ライフサイエンスコーパス: neurovascular coupling

1 cerebral blood flow to neuronal metabolism (neurovascular coupling).

2 associated with increased neuronal activity (neurovascular coupling).

3 one of the key players in coordinating this neurovascular coupling.

4 f this glial cell-K+ siphoning hypothesis of neurovascular coupling.

5 only indirectly, by way of hemodynamics and neurovascular coupling.

6 zed changes in blood flow, a response termed neurovascular coupling.

7 retina does not contribute significantly to neurovascular coupling.

8 nd may help to refine quantitative models of neurovascular coupling.

9 a longer time span and is less dependent on neurovascular coupling.

10 derstand temporal correlations that describe neurovascular coupling.

11 t release Ca(2+) from stores does not affect neurovascular coupling.

12 y visual cortex to investigate the limits of neurovascular coupling.

13 hese networks, over and above the effects on neurovascular coupling.

14 ishing astrocytes as potential regulators of neurovascular coupling.

15 ulation, endothelial-mediated signaling, and neurovascular coupling.

16 nge in cerebral blood flow, a process termed neurovascular coupling.

17 ggesting that pericytes could have a role in neurovascular coupling.

18 gs, as well as a more principled modeling of neurovascular coupling.

19 tigators to probe the role of capillaries in neurovascular coupling.

20 rlying neuronal activity by a process termed neurovascular coupling.

21 Roy and Sherrington, 1890), a process termed neurovascular coupling.

22 e been proposed to play a role in functional neurovascular coupling.

23 V4 channels are engaged in and contribute to neurovascular coupling.

24 endfoot microdomain and assess their role in neurovascular coupling.

25 e synthase is involved in astrocyte-mediated neurovascular coupling.

26 erent conditions of neuronal stimulation and neurovascular coupling.

27 ha, and ultimately lead to the impairment of neurovascular coupling.

28 rocytes, and arterioles-causing inversion of neurovascular coupling.

29 l and impose constraints on future models of neurovascular coupling.

30 stent reduction in CBF, but not the impaired neurovascular coupling after CSD.

31 Furthermore, disturbed neurovascular coupling after stroke can confound hemodyn

32 tant vascular diseases, or medication on the neurovascular coupling and consequently the functional M

33 amic response is important for understanding neurovascular coupling and elucidating the physiological

34 mutase (CuZnSOD) prevented the alteration in neurovascular coupling and endothelium-dependent respons

35 altered calcium signaling that could disrupt neurovascular coupling and gliotransmission.

36 may regulate experience-dependent changes in neurovascular coupling and myelination.

37 ions of mural cells in vascular development, neurovascular coupling and neuropathology.

38 ron, a direction opposite to that of classic neurovascular coupling and referred to here as vasculo-n

39 ults indicate that glial cells contribute to neurovascular coupling and suggest that regulation of bl

40 nitrite were not enough to entirely restore neurovascular coupling and supra-physiological concentra

41 esponses to investigate cocaine's effects on neurovascular coupling and to differentiate its effects

42 d with release of arachidonic acid, impaired neurovascular coupling, and reduced cerebral blood flow

43 ms based on recent astrocyte-based models of neurovascular coupling are discussed.

44 001), indicating that cocaine did not affect neurovascular coupling at rest and that the reduction in

45 The investigation of mechanisms underlying neurovascular coupling at the capillary level requires a

46 red hippocampal cytoarchitectonics; impaired neurovascular coupling; attenuated prepulse inhibition (

47 Neurovascular coupling between resting-state neural acti

48 responses were not, suggesting differential neurovascular coupling between the two vasculatures.

49 According to the current model of neurovascular coupling, blood flow is controlled regiona

50 Astrocytes play a critical role in neurovascular coupling by providing a physical linkage f

51 Here, we reexamined their role in neurovascular coupling by selectively expressing a genet

52 both adults and neonates, and a reduction in neurovascular coupling could deprive active neurons of a

53 ked neuronal activity.SIGNIFICANCE STATEMENT Neurovascular coupling, defined as the tight relationshi

54 We conclude that neurovascular coupling depends critically on anesthesia

55 nse, showing that the degree and polarity of neurovascular coupling depends on astrocytic endfoot Ca(

56 Neurovascular coupling describes the link between neuron

57 min after cocaine injection, indicating that neurovascular coupling during stimulation was temporaril

58 The data are consistent with a neurovascular coupling effect in the retina.

59 orts a conceptual shift in the mechanisms of neurovascular coupling, from a unidimensional process in

60 The involvement of astrocytes in neurovascular coupling has broad implications for the in

61 One widely recognized hypothesis of neurovascular coupling holds that glial cell depolarizat

62 mechanism is essential to preserving healthy neurovascular coupling; however, to our knowledge, no st

63 ral blood flow that range from physiological neurovascular coupling (hyperaemia) to pathological inve

64 transcriptional regulator of SEMA3E-mediated neurovascular coupling in a mouse model of oxygen-induce

65 sis, and activity-induced neurometabolic and neurovascular coupling in adult (6 months) and aged (12

66 Here we address this issue by examining neurovascular coupling in both ex vivo and in vivo rat r

67 Wavelet coherence analysis of neurovascular coupling in NE may identify infants at ris

68 transcriptional regulator of SEMA3E-mediated neurovascular coupling in pathological retinal angiogene

69 nd a suite of in vivo imaging tools to study neurovascular coupling in rat primary somatosensory cort

70 estigated the contribution of glial cells to neurovascular coupling in the acutely isolated mammalian

71 hyperglycemia has a detrimental influence on neurovascular coupling in the brain-an effect linked to

72 direct proportionality of volumetric spatial neurovascular coupling in the cerebral cortex.

73 Our study examines the association between neurovascular coupling in the middle cerebral artery and

74 Here, we investigate spatial correlations of neurovascular coupling in three dimensions, by applying

75 -dependent Ca(2+) signaling does not mediate neurovascular coupling in visual cortex of awake, lightl

76 gs demonstrate that hyperoxia does not alter neurovascular coupling in vivo, ensuring that active neu

77 hindered by uncertainty as to the nature of neurovascular coupling in young individuals.

78 Under nitroprusside infusion, a neurovascular-coupling inhibitor, the diffusion response

79 ystem, the olfactory glomerulus, to show how neurovascular coupling involves an elaborate dance betwe

80 Neurovascular coupling is a process through which neuron

81 Fundamental to the interpretation of neurovascular coupling is determining the neuronal activ

82 superiorly to the optic nerve suggests that neurovascular coupling is perturbed.

83 Although this response, termed neurovascular coupling, is widely used to monitor human

84 lity and consequences of conditions in which neurovascular coupling may be altered, including during

85 Neurovascular coupling may be involved in compensatory m

86 Inversion of neurovascular coupling may contribute to the decreased c

87 Our results suggest that intact neurovascular coupling may help preserve mobility in eld

88 This suggests that neurovascular coupling mechanism is likely to contain a

89 may fail in situations interfering with the neurovascular coupling mechanisms (drugs, anesthesia).

90 Here, we review current candidate neurovascular coupling mechanisms and propose that previ

91 is needed for improving our understanding of neurovascular coupling mechanisms and the related measur

92 standing of the signalling events underlying neurovascular coupling mechanisms in the brain is a cruc

93 he effects of wakefulness reflect changes in neurovascular coupling, not in neural activity.

94 The classical model of neurovascular coupling (NVC) implies that activity-depen

95 Neurovascular coupling (NVC) is the process whereby neur

96 Physiologically, neurovascular coupling (NVC) matches focal increases in

97 a proof of concept study aiming to quantify neurovascular coupling (NVC) using wavelet analysis of t

98 They play an important role in mediating neurovascular coupling (NVC) via several astrocytic Ca(2

99 Here we report that stress impairs neurovascular coupling (NVC), the process that matches n

100 sodilatory prostaglandins play a key role in neurovascular coupling (NVC), the tight link between neu

101 d hemodynamics, a phenomenon referred to as "neurovascular coupling" (NVC).

102 , we determined whether pathological inverse neurovascular coupling occurred as a mechanism of second

103 concept from the current electrochemical and neurovascular coupling principles used for brain imaging

104 del that incorporates internalization into a neurovascular-coupling relationship.

105 overed capillaries control vasomotion during neurovascular coupling remains controversial.

106 regulation of cerebral blood flow (CBF) and neurovascular coupling remains, however, under debate.

107 ling lead to a switch in the polarity of the neurovascular coupling response from vasodilation to vas

108 t improvement in cerebral blood flow and the neurovascular coupling response, as well as increased ex

109 ies such as Alzheimer's disease, would alter neurovascular coupling responses to sensory stimulation.

110 erebrovascular reactivity and whisker-evoked neurovascular coupling responses were measured at end po

111 nt for the full expression of sensory-evoked neurovascular coupling responses.

112 in slices, 100% O(2) has been shown to alter neurovascular coupling, suppressing activity-dependent v

113 simultaneous PET/fMRI for investigations of neurovascular coupling that correlate neurochemistry wit

114 Ca(2+) signaling within the endfoot mediates neurovascular coupling; thus, these functional microdoma

115 three patients exhibited dynamic changes in neurovascular coupling to depolarizations throughout the

116 physiological concentration fully recovered neurovascular coupling to its original magnitude.

117 These results establish inverse neurovascular coupling to spreading depolarization as a

118 This neurovascular coupling underlies blood oxygen level-depe

119 The mechanisms of neurovascular coupling underlying generation of BOLD fMR

120 its newly recognized precursor, nitrite, in neurovascular coupling using a well-established rat mode

121 sed to 14.5 (95% CI, 2.3-91.1; p = 0.004) if neurovascular coupling was also attenuated.

122 Neurovascular coupling was assessed in bilateral middle

123 Neurovascular coupling was attenuated in slow compared t

124 Persistent disruption of neurovascular coupling was demonstrated by a loss of coh

125 Further, neurovascular coupling was intact in lightly sedated, re

126 We found that neurovascular coupling was similar across states and tha

127 , indicating that although O(2) can modulate neurovascular coupling when raised sufficiently high, th

128 mic responses consistent with more efficient neurovascular coupling within the left DLPFC.