ライフサイエンスコーパス: neutrophil chemotaxis

1 duced the ability of keratinocytes to induce neutrophil chemotaxis.

2 ectodomain was assessed in wound healing and neutrophil chemotaxis.

3 macrophage- and DC-mediated monocyte but not neutrophil chemotaxis.

4 cell migration and is involved in regulating neutrophil chemotaxis.

5 renines, which act through the AHR to impair neutrophil chemotaxis.

6 his in turn results in elevated monocyte and neutrophil chemotaxis.

7 umulation of leukocytes in the airspaces and neutrophil chemotaxis.

8 a lower secretion of cytokines and a lack of neutrophil chemotaxis.

9 actin synthesis and cell polarization during neutrophil chemotaxis.

10 Akt activity also inhibited fMLP-stimulated neutrophil chemotaxis.

11 The chemokine receptor CXCR2 mediates neutrophil chemotaxis.

12 important role in regulation of IL-8-induced neutrophil chemotaxis.

13 ningitis through inhibition of IL-8-mediated neutrophil chemotaxis.

14 o degrade CXC chemokines, thereby preventing neutrophil chemotaxis.

15 LPS-stimulated alveolar macrophages induced neutrophil chemotaxis.

16 HLA-DR alleles was associated with impaired neutrophil chemotaxis.

17 th 875 microg/mL of surfactant did not alter neutrophil chemotaxis.

18 ntial, and impaired cellular ATP release and neutrophil chemotaxis.

19 d cell differentiation, cell activation, and neutrophil chemotaxis.

20 eta-glucan-stimulated B lymphocytes elicited neutrophil chemotaxis.

21 rophil chemokine production but promotion of neutrophil chemotaxis.

22 ablish domains for asthma diagnosis based on neutrophil chemotaxis.

23 nt AC9 activation and back retraction during neutrophil chemotaxis.

24 and mechanism of Rictor in the regulation of neutrophil chemotaxis.

25 ng assembly of the actin cytoskeleton during neutrophil chemotaxis.

26 receptors, causing significant impairment of neutrophil chemotaxis.

27 LR) activation motif and activates CXCR2 for neutrophil chemotaxis.

28 - and beta2-integrin activation and controls neutrophil chemotaxis.

29 ed Rac activation is necessary for efficient neutrophil chemotaxis.

30 t sacrificing the animal; and both 2D and 3D neutrophil chemotaxis.

31 ective for understanding the signals driving neutrophil chemotaxis.

32 ation experiment demonstrates MCP-1-mediated neutrophil chemotaxis.

33 of ARAP3 interferes with integrin-dependent neutrophil chemotaxis.

34 independently of actin reorganization during neutrophil chemotaxis.

35 in 1 and flotillin 2 in uropod formation and neutrophil chemotaxis.

36 neutrophil mobilization and MIP-2-dependent neutrophil chemotaxis.

37 further revealed an indirect effect of PT on neutrophil chemotaxis.

38 arget of rapamycin complex 2 (mTORC2) during neutrophil chemotaxis, a process that is mediated throug

39 ffects of anthrax lethal toxin (LT) on human neutrophil chemotaxis, a process that requires actin fil

40 pha9beta1 and alpha4 integrins contribute to neutrophil chemotaxis across activated endothelial monol

41 th human leukocytes each n-3 DPA-SPM reduced neutrophil chemotaxis, adhesion and enhanced macrophage

42 (4), LXA(4) analogs, and ATL analogs inhibit neutrophil chemotaxis, adhesion to epithelium, and epith

43 .5% mucus, whereas 2.5% mucus best supported neutrophil chemotaxis against gravity.

44 potent in stimulating eosinophil as well as neutrophil chemotaxis, also capable of initiating actin

45 Likewise, patient plasma induced neutrophil chemotaxis, an effect decreased by reduction

46 It is established that H. pylori stimulates neutrophil chemotaxis and a robust respiratory burst, bu

47 ding of syndecan-1 is an underlying cause of neutrophil chemotaxis and aberrant wound healing that ma

48 tudy the mechanism by which mTORC2 regulates neutrophil chemotaxis and AC9 activity.

49 s on these cells will promote macrophage and neutrophil chemotaxis and activation and thereby play a

50 y of chemokines that play a critical role in neutrophil chemotaxis and activation both in vitro and i

51 Although the effects of leukotrienes on neutrophil chemotaxis and activation have been establish

52 e with this, the response was accompanied by neutrophil chemotaxis and activation of the superoxide-p

53 ne response to bacterial infections includes neutrophil chemotaxis and activation, but regulation of

54 athogens must devise means to interfere with neutrophil chemotaxis and activation.

55 own to contribute to monocyte/macrophage and neutrophil chemotaxis and activation.

56 by recurrent pyogenic infections, defective neutrophil chemotaxis and bactericidal activity, and lac

57 disorders, GPP, PPP, and AGEP, converged on neutrophil chemotaxis and diapedesis and cytokines known

58 Accordingly, calpain inhibition decreased neutrophil chemotaxis and directional persistence in a g

59 8 MAPK pathway responsible for regulation of neutrophil chemotaxis and exocytosis are unknown.

60 Our results suggest that Hsp27 regulates neutrophil chemotaxis and exocytosis in an actin-depende

61 he calcium-dependent protease calpain during neutrophil chemotaxis and found that calpain inhibition

62 Neutrophil chemotaxis and glucose metabolism were not si

63 Although DPPI(-/-) mice have normal in vitro neutrophil chemotaxis and in vivo neutrophil accumulatio

64 Here, we show that FGP phage stimulate neutrophil chemotaxis and induce a pertussis toxin-sensi

65 nin receptor agonists inhibited IL-8-induced neutrophil chemotaxis and LPS-induced neutrophil recruit

66 ndings suggest that CXCR2 is responsible for neutrophil chemotaxis and margination induced by IL-8.

67 al, purinergic, and mTOR signaling regulates neutrophil chemotaxis and may be a pharmacological targe

68 iate an inflammatory cascade that can elicit neutrophil chemotaxis and neovascularization of the corn

69 n vivo effects of betaarr2 on CXCR2-mediated neutrophil chemotaxis and on cutaneous wound healing.

70 protein coupled receptor signaling, inhibits neutrophil chemotaxis and other inflammatory responses i

71 chemokine receptor-2 (CXCR2) ligand-mediated neutrophil chemotaxis and subsequent clearance of the in

72 kinase B) plays a central role in modulating neutrophil chemotaxis and superoxide generation in respo

73 ion and determine the specificity of Rac2 in neutrophil chemotaxis and superoxide generation.

74 isoform exhibit agonist-specific defects in neutrophil chemotaxis and superoxide production, despite

75 tion through p38 MAP kinase is necessary for neutrophil chemotaxis and that CRP intercedes through th

76 ntation of hyaluronan results in polymorphic neutrophil chemotaxis and that EC-SOD can completely pre

77 Baclofen, stimulated neutrophil chemotaxis and tubulin reorganization in a PI

78 vivo studies suggest that PT and ACT affect neutrophil chemotaxis and/or function, thereby altering

79 toration of innate immune functions of blood neutrophils (chemotaxis and reactive oxygen species prod

80 al allografts induced epithelial activation, neutrophil chemotaxis, and a shift toward a Th17 adaptiv

81 ade and tested for heparin binding, in vitro neutrophil chemotaxis, and in vivo neutrophil recruitmen

82 In vitro, thymosin beta4 sulfoxide inhibited neutrophil chemotaxis, and in vivo, the oxidized peptide

83 e tetrazolium tests, myeloperoxidase assays, neutrophil chemotaxis, and neutrophil chemotaxis assays,

84 aureus has the potential to thwart effective neutrophil chemotaxis, and phagocytosis, and succeeds in

85 ntribute to chronic inflammation by inducing neutrophil chemotaxis, and the reduction of these microv

86 ell arrays; microenvironment fabrication for neutrophil chemotaxis; and complex, covert tags by the t

87 effects of E. coli capsule and O antigen on neutrophil chemotaxis are novel, and they expand our und

88 mechanisms that regulate 3-dimensional (3D) neutrophil chemotaxis are poorly understood.

89 n response to deltaPT infection, implicating neutrophil chemotaxis as a possible target of PT activit

90 he stimulated alveolar macrophages increased neutrophil chemotaxis as compared with unstimulated alve

91 In addition, the FMLP-induced neutrophil chemotaxis as well as superoxide generation w

92 emokines involved in monocyte/macrophage and neutrophil chemotaxis, as well as numerous receptors and

93 action (2 and 24 hours), ELISA (6 hours), or neutrophil chemotaxis assay (24 hours).

94 Second, we validated the mouse neutrophil chemotaxis assay by comparing the adhesion an

95 ity of the cell supernatants was tested by a neutrophil chemotaxis assay.

96 Improvements in neutrophil chemotaxis assays have advanced our understan

97 Neutrophil chemotaxis assays were also used to evaluate

98 eroxidase assays, neutrophil chemotaxis, and neutrophil chemotaxis assays, revealed no identifiable a

99 e, and sample volume requirements to perform neutrophil chemotaxis assays.

100 )) from S. aureus were found to induce mouse neutrophil chemotaxis at 1-10 nM and superoxide producti

101 ata suggest that NO does not directly affect neutrophil chemotaxis but may indirectly alter chemotact

102 Thus, spinorphin blocks fMLF-induced neutrophil chemotaxis by acting as a specific antagonist

103 ScpB inhibits neutrophil chemotaxis by enzymatically cleaving the comp

104 esponse involves both a direct inhibition of neutrophil chemotaxis by estrogen and an altered express

105 PDase1 plays an important role in regulating neutrophil chemotaxis by facilitating the hydrolysis of

106 These results suggest that PECAM-1 regulates neutrophil chemotaxis by modulating cell motility and di

107 Third, we show that 2D and 3D neutrophil chemotaxis can be directly compared using our

108 Therefore, the neutrophil chemotaxis defect of IDDM appears to be indep

109 Mouse MCP-6 did not induce neutrophil chemotaxis directly in an in vitro assay, but

110 oepithelial layer; YbcL(UTI) did not inhibit neutrophil chemotaxis directly.

111 modulation of calpain activity may regulate neutrophil chemotaxis downstream of G-protein-coupled re

112 Molecules and pathways related to neutrophil chemotaxis emerged as common alterations in p

113 Rho GTPases control fundamental aspects of neutrophil chemotaxis: establishment of front and back a

114 , N-t-BOC-sensitive, and N-t-BOC-insensitive neutrophil chemotaxis ex vivo when cell-free bronchoalve

115 patients with OB was bioactive, we performed neutrophil chemotaxis experiments that showed that IL-8

116 Decreased neutrophil chemotaxis following exposure to rhAPC was co

117 ementation of neutrophils, and assessment of neutrophil chemotaxis following FL treatment.

118 Ad19 infection of HCFs increased neutrophil chemotaxis from a baseline of 0.4+/-0.7 cells

119 Neutralization of CXCL1 and IL-8 reduced neutrophil chemotaxis >50% to supernatants from IL-1beta

120 Depressed neutrophil chemotaxis has been demonstrated in IDDM and

121 cyl-phenylalanine (fMLP) and plays a role in neutrophil chemotaxis, has been implicated as a fluid sh

122 Blockade of interleukin-1, or of neutrophil chemotaxis, has reduced infarct volume in mod

123 bind to chemoattractants and play a role in neutrophil chemotaxis, have been implicated as fluid she

124 Vitamin D deficiency modestly impairs neutrophil chemotaxis; however, it does not affect lung

125 Discoidin domain receptor 2 (DDR2) promotes neutrophil chemotaxis in 3D by triggering matrix metallo

126 2D surfaces but is an important regulator of neutrophil chemotaxis in 3D collagen matrices.

127 lagen-derived extracellular signaling during neutrophil chemotaxis in 3D matrices.

128 (10 to 500 micrograms/ml) inhibited in vitro neutrophil chemotaxis in a concentration-dependent fashi

129 on of HLA-DR3, -DR4, and -DR53 with impaired neutrophil chemotaxis in an IDDM sample.

130 We describe neutrophil chemotaxis in response to a combination of a

131 Functionally, this was related to impaired neutrophil chemotaxis in response to CWF-conditioned med

132 Neutrophil chemotaxis in response to exogenous interleuk

133 This study brings new knowledge about neutrophil chemotaxis in the context of cell-to-cell com

134 Neutrophil chemotaxis in the direction of gravity was op

135 PAF mediates both apoptosis and neutrophil chemotaxis in the pancreas.

136 dogenous anti-inflammatory agents that block neutrophil chemotaxis in vitro and inhibit neutrophil in

137 Consistent with this, neutrophil chemotaxis in vitro and neutrophil mobilizati

138 oncentrations of 2-chlorohexadecanal induced neutrophil chemotaxis in vitro suggesting that alpha-chl

139 We investigated the involvement of STIM1 in neutrophil chemotaxis in vitro, as well as during chroni

140 , N-t-BOC-sensitive, and N-t-BOC-insensitive neutrophil chemotaxis in vitro.

141 RP shown to inhibit C5a- and FMLP-stimulated neutrophil chemotaxis in vitro.

142 The mutants have a 10-fold decrease in neutrophil chemotaxis in vitro.

143 iously unknown mechanism of bacterial-guided neutrophil chemotaxis in vivo, providing insight into th

144 cally activates IL-8 and, thereby, regulates neutrophil chemotaxis in vivo.

145 The neutrophil chemotaxis index of 41 diabetics and 27 contr

146 B 225002 potently inhibited human and rabbit neutrophil chemotaxis induced by both IL-8 and GROalpha.

147 Spinorphin did not affect mouse neutrophil chemotaxis induced by concentrations of fMLF

148 chemotactic agonist and effectively blocked neutrophil chemotaxis induced by fMLF at concentrations

149 Recombinant IL-26 potentiated neutrophil chemotaxis induced by IL-8 and fMLP but decre

150 In addition, neutrophil chemotaxis induced by interleukin-8 was signi

151 d and exogenous syndecan-1 ectodomain induce neutrophil chemotaxis, inhibit alveolar epithelial wound

152 Neutrophil chemotaxis is a critical component of the inn

153 In vitro, neutrophil chemotaxis is affected in the mutant.

154 poxilin A3-driven transepithelial migration, neutrophil chemotaxis is amplified through neutrophil pr

155 of neutrophils, and in the absence of PDK1, neutrophil chemotaxis is impaired.

156 ther well-known eicosanoid mediating general neutrophil chemotaxis is leukotriene B4 (LTB4).

157 relevance of this TRPC6-depending defect in neutrophil chemotaxis is underscored by our in vivo find

158 CP-105,696 inhibited LTB4-mediated monkey neutrophil chemotaxis (isolated cells, LTB4 = 5 nM) and

159 howed that Rac2 is an essential regulator of neutrophil chemotaxis, L-selectin capture and rolling, a

160 trophils and is responsible for the abnormal neutrophil chemotaxis LAP.

161 r understanding of biochemical regulation of neutrophil chemotaxis, little is known about how mechani

162 understanding of the molecules that control neutrophil chemotaxis may impact our knowledge of autoim

163 examined the involvement of CD38 in abnormal neutrophil chemotaxis of LAgP patients.

164 As shown previously for neutrophils, chemotaxis of primary dermal fibroblasts to

165 First, the neutrophil chemotaxis on endothelial cells revealed 2 di

166 o-L-arginine) altered FMLP- or IL-8-elicited neutrophil chemotaxis (P > .25 for all).

167 Neutrophil chemotaxis plays an essential role in innate

168 These data suggest that PI3Kgamma regulates neutrophil chemotaxis primarily by controlling the direc

169 ed to affect primarily the directionality of neutrophil chemotaxis rather than motility, whereas knoc

170 ontribution of this GSK3-mediated pathway to neutrophil chemotaxis regulation depended on neutrophil

171 Neutrophil chemotaxis requires excitatory signals at the

172 In vitro human polymorphic neutrophil chemotaxis studies indicate that oxidative fr

173 t with 292 microg/mL significantly decreased neutrophil chemotaxis suggesting that at low concentrati

174 ynergy between intact SAA1alpha and CXCL8 in neutrophil chemotaxis, suggesting that this peptide bind

175 s mitochondrial protein biosynthesis, induce neutrophil chemotaxis, the generation of reactive oxygen

176 the CXC subfamily of chemokines, induces in neutrophils chemotaxis, the respiratory burst, granule r

177 rin and reversed fMLP's inhibitory effect on neutrophil chemotaxis through fibrin.

178 Thus, CD38 controls neutrophil chemotaxis to bacterial chemoattractants thro

179 was used to explore conditions that trigger neutrophil chemotaxis to Chlamydia trachomatis infected

180 Finally, we demonstrate that neutrophil chemotaxis to fMLP is dependent on Ca++ mobil

181 al-relay molecule that exquisitely regulates neutrophil chemotaxis to formyl peptides, which are prod

182 Similarly, C5a inhibited neutrophil chemotaxis to IL-8 and Gro-alpha.

183 use of morpholino oligonucleotides restores neutrophil chemotaxis to wounds.

184 dentify Fer as a novel inhibitory kinase for neutrophil chemotaxis toward end target chemoattractants

185 -induced upregulation of proinflammatory and neutrophil chemotaxis transcripts and there was downregu

186 The dynamics of neutrophil chemotaxis under competing chemoattractant gr

187 Whereas dasatinib inhibited neutrophil chemotaxis under static conditions in 2 dimen

188 This study identifies neutrophil chemotaxis velocity as a potential biomarker

189 proteins, we hypothesized that CRP inhibits neutrophil chemotaxis via inhibition of MAP kinase activ

190 Ex vivo neutrophil chemotaxis was evaluated, using neutrophils f

191 reduced in Tph1(-/-) mice, whereas in vitro neutrophil chemotaxis was independent of serotonin.

192 Neutrophil chemotaxis was significantly suppressed by th

193 In vitro, neutrophil chemotaxis was stimulated by PTHrP 1-34.

194 he hemopoietic cell-restricted PI3K delta in neutrophil chemotaxis, we have developed a potent and se

195 The random migration and neutrophil chemotaxis were significantly reduced.

196 thelial barrier function along with impaired neutrophil chemotaxis were the underlying mechanisms tha

197 Exudate levels of NO, a known inhibitor of neutrophil chemotaxis, were higher in F344, compared wit

198 each chemoattractant contributes to overall neutrophil chemotaxis within complex physiological envir

199 rophils under inflammatory conditions; mouse neutrophil chemotaxis without sacrificing the animal; an