ライフサイエンスコーパス: neutrophil activation

1 utagenesis to identify LVS genes that affect neutrophil activation.

2 P2], a lipid second messenger generated upon neutrophil activation.

3 tinct from those that are involved in normal neutrophil activation.

4 rnea, including corneal fibroblasts, and for neutrophil activation.

5 ther inflammatory conditions associated with neutrophil activation.

6 ement activates tyrosine kinases, leading to neutrophil activation.

7 to examine the role of SHIP in TLR2-induced neutrophil activation.

8 yeloperoxidase from neutrophils, a marker of neutrophil activation.

9 ma-hemorrhagic shock-induced lung injury and neutrophil activation.

10 s the degree of T/HS-induced lung injury and neutrophil activation.

11 and Hsp27 dissociates from the complex upon neutrophil activation.

12 ilable, could prove an accurate biomarker of neutrophil activation.

13 etabolic enzyme trafficking affects maternal neutrophil activation.

14 ating endothelial barrier dysfunction during neutrophil activation.

15 ore IR prevented endothelial dysfunction and neutrophil activation.

16 stained endothelial dysfunction and systemic neutrophil activation.

17 es including receptor-mediated responses and neutrophil activation.

18 e interaction would be sufficient to trigger neutrophil activation.

19 or Stim2 to investigate the role of STIM2 in neutrophil activation.

20 on of capillary endothelium by prevention of neutrophil activation.

21 cts of cytokines such as TNF and by blocking neutrophil activation.

22 both be active participants in ANCA-induced neutrophil activation.

23 owth factor-beta (TGF-beta), which inhibited neutrophil activation.

24 in initiating and perpetuating ANCA-induced neutrophil activation.

25 ent; secretory component showed no effect on neutrophil activation.

26 little is known of their individual roles in neutrophil activation.

27 pears to function as a negative regulator of neutrophil activation.

28 matory actions of macrophages and subsequent neutrophil activation.

29 -CSF, at concentrations sufficient to affect neutrophil activation.

30 nal assays, including analysis of downstream neutrophil activation.

31 d as fluid shear stress sensors that control neutrophil activation.

32 ompetitively inhibits the FPR1-induced human neutrophil activation.

33 alize at the cell surface without triggering neutrophil activation.

34 ficiency was shown to contribute to impaired neutrophil activation.

35 hat, unlike M1 or fibrinogen alone, leads to neutrophil activation.

36 trophil binding to erythrocytes and restored neutrophil activation.

37 t kinase isoforms have distinct functions in neutrophil activation.

38 signaling activity can set the timescale of neutrophil activation, adhesion, and diapedesis.

39 a indicate that the pathways leading to lung neutrophil activation after hemorrhage are different fro

40 Aldehyde generation required neutrophil activation and a free hydroxy-amino acid; it

41 than or equal to 55[corrected]%, indicating neutrophil activation and a reduced phagocytic capacity

42 In its early exudative phase, neutrophil activation and accumulation in the lung lead

43 However, neutrophil activation and accumulation into tissues trig

44 This study suggests that the neutrophil activation and adhesion may vary, depending o

45 We hypothesized that human neutrophil activation and adhesion vary, depending on th

46 e maladaptive activation of genes that cause neutrophil activation and adhesion, and induction of NO

47 demonstrated by the dose-related increase in neutrophil activation and adhesion.

48 tate in SCD between painful crises involving neutrophil activation and an abnormality of cytokine-reg

49 In this study, the relationship of neutrophil activation and apoptosis as related to releas

50 is work, we construct an integrated model of neutrophil activation and arrest that combines a biomech

51 2 has the ability to specifically potentiate neutrophil activation and chemotaxis in response to a ra

52 IL-8 involvement in neutrophil activation and chemotaxis may be important in

53 ravascular and extravascular fibrinogenesis, neutrophil activation and clearance, and alveolar fluid

54 impact of streptococcus-secreted factors on neutrophil activation and degranulation.

55 or that, in the absence of SpeB, can trigger neutrophil activation and degranulation.

56 s associated with systemic polymorphonuclear neutrophil activation and degranulation.

57 TLR2 mediates O. volvulus/Wolbachia-induced neutrophil activation and development of corneal haze.

58 receptors may act synergistically to amplify neutrophil activation and emigration in the inflamed vas

59 ired fibrinogen function are associated with neutrophil activation and enhanced reactive oxygen speci

60 rolling to firm adhesion is a key element of neutrophil activation and essential to the inflammatory

61 uggest that TF/FVIIa/PAR2 signaling mediates neutrophil activation and fetal death in APS and that st

62 These data suggest possible roles for neutrophil activation and for fibronectin in mediating s

63 y state granulopoiesis, as well as in mature neutrophil activation and function.

64 findings, inhibition of PGE2 led to enhanced neutrophil activation and host mortality after infection

65 Given roles for FcRs in ANCA-mediated neutrophil activation and IgA antibodies in mucosal immu

66 s a negative regulatory role in TLR2-induced neutrophil activation and in the development of related

67 -supplemented CHAB was sufficient to prevent neutrophil activation and intramacrophage killing and su

68 ts Cl, Br, or I) are metabolites mediated by neutrophil activation and its accompanying respiratory b

69 te that a main role of exogenous hVPLA(2) in neutrophil activation and LTB(4) biosynthesis is to acti

70 onstrate that LTB(4) plays a central role in neutrophil activation and migration to formyl peptides.

71 We first describe the discrete steps of neutrophil activation and migration to the site of infec

72 ntial for vagus nerve-mediated regulation of neutrophil activation and migration.

73 ion of proinflammatory genes associated with neutrophil activation and molecular pathways important t

74 w PSDP structural mimetic that blocked human neutrophil activation and mouse lung PI3K activity and i

75 Type I IFN-mediated neutrophil activation and NET formation may contribute t

76 2-/- mice treated with aPL exhibited reduced neutrophil activation and normal pregnancies, which indi

77 sed neutrophil recruitment, while increasing neutrophil activation and p38 activity at the site of in

78 r pathological venous thrombosis and present neutrophil activation and PAD4 as potential drug targets

79 One hallmark of inflammation is neutrophil activation and production of reactive oxygen

80 Analysis of signaling molecules mediating neutrophil activation and recruitment indicates reductio

81 he adhesion protein P-selectin would prevent neutrophil activation and reduce myocardial reperfusion

82 nks stress-induced inflammatory attacks with neutrophil activation and release of IL-1beta-bearing ne

83 estigate the relationships between H. pylori neutrophil activation and reported variations in HpNAP e

84 The effect was due to their regulation of neutrophil activation and sequestration.

85 n was inhibited by EDTA, which suggests that neutrophil activation and sheddase cleavage occurred.

86 trates that stimulation of FPRL-1 results in neutrophil activation and suggests that the receptor fun

87 evidence of platelet-neutrophil aggregates, neutrophil activation and surface MPO, and plasma MPO el

88 polymers act as a decoy mechanism to prevent neutrophil activation and that this represents an import

89 However, no relationship was found between neutrophil activation and the expression of HpNAP or dif

90 igens in FS implies a direct contribution of neutrophil activation and the production of NET-associat

91 e human-specific variant of resistin affects neutrophil activation and the severity of LPS-induced ac

92 epi LXA4), plays a critical role in limiting neutrophil activation and tissue inflammation, thus prom

93 The neutrophil uptake of NPs does not alter neutrophil activation and transmigration.

94 Here we analyzed how TF contributes to neutrophil activation and trophoblast injury in this mod

95 The association between neutrophil activation and vacuolating cytotoxin activity

96 Blocking FcalphaRI inhibited neutrophil activation and, as such, may represent an add

97 and lung microvascular thrombosis, decreased neutrophil activation, and averted histone-induced produ

98 es, production of proinflammatory mediators, neutrophil activation, and bacterial clearance.

99 increased neutrophil recruitment, decreased neutrophil activation, and decreased p38 activity at the

100 poor outcome are degree of oxidative stress, neutrophil activation, and infiltration of tissues, espe

101 hout affecting Mac-1 mobilization or general neutrophil activation, and inhibit cleavage of L-selecti

102 downregulation of PECAM-1 indicates an early neutrophil activation, and its inhibition may represent

103 risk factors, biomarkers of inflammation and neutrophil activation, and the presence of magnetic reso

104 f ADAM17 is highly inducible and occurs upon neutrophil activation as well as apoptosis.

105 roparticles/neutrophil count, a surrogate of neutrophil activation associated with septic shock-induc

106 supramolecular network that was required for neutrophil activation but was distinct from a fibrin clo

107 marrow chimeric mice and in vitro studies of neutrophil activation by anti-MPO IgG indicated that sev

108 pand on the possible roles of complement and neutrophil activation by dialysis membranes, which may p

109 ukocyte surface chondroitin sulfates promote neutrophil activation by enhancing immune-complex bindin

110 Neutrophil activation by FN, but not other extracellular

111 These studies demonstrate neutrophil activation by influenza virus and highlight t

112 depending on other stimuli, HS can suppress neutrophil activation by intercepting multiple receptor

113 r integrity, enterohepatic recirculation and neutrophil activation by luminal contents including bact

114 integrity, enterohepatic recirculation, and neutrophil activation by luminal contents, including bac

115 I3K) and PI3K-associated signaling events in neutrophil activation by MBP.

116 We evaluated neutrophil activation by measuring degranulation marker

117 fects of LPS required the presence of serum, neutrophil activation by MTB 19-kDa lipoprotein occurred

118 analysis, alanine aminotransferase, hepatic neutrophil activation by myeloperoxidase activity, and c

119 e that fluid shear stress exposure increases neutrophil activation by PAF, and, taken together with p

120 examined the intracellular signals following neutrophil activation by soluble E-selectin.

121 ns that mediate these functions, we examined neutrophil activation by the basement membrane protein,

122 eutrophil attractant IL-8, while PEPI blocks neutrophil activation by tumor necrosis factor, preventi

123 hrombosis, and specifically examined whether neutrophil activation can affect fibrinogen modification

124 Excessive neutrophil activation causes posttraumatic complications

125 In this study, neutrophil activation conditions generating high-affinit

126 Inappropriate neutrophil activation contributes to the pathogenesis of

127 zonensis or its lipophosphoglycan can induce neutrophil activation, degranulation, and LTB4 productio

128 l tumor cells, there is growing evidence for neutrophil activation driving tumor progression and meta

129 Acute CO poisoning causes intravascular neutrophil activation due to interactions with platelets

130 gocytic activation, and provides a marker of neutrophil activation during infection and inflammation.

131 ajor protein targets of calcium signaling in neutrophil activation during inflammatory disease.

132 An increase in markers of neutrophil activation (e.g., serum elastase) accompanies

133 ely with rising concentrations of markers of neutrophil activation (elastase/alpha 1 antitrypsin) and

134 Further supporting the role in neutrophil activation, EMR2 expression on circulating ne

135 On neutrophil activation, EMR2 is rapidly translocated to m

136 We discovered that erythrocytes suppressed neutrophil activation ex vivo and in vitro, including re

137 monocyte production of interleukins (IL) and neutrophil activation factors.

138 Neutrophil activation follows a 2-step process in which

139 Conversely, neutrophil activation for generation of Mac-1/CR3/uPAR c

140 f uPA to participate directly in LPS-induced neutrophil activation has not been examined.

141 d calcium entry (SOCE) are known to regulate neutrophil activation; however, the precise mechanism of

142 inflammatory monocytes can directly inhibit neutrophil activation in a PGE2-dependent manner.

143 Finally, LGALS3BP was able to inhibit neutrophil activation in a sialic acid- and Siglec-depen

144 ion between TF and PAR2, reduced aPL-induced neutrophil activation in aPL-treated mice.

145 We have previously reported a defect in neutrophil activation in children with polyarticular juv

146 ween acute respiratory distress syndrome and neutrophil activation in experimental pancreatitis in ra

147 ignaling through PAR2, inhibited aPL-induced neutrophil activation in mice that expressed human TF.

148 e than a decade ago it was demonstrated that neutrophil activation in plasma results in the time-depe

149 Mechanisms of neutrophil activation in response to chemoattractants re

150 shear stress exposure increased PAF-induced neutrophil activation in terms of L-selectin shedding, a

151 Together, these events induce neutrophil activation in the lungs, causing endothelial

152 was shown to increase, rather than decrease, neutrophil activation in the presence of platelet activa

153 in the microvasculature was shown to reduce neutrophil activation in the presence of the chemoattrac

154 d myeloperoxidase activity (one indicator of neutrophil activation in the recruited cells).

155 ular signaling pathways that are involved in neutrophil activation in the setting of ALI.

156 TAFIa abrogated C5a-induced neutrophil activation in vitro.

157 itiated phenotypic changes characteristic of neutrophil activation, including down-regulation of CD62

158 found that a variety of stimuli involved in neutrophil activation, including fMet-Leu-Phe (fMLP), pl

159 ral position in regulating endotoxin-induced neutrophil activation, including that involved in ALI.

160 rrelate with fluid shear stress exposure, as neutrophil activation increased in a shear stress magnit

161 OspA induce surface markers associated with neutrophil activation: increased CD10 and CD11b expressi

162 Recently, spinorphin was reported to block neutrophil activation induced by the chemotactic N-formy

163 inhibited the recruitment of T lymphocytes, neutrophil activation/infiltration, and repressed the ex

164 -induced matrix degradation, originated from neutrophil activation, initiated the formation of an amp

165 Neutrophil activation (intracellular oxidative burst act

166 tis (SAH) patients and their contribution to neutrophil activation, intracellular stress, and alterat

167 Limitation of unnecessary intravascular neutrophil activation is also important to prevent serio

168 However, neutrophil activation is also linked to autoimmune disea

169 Taken together, these findings indicate that neutrophil activation is an important mechanism by which

170 The appropriate regulation of neutrophil activation is critical for maintaining host d

171 ri factors previously suggested to stimulate neutrophil activation is the H. pylori neutrophil-activa

172 Thus, mechanically induced neutrophil activation is understood as the competition b

173 Upon neutrophil activation, L-selectin is rapidly and efficie

174 ecidual neutrophils expressed high levels of neutrophil activation markers and the angiogenesis-relat

175 included altered B-cell pathways, increased neutrophil activation markers, and increased reactive ox

176 n impaired host defenses, while simultaneous neutrophil activation may aggravate inflammation.

177 Although neutrophil activation may be beneficial at early stages

178 Neutrophil activation may play an important role in the

179 Understanding the mechanisms that underlie neutrophil activation, migration, survival and their var

180 During neutrophil activation, NE translocates to the nucleus to

181 fied a mechanistic link between ANCA-induced neutrophil activation, necroptosis, NETs, the AP, and en

182 Upon neutrophil activation, NSP4 was released into the supern

183 These data indicate that in neutrophils activation of MEKK in addition to Raf may un

184 epletion of DCs did not require infiltrating neutrophils, activation of nuclear factor-kappaB, or sig

185 In this study, we investigated the effect of neutrophil activation on endothelial monolayer integrity

186 ferences between the 2 major Akt isoforms in neutrophil activation on the basis of studies in which w

187 gen species production, suggesting decreased neutrophil activation or increased neutrophil exhaustion

188 ed cytokine and chemokine genes required for neutrophil activation or recruitment, growth factor rece

189 ate TREM-1 signaling to evaluate its role in neutrophil activation, pathogen clearance, proinflammato

190 This identifies a second neutrophil-activation pathway that is as important as ac

191 gnificantly correlated with peripheral blood neutrophil activation patterns (r = 0.75, p = 0.001 for

192 se results suggest that early alterations in neutrophil activation patterns, particularly involving t

193 ammatory diseases characterized by excessive neutrophil activation, PIPPs can serve as structural tem

194 ring episodes of vascular occlusion in which neutrophil activation plays a major role.

195 Neutrophil activation plays an important role in the inf

196 On neutrophil activation, polyisoprenyl diphosphate phospha

197 e investigated the role of B. cepacia LPS in neutrophil activation processes.

198 n levels, which highlights the importance of neutrophil activation, rather than the presence of neutr

199 Neutrophil activation releases granule proteins together

200 However, significant reduction in neutrophil activation remained compared to that of PBS a

201 presence of surface bound factor H enhanced neutrophil activation resulting in a two- to fivefold in

202 the vinyl ether bond of plasmalogens during neutrophil activation resulting in the production of alp

203 is secreted from mononuclear cells, causing neutrophil activation, resulting in the secretion of bac

204 ts (P < 0.01) which strongly correlated with neutrophil activation, rolling ligand P-selectin glycopr

205 Genes associated with neutrophil activation, ROS production, intracellular ant

206 ) binding to anti-PF4 antibody can stimulate neutrophil activation, similar to previous reports with

207 Neutrophil activation studies suggest that Pactolus does

208 lar diseases, this can result in exacerbated neutrophil activation, subsequent vascular injury and ob

209 ole of shear forces on earlier indicators of neutrophil activation, such as L-selectin shedding and a

210 degranulation, and Alternaria did not induce neutrophil activation, suggesting specificity for fungal

211 tor usage, and differential peripheral blood neutrophil activation that could contribute to HCMV diss

212 otential for rapid release of IFN-gamma upon neutrophil activation, the first step during responses t

213 e repairing the vascular damage inflicted by neutrophil activation, thereby maintaining vascular inte

214 atients, vary in level over time, and induce neutrophil activation through engagement with Fc recepto

215 olipids (lyso-PLs) may also signal for human neutrophil activation through G2A.

216 rocesses and also can potentiate LPS-induced neutrophil activation through interactions with its krin

217 Conversely, neutrophil activation through TLR4, as well as through a

218 Neutrophil activation to release granules containing pro

219 R2), and stimulation of this receptor led to neutrophil activation, trophoblast injury, and fetal dea

220 ce posttraumatic complications by preventing neutrophil activation via chemotactic factors released d

221 uggest that physiological shear forces alter neutrophil activation via FPR by reducing L-selectin she

222 Neutrophil activation via PAF was found to correlate wit

223 Neutrophil activation was assessed by measurement of sec

224 Neutrophil activation was assessed by measuring down-reg

225 egulation of inflammatory mediators of human neutrophil activation was investigated.

226 Neutrophil activation was observed at 30 min after reper

227 eaction was followed for 90 minutes, and the neutrophil activation was recorded as the total integrat

228 IgA and IgG ANCA together, IgG ANCA induced neutrophil activation was reduced (P = 0.0001).

229 Neutrophil activation was reduced by curcumin treatment

230 In this study, the effects of CD50 mAbs on neutrophil activation were examined.

231 Genes associated with platelet and neutrophil activation were expressed at higher levels in

232 LPS has been shown to be a major mediator of neutrophil activation which is accompanied by an early d

233 us, the secreted glycoprotein inhibits early neutrophil activation, which likely affects the host res

234 We also present a state diagram for neutrophil activation, which relates beta(2)-integrin de

235 different from ADAM17 stimulation upon overt neutrophil activation, which requires MAPK p38 or ERK, b

236 nate substances in blood products, result in neutrophil activation, which, in a susceptible patient,

237 to our knowledge, fully stochastic model of neutrophil activation, which, though simplified, can rec

238 ne the microvascular endothelial response to neutrophil activation with a focus on myosin light chain

239 -stage and midstage disease, and evidence of neutrophil activation with advanced disease.

240 n of both IL-12 and CCL2 was increased after neutrophil activation with IFN-gamma.