics of neurotrophin receptor-containing endosomes in motor neur

235 rotrophic factor ratio, which aggravates p75 neurotrophin receptor-mediated cell death.

236 tracellular neurotrophin binding site of p75 neurotrophin receptor.

237 similar gamma-secretase cleavage is the p75 neurotrophin receptor.

238 BDNF acts via TrkB and p75 neurotrophin receptors (NTR), and restoring its signalin

239 ng cells (BTICs) and show that BTICs express neurotrophin receptors (p75NTR, TrkA, TrkB, and TrkC) an

240 egulation of neurotrophins and their cognate neurotrophin receptors among other classes of transcript

241 Neurotrophin receptors are emerging targets in oncology,

242 not fully understood how genes encoding Trk neurotrophin receptors are regulated.

243 Neurotrophin receptors corresponding to vertebrate Trk,

244 hat Toll paralogs unrelated to the mammalian neurotrophin receptors function as neurotrophin receptor

245 mammalian neurotrophin receptors function as neurotrophin receptors in fruit flies.

246 dings indicate that intracellular sorting of neurotrophin receptors is critical for postnatal neuroge

247 ss sensory neuron-associated markers such as neurotrophin receptors TrkA, TrkB, TrkC, and RET and the

248 n and is mediated by the opposing actions of neurotrophin receptors TrkB and p75(NTR) .

249 om fresh human malignant gliomas express the neurotrophin receptors TrkB and TrkC, not TrkA, and they

250 and increasing the co-localisation of these neurotrophin receptors with retromer-associated sorting

251 During this process, target-derived neurotrophins regulate both transcription and translatio

252 Neurotrophins regulate diverse aspects of neuronal devel

253 t control transcription are coordinated with neurotrophin-regulated actions that transpire in the axo

254 e neuroD1 differentiation marker and BDNF, a neurotrophin required for the terminal differentiation o

255 theless, the poor pharmacokinetic profile of neurotrophins severely restricts their clinical use.

256 s an essential scaffold protein coordinating neurotrophin signal pathways in neurites and is spatiall

257 Neurotrophins signal through the tropomyosin related kin

258 s provide new insight into synaptic roles of neurotrophin signaling and mechanisms controlling synapt

259 iguing link between Abeta catabolism and pro-neurotrophin signaling converging on this receptor.

260 rneurons is disrupted due to a deficiency in neurotrophin signaling during early development in FXS.

261 Abnormal glucocorticoid and neurotrophin signaling has been implicated in numerous p

262 Our results highlight a novel role for neurotrophin signaling in brain tumor and suggest that T

263 ns: instead, SAD-A/B functions downstream of neurotrophin signaling in sensory neurons to mediate a l

264 provides new insight into the involvement of neurotrophin signaling in synapse development and plasti

265 by activation of neurotrophin signaling, and neurotrophin signaling is sufficient for long term BTIC

266 holipid metabolism (P=1.3x10(-10) ), and the neurotrophin signaling pathway (P=7.0x10(-6) ).

267 n ACC a previously unrecognized pro-survival neurotrophin signaling pathway and link it with cancer p

268 results demonstrate the existence of a novel neurotrophin signaling pathway that is required for syna

269 NF levels and amelioration of alterations in neurotrophin signaling pathways.

270 cules of the transcriptional program linking neurotrophin signaling to sensory neuronal differentiati

271 f neuronal IL-4 receptors, which potentiated neurotrophin signaling via the AKT and MAPK pathways.

272 neurotrophic factor (BDNF) levels, impaired neurotrophin signaling, and compromised mitochondrial fu

273 nhibitors could be overcome by activation of neurotrophin signaling, and neurotrophin signaling is su

274 ing of Trk-family receptor tyrosine kinases, neurotrophin signaling, and possibly neuronal differenti

275 al membrane protein that plays a key role in neurotrophin signaling.

276 ojections in vivo in the absence of upstream neurotrophin signaling.

277 ression peaks, indicate that BICD1 regulates neurotrophin signalling by modulating the endosomal sort

278 Interestingly, loss of the secreted neurotrophin Spatzle 3 (Spz3) phenocopied alphaSNAP phen

279 Genetic interactions also revealed that the neurotrophin Spatzle3 (Spz3) is a likely Tollo ligand.

280 Neurotrophins specifically regulate the expression of IP

281 ation provides a mechanism whereby sustained neurotrophin stimulation can be integrated over time, so

282 We show that neurotrophin stimulation of nerve terminals elicits new

283 Synaptic neuropeptide and neurotrophin stores are maintained by constitutive bidir

284 to elevate cAMP is pretreating neurons with neurotrophins, such as brain-derived neurotrophic factor

285 hese findings suggest a target organ-derived neurotrophin suppresses development of that organ's sens

286 Induction of astrocytic neurotrophin synthesis is a poorly understood phenomenon

287 Nerve growth factor (NGF) is a neurotrophin that is implicated in the modulation of pai

288 Neuregulin 1 (NRG1) is a multifunctional neurotrophin that mediates neurodevelopment and schizoph

289 rain-derived neurotrophic factor (BDNF) is a neurotrophin that promotes neuronal proliferation, survi

290 rain-derived neurotrophic factor (BDNF) is a neurotrophin that regulates synaptic function and plasti

291 genetically re-engineers neurons to produce neurotrophins that are neuroprotective to vulnerable dop

292 m by which glucose recruits vascular-derived neurotrophins to control insulin secretion.

293 phic action in the nervous system by linking neurotrophins to the survival of immature neurons at the

294 The binding of neurotrophins to tropomyosin receptor kinase receptors i

295 ink between calcineurin signalling, impaired neurotrophin trafficking and neurodevelopmental deficits

296 onclusion, clinically practicable short-term neurotrophin treatment is sufficient for long-term survi

297 owed that variation in the expression of the neurotrophin tyrosine kinase receptor type 3 (NTRK3) in

298 In this study, the neurotrophin tyrosine receptor kinase TrkA (also called

299 Neuregulin 3 (NRG3), a brain-enriched neurotrophin, undergoes alternative splicing and is impl

300 experiments demonstrate robust elevation of neurotrophins with these viral vectors.