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1 s of SIV/17E-Br is macrophage tropic but not neurovirulent.
2 ore, neurotropic strains are not necessarily neurovirulent.
4 eurovirulent (Jeryl Lynn vaccine) and highly neurovirulent (88-1961 wild type) mumps virus strains we
5 V-JHM strain and the hepatotropic and mildly neurovirulent A59 strain in acute infection of the mouse
6 wild-type JHM spike (SJHM/RA59) were highly neurovirulent, A59 recombinants containing the N514S mut
8 ine encephalitis virus (NA-EEEV) is uniquely neurovirulent among encephalitic alphaviruses, causing m
9 SU/TM) within the CNS using either the "non-neurovirulent" amphotropic helper virus, 4070A, or pgag-
12 cellular GADD34 gene, renders the virus non-neurovirulent and imposes a block to viral replication i
15 tly into the bulb, both viruses were equally neurovirulent, and they were transported retrogradely to
20 aging/producer cells in order to deliver the neurovirulent CasBrE env gene to endogenous CNS cells.
21 seudotype, disseminate, and trans-complement neurovirulent (CasBrE, CasE, and CasES) or non-neuroviru
24 rus for this type of modification, we used a neurovirulent chimeric tick-borne encephalitis/dengue vi
27 viruses SIVmac239, a lymphocyte-tropic, non-neurovirulent clone, and SIV/17E-Br, a macrophage-tropic
29 ned the PreM-E genes or only the NS1 gene of neurovirulent DEN2 NGC substituting for the correspondin
31 lly protected from challenge with homologous neurovirulent dengue viruses by intracerebral inoculatio
34 alaysia, and the appearance in Asia of a new neurovirulent enterovirus 71 strain that causes severe n
35 icroglia-mediated disease appears to require neurovirulent Env protein interaction with other viral p
37 r, we produced four chimeras which contained neurovirulent FMCF98 envelope sequences combined with en
38 gue-4 virus, but not YFV/dengue-2 virus, was neurovirulent for 3-week-old mice by intracerebral inocu
40 er, laboratory strains of SB can be rendered neurovirulent for adult mice by introduction of a glutam
42 we examined here whether their infection by neurovirulent (FrCasE) or nonneurovirulent (Fr57E) ecotr
43 urovirulent (CasBrE, CasE, and CasES) or non-neurovirulent (Friend and SFF-FE) env sequences (SU or S
44 o whether the test can reliably discriminate neurovirulent from nonneurovirulent mumps virus strains.
47 and replication, the evolution/selection of neurovirulent HIV-1 strains and the production of viral
49 ~7.5 log(10) PFU/ml in Vero cells, were not neurovirulent in 3- to 4-week-old ICR mice inoculated by
50 ber of the Sindbis group of alphaviruses, is neurovirulent in adult mice and has a unique threonine a
53 ; the chimera was at least 28,500 times less neurovirulent in suckling mice inoculated intracerebrall
54 subsequent intracerebral challenge with the neurovirulent influenza A/WSN and this heterotypic prote
56 encephalitis and hepatitis, while the highly neurovirulent JHM strain induces a fatal encephalitis wi
57 ted the ability of this model to distinguish neurovirulent (Kilham) from nonneurovirulent (Jeryl Lynn
59 ch circulated and evolved into both a highly neurovirulent lineage and a less neurovirulent lineage.
62 MPRSS2 greatly enhanced entry, of the highly neurovirulent MHV strain JHM.SD relative to their effect
63 fluence of the replicase genes of the highly neurovirulent MHV-JHM strain and the hepatotropic and mi
64 stigated here whether their infection by the neurovirulent MLV FrCasE contributed to neurodegeneratio
65 mmunosuppressive virus (SIV/DeltaB670) and a neurovirulent molecularly cloned virus (SIV/17E-Fr), and
66 rrelate with neurovirulence, we compared two neurovirulent MuLV, Fr98 and Fr98/SE, with a nonneurovir
67 irus replication, Glycogag-null mutants of a neurovirulent murine oncornavirus are slow to spread in
69 fection by FrCas(E) as well as that by other neurovirulent murine retroviruses has been described in
70 lpha to neurological disease induced by four neurovirulent murine retroviruses, with three of these v
71 Guinea C (NGC) strain and its mouse-adapted, neurovirulent mutant revealed that 10 nucleotide changes
72 ssage of dengue viruses in mice selected for neurovirulent mutants that also exhibited significant at
73 (MAPREC) is used to measure the frequency of neurovirulent mutations at the 5' untranslated region (U
75 , the miRNA-targeted viruses can revert to a neurovirulent phenotype by accumulating deletions or mut
77 covery that this region strongly affects the neurovirulent phenotype of poliovirus, we have embarked
78 gene alone is sufficient to confer a highly neurovirulent phenotype to a recombinant virus deriving
79 n of the JHM spike is sufficient to confer a neurovirulent phenotype, as well as increased macrophage
82 o confer the neurotropic, neuroinvasive, and neurovirulent phenotypes, in spite of all being at reduc
85 rm asymptomatic excretion of vaccine-derived neurovirulent poliovirus 2 was identified in this hypoga
86 studies, with a view to clearing persistent neurovirulent poliovirus infection in an individual with
88 seful role for environmental surveillance of neurovirulent polioviruses in the overall polio eradicat
90 riants are tested in CD155 tg mice for their neurovirulent potential, particularly in assays of live
91 for the first time, potent neuroinvasive and neurovirulent properties of a WNV-like virus outside lin
94 ed in the manufacture of mumps vaccines have neurovirulent properties, a monkey neurovirulence safety
95 virus; however, previous work indicated that neurovirulent PV type 1 Mahoney [PV(1)Mahoney] can produ
98 ning, was detected in mice infected with the neurovirulent retrovirus Fr98 but not in mice infected w
99 NTES, are upregulated in the brain following neurovirulent retrovirus infection in humans and in anim
100 nvestigate these possibilities, we studied a neurovirulent retrovirus, Fr98, that induces severe non-
107 ontribute to adult mouse neurovirulence, the neurovirulent Sindbis virus strain AR86 was compared to
109 ithelial cells (MEC), but laboratory-derived neurovirulent SINV strain TE/5'2J infects MEC poorly.
110 loped a reverse genetics system based on the neurovirulent Snyder Hill (SH) strain of CDV (CDV(SH)) a
111 4) A(2254) nucleotide mutation introduced in neurovirulent strain Ab4, which resulted in an asparagin
113 myelitis and demyelination, while the highly neurovirulent strain JHM.SD (MHV-4) causes fatal encepha
114 o sensitively assess the in vivo spread of a neurovirulent strain of CDV provides a novel model syste
115 munodominant CD8+ T-cell epitope of a highly neurovirulent strain of mouse hepatitis virus (MHV), JHM
119 rom sural nerves of macaques infected with a neurovirulent strain of SIV showed impaired mitochondria
120 , SIV/17E-Fr, that contained the 3' end of a neurovirulent strain of SIV, SIV/17E-Br, derived by in v
121 mortality rates after infection with NSV, a neurovirulent strain of SV, were as follows v: 81% (17 o
123 ease in the current epidemic suggests a more neurovirulent strain of virus than the one classically a
125 on to introduce the S gene of MHV4, a highly neurovirulent strain, into the genome of MHV-A59, a mild
126 strain, into the genome of MHV-A59, a mildly neurovirulent strain, we have been able to directly addr
132 course of infection in older animals, a more neurovirulent SV vector (dsNSV) was constructed from a v
134 esults which showed that while SHBRV is less neurovirulent than COSRV when administered via the intra
135 YFV/JEV SA14-14-2, or ChimeriVax-JE) is less neurovirulent than is YFV 17D vaccine in mouse and nonhu
137 ronavirus mouse hepatitis virus is much more neurovirulent than the MHV-A59 strain, although both str
138 the chimeras were at least 5,000 times less neurovirulent than their parental LGT virus in suckling
139 we show that an HSV-1 ICP47- mutant is less neurovirulent than wild-type HSV-1 in mice, but replicat
143 nd wild-type 129 SV(ev) mice infected with a neurovirulent viral strain, neuroadapted Sindbis virus (
145 eptibility to excitotoxic insult mediated by neurovirulent virus effects on other glial subtypes.
146 wise, only viruses containing the RBD of the neurovirulent virus exhibited increased binding of the E
150 s increased when envelope sequences from the neurovirulent virus outside the RBD were also present.
151 l of viral envelope glycoprotein gp41 of the neurovirulent virus SIVsm804E that enhance replication i
152 e role of gK/UL20 in the context of a highly neurovirulent virus strain, the HSV-1(McKrae) genome was
155 ation, was able to convert rJL into a highly neurovirulent virus, highlighting mechanistic difference
158 , as well as the infection of the brain with neurovirulent viruses in this behavioural disorder.
159 est that the selection of macrophage-tropic, neurovirulent viruses occurs not at the level of the blo
160 only a limited subset of macrophage-tropic, neurovirulent viruses replicate terminally in the brains
161 , we demonstrate that the macrophage-tropic, neurovirulent viruses SIV/17E-Br and SIV/17E-Fr replicat
164 and members of the GDVII subgroup are highly neurovirulent, while the DA strain and members of the TO
165 ns of genes derived from a cDNA clone of the neurovirulent wild-type 88-1961 strain (r88) and from a
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