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1 els and the efficacy of MEDI-573, an IGF-1/2-neutralizing antibody.
2 s was abrogated in the presence of an irisin-neutralizing antibody.
3 todomain in complex with G4, a stem-directed neutralizing antibody.
4 plex of the HAstV capsid protein and a virus-neutralizing antibody.
5 ce-presented Env, and are targets of broadly neutralizing antibodies.
6 coreceptor binding site and is a target for neutralizing antibodies.
7 ron response and delayed production of virus-neutralizing antibodies.
8 fusion (F) glycoprotein is a key target for neutralizing antibodies.
9 d clonal selection to generate high affinity neutralizing antibodies.
10 ctures of gp120/gp41 or their complexes with neutralizing antibodies.
11 mutants that in turn select affinity-matured neutralizing antibodies.
12 sigma1 protein is also the primary target of neutralizing antibodies.
13 membrane fusion and is the primary target of neutralizing antibodies.
14 fort to identify a vaccine to elicit broadly neutralizing antibodies.
15 ch overlapped with epitope surfaces of known neutralizing antibodies.
16 c Ig produced but not with the production of neutralizing antibodies.
17 nter B cells and eliciting tier-2 autologous neutralizing antibodies.
18 d seemingly opposing results regarding cross-neutralizing antibodies.
19 immune responses that include production of neutralizing antibodies.
20 -H) protein is the main target of protective neutralizing antibodies.
21 It is also the viral component targeted by neutralizing antibodies.
22 ry and is thought to be the major target for neutralizing antibodies.
23 usion (pre-F) state is a superior target for neutralizing antibodies.
24 roducibility with specific detection of ZIKV neutralizing antibodies.
25 -dependent epitopes, which are recognized by neutralizing antibodies.
26 r influence the epitopes of numerous broadly neutralizing antibodies.
27 ly inactivated BNSP333-S1 induced high-titer neutralizing antibodies.
28 on, and the elicitation of tier-2 autologous neutralizing antibodies.
29 d in future clinical trials in patients with neutralizing antibodies.
30 served epitope that is the target of broadly neutralizing antibodies.
31 irus serotypes 1, 2, and 3 targeted by human neutralizing antibodies.
32 e or therapeutic strategies based on broadly neutralizing antibodies.
33 nt cellular cytotoxicity responses and HIV-1-neutralizing antibodies.
34 acaques, but so far failed to induce broadly neutralizing antibodies.
35 ity, such as therapeutic vaccines or broadly neutralizing antibodies.
36 he neutralizing antibodies compared with non-neutralizing antibodies.
37 ocesses controlling the development of HIV-1-neutralizing antibodies.
38 vely resistant to State 1-preferring broadly neutralizing antibodies.
39 on-associated spike, which is the target for neutralizing antibodies.
40 g trimer at 3.2-A resolution in complex with neutralizing antibodies 35O22 and 9H+109L reveals a nati
41 lated a pre-F protein-specific, high-potency neutralizing antibody (5C4) that recognizes antigenic si
44 d that cis P-tau elimination with a specific neutralizing antibody administered immediately or at del
46 Similarly, treatment of mice with an IFNAR-neutralizing antibody after MI ablated the interferon re
47 eta-chemokine CCL4, as IFNAR1 deficiency and neutralizing antibodies against CCL4, respectively, abol
48 es.IMPORTANCE One approach to elicit broadly neutralizing antibodies against HIV-1 is to stabilize th
49 inhibitors, bacterial isogenic mutants, and neutralizing antibodies against host proteins recognized
50 e to induce highly potent and broad-spectrum neutralizing antibodies against infection by divergent c
51 mmunogenicity, and they induced strong cross-neutralizing antibodies against infection by divergent p
53 ty-determining region loops of human broadly neutralizing antibodies against the hemagglutinin (FI6v3
54 nal center formation and enhanced autologous neutralizing antibodies against the neutralization-resis
56 de valuable tools for functionally assessing neutralizing antibodies against vaccine-candidate antige
57 lysis defines reovirus interactions with two neutralizing antibodies, allows us to propose a mechanis
58 ith neutralization titers against 16 broadly neutralizing antibodies and 30 sera from chronic clade C
59 sence of GLA-SE induced high titers of virus-neutralizing antibodies and conferred complete lung prot
60 P1, is an important impediment to binding of neutralizing antibodies and contributes to the poor cros
61 ppress elicitation of V3-directed and tier-1 neutralizing antibodies and induce robust autologous tie
63 ogenic, eliciting complement-independent RSV-neutralizing antibodies and providing protection against
64 apid development of alemtuzumab-binding and -neutralizing antibodies and subsequent occurrence of sec
65 pes on DENV4 E protein targeted by the human neutralizing antibodies and the mechanisms of serotype 4
66 efusion (pre-F) conformation is a target for neutralizing antibodies and therefore an attractive anti
71 /-) mice and those administered a sclerostin-neutralizing antibody are resistant to obesogenic diet-i
72 s interaction with receptor CD4-binding site neutralizing antibodies as a model system, we both corro
73 of time than in serum, and (3) generation of neutralizing antibodies as well as an antiviral immunolo
74 gs are delayed onset and low levels of virus neutralizing antibodies, as well as weak cell-mediated i
75 rred complement-independent high-quality RSV-neutralizing antibodies at titers similar to those of wi
76 protection merits parallel investigation to neutralizing antibody-based vaccine design approaches.
77 AIDS, the search for epitopes recognized by neutralizing antibodies became the driving strategy for
78 angiogenic therapies for cancer such as VEGF neutralizing antibody bevacizumab have limited durabilit
79 defining the immunodominant epitopes and how neutralizing antibodies bind to them will provide great
81 recognized by trimer cross-reactive broadly neutralizing antibody (bnAb) and not by nonneutralizing
84 VRC01 is an HIV-1 CD4 binding site broadly neutralizing antibody (bnAb) that is active against a br
85 oposes that engineered expression of broadly neutralizing antibodies (bNAbs) against HIV-1 could over
86 are demonstrably less effective than broadly neutralizing antibodies (bNAbs) against HIV-1 in vitro a
89 covery and characterization of human broadly neutralizing antibodies (bnAbs) against influenza virus
93 quantify neutralization titers by 16 broadly neutralizing antibodies (bnAbs) and sera from 30 subject
94 protein (Env) is the sole target for broadly neutralizing antibodies (bnAbs) and the focus for design
97 rs display the epitopes for multiple broadly neutralizing antibodies (bNAbs) but can also expose bind
100 virus entry and is a major target of broadly neutralizing antibodies (bnAbs) developed during infecti
101 ermline (iGL) forms of several HIV-1 broadly neutralizing antibodies (bNAbs) did not display measurab
104 erstanding the mechanism(s) by which broadly neutralizing antibodies (bNAbs) emerge naturally followi
105 macaque suggests that elicitation of broadly neutralizing antibodies (bNAbs) for ebolaviruses is poss
109 o define envelope (Env) evolution of broadly neutralizing antibodies (bnAbs) in infection and to recr
110 n (Env) immunogen for elicitation of broadly neutralizing antibodies (bNAbs) is a challenging task be
112 are the mainstay for treatment, but broadly neutralizing antibodies (bNAbs) may be a viable alternat
113 lope glycoprotein of HIV-1 and three broadly neutralizing antibodies (bNAbs) of the VRC01 class.
114 ventative HIV vaccine able to elicit broadly neutralizing antibodies (bNAbs) remains a major challeng
119 a123) increases the ability of human broadly neutralizing antibodies (bNAbs) to inhibit E2-CD81 recep
120 ainst HIV-1 will most likely require broadly neutralizing antibodies (bnAbs) with maximum breadth and
121 iral infectivity and bind to several broadly neutralizing antibodies (bNAbs), including trimer-specif
122 IV-1-infected human subjects develop broadly neutralizing antibodies (bnAbs), such as the potent VRC0
130 1 primary virus isolates (designated broadly neutralizing antibodies [bNAbs]) remains a high priority
133 as the RV144 vaccine trial indicate that non-neutralizing antibodies can contribute to protection.
135 ency and magnitude of multiple HIV-1 broadly neutralizing antibody classes are decreased during cell-
136 hat the pre-F state is a superior target for neutralizing antibodies compared to the post-F state.
137 ts of IFN, cellular restriction factors, and neutralizing antibodies compared with cell-free entry.
138 12C trimeric Env preferentially bound to the neutralizing antibodies compared with non-neutralizing a
143 with tumor necrosis factor alpha (TNF-alpha)-neutralizing antibodies decreased the frequency of CD45(
144 ific CD8 T cell responses and high titers of neutralizing antibodies, demonstrating its superiority t
146 rus, to which most of the broadly prevalent, neutralizing antibodies did not bind, conferred a select
148 uenza vaccines confer protection by inducing neutralizing antibodies efficiently against homologous a
149 l glycans are components of multiple broadly neutralizing antibody epitopes, while shielding other si
152 ogens, have led to the first vaccine-induced neutralizing antibodies for structural and functional an
156 prefusion ectodomain of Lassa GP bound to a neutralizing antibody from a human survivor at 3.2-angst
158 scuss antibody immunodominance pertaining to neutralizing antibody generation and the GC response, pr
159 n the negative effects of immunodominance on neutralizing antibody generation, and consider means of
160 The aptamer competes for binding with the neutralizing antibody H16.V5, indicating at least partia
161 r TNF-alpha gene deletion nor anti-TNF-alpha neutralizing antibodies had any impact sustained eosinop
165 minus in cell-surface binding and a role for neutralizing antibodies in defining structural features
166 erum neutralization to identify and quantify neutralizing antibodies in donor cohorts (Antibodyomics3
167 ene responsible for production of retrovirus-neutralizing antibodies in mice of the I/LnJ strain.
169 ll, the RVNT accurately and reliably detects neutralizing antibodies in patient serum specimens, with
170 haracterized epitopes on DENV4 recognized by neutralizing antibodies in people previously exposed to
171 ta clearly indicate the superior efficacy of neutralizing antibodies in preventing mucosal acquisitio
172 derstanding the role of neutralizing and non-neutralizing antibodies in the immune control of HIV inf
173 also positively correlate with the levels of neutralizing antibodies in Zika-virus-infected macaques.
175 -Ob allele supported the production of virus-neutralizing antibodies independently of the classical M
176 rface glycoprotein and is the main target of neutralizing antibodies induced by natural infection.
177 The development of anti-factor VIII (FVIII) neutralizing antibodies (inhibitors) is the major compli
180 tion that the RBS is an important target for neutralizing antibodies, it is not clear how these virus
181 aturation pathway, and prevalence of broadly neutralizing antibody lineages (Antibodyomics1, 2, 4, an
183 tructure of CVA6 A-particle complexed with a neutralizing antibody maps an immune-dominant neutralizi
184 this action of heparin recapitulates that of neutralizing antibodies, membrane perforation presents a
186 th hemophilia or blindness, but pre-existing neutralizing antibodies (Nab) are common in the general
187 lates of protection are only poorly defined, neutralizing antibodies (NAb) targeting the envelope pen
188 against congenital HCMV infection.IMPORTANCE Neutralizing antibodies (NAb) targeting the human cytome
189 vaccines are found to induce lower level of neutralizing antibodies (nAb) than do their seasonal cou
193 nantly tier 1 and/or autologous tier 2 virus neutralizing antibody (NAb) responses, as well as weak a
194 is widely accepted that dengue virus (DENV)-neutralizing antibody (nAb) titers are associated with p
195 To assess the value of BKV genotype-specific neutralizing antibody (NAb) titers as a predictive marke
197 the structural basis for how a mouse-derived neutralizing antibody (nAb), OD01, disrupts this interac
199 c the native Env spike can induce autologous neutralizing antibodies (NAbs) against relatively resist
200 s, with the goal of eliciting broadly active neutralizing antibodies (NAbs) that are active against a
201 these vaccines have generated high titers of neutralizing antibodies (NAbs), their induction of robus
202 native-like trimers expose epitopes for non-neutralizing antibodies (non-nAbs), which may hinder bnA
204 tially favors binding by established broadly neutralizing antibodies; omission of several specific gl
205 (OXA) EoE mice were treated with anti-GM-CSF neutralizing antibody or isotype control and assessed fo
207 altering neutralization by human CD4-Ig, SIV neutralizing antibodies, or sera from SIV-infected macaq
210 1 SOSIP.664 gp140, does not bind the broadly neutralizing antibody PGT151 and so was used here to ide
212 for the first time that HVEM-specific HSV-1 neutralizing antibodies protect mice from HSV-1 eye dise
213 thod provides critical insights into broadly neutralizing antibody recognition of Env, which may info
214 We apply this approach to PGT151, a broadly neutralizing antibody recognizing a combination of Env r
215 velopment of vaccines able to induce broadly neutralizing antibodies remains the ultimate goal, to da
216 year after HIV infection, a relatively weak neutralizing antibody response against primary and subty
218 y produced a more potent secondary anti-RABV neutralizing antibody response than rLBNSE-immunized mic
220 ly in the trauma-induced corneas; however, a neutralizing antibody response to the vector capsid was
224 new gp120 trimer immunogens elicited potent neutralizing antibody responses against highly sensitive
225 e dose of the rISFV vaccine vectors elicited neutralizing antibody responses and protected mice from
227 nd 2, plasma immunoglobulin (Ig) G, IgA, and neutralizing antibody responses at week 2 were all signi
229 In stark contrast to SUDV survivors, rare neutralizing antibody responses in MARV survivors dimini
231 P-based vaccines showed significantly better neutralizing antibody responses than those with their DN
235 highly sensitive Tier 1A isolates and weaker neutralizing antibody responses with an average titer of
238 Treatment of animals with an anti-podoplanin neutralizing antibody resulted in development of smaller
239 acid mutations to HIV Envelope (Env) affect neutralizing antibody sensitivity in the context of repl
240 ompared to overlapping early strain-specific neutralizing antibody (ssNAb) responses to the V3/C3 reg
242 us FGF2 function in the DMS, by an anti-FGF2 neutralizing antibody, suppressed alcohol consumption an
243 d 2D_M0,12 versus 2D_M0,6; and assessment of neutralizing antibodies, T cells, B cells, and safety.
244 previous studies, we demonstrated that toxin-neutralizing antibodies target four spatially distinct h
245 IV-1 B/C recombinant Env (LT5.J4b12C) to non-neutralizing antibodies targeting CD4-induced Env epitop
246 complex, rhesus macaques can develop broadly neutralizing antibodies targeting multiple immunogenic s
248 live attenuated serotype 4 vaccine developed neutralizing antibodies that bound to similar sites on t
249 nsmitted/founder (TF) Env induces autologous neutralizing antibodies that can not only neutralize the
250 The vaccine confers protection by inducing neutralizing antibodies that interfere with the function
251 rapid (within 4 d) and long-lasting (>290 d) neutralizing antibodies that provided complete protectio
252 on the surface of HIV-1 and is the target of neutralizing antibodies that reduce viral infectivity.
253 tural and functional characterization of two neutralizing antibodies that target sigma1 of serotype 1
254 infection and vaccination also induced serum-neutralizing antibodies that targeted similar epitope do
255 lation are not correlated with production of neutralizing antibodies, the levels of which are similar
256 eim Vetmedica) resulted in the production of neutralizing antibodies, the levels of which were signif
257 nduced sterilizing immunity with a saturated neutralizing antibody titer, which no longer increased a
258 Of 47 subjects, 43 (91.5%) subjects had JE neutralizing antibody titers >/=10 (reciprocal serum dil
259 oduced virus-like particles resulted in high neutralizing antibody titers ( approximately 1/100,000)
261 ssive immunity of the offspring, measured by neutralizing antibody titers and survival rates after vi
262 total anti-IAV IgG and IgA titers and virus-neutralizing antibody titers but not hemagglutinin stalk
263 ody cloning shows that donors with high ZIKV neutralizing antibody titers have expanded clones of mem
264 fusion conformation (DS-Cav1 F) induces high neutralizing antibody titers in naive animals, but it re
265 es in mice showed that VLPs generated higher neutralizing antibody titers than those with the DNA vac
268 RNT, nine were negative, eight specimens had neutralizing antibodies to a flavivirus (unable to be id
269 th no preexisting immunity to DENV developed neutralizing antibodies to all 4 serotypes of DENV.
275 experimental animals have shown that broadly neutralizing antibodies to HIV-1 can prevent infection,
276 natural immunity, we used a panel of broadly neutralizing antibodies to identify the immunogenic site
277 ficance of the phenomenon for the ability of neutralizing antibodies to mediate protective effects in
280 a vaccine most likely has to induce broadly neutralizing antibodies to the HIV-1 envelope glycoprote
282 masome and fibrosis markers in HSCs and that neutralizing antibody to CCL5 inhibited activation.
283 correlate of protection and the failure of a neutralizing antibody to correlate with protection again
284 3 predominantly blocked the binding of a non-neutralizing antibody to Delta123, while having reduced
287 No participants tested positive for AAV5-neutralizing antibodies using a green-fluorescent protei
288 The induction of similar cross-reactive neutralizing antibodies using structural vaccinology app
289 ression of CXCL13 resulted in enhanced virus-neutralizing antibody (VNA) production and protection ag
290 with LBNSE-CXCL13 produced more rabies virus-neutralizing antibodies (VNAs) and developed better prot
291 lived PCs, it also generated prolonged virus-neutralizing antibodies (VNAs), resulting in better prot
295 In addition, intra-mPFC infusion of a BDNF-neutralizing antibody was performed to test the necessit
298 ed that anti-transforming growth factor beta neutralizing antibody, when incubated with conditioned m
299 also leads to the production of tier 2 HIV-1-neutralizing antibodies, which increase in breadth and p
300 er development programs is to induce broadly neutralizing antibodies with the potential to intervene
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