ライフサイエンスコーパス: neutrophil elastase

1 lung against proteolytic damage (e.g., from neutrophil elastase).

2 granule enzymes, myeloperoxidase, and human neutrophil elastase.

3 with human histone H3 and with the specific neutrophil elastase.

4 helial cells was upregulated by wounding and neutrophil elastase.

5 een in normal HBECs, even in the presence of neutrophil elastase.

6 nsisted of eDNA, histones, cathelicidin, and neutrophil elastase.

7 ly on the NADPH oxidase, myeloperoxidase, or neutrophil elastase.

8 with severe asthma were stained for OSM and neutrophil elastase.

9 in significant levels of the histone H2Ax or neutrophil elastase.

10 realized a selectivity of 307 against human neutrophil elastase.

11 ect the lung against proteolytic damage from neutrophil elastase.

12 as a minimal promoter for the expression of neutrophil elastase.

13 orbol 12-myristate 13-acetate and with human neutrophil elastase.

14 efore strongly influenced by the presence of neutrophil elastase.

15 ol) is a small molecular weight inhibitor of neutrophil elastase.

16 ssion in early myeloid cells with or without neutrophil elastase.

17 residue domain required for interaction with neutrophil elastase.

18 P3 perturbs the intracellular trafficking of neutrophil elastase.

19 xpression of matrix metalloproteinase-12 and neutrophil elastase.

20 rease of the stoichiometry of inhibition for neutrophil elastase.

21 n lead to emphysema by loss of inhibition of neutrophil elastase.

22 in that retained inhibitory activity against neutrophil elastase.

23 ecies, the enzymes myeloperoxidase (MPO) and neutrophil elastase.

24 tion of injury, depending on the presence of neutrophil elastase.

25 uding myeloperoxidase (MPO), azurocidin, and neutrophil elastase.

26 rations and reduced levels of membrane-bound neutrophil elastase.

27 acids to explore the S1-S4 pockets of human neutrophil elastase.

28 cting its selectivity against pancreatic and neutrophil elastases.

29 We investigated whether neutrophil elastase, a biased agonist of PAR(2), causes

30 Neutrophil elastase, a component of the innate host defe

31 with anthrax lethal toxin release bioactive neutrophil elastase, a proinflammatory mediator of tissu

32 h is synthesized by the liver, is to inhibit neutrophil elastase, a protease that degrades connective

33 for ensuring tissue integrity by inhibiting neutrophil elastase, a protease that degrades elastin.

34 gic basis for the prognostic significance of neutrophil elastase, a serine protease found in neutroph

35 ses have mutations in the ELA2 gene encoding neutrophil elastase, a significant proportion remain und

36 cyte viability, and inhibited the release of neutrophil elastase--a marker of neutrophil extracellula

37 city that was dependent on the expression of neutrophil elastase; a mutant form of PML-RARalpha that

38 inases (i.e., collagenases, gelatinases) and neutrophil elastase activities.

39 , 2.27; 95% CI, 1.24 to 4.14; P=0.008), free neutrophil elastase activity in BAL fluid (odds ratio, 3

40 Free neutrophil elastase activity in BAL fluid at 3 months of

41 Neutrophil elastase activity in BAL fluid in early life

42 , measured as matrix metalloproteinase 9 and neutrophil elastase activity in culture supernatant, as

43 n anthrax lethal toxin-dependent increase in neutrophil elastase activity in vivo as well.

44 Sputum neutrophil elastase activity is a biomarker of disease s

45 elivery and utilize more specific markers of neutrophil elastase activity to inform on the efficacy o

46 Furthermore, neutrophil elastase activity was significantly increased

47 lay low cytotoxicity in vitro, inhibit human neutrophil elastase activity, and inhibit the migration

48 Hydroxy-2'-deoxyguanosine (8-OHdG) and human neutrophil elastase/alpha1-proteinase inhibitor (HNE/alp

49 Platelet SLPI inhibits neutrophil elastase, an activity that is reduced when be

50 Neutrophil elastase and alpha 1-antitrypsin are a pair o

51 ced mucin secretion induced by PAR agonists, neutrophil elastase and ATP in two airway epithelial cel

52 mutants were more effective in reducing the neutrophil elastase and cathepsin G activities in an in

53 Neutrophil elastase and cathepsin G are abundant intrace

54 pithelial surface, and allows the control of neutrophil elastase and cathepsin G by their natural inh

55 ants is not affected by the sequestration of neutrophil elastase and cathepsin G onto surfaces.

56 of cathepsin C and its downstream proteases (neutrophil elastase and cathepsin G) and serum levels of

57 I-1 could be engineered to inhibit and clear neutrophil elastase and cathepsin G.

58 ucted yeast two-hybrid screens with Gfi1 and neutrophil elastase and detected a novel protein, PFAAP5

59 The inverse relationship identified between neutrophil elastase and IRS-1 in LSL-K-ras mice was also

60 the loss of function of AAT in neutralizing neutrophil elastase and other pro-inflammatory enzymes.

61 ode proinflammatory molecules; and levels of neutrophil elastase and p50 nuclear factor kappaB) were

62 bone marrow that lacked DPPI or lacked both neutrophil elastase and proteinase 3 protected mice from

63 We report here that both neutrophil elastase and proteinase-3 cleave the human PA

64 t non-canonical tethered ligands unmasked by neutrophil elastase and proteinase-3, as well as synthet

65 RATIONALE: Sputum neutrophil elastase and serum desmosine, which is a link

66 d with SIV, which dose-dependently inhibited neutrophil elastase and shortened resolution intervals.

67 ishmania major by macrophages in response to neutrophil elastase and TLR4 via TNFalpha and IFNbeta.

68 Neutrophil elastase and TNF, present in higher amounts i

69 dition, neutrophils genetically deficient in neutrophil elastase and/or cathepsin G were impaired in

70 staining using neutrophil markers (CD66b and neutrophil elastase) and NET markers (citrullinated hist

71 bset markers (CD68, CD3, CD8, CD4, CD20, and neutrophil elastase) and selected inflammatory markers (

72 n of azurophilic (CD63, myeloperoxidase, and neutrophil elastase) and specific (CD66b and lactoferrin

73 matrix metalloproteinases, cathepsin K, and neutrophil elastase, and a variety of invertebrates and

74 ions in the gene ELA2, encoding the protease neutrophil elastase, and familial platelet disorder with

75 ociated with increases in neutrophil counts, neutrophil elastase, and IL-1beta and declines in NEAPCs

76 granule proteases, such as myeloperoxidase, neutrophil elastase, and matrix metalloproteinase 9, act

77 trophil serine proteases (NSPs) cathepsin G, neutrophil elastase, and proteinase 3, which are enzymes

78 h the proteases trypsin, chymotrypsin, human neutrophil elastase, and Pseudomonas aeruginosa elastase

79 e have a significant survival advantage over neutrophil elastase(+/+) animals following exposure to a

80 nduced intestinal ulceration and bleeding in neutrophil elastase(+/+) animals, but not in neutrophil

81 neutrophil elastase(+/+) animals, but not in neutrophil elastase(-/-) animals.

82 , and TNF-alpha increased over time, whereas neutrophil elastase antiprotease complexes (NEAPCs) and

83 hil-derived serine proteases cathepsin G and neutrophil elastase are implicated in the host defense a

84 size that small molecule inhibitors of human neutrophil elastase are ineffective because of rapid cle

85 Inhibitors of neutrophil elastase are now entering clinical trials wit

86 Mutations of ELA2, encoding neutrophil elastase, are present in approximately 50% of

87 identified serine proteases, and especially neutrophil elastase, as candidates.

88 P. aeruginosa to the bactericidal effect of neutrophil elastase, as well as this organism's ability

89 as attenuated significantly by inhibition of neutrophil elastase but not caspase-1.

90 ulting in alphaMbeta2-independent release of neutrophil elastase, but inhibition of elastase activity

91 ecombinant proteins, we have identified that neutrophil elastase, but not other neutrophil derived pr

92 ion by 0.5 +/- 1.3 log10 pg/ml (p<0.05), and neutrophil elastase by 0.4 +/- 0.7 log10 microg/ml (p<0.

93 Mutations of ELA2, encoding the protease neutrophil elastase, can cause both disorders.

94 yeloid molecular markers such as PRTN3, MPO, Neutrophil elastase, Cathepsin G, and Eosinophil peroxid

95 man patients we also excluded ADAM10, ADAM8, neutrophil elastase, cathepsin G, and proteinase 3 from

96 Whereas neutrophil elastase, cathepsin G, and proteinase 3 have

97 The activities of three serine proteases (neutrophil elastase, cathepsin G, and proteinase 3), whi

98 anule-associated serine proteases, including neutrophil elastase, cathepsin G, and proteinase 3.

99 e we show that treatment of hepatocytes with neutrophil elastase causes cellular insulin resistance a

100 le-3-Grabbing Non-integrin (DC-SIGN), CD123, neutrophil elastase, CD31, and carbonic anhydrase 9.

101 ient in the serine proteases cathepsin G and neutrophil elastase (CG/NE neutrophils) exhibit severe d

102 a mutant form of PML-RARalpha that resisted neutrophil elastase cleavage was not toxic.

103 Neutrophil elastase cleaves N2N within EGF repeats in vi

104 Here, we show that human neutrophil elastase cleaves thrombin, generating 11-kDa

105 L-1beta, TNFalpha, IL-6, procathepsin B, and neutrophil elastase concentrations in SF from injured kn

106 lavage fluid, which correlated with IL-8 and neutrophil elastase, consistent with neutrophil recruitm

107 ophils migrate into the airway, and released neutrophil elastase contributes to the progression of th

108 Systemic expression of CXCL1, CXCL5, and neutrophil elastase correlated with measures of MS lesio

109 PMN lysates and neutrophil elastase could degrade recombinant human IL-1

110 , thus delineating a mechanism through which neutrophil elastase could regulate its own synthesis.

111 In contrast to neutrophil elastase, CTSS activity was detectable in 100

112 , we show that IC-activated cathepsin G- and neutrophil elastase-deficient (CG/NE) PMNs adhered norma

113 neutrophil elastase in pulmonary emphysema, neutrophil elastase-deficient mice and wild-type litterm

114 ting NET components by DNAse1 application or neutrophil elastase-deficient mice protected mice from A

115 dary to decreased macrophage accumulation in neutrophil elastase-deficient mice.

116 Immunoprecipitation studies showed that, as neutrophil elastase degraded IRS-1, there was increased

117 -related enzymes such as myeloperoxidase and neutrophil elastase did not contribute in mounting CNS i

118 ane(+/+) mice died, none of the mice lacking neutrophil elastase died.

119 Neutrophil elastase directly induced tumor cell prolifer

120 synthesis is initiated at the codon ATG) of neutrophil elastase (ELANE) result in the production of

121 Mutations in the gene for neutrophil elastase, ELANE, cause cyclic neutropenia (Cy

122 To determine the role of neutrophil elastase (encoded by Elane) on tumor progress

123 n and early emphysema in a low AAT, and high neutrophil elastase environment in the lungs of affected

124 the microenvironment that was independent of neutrophil elastase enzymatic activity.

125 lar-mass forms by direct inhibition of human neutrophil elastase enzymatic activity.

126 C-terminal processing of neutrophil elastase exposes an AP3 interaction signal re

127 ML-RARalpha functions should be evaluated in neutrophil elastase-expressing early myeloid cells.

128 -17 upregulated matrix-metalloprotease-9 and neutrophil elastase expression, two proteases involved i

129 To better understand the role of neutrophil elastase for the pathogenesis of APL, we exam

130 leukemia-specific antigens proteinase 3 and neutrophil elastase found in the primary (azurophil) gra

131 ant mutations of ELA2, encoding the protease neutrophil elastase, found in lysosome-like granules, ca

132 defective translocation of VLA-3, VLA-6, and neutrophil elastase from intracellular vesicles to the s

133 xhibited striking antigen-specific uptake of neutrophil elastase from the microenvironment that was i

134 F), and the majority harbor mutations in the neutrophil elastase gene.

135 Mast cell/neutrophil cathepsin G and neutrophil elastase generate similar fragments of HGF by

136 demonstrated that the initial measurement of neutrophil elastase had the highest individual predictiv

137 Neutrophil elastase has been shown to be present in the

138 rmination of sputum biomarkers, particularly neutrophil elastase, has predictive value for subsequent

139 Recent descriptions of antibodies to human neutrophil elastase have provided insight into the occur

140 rated that SPLUNC1 enhanced Mp-induced human neutrophil elastase (HNE) activity, and HNE directly inh

141 inhibitor of serine proteases such as human neutrophil elastase (HNE) and a NF-kappaB regulatory age

142 the TSP-1 type 3 repeats that inhibits human neutrophil elastase (HNE) and binds to human neutrophils

143 ical inflammatory salivary biomarkers, Human Neutrophil Elastase (HNE) and Cathepsin-G, was construct

144 Human neutrophil elastase (HNE) and proteinase 3 (PR3) are str

145 The serine proteases, neutrophil elastase (HNE) and proteinase 3 (PR3), are ab

146 Human neutrophil elastase (HNE) and proteinase 3 (PRO3) are my

147 Human neutrophil elastase (HNE) exists in high concentrations

148 Human Neutrophil Elastase (HNE) is a serine protease that is h

149 Human neutrophil elastase (HNE) is an attractive target for tr

150 Human neutrophil elastase (HNE) is an important therapeutic ta

151 ha1PI complexes with trypsin, PPE, and human neutrophil elastase (HNE) showed similar rates of deacyl

152 bodies that inhibit bovine trypsin and human neutrophil elastase (HNE) with low nanomolar affinities.

153 rine proteases, proteinase 3 (PR3) and human neutrophil elastase (HNE), are considered as targets for

154 components, myeloperoxidase (MPO) and human neutrophil elastase (HNE), are inflammatory markers in C

155 ibitors of serine proteases, including human neutrophil elastase (HNE), has been elucidated by determ

156 tion of 2'-F purine aptamers that bind human neutrophil elastase (HNE).

157 requirements of heparin inhibition of human neutrophil elastase (HNE).

158 s it different from its structural homologue neutrophil elastase (HNE).

159 deficient patients is based on inhibition of neutrophil elastase; however, the benefit of this treatm

160 or subsequent lung function decline, whereas neutrophil elastase, IL-8, and IL-6 had the highest comb

161 Although neutrophil elastase immunostaining was intense in the ep

162 This study demonstrates a direct role for neutrophil elastase in emphysema and highlights the inte

163 ular insulin resistance and that deletion of neutrophil elastase in high-fat-diet-induced obese (DIO)

164 l toxin, thereby establishing a key role for neutrophil elastase in mediating the deleterious effects

165 ted study from our laboratory had identified neutrophil elastase in mucus as the molecule responsible

166 A model is proposed wherein neutrophil elastase in mucus proteolytically cleaves the

167 lso no role for lysosomal destabilization or neutrophil elastase in pneumolysin-mediated IL-1beta pro

168 To address the role of neutrophil elastase in pulmonary emphysema, neutrophil e

169 omenon occurs in response to the presence of neutrophil elastase in such mucus.

170 of the enzymes plasmin, myeloperoxidase, and neutrophil elastase in the inflamed paw joints of Tnfip6

171 t validation cohort, a high concentration of neutrophil elastase in the wound was associated with inf

172 ociation of autoimmunity to proteinase 3 and neutrophil elastase in Wegener's granulomatosis, support

173 ly reported that in addition to neutralizing neutrophil elastases in the extracellular compartment, A

174 int to a novel role for the serine protease, neutrophil elastase, in matrix breakdown by macrophages,

175 Matrix metalloproteinase-7 and neutrophil elastase induced the release of MUC16 but not

176 We used this construct to prevent human neutrophil elastase-induced emphysema in a rodent model.

177 Rottlerin also reduced PMA- or human neutrophil elastase-induced phosphorylation of myristoyl

178 ese altered proteins, expression of monocyte/neutrophil elastase inhibitor was increased, whereas ela

179 dy blocker of AQP4-IgG binding), sivelestat (neutrophil elastase inhibitor), and eculizumab (compleme

180 Sivelestat, a neutrophil elastase inhibitor, and aquaporumab, a nonpat

181 tor, alpha(1)-antichymotrypsin, and monocyte-neutrophil elastase inhibitor.

182 g effect, which was negated using a specific neutrophil elastase inhibitor.

183 abrogated by NET inhibition with DNAse or a neutrophil elastase inhibitor.

184 Clinical trials with neutrophil elastase inhibitors in lung and cardiovascula

185 nslating results of preclinical studies with neutrophil elastase inhibitors remains challenging.

186 biological characterization of potent human neutrophil elastase inhibitors, which offer reversible c

187 aminoalkylphosphonate diaryl esters as human neutrophil elastase inhibitors.

188 d that mucin hypersecretion induced by human neutrophil elastase involves activation of protein kinas

189 In vitro studies demonstrate that neutrophil elastase is a key player in the LTB4 inflamma

190 Neutrophil elastase is a likely effector of Mac-1 becaus

191 Neutrophil elastase is believed to be an important media

192 own that the early myeloid-specific protease neutrophil elastase is important for APL development in

193 Elafin, an endogenous inhibitor of neutrophil elastase, is expressed in human mammary epith

194 components of neutrophil granules, including neutrophil elastase, lactoferrin, cathepsin G, proteinas

195 Using caspase-3, caspase-7, caspase-8, neutrophil elastase, legumain, and two matrix metallopro

196 roteases, including dipeptidyl peptidase-IV, neutrophil elastase, matrix metalloproteinase-2 (MMP-2),

197 al peptides SLPI and elafin by virus-induced neutrophil elastase may precipitate these secondary bact

198 e and aprotinin), affords protection against neutrophil elastase-mediated ENaC activation and Pseudom

199 Moreover, neutrophil elastase(-/-) mice have a significant surviva

200 Excess neutrophil elastase might facilitate cancer development

201 Conversely, raised concentrations of neutrophil elastase might promote the development, invas

202 Neutrophil elastase modulated killing of breast cancer c

203 The propensity of individual neutrophil elastase mutants to misfold may determine the

204 Nucleosomes, double-stranded DNA, neutrophil elastase, myeloperoxidase, and myeloid-relate

205 observed in NPs, showed colocalization with neutrophil elastase (n = 10), and did not colocalize wit

206 ent inhibitor of neutrophil serine proteases neutrophil elastase (NE) and cathepsin G (CG).

207 y related to neutrophil proteases, including neutrophil elastase (NE) and cathepsin G.

208 The expression of neutrophil elastase (NE) and CCAAT enhancer-binding prot

209 densation dependent upon the enzymes (PAD4), neutrophil elastase (NE) and myeloperoxidase (MPO).

210 hil cytoplasmic antibodies (ANCA) binding to neutrophil elastase (NE) and proteinase 3 (PR3) are dete

211 on fine-tunes the RCL cleavage rate by human neutrophil elastase (NE) and Pseudomonas aeruginosa elas

212 Levels of neutrophil elastase (NE) and the nuclear factors CCAAT/e

213 rophil serine proteases cathepsin G (CG) and neutrophil elastase (NE) are involved in immune-regulato

214 Mutations in the ELA2 gene encoding neutrophil elastase (NE) are present in most patients wi

215 Mutations of the ELA2 gene encoding neutrophil elastase (NE) are responsible for most cases

216 Neutrophil elastase (NE) can be rapidly taken up by tumo

217 nstrated that the azurophil granule protease neutrophil elastase (NE) cleaves promyelocytic leukemia-

218 Local proteolytic cleavage of EC JAM-C by neutrophil elastase (NE) drove this cascade of events as

219 inhibitor) expression and downregulation of neutrophil elastase (NE) expression induced by obstructi

220 Mutations in ELANE encoding neutrophil elastase (NE) have been identified in the maj

221 ation constant with its primary target human neutrophil elastase (NE) in lipoprotein-containing plasm

222 of MMP (TIMP)-1, myeloperoxidase (MPO), and neutrophil elastase (NE) in patients with hypertension a

223 BACKGROUND.: A neutrophil elastase (NE) inhibitor, Sivelestat, has been

224 Neutrophil elastase (NE) is a neutrophil-derived serine

225 Neutrophil elastase (NE) is a serine protease of relevan

226 Human neutrophil elastase (NE) plays an important role in the

227 von Willebrand factor and reveal significant neutrophil elastase (NE) proteolytic activity.

228 We show that C-sep isolated PMNs show higher neutrophil elastase (NE) release following activation by

229 evidence from clinical studies suggests that neutrophil elastase (NE) released in neutrophilic airway

230 ssociated peptide from proteinase 3 (P3) and neutrophil elastase (NE) that is recognized by PR1-speci

231 lease by downregulating the translocation of neutrophil elastase (NE) to the nucleus.

232 y of purified human lubricin to digestion by neutrophil elastase (NE) was examined by Western blottin

233 ease inhibitors and was impaired in infected neutrophil elastase (NE)(-/-) corneas.

234 We investigated neutrophil elastase (NE), a potent serine protease detec

235 ied with the extracellular release of active neutrophil elastase (NE), a potent serine protease.

236 Neutrophil elastase (NE), a serine protease stored in th

237 loproteinase (MMP)-9, myeloperoxidase (MPO), neutrophil elastase (NE), and MMP-9/tissue inhibitor of

238 Purified NSPs cathepsin G (CG), neutrophil elastase (NE), and proteinase 3 cleaved C5aR

239 A2 encoding the neutrophil granule protease, neutrophil elastase (NE), are the major cause of the 2 m

240 decades, only three active serine proteases, neutrophil elastase (NE), cathepsin G (CG), and proteina

241 azurophil granule serine proteinases, human neutrophil elastase (NE), cathepsin G (CG), and proteina

242 llowing neutrophil and macrophage proteases: neutrophil elastase (NE), cathepsin G, proteinase-3, and

243 itor (ISP2; Deltaisp2/isp3), an inhibitor of neutrophil elastase (NE), died in RAW cells or macrophag

244 rine proteases, such as cathepsin G (CG) and neutrophil elastase (NE), have been implicated in the pr

245 To investigate the levels of neutrophil elastase (NE), matrix metalloproteinases (MMP

246 ivity of neutrophil serine proteases (NSPs): neutrophil elastase (NE), proteinase 3, and cathepsin G.

247 iminished levels of the natural inhibitor of neutrophil elastase (NE), secretory leukocyte protease i

248 Plasma levels of neutrophil elastase (NE), total and active matrix metall

249 phil granule proteases proteinase 3 (P3) and neutrophil elastase (NE), which are both found in the tu

250 y mutations of the ELANE gene, which encodes neutrophil elastase (NE).

251 ice deficient in the antimicrobial molecule, neutrophil elastase (NE).

252 rways are chronically injured by exposure to neutrophil elastase (NE).

253 gous point mutations in ELANE, which encodes neutrophil elastase (NE).

254 component of the epithelial barrier against neutrophil elastase (NE).

255 elop emphysema, much interest has focused on neutrophil elastase (NE).

256 ermline mutations in the ELANE gene encoding neutrophil elastase (NE).

257 Proteolytic resistance analysis with human neutrophil elastase, one major protease contained in azu

258 Disruption of either neutrophil elastase or AP3 perturbs the intracellular tr

259 onstrate that inhibiting NETosis by blocking neutrophil elastase or by degrading NETs with DNase prot

260 Therapy targeting neutrophil elastase or enhancing innate immunity may be

261 ADAMTS13 treated with either neutrophil elastase or plasmin was inhibited to a lesser

262 hange in bronchiectasis score was related to neutrophil elastase (P < 0.001) with CF-CT.

263 Bx (P = 0.001) with PRAGMA-CF was related to neutrophil elastase presence at age 3, whereas only the

264 Finally, siRNA ablation of neutrophil elastase protein production in MDA-MB-231 cel

265 ations result in the production of misfolded neutrophil elastase protein, activation of the unfolded

266 eutrophil-derived serine proteinases (NSPs): neutrophil elastase, proteinase-3, and cathepsin G degra

267 a deficiency of Mac-1 or the kinases blocked neutrophil elastase release in vitro.

268 This led to neutrophil elastase release, causing hemorrhage, fibrin

269 Neutrophil elastase removed 68% of MUC16, 78% of which w

270 ent irreversible peptidyl inhibitor of human neutrophil elastase reported to date.

271 Immunostaining of human NMO lesions for neutrophil elastase revealed many degranulating perivasc

272 by phorbol 12-myristate 13-acetate and human neutrophil elastase, suggesting that PKCdelta and PKC ar

273 ividuals without mutations in ELA2 (encoding neutrophil elastase), the most common cause of severe co

274 Sputum neutrophil elastase, tissue inhibitor of metalloproteina

275 These findings strongly indicate neutrophil elastase to be a key enzyme in the biological

276 Expression of PFAAP5 allows neutrophil elastase to potentiate the repression of Gfi1

277 l application of recombinant mMCP-5 or human neutrophil elastase to the scalded area increases epider

278 teraction signal responsible for redirecting neutrophil elastase trafficking from membranes to granul

279 phil extracellular trap (NET) formation, and neutrophil elastase translocation.

280 Neutrophil elastase-treated HCLE cells showed significan

281 ease or shedding of MAMs in other epithelia (neutrophil elastase, tumor necrosis factor [TNF]), TNF-a

282 Furthermore, neutrophil elastase uptake increased expression of low m

283 rostasin (RKRK(178)), plasmin (Lys-189), and neutrophil elastase (Val-182 and Val-193) sites.

284 id expansion and delayed myeloid maturation; neutrophil elastase was also required for these activiti

285 Higher detectable baseline neutrophil elastase was associated with more rapid lung

286 We established that neutrophil elastase was expressed by TAN within breast c

287 Neutrophil elastase was identified to cleave an N-termin

288 Sputum neutrophil elastase was significantly increased and SLPI

289 the phenotype in mice deficient in Mac-1 or neutrophil elastase was similar.

290 Based on our results, sputum neutrophil elastase was the most informative biomarker t

291 rocidin (CAP37/heparin-binding protein), and neutrophil elastase were each found to be single copy pe

292 ensins and beta-defensin-2, and the protease neutrophil elastase were measured in sputum supernatants

293 Similar results for neutrophil elastase were observed in a validation cohort

294 Immunostains for gel-forming mucins and neutrophil elastase were quantified.

295 ype littermates, mice that were deficient in neutrophil elastase were significantly protected (59%) f

296 ), and catabolic enzymes (procathepsin B and neutrophil elastase) were measured in SF from injured an

297 s secrete several proteases, one of which is neutrophil elastase, which can promote inflammatory resp

298 Patients with CML have high levels of neutrophil elastase, which has recently been shown to an

299 nhibited by treatment of HUVEC with purified neutrophil elastase, which selectively cleaved the amino

300 ay be cleaved away from the main molecule by neutrophil elastase, which suggests that it may still be

301 eavage site shared by human proteinase 3 and neutrophil elastase, yielded an agonist that was resista