ライフサイエンスコーパス: neurulation

1 eath (apoptosis) in the tissues required for neurulation.

2 extension movements during gastrulation and neurulation.

3 MEKK4-regulated p38 activity is critical for neurulation.

4 the role of blf in convergent extension and neurulation.

5 ion, whereas hypochordal cells ingress after neurulation.

6 ial region of the presumptive somites during neurulation.

7 phogenetic movements during gastrulation and neurulation.

8 spatially restricted during gastrulation and neurulation.

9 n of FLASH in the notochord of embryos after neurulation.

10 the mouse Zic2 is required for the timing of neurulation.

11 tial regulator of apical constriction during neurulation.

12 estis and in a highly dynamic pattern during neurulation.

13 g roles for both cobl and Vangl2 in midbrain neurulation.

14 opore closure and a stimulation of secondary neurulation.

15 ry role for heparan sulphate in mouse spinal neurulation.

16 convergent extension from other processes of neurulation.

17 n movements are crucial to proper vertebrate neurulation.

18 ing of the neural plate during initiation of neurulation.

19 s have focused primarily on gastrulation and neurulation.

20 h as those occurring during gastrulation and neurulation.

21 In Xenopus, the first of these is neurulation.

22 ecificity of this genetic effect for cranial neurulation.

23 roduction during late gastrulation and early neurulation.

24 ted and the expression domain altered during neurulation.

25 s capacity was restricted to early stages of neurulation.

26 ism controlling tail outgrowth and secondary neurulation.

27 egulation of electrical development prior to neurulation.

28 teratogens acting at the earliest stages of neurulation.

29 he cellular architecture required for proper neurulation.

30 oning cells along the caudal neuraxis during neurulation.

31 nteracting their tendency to disperse during neurulation.

32 n events, we term this phenomenon junctional neurulation.

33 changes in tissue morphology associated with neurulation.

34 produce the morphogenetic forces that drive neurulation.

35 epithelium and epidermal ectoderm throughout neurulation.

36 ed closure of the cranial neural tube during neurulation.

37 rmation of the hindbrain is disrupted during neurulation.

38 overgrowth of the neural plate during early neurulation.

39 6) are not dependent on rax activity through neurulation.

40 ocesses referred to as primary and secondary neurulation.

41 dysraphism results from defective secondary neurulation.

42 ns in embryonic neuroepithelial cells during neurulation.

43 ed fluid flow during late gastrulation/early neurulation.

44 oth pathways maintains the population during neurulation.

45 e-field and telencephalic cells during early neurulation.

46 such as gastrulation, mesoderm formation and neurulation.

47 y ability, and gene expression profile after neurulation.

48 correct de novo asymmetry orientation during neurulation.

49 uces multiaxial mirror symmetry in zebrafish neurulation.

50 larity plays an essential role in vertebrate neurulation.

51 the establishment of the neural tube during neurulation.

52 he extensive morphogenetic cell movements in neurulation.

53 issue plasticity and tissue integrity during neurulation.

54 he potentially disruptive process of teleost neurulation.

55 es such as gastrulation, tube formation, and neurulation.

56 phalic pallial (dorsal) specification during neurulation.

57 efects in mitotic spindle orientation during neurulation.

58 erm and neuroepithelium, before the onset of neurulation.

59 ion in the mammalian PCP gene Vangl2, during neurulation.

60 d for the predominance of filopodia in early neurulation.

61 contribute to the final events of vertebrate neurulation.

62 extension movements during gastrulation and neurulation.

63 o the junction between primary and secondary neurulations.

64 bation, earlier stages (from laying to early neurulation, 0-1 d) present special challenges.

65 ogenetic movements such as gastrulation [3], neurulation [4, 5], and organogenesis [6].

66 evelled homologs, Dvl1 and Dvl2, that during neurulation a homologous mammalian PCP pathway regulates

67 d undergo convergence-extension movements of neurulation, although their principal contribution was t

68 During early neurulation, AmphiDll-expressing epidermal cells flankin

69 n continues in the same cell lineages during neurulation and axis formation, however, during the tail

70 Thus, Abl and Arg play essential roles in neurulation and can regulate the structure of the actin

71 We postulate a new model for forebrain neurulation and demonstrate how mutations affecting two

72 yos are retarded in growth, fail to complete neurulation and die around E 9.5.

73 t in both Abl and Arg suffer from defects in neurulation and die before 11 days postcoitum (dpc).

74 We find that ZIP12 is expressed during neurulation and early nervous system development in Xeno

75 and extension movements during gastrulation, neurulation and epidermis defects and enhanced phenotypi

76 regulation of PP1 and the cell cycle during neurulation and eye development.

77 f frog (Xenopus laevis) from gastrulation to neurulation and find dorsal tissues stiffen from less th

78 coupling cell division and morphogenesis at neurulation and indicate a previously unrecognized mecha

79 is recruited specifically during junctional neurulation and its misexpression within a limited time

80 events within the nervous system, including neurulation and neural tube closure, cellular migration,

81 thelial to mesenchyme cell transition during neurulation and plays a role in limb bud development.

82 hypophyseal canal is present from the end of neurulation and represents the anteriormost neural tube,

83 ng to focus cellular events occurring during neurulation and reveal novel molecular mechanisms implic

84 The MAPK kinase kinase MEKK4 is required for neurulation and skeletal patterning during mouse develop

85 e time of gastrulation and neurulation, both neurulation and somitogenesis initiate apparently normal

86 with the role of PCD in events ranging from neurulation and synaptogenesis to the elimination of adu

87 from a radial to linear organization during neurulation and that microtubules function in conjunctio

88 ogenous PtdCho synthesis is important during neurulation and that perturbed choline metabolism contri

89 ve junctions of neuroepithelial cells during neurulation and that Xena knockdown disrupts cell behavi

90 cation of migratory epidermal cells early in neurulation and the specification of forebrain.

91 sary for induction of Pax3 expression during neurulation and thus providing a molecular mechanism for

92 tion of several genes that are important for neurulation and vascular development in the Ikbkap(-)(/)

93 nial neural crest cells during gastrulation, neurulation, and in tail bud stages.

94 and provides tangible links between Zn(2+), neurulation, and neuronal differentiation.

95 pithelial tissue occurs during gastrulation, neurulation, and organogenesis in many organisms.

96 r morphogenetic events such as gastrulation, neurulation, and organogenesis.

97 tion of dorsal cell fates of ectoderm during neurulation, and regional differentiation of the neural

98 edict that the critical time is early during neurulation, and the critical cells are the ectodermal c

99 ly colonization of the hindgut shortly after neurulation, and the other states that sacral crest cell

100 undergo progressive epithelialization during neurulation, and thus provide a convenient in vivo cellu

101 ks regulating normal skeletal patterning and neurulation are largely unknown.

102 Additional defect in neurulation associated with enhanced apoptosis in the ne

103 Despite these pronounced effects on neurulation, axial patterning of the neural tube appears

104 is expressed at the time of gastrulation and neurulation, both neurulation and somitogenesis initiate

105 in; Ncdh) is known for its important role in neurulation, brain development and regulation of synapti

106 related gene), play essential roles in mouse neurulation, but their functions in the subsequent devel

107 ational alterations occurring at the time of neurulation by assessing differential roles of Htt and m

108 These data support a direct normalization of neurulation by folic acid in humans and suggest a metabo

109 Loss of Lpp1 function disrupts neurulation by permitting more extensive floor plate ind

110 cell polarity (PCP) signalling might control neurulation by promoting the convergence of neural proge

111 PGC-1alpha supports neurulation by stimulating autophagy in neuroepithelial

112 y days), which results in aberrant secondary neurulation, can explain the observed pattern of anomali

113 and 11.5 of gestation, exhibiting defects in neurulation, cell proliferation, and heart development.

114 Midway in neurulation, cells near the anterior end of the neural p

115 Following neurulation, commissural axons are observed crossing the

116 tants die perinatally and display defects in neurulation, craniofacial structures, and the formation

117 istinct from the known genes associated with neurulation defects, and isolation of this gene will ass

118 perturbed gastrulation not only explains the neurulation defects, but also provides a unifying etiolo

119 yos are developmentally retarded and exhibit neurulation defects, suggesting that YY1 may have additi

120 deletion die in utero and display defects in neurulation, demonstrating an important functional role

121 While gastrulation and neurulation depend largely on active cell rearrangement

122 We demonstrate that although the mode of neurulation differs at the morphological level between a

123 cdh 19 or ncad impairs cell movements during neurulation, disrupting both the directedness of cell mo

124 Changes in Vmem induced late in neurulation do not affect craniofacial development.

125 ants, the remaining morphogenic processes of neurulation do not appear to occur in absence of vertica

126 distinct ectodermal domains in the course of neurulation, during the establishment of cell lineages.

127 Because it is distinct from the other neurulation events, we term this phenomenon junctional n

128 During vertebrate neurulation, extensive cell movements transform the flat

129 s in cranial mesenchyme are essential during neurulation for elevation of the neural folds.

130 c asymmetry pathway, but are required during neurulation for the maintenance of adequate levels of th

131 ed universal perinatal death with defects in neurulation, fusion of the cerebral hemispheres, formati

132 inally, we show that cobl interacts with the neurulation gene Vangl2 to facilitate midbrain neural tu

133 and diethylaminobenzaldehyde (DEAB), during neurulation, greatly reduces transgene expression.

134 o, an understanding of the dynamic nature of neurulation has been hampered due to its in utero develo

135 e of the cellular mechanisms responsible for neurulation have been described in a number of vertebrat

136 development, whereas CREBBP is essential for neurulation, hematopoietic differentiation, angiogenesis

137 Removal of the notochord during late neurulation, however, does not interfere with hypochord

138 At neurulation IK(IR), which had been present since fertili

139 oggin-secreting cells at different stages of neurulation in chick embryos.

140 erferes with embryonic development, and with neurulation in particular.

141 at measures changes in cell movements during neurulation in response to differential cell adhesion.

142 e domain and cooperates with ABL to regulate neurulation in the developing mouse embryo.

143 e induction of the cell behaviors underlying neurulation in the frog, Xenopus laevis.

144 upling of the entire region of active spinal neurulation in the mouse embryo as a prerequisite for su

145 n of the zebrafish neural keel and secondary neurulation in the posterior axis of chicken and mouse.

146 which developmental processes operate during neurulation in this region is therefore pivotal to unrav

147 Thus, Noggin is required for mammalian neurulation in two contexts, dependent on position along

148 Neurulation in vertebrates is an intricate process requi

149 nd neuronal differentiation during mammalian neurulation in vivo.

150 C5 to be expressed throughout the period of neurulation in wild-type mice and localized the expressi

151 eletal dynamics and cellular adhesion during neurulation in Xenopus.

152 nd its cytosolic partner TAF1/Set for proper neurulation in Xenopus.

153 show a novel role for PCP signalling during neurulation in zebrafish.

154 cally with n-cadherin (ncad) during anterior neurulation in zebrafish.

155 Bmp2 expression correlates with upper spinal neurulation (in which DLHPs are absent); that Bmp2-null

156 tion of folate action by methotrexate during neurulation induces NTDs by inhibiting folate interactio

157 Additionally, disrupting endocytosis during neurulation inhibits AC in hingepoint cells, resulting i

158 Neurulation is a morphogenetic event par excellence.

159 ring gastrulation and declines rapidly after neurulation is complete.

160 Mammalian neurulation is completed when the dorsolateral neural fo

161 tage-gated K+ current (IKv) near the time of neurulation is followed about 6 h later by a rapidly act

162 Neurulation is of particular interest in view of the sev

163 revin), which is normally detectable late in neurulation, is abolished in these alpha6 integrin-pertu

164 Failures in neurulation lead to severe anomalies of the nervous syst

165 xample, failure of neural fold fusion during neurulation leads to open neural tube defects including

166 w that removal of the notochord during early neurulation leads to the complete failure of hypochord d

167 l margin of the neural plate at the start of neurulation move to the dorsal midline using distinctive

168 pite recent advances in our understanding of neurulation, neural tube defects continue to be a major

169 Neurulation, neurogenesis and its genetic bases, as well

170 hylation of a Pax3 CpG island decreased upon neurulation of embryos and formation of neuronal precurs

171 cal development could be analyzed only after neurulation, once myocytes could be morphologically iden

172 neural plate border during gastrulation and neurulation, overlapping the domain of neural crest indu

173 NC-1 expression is highly dynamic and, after neurulation, preferentially defines prospective cortical

174 complete gastrulation normally but arrest at neurulation prior to the formation of the neural plate.

175 As mouse neurulation progresses along the spinal axis, there is a

176 During neurulation, RA and class IV ADH mRNA were colocalized i

177 During gastrulation and neurulation RALDH-2 and CYP26 were expressed in nonoverl

178 y the proteins that became methylated during neurulation, rat embryos were first cultured on methioni

179 ress two issues: (1) which aspects of normal neurulation require Xdsh function; and (2) what role con

180 Indeed normal neurulation requires several different cell polarity dec

181 e exencephaly is due to a primary failure of neurulation, resulting from a lack of mid/hindbrain dors

182 ession is diminished in the spinal region of neurulation-stage curly tail embryos.

183 nt the nature of the metabolic defect in the neurulation-stage embryo that is corrected by folic acid

184 C) is known to be essential, and we examined neurulation-stage embryos for PKC expression and applied

185 Application of peptide inhibitors to neurulation-stage embryos revealed an absolute dependenc

186 a typical duration of 2 h (gastrulation and neurulation stages), intricacies of image pre-processing

187 nic development, between the midblastula and neurulation stages.

188 Thus, FGFR-1 plays a role in neurulation, suggesting that there may be a connection b

189 ural plate begin expressing AmphiDll and, as neurulation terminates, these cells are incorporated int

190 Our results suggest three phases of neurulation that relate to neural crest formation: (1) a

191 cts on morphogenesis during gastrulation and neurulation that result in dramatic shortening of the an

192 During vertebrate neurulation, the embryonic ectoderm is patterned into li

193 After neurulation, the expression of all retinoid receptors in

194 During neurulation, the neural tube is disorganized.

195 Neurulation, the process of neural tube formation, is a

196 idisation, we show that, at the beginning of neurulation, the ventral-to-dorsal gradient of BMP activ

197 d interactions with laminin are required for neurulation, they are not required for the initial proce

198 forced to occur in ectopic locations during neurulation, they orchestrate the development of mirror-

199 n and cytoskeletal dynamics is essential for neurulation, though it remains unclear how these two pro

200 road embryonic midline prevents the onset of neurulation through wide spacing of the neural folds.

201 amma, RARgamma2, RXRalpha, and RARgamma from neurulation to HH10 in the normal and vitamin A-deficien

202 Many tissues interact during neurulation to induce and regionalize the neuroectoderm

203 morphoregulatory molecules expressed during neurulation underlie induction and patterning of the for

204 nsient ectopic Wnt-8 expression during early neurulation was sufficient to repress anterior head deve

205 paran sulphate proteoglycans in mouse spinal neurulation, we administered chlorate, a competitive inh

206 To begin addressing its role in neurulation, we analyzed a microdeletion mouse strain la

207 dous increase in retinoic acid occurs during neurulation when ALDH1 is first expressed.

208 their delamination and differentiation after neurulation when NPCs normally acquire organized apical

209 e gastrocoel and into the deep region during neurulation, whereas hypochordal cells ingress after neu

210 orachischisis result from failure of primary neurulation, whereas skin-covered spinal dysraphism resu

211 enic during late blastula, gastrulation, and neurulation; whereas MMI is not.

212 xt of the complex morphogenesis required for neurulation, which in zebrafish involves a characteristi

213 isation of the forebrain neural plate during neurulation, which must fold a sheet into a tube while e

214 phogenetic movements during gastrulation and neurulation while its role in hematopoiesis may be redun

215 tube closure and arrests development during neurulation with concomitant reduction in tubulin polyme

216 after laying (stage XI) to stages 6-7 (early neurulation), with precise spatial and temporal control.