ライフサイエンスコーパス: neurotrophin 3

1 lls still begin to develop in the absence of neurotrophin 3.

2 eurotrophic factor, nerve growth factor, and neurotrophin 3.

3 M1 activates TrkC by inducing the release of neurotrophin-3.

4 252a did not prevent GM1-mediated release of neurotrophin-3.

5 rs for brain-derived neurotrophic factor and neurotrophin-3.

6 utants, but were less severe in mice lacking neurotrophin-3.

7 factor, brain-derived neurotrophic factor or neurotrophin-3.

8 phosphorylated ERK5 with MEF2 in response to neurotrophin-3.

9 Taken together, these results suggest that neurotrophin 3 activation of TrkC induces Schwann cell m

10 Previously, we demonstrated that neurotrophin 3 activation of TrkC inhibits Schwann cell

11 Eliminating one or both neurotrophin-3 alleles in mice that lack nerve growth fa

12 Neurotrophin-3 also enhanced locomotor recovery.

13 ligands, brain-derived neurotrophic factor, neurotrophin 3 and neurotrophin 4, are survival factors

14 mbination of basic fibroblast growth factor, neurotrophin-3 and brain derived growth factor delivered

15 ession of GDNF by glia and overexpression of neurotrophin-3 and neurotrophin-4 in muscle did not caus

16 ition to modulate intracellular responses to neurotrophin-3 and/or nerve growth factor.

17 rain-derived neurotrophic factor (BDNF), and neurotrophins 3 and 4 (NT3 and NT4).

18 (NGF, brain-derived neurotrophic factor, and neurotrophin 3) and secrete NGF.

19 or (NGF), brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4.

20 oreactive brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 were detected in 22

21 TrkC, ie, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5, showed that immuno

22 s--brain-derived neurotrophic factor (BDNF), neurotrophin-3, and neurotrophin-4/5.

23 FGF-2/Adts), nerve growth factor (NGF/Adts), neurotrophin-3, and the cell adhesion molecules N-cadher

24 enteric nervous system suggest that trkC and neurotrophin-3 are a major neurotrophin system in the ga

25 t that brain-derived neurotrophic factor and neurotrophin-3 are anterogradely transported from midbra

26 NGF, brain-derived neurotrophic factor, and neurotrophin-3 are likely to be sorted similarly and rel

27 Our findings pave the way for Neurotrophin-3 as a therapy that treats the underlying c

28 tor receptors, namely, the trkC receptor for neurotrophin 3, as well as receptors for neurturin and g

29 nd brain-derived neurotrophic factor but not neurotrophin-3, as measured by ELISA.

30 associated viral vector (AAV) encoding human Neurotrophin-3 at a clinically-feasible time-point after

31 embryonic spinal cord tissue and delivery of neurotrophin-3 at the injury site further increased spin

32 In vitro, neurotrophin 3 binding to p75NTR increases neurite lengt

33 inding of NGF equivalent to TrkA, maintained neurotrophin-3 binding equivalent to TrkC, and also boun

34 GM1 failed to displace neurotrophin-3 binding, suggesting that this ganglioside

35 r survival were unaffected by the absence of neurotrophin-3 but neuronal survival was compromised so

36 GM1 induced neurotrophin-3 (but not brain-derived neurotrophic facto

37 sciatic nerves, is significantly enhanced by neurotrophin 3, but not by nerve growth factor or brain-

38 Furthermore, expression of neurotrophin-3, but not nerve growth factor, brain-deriv

39 id and significant increase in the amount of neurotrophin-3, but not other neurotrophins.

40 Application of neurotrophin-3, but not related neurotrophins, prevented

41 ial treatment with embryonic transplants and neurotrophin-3 can potentiate the effects of enriched ho

42 this possibility, we compared neuron loss in neurotrophin-3-deficient mice with that in nerve growth

43 us, closely relating this mouse model to the neurotrophin-3-deficient one.

44 abilized chABC in combination with sustained neurotrophin-3 delivery showed significant improvement i

45 Excess brain-derived neurotrophic factor or neurotrophin-3 did not inhibit neurite outgrowth.

46 ise in brain-derived neurotrophic factor and neurotrophin 3 during exercise, the increased growth pot

47 ic nerves of p75NTR-/- mice, indicating that neurotrophin 3 enhances cell migration through TrkC.

48 ons in brain-derived neurotrophic factor and neurotrophin 3 expression in muscle without appreciably

49 At the time of neuron loss, neurotrophin-3 expression, assayed with a lacZ reporter,

50 imulation with either nerve growth factor or neurotrophin-3 failed to evoke any changes in Kv1.3 func

51 C-expressing neurons and their dependence on neurotrophin-3 for survival.

52 nglion in vivo, and found that expression of neurotrophin-3 from the vector protected peripheral sens

53 rneal expressions of nerve growth factor and neurotrophin-3 genes were unchanged; receptor gene expre

54 e with a targeted disruption of the gene for neurotrophin-3 have 50% fewer neurons than those of wild

55 GF) and those in TrkC involved in binding to neurotrophin-3 have been mapped in this domain, the Trk

56 nervous system cells, fibroblasts expressing neurotrophin-3, hybridoma cells expressing inhibitory pr

57 thelial growth factor A, angiopoietin 1, and neurotrophin 3 in the ischemic muscle.

58 ired availability of nerve growth factor and neurotrophin 3 in the sciatic nerve and significant prev

59 Here, we demonstrate a novel role of neurotrophin-3 in synaptic assembly and function as a po

60 th factor (NGF), or antibody inactivation of neurotrophin-3 in the presence of NGF.

61 neurotrophic factor, nerve growth factor and neurotrophin-3 in the supernatant and increased intracel

62 on of neurotrophins (nerve growth factor and neurotrophin-3) in FAP nerves.

63 The trkC locus encodes several receptors for neurotrophin-3, including the well studied full-length t

64 In culture, neurotrophin-3 increases the survival of proliferating s

65 n, and brain-derived neurotrophic factor and neurotrophin-3 induced cellular maturation.

66 RK5 activator, MEK5, significantly inhibited neurotrophin-3-induced cell death.

67 Additionally, the neurotrophin-3-induced cell migration depended on Rho GT

68 tide exchange factor (RhoGEF) that regulates neurotrophin-3-induced cell migration in Schwann cells.

69 The neurotrophin-3-induced cell migration was also observed

70 , whereas TrkC receptors are responsible for neurotrophin-3 inhibition.

71 nfusion also increased hippocampal levels of neurotrophin 3, insulin-like growth factor 1, and nerve

72 y expressed on all the follicle cells, while neurotrophin 3 is transiently expressed only in the cell

73 Taken together these results suggest that neurotrophin-3 is required for survival of some sympathe

74 In transgenic neurotrophin-3 lacZ-neo (NT-3(lacZneo)) mice, in which t

75 richia coli lacZ gene is integrated into the neurotrophin-3 locus (NT-3(lacZneo)).

76 Neurotrophin-3 mRNA levels decrease in the hippocampus f

77 hippocampal neurons inversely correlate with neurotrophin-3 mRNA levels.

78 ts in an increase in miR21 and a decrease in neurotrophin-3 mRNA.

79 ed brain-derived neurotrophic factor (BDNF), neurotrophin-3, neurotrophin-4, ciliary neurotrophic fac

80 eurons by brain-derived neurotrophic factor, neurotrophin-3, neurotrophin-4, or glial-cell-line-deriv

81 Neurotrophin-3 normalized the short latency Hoffmann ref

82 Neurotrophin-3 not only enhanced ERK5 phosphorylation bu

83 e percentage of hSK1-positive cells, whereas neurotrophin 3 (NT-3) and glial cell line-derived neurot

84 ), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3) and neurotrophin 5 (NT-5) and basi

85 mice that overexpress neurotrophins NGF and neurotrophin 3 (NT-3) at high levels in skin have shown

86 Neurotrophin 3 (NT-3) can support the survival of some e

87 suggested qualitatively different effects of neurotrophin 3 (NT-3) in cochlear innervation patterning

88 Essential functions of neurotrophin 3 (NT-3) in regulating afferent and efferen

89 The genetic locus for the TrkC/neurotrophin 3 (NT-3) receptor tyrosine kinase encodes m

90 Tie2 also exhibit a chemotactic response to neurotrophin 3 (NT-3), a specific ligand for TrkC.

91 ADNF causes secretion of neurotrophin 3 (NT-3), and both proteins regulate NMDA r

92 nd neonatal mice with mutations in the BDNF, neurotrophin 3 (NT-3), and TrkC genes.

93 tional and structural synaptic regulation by neurotrophin 3 (NT-3), using the neuromuscular synapse a

94 mpounds have been identified that potentiate neurotrophin 3 (NT-3)-mediated activation of trk A.

95 also be activated by high concentrations of neurotrophin 3 (NT-3).

96 r activity is composed of two neurotrophins, neurotrophin-3 (NT-3) and Brain-Derived Neurotrophic Fac

97 esence of fibroblast growth factor (FGF) and neurotrophin-3 (NT-3) and differentiate in the presence

98 Administration of neurotrophin-3 (NT-3) and insulin-like growth factor-I (

99 Neurotrophin-3 (NT-3) and its high-affinity receptor Trk

100 have evaluated changes in the expression of neurotrophin-3 (NT-3) and its tyrosine kinase C (TrkC) r

101 The binding sites of neurotrophin-3 (NT-3) and nerve growth factor (NGF) to t

102 The effects of neurotrophin-3 (NT-3) and NT-4/5 on the function of axot

103 metics 1 were designed to mimic hot spots of neurotrophin-3 (NT-3) and others.

104 d to p75NTR and the 2:2 symmetric complex of neurotrophin-3 (NT-3) and p75NTR.

105 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) and their receptors trkB and trkC,

106 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) and their respective high-affinity

107 Animals lacking neurotrophin-3 (NT-3) are born with deficits in almost a

108 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are hypothesized to play an import

109 neurotrophins nerve growth factor (NGF) and neurotrophin-3 (NT-3) are potent chemotactic agents for

110 Nerve growth factor (NGF) and neurotrophin-3 (NT-3) are target-derived proteins that r

111 Similar effects were observed with neurotrophin-3 (NT-3) but not nerve growth factor.

112 to synaptic plasticity, we examined whether neurotrophin-3 (NT-3) changed the number, size, vesicle

113 rain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) contribute to those trophic effect

114 he present investigation, we studied whether neurotrophin-3 (NT-3) contributes to the rescue of axoto

115 brain-derived neurotrophin factor (BDNF) and neurotrophin-3 (NT-3) did not induce cell death.

116 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) differ among rat strains exhibitin

117 se and transfer of anterogradely transported neurotrophin-3 (NT-3) from a presynaptic to a postsynapt

118 Removal of the TrkC ligand neurotrophin-3 (NT-3) from cerebellar granule cells, whi

119 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) have been localized to the sensory

120 Mice lacking neurotrophin-3 (NT-3) have been shown previously to be b

121 een identified, the biological functions for neurotrophin-3 (NT-3) in early retinal development remai

122 ld-type and transgenic mice that overexpress neurotrophin-3 (NT-3) in muscle (myo/NT-3 mice).

123 To clarify the role of muscle-derived neurotrophin-3 (NT-3) in the development of sensory neur

124 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) in the development of synaptic tra

125 Here, we report that overexpression of neurotrophin-3 (NT-3) in the eye accelerates RGC laminar

126 We show that genetic ablation of neurotrophin-3 (NT-3) in the mouse neocortex results in

127 To obtain insights into the expression of neurotrophin-3 (NT-3) in the mouse, we have utilized mic

128 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) into C7 lesion sites, we found bot

129 roinjection of nerve growth factor (NGF) and neurotrophin-3 (NT-3) into the rostral pontine tegmentum

130 Neurotrophin-3 (NT-3) is a cystine knot growth factor th

131 Neurotrophin-3 (NT-3) is a member of the neurotrophin fa

132 Neurotrophin-3 (NT-3) is expressed specifically in cells

133 Since neurotrophin-3 (NT-3) is highly expressed in non-neural

134 Neurotrophin-3 (NT-3) is known to promote enteric neuron

135 Interestingly, neurotrophin-3 (NT-3) is upregulated in the brains of wi

136 actor (BDNF), nerve growth factor (NGF), and neurotrophin-3 (NT-3) mRNA expression patterns in the at

137 edicted to target (and thus inhibit) NGF and neurotrophin-3 (NT-3) mRNA.

138 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) mRNAs were revealed in OLGs in viv

139 neuron loss in nerve growth factor (NGF) and neurotrophin-3 (NT-3) null mutant mice have supported th

140 (STZ)-diabetic rats and examined effects of neurotrophin-3 (NT-3) on diabetes-induced events.

141 e effects of transgenic cellular delivery of neurotrophin-3 (NT-3) on morphological and functional di

142 To investigate the effects of neurotrophin-3 (NT-3) on postnatal proprioceptive neuron

143 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) on the dendritic complexity of lay

144 rain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) on the intraspinal regeneration of

145 neurotrophins nerve growth factor (NGF) and neurotrophin-3 (NT-3) on trigeminal axon growth patterns

146 Addition of either neurotrophin-3 (NT-3) or BDNF increases axon growth and

147 tral tegmental area (VTA) microinjections of neurotrophin-3 (NT-3) or brain-derived neurotrophic fact

148 Concurrently, lentiviral vectors expressing neurotrophin-3 (NT-3) or green fluorescent protein (GFP)

149 Mice lacking neurotrophin-3 (NT-3) or its receptor, TrkC, lose many s

150 th was prevented by co-treatment with either neurotrophin-3 (NT-3) or nerve growth factor (NGF).

151 ecause neither nerve growth factor (NGF) nor neurotrophin-3 (NT-3) prevented NO-induced growth cone c

152 ent receptor potential channel M5 (TrpM5) or neurotrophin-3 (NT-3) project to defined clusters of glo

153 Neurotrophin-3 (NT-3) promotes enteric neuronal developm

154 Endogenous neurotrophin-3 (NT-3) protein is present in the ganglion

155 Elevated expression of the neurotrophin-3 (NT-3) receptor TrkC by childhood medullo

156 rlier work in our laboratory showed that the neurotrophin-3 (NT-3) receptor TrkC is activated by T. c

157 Here, we investigate how neurotrophin-3 (NT-3) regulates DA cell density in the m

158 n the perirhinal cortex, although endogenous neurotrophin-3 (NT-3) regulates the expression of VGF in

159 on site if axons are guided by a gradient of neurotrophin-3 (NT-3) rostral to the lesion.

160 Neurotrophin-3 (NT-3) signaling has been shown to be req

161 Neurotrophin-3 (NT-3) supported striking terminal arbori

162 Neurotrophin-3 (NT-3) supports the survival and differen

163 ophins brain-derived neurotrophin (BDNF) and neurotrophin-3 (NT-3) synergistically enhance survival o

164 The ability of neurotrophin-3 (NT-3) to prevent abnormalities in neurof

165 were treated with either saline or exogenous neurotrophin-3 (NT-3) to promote the survival of proprio

166 he present study, we evaluate the ability of neurotrophin-3 (NT-3) to protect neurons against the tox

167 Addition of neurotrophin-3 (NT-3) to the culture medium rescued some

168 in noise-exposed mice that local delivery of neurotrophin-3 (NT-3) to the round window niche, 24 hour

169 al perfusion technique for local delivery of neurotrophin-3 (NT-3) to various regions of developing X

170 y of NGF leads to axonal elongation, whereas neurotrophin-3 (NT-3) treatment leads to short branching

171 and neurotrophin-4/5 (NT-4/5) via TrkB, and neurotrophin-3 (NT-3) via TrkC.

172 Finally, potentiation by neurotrophin-3 (NT-3) was also target specific.

173 ascular endothelial growth factor (VEGF) and neurotrophin-3 (NT-3) were significantly elevated in fem

174 Lentiviral vectors expressing neurotrophin-3 (NT-3) were then injected into an appropr

175 Using an antiserum specific for neurotrophin-3 (NT-3) with the microglial/macrophage mar

176 e injured axon was administered by injecting neurotrophin-3 (NT-3) within and beyond a cervical spina

177 sustained release of the neurotrophic factor neurotrophin-3 (NT-3) would support axonal plasticity in

178 erent neurons retrogradely transported [125I]neurotrophin-3 (NT-3), [125I]nerve growth factor (NGF),

179 neurons and thereby induces transcription of neurotrophin-3 (NT-3), a novel gene target of MEF2.

180 effect of this s-ODN on subsequent Fos, NGF, neurotrophin-3 (NT-3), and actin expression.

181 or brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and glial cell line-derived neuro

182 Brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4) activat

183 ns brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4/5 (NT-4/5) upo

184 ly brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4/5 (NT-4/5), co

185 retion of brain-derived neurotrophic factor, neurotrophin-3 (NT-3), and neurotrophin-4/5.

186 IYIY-I2-BODIPY binds TrkC similar to neurotrophin-3 (NT-3), and NT-3 has been reported to mod

187 ng brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and NT-4.

188 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), are able to produce a long-lastin

189 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), are believed to be genuine molecu

190 rain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3), are critical for the maintenance

191 phins, such as nerve growth factor (NGF) and neurotrophin-3 (NT-3), are essential for development, fu

192 that the endogenous neurotrophins, BDNF and neurotrophin-3 (NT-3), are transported anterogradely by

193 ntitative PCR (qPCR) to assay NTF expression-neurotrophin-3 (NT-3), BDNF, GDNF, neurturin, artemin, a

194 In this study, fibroblasts producing neurotrophin-3 (NT-3), brain-derived neurotrophic factor

195 This effect is neutralized by NGF and neurotrophin-3 (NT-3), but not by brain-derived neurotro

196 brain-derived neurotrophic factor (BDNF) or neurotrophin-3 (NT-3), but not nerve growth factor (NGF)

197 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), but not proinflammatory molecules

198 We have shown previously that BDNF, neurotrophin-3 (NT-3), chlorphenylthio-cAMP (cpt-cAMP) (

199 We report that neurotrophin-3 (NT-3), delivered chronically via fibrobl

200 ic factor (BDNF), nerve-growth factor (NGF), neurotrophin-3 (NT-3), fibroblast growth factor-2 (FGF-2

201 Brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), glial cell line-derived neurotrop

202 from the brain metastatic protein signature, neurotrophin-3 (NT-3), has a dual function of regulating

203 Neurotrophic factors, particularly neurotrophin-3 (NT-3), may increase the regenerative cap

204 tors expressing nerve growth factor (NGF) or neurotrophin-3 (NT-3), neurons in the DRG were transduce

205 ), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), and glial

206 ell line-derived neurotrophic factor (GDNF), neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), and their

207 1: brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), ciliary ne

208 F, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), tyrosine k

209 ic neurotrophins [nerve growth factor (NGF), neurotrophin-3 (NT-3), neurotrophin-4 (NT-4)].

210 ophins, including nerve growth factor (NGF), neurotrophin-3 (NT-3), NT-4/5 and brain-derived neurotro

211 ), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), or neurotrophin-4 (NT-4) results

212 ), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), or neurotrophin-4 (NT-4), each at

213 , particularly nerve growth factor (NGF) and neurotrophin-3 (NT-3), play a role in the regulation of

214 to platelet-derived growth factor (PDGF) and neurotrophin-3 (NT-3), primary cultures of cortical olig

215 nar release of nerve growth factor (NGF) and neurotrophin-3 (NT-3), respectively.

216 ure to brain-derived neurotrophic factor and neurotrophin-3 (NT-3), suggesting that the electrophysio

217 rain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3), the cognate ligands for TrkA, Trk

218 se expression of the analogous neurotrophin, neurotrophin-3 (NT-3), was unaltered in the same irises.

219 by evidence that neurotrophins, particularly neurotrophin-3 (NT-3), which has been shown to promote s

220 , many of which are muscle afferents and are neurotrophin-3 (NT-3)-responsive, were severely decrease

221 in resting membrane potential (RMP) or added neurotrophin-3 (NT-3).

222 cones of forebrain neurons is stimulated by neurotrophin-3 (NT-3).

223 gradient of collapsin-1/semaphorin III/D or neurotrophin-3 (NT-3).

224 ons in p75NTR, nerve growth factor (NGF) and neurotrophin-3 (NT-3).

225 lcholine, but not for the turning induced by neurotrophin-3 (NT-3).

226 ophins such as nerve growth factor (NGF) and neurotrophin-3 (NT-3).

227 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3).

228 ions as an active protein tyrosine kinase by neurotrophin-3 (NT-3).

229 t not acute, forms of synaptic modulation by neurotrophin-3 (NT-3): endocytosis of NT-3-receptor comp

230 coadministration of the neurotrophic factor neurotrophin-3 (NT-3; 5-20 mg . kg-1 . d-1, s.c.) during

231 Neurotrophin 3 (NT3) ablation in mice causes a more seve

232 roliferation and survival in the presence of neurotrophin 3 (NT3) and brain-derived neurotrophin fact

233 ides 1315-1412 show ligand responsiveness to neurotrophin 3 (NT3) and myelin-associated glycoprotein

234 The selective elimination of neurotrophin 3 (NT3) from muscle spindles had no effect

235 on neurotrophins, however, has revealed that neurotrophin 3 (NT3) is critically involved in several a

236 Neurotrophin 3 (Nt3) is one of five neurotrophin growth

237 Recent studies indicate that neurotrophin 3 (NT3) may be important for the maintenanc

238 ), platelet-derived growth factor (PDGF), or neurotrophin 3 (NT3) to clonal density cultures of corti

239 ), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and neurotrophin 4 (NT4), is impli

240 ), brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and neurotrophin 4/5 (NT4/5).

241 ey also express neurotrophins NGF, BDNF, and neurotrophin 3 (NT3).

242 Neurotrophin-3 (NT3) acting through the TrkC receptor ty

243 We previously demonstrated that endogenous neurotrophin-3 (NT3) acting through the TrkC tyrosine ki

244 s, treatment with nerve growth factor (NGF), neurotrophin-3 (NT3) and glial-cell-line-derived neurotr

245 fication to probe cDNA arrays, we found that neurotrophin-3 (NT3) and trkB mRNA expression were reduc

246 , we report that embryonic overexpression of neurotrophin-3 (NT3) in muscles disrupts the development

247 s a specific downregulation in expression of neurotrophin-3 (NT3) in the transgenic cochleas before t

248 In the chick embryo, exogenous neurotrophin-3 (NT3) is sufficient to promote the differ

249 We show that the neurotrophin-3 (NT3) TrkCT1-truncated receptor binds to

250 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT3) were identified in Schwann cell/dor

251 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT3), act to enhance cell growth and bra

252 or (NGF), brain-derived neurotrophin (BDNF), neurotrophin-3 (NT3), and neurotrophin-4 (NT4)-and their

253 We expressed neurotrophin-3 (NT3), deoxyribonuclease (DNase), or vasc

254 RT-PCR analyses, that TrkC, the receptor for neurotrophin-3 (NT3), is expressed by mouse perisynaptic

255 rophic factors nerve growth factor (NGF) and neurotrophin-3 (NT3), the actions of which must be execu

256 brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT3), to the tyrosine-kinase (Trk) recep

257 the neuromuscular junction (NMJ) induced by neurotrophin-3 (NT3), using Xenopus nerve-muscle co-cult

258 Here we show that neurotrophin-3 (NT3)-induced potentiation of synaptic tr

259 One necessary factor for these neurons is neurotrophin-3 (NT3).

260 We show here that intramuscular delivery of neurotrophin-3 (NT3, encoded by NTF3) can induce sensori

261 rs (brain-derived neurotrophic factor, BDNF; neurotrophin 3, NT3; neurotrophin 4/5, NT4/5; or glial-d

262 Neurotrophin-3 (Ntf3) and brain derived neurotrophic fac

263 ts of enriched environment, transplants, and neurotrophin-3 on the plasticity of synaptic structures

264 th BDNF during activity blockade, but not by neurotrophin 3 or nerve growth factor.

265 sponse to brain-derived neurotrophic factor, neurotrophin 3, or neurotrophin 4/5.

266 ed neurotrophic factor, nerve growth factor, neurotrophin-3, or ciliary neurotrophic factor could pro

267 eric neurons along with recent evidence that neurotrophin-3 plays a role in the development of the en

268 neurotrophic factor, nerve growth factor, or neurotrophin-3 provided no protection of striatal output

269 GFbetaR), TEL/Janus kinase 2 (JAK2), and TEL/neurotrophin-3 receptor (TRKC).

270 PTK (protein-tyrosine kinase) domain of the neurotrophin-3 receptor NTRK3.

271 cers, we identified in ACC expression of the neurotrophin-3 receptor TrkC/NTRK3, neural crest marker

272 y nerve growth factor receptor, or TrkC, the neurotrophin-3 receptor, and immunoreactive mPTPRO and T

273 mas, mouse tumors with reduced levels of the neurotrophin-3 receptor, trkC/Ntrk3, display decreased a

274 Expression of the neurotrophin-3 receptor, tyrosine kinase C (TrkC), is as

275 in growth factor-1, nerve growth factor, and neurotrophin 3 receptors in dorsal root ganglion cells.

276 ctor, brain-derived neurotrophic factor, and neurotrophin-3) regulate axonal mRNA levels and use dist

277 Finally, neurotrophin 3 released from muscle spindles regulates t

278 demonstrate that axonal growth triggered by neurotrophin-3 remotely inhibits neurite outgrowth throu

279 rs for brain-derived neurotrophic factor and neurotrophin-3, respectively) displayed a widespread dis

280 ically significant increase in cell death of neurotrophin-3-responsive and nonresponsive medulloblast

281 Brain-derived neurotrophic factor, but not neurotrophin-3, selectively regulated immunoglobulin dom

282 Nerve growth factor (NGF) and neurotrophin-3 serve as attractive cues for chick embryo

283 MiR21 is a candidate for regulating neurotrophin-3 signaling in the hippocampus following st

284 tin filaments, nerve growth factor (NGF) and neurotrophin-3 still induced growth cone protrusion and

285 Additionally, human NGF and neurotrophin-3 stimulated c-Yes in brain-metastatic 70W

286 ed higher brain-derived neurotrophic factor, neurotrophin 3, synapsin I, and GAP43 mRNA levels than t

287 ified a miR21 binding site, in the 3' UTR of neurotrophin-3 that inhibits translation.

288 hat the binding is specifically inhibited by neurotrophin-3, the natural TrkC ligand.

289 ed vector containing the coding sequence for neurotrophin-3 to transduce sensory neurons of the rat d

290 had no effect on TrkB or TrkC activation in neurotrophin 3 treatment.

291 phic factor and neurotrophin-4/5 (trkB), and neurotrophin-3 (trkC).

292 NA encoding the receptor tyrosine kinase for neurotrophin-3, TrkC, were unchanged.

293 Our investigation of the mechanism of neurotrophin-3/TrkC-induced apoptosis has identified a n

294 Neurotrophin-3/TrkC-induced apoptosis is inhibited by th

295 s target myocyte enhancer factor 2 (MEF2) to neurotrophin-3/TrkC-induced medulloblastoma cell death.

296 rograde transport of nerve growth factor and neurotrophin-3 was not evident.

297 microm), and large-(> 40 microm), neurones, neurotrophin-3 was seen in medium and small neurones, wh

298 -derived neurotrophic factor (BDNF), but not neurotrophin 3, was prevented by blockers of adenosine 3

299 nnel, brain-derived neurotrophic factor, and neurotrophin 3) were also abnormal, in parallel with the

300 ons of brain-derived neurotrophic factor and neurotrophin 3, which stimulated neurite outgrowth from