ライフサイエンスコーパス: new

1 rvival (OS) could expedite the evaluation of new adjuvant therapies.

2 Second, 6 second-line new agents have been recently developed and offer new po

3 exhibit plastochron defects and/or produce a new, albeit equally reproducible, phyllotactic pattern.

4 New albumin, bilirubin, and alkaline phosphatase grade 3

5 The new algorithm was tested on the human microbiome project

6 atment, including prevention of the onset of new allergen sensitizations.

7 s and have led to identification of numerous new amyloid types, including ALECT2 amyloidosis, which i

8 number of volume channels, but also enables new analysis functions for many-channel data from emergi

9 estigational trial design may be informed by new anatomic and perfusion insights.

10 We argue that aDNA analyses add new and additional perspectives for the study of ancient

11 d is sensitive, reproducible, and provides a new and comparatively cheap tool for a rapid characteris

12 As a result linking new and existing laboratory syntheses of natural product

13 a graphene-related hybrid material, is truly new and may have broad interest in combination of experi

14 in the report were hardly novel, they gave a new and powerful voice to the cancer survivorship moveme

15 Our results demonstrate that this new and unexpected behaviour can be ascribed to an inter

16 in the design of peptoid foldamers yields a new and unique secondary structure that we term an "eta-

17 New animal models to explore these recently-identified m

18 based lead discovery with efforts to develop new antimicrobials for mycobacterial infections.

19 This new approach complements available prodrugs/donors that

20 d suggest that PXR antagonists may provide a new approach for ALD therapy.

21 The sealed vessel method is a new approach for fast cleavage of PCB from phycocyanin a

22 brane biology and illustrate a fundamentally new approach for systematic in vivo investigations of ce

23 -of-its kind theranostic that may serve as a new approach in our growing therapeutic toolbox.

24 As a fundamentally new approach to bioconjugation this methodology provides

25 ford permanent porosity, and thus opens up a new approach to prepare porous carbon liquids.

26 A new approach to the analysis of Cu, Fe, Mn and Zn in fla

27 Such a strategy may offer an important new approach to the treatment of patients awaiting LT wh

28 In this paper, we propose a new approach to use Parylene C as a versatile template f

29 In this study, we introduce a new approach, a combination of EEG and NIRS, to detect d

30 In this Perspective, we present new approaches directed at the design of efficient entry

31 acteria could be a useful strategy to design new approaches to antibacterial therapy.

32 Recently, many new approaches, study designs, and statistical and analy

33 In addition, we address new areas of lncRNA biology, such as the functions of en

34 the optimization of azobenzene switching in new as well as indirect ways.

35 ed at genome-wide significance, including 13 new associations with COPD.

36 ated by vibrational excitation, suggesting a new avenue for active control over molecular function.

37 Our design approach opens new avenues for optically controlling enzyme function.

38 This opens new avenues for the exploration of adaptation of mammali

39 New bifunctional phase transfer agents were synthesized

40 can be of invaluable assistance in designing new bioactive compounds.

41 unmet clinical demands for the discovery of new biomarkers and development of treatment solutions to

42 rmal liver function and the incorporation of new biomarkers to help manage CHB require further explor

43 al species whenever the benefits of building new bonds outweigh the costs.

44 es (predominately PVC ablations) experienced new brain emboli after the procedure.

45 sly for 1 year, unless disease recurrence or new breast cancer, intolerable adverse events, or consen

46 There were 63 new cases of IIH, yielding an overall age- and gender-ad

47 talysts are not adequate, we aim to discover new catalysts by obtaining a detailed understanding of t

48 This work showcases a new catalytic cyclization reaction using a highly Lewis

49 cells of land plants divide by initiating a new cell-wall segment from their center.

50 Notably, the first new central nervous system (CNS)-targeted oligonucleotid

51 stage to this hopeful era of possibilities, new challenges expectedly arise, and our focus now must

52 This signals a new chapter in the long and unusual story of GO, which w

53 The estimated ITRIs were shorter with each new class of HIV tests, ranging from 5.9 to 24.8 days.

54 e introduce a facile route for fabricating a new class of instrumented cardiac microphysiological dev

55 This new class of site-specifically metal-modified DNA films

56 he inorganic thiometallate ATTM represents a new class of sulfide-releasing drugs.

57 trates revealed that the enzyme represents a new class of zinc-binding flavin-dependent halogenases a

58 ns, including concepts for drug delivery and new classifications and therapeutic options for various

59 We describe two new complementary approaches - stable isotope probing co

60 These results define a new component of the signaling network by which activati

61 scovery and development of improved or novel new compounds, including D1 agonists with better pharmac

62 ver, this technology has also raised several new computational challenges.

63 This new concept of switching of excited-state configuration

64 provides a simple framework for identifying new conditions that tolerate challenging functional grou

65 exploitation of phase reactions to create a new conductive phase along the grain boundaries of dual-

66 Nitrate isotope measurements provide a new constraint on the controls of surface nitrate concen

67 A new control mechanism employing two-beam refraction and

68 ts, crack deflections, and the initiation of new cracks within the enamel (internal cracks) were obse

69 Haematopoietic and Lymphoid Tissues includes new criteria for the diagnosis of these disorders.

70 ffinity, and thus cooperativity, renders our new cuboctahedral receptor attractive for incorporation

71 ation type on mercury wet deposition using a new database of individual rain events spanning the cont

72 valuated 12 public datasets, together with a new dataset of 265 ccRCC gene expression profiles.

73 within brain tumors and provide a promising new delivery platform for localized gene therapy in the

74 Therefore, the new design allows a 30-fold longer reaction time and a 4

75 ng ways in which this framework can motivate new developmental, comparative, and cross-cultural resea

76 Here, we present new developments in the Reactome visualization system th

77 During 7 y of follow-up, 9,504 new diabetes cases were recorded among 482,591 participa

78 treatments can be linked to the approval of new diagnostic assays used to measure efficacy or to pre

79 ting these associations in vivo will lead to new diagnostic tools for Alzheimer disease and better un

80 pathways; these accessory proteins provide a new dimension for drug discovery.

81 The discovery of alpha-Gal stimulated new discussions and investigations regarding the relevan

82 hypotheses for disease mechanisms, identify new disease biomarkers, and reposition drugs for disease

83 aromatic hydroxylation reactions represent a new domain for high-valent bis(mu-oxido)dimetal reactivi

84 L1-interacting molecules that could serve as new drug targets to treat APOL1-associated renal disease

85 New drugs with novel mechanisms of action, such as cardi

86 eliorated by treatment with NitroSynapsin, a new dual-action compound related to the FDA-approved dru

87 These new dyes showed large Stokes shifts (>110 nm).

88 stability under electrical stimulation of a new electrode material fabricated from lithographically

89 iberately using ion irradiation could enable new electronic applications.

90 New electronic states emerge as a result of multiple cop

91 After 44 days, 2 new employees presented with the same skin changes.

92 ells were likely to proliferate and generate new endothelium following injury.

93 New engineered materials have critical applications in d

94 lly peopled the New World they encountered a new environment with extreme climate conditions and dist

95 g ordered trimeric symmetry has ushered in a new era in HIV-1 vaccination.

96 iology to S. aureus infection can usher in a new era of highly focused personalized therapy that may

97 Therefore, the focus in this new era, characterized by the confluence of understandin

98 alyses of extant species that are uncovering new evidence for evolutionary changes in the size and th

99 These findings provide new evidence linking cognition with WM via the reliance

100 The current review assessed new evidence on the benefits and harms of folic acid sup

101 Here, a new evolutionary algorithm is proposed to train FCMs, wh

102 ity system for rodents, we discovered that a new experience increased firing of active dentate granul

103 Here we describe a new, exquisitely three-dimensionally preserved nodosauri

104 The aversive valence of these new extinction memories neutralizes previously learned o

105 In this study, we report a new family of proteins distantly related to outer kineto

106 tion of these structures, we observe several new features.

107 mperature patterns may therefore represent a new floral cue that could assist pollinators in the reco

108 ould make or break electrical connections in new forms of reconfigurable nanocircuitry.

109 The results suggest a new framework for developing effective fusion inhibitory

110 great promise for the tailor-made design of new functional materials.

111 In this study, we identify new functional roles of RASSF4.

112 in chromosome folding, these results provide new fundamental insights into the rules governing mammal

113 vely understudied mechanism of evolution for new gene functions, particularly under conditions of rap

114 anization of these four TFs and PHO1;H3 in a new gene regulatory network controlling phosphate accumu

115 tibodies have led to the identification of a new generation of potent broadly neutralizing antibodies

116 There is a need for new greener materials (than for example polyethylene gly

117 Here we analyze a new high-resolution deep-sea oxygen isotope (delta(18)O)

118 With the development of new high-throughput DNA sequencing technologies and decr

119 y relationship may aid in the development of new highly efficient photoreactions.

120 ely result in communicable infections in the new host.

121 Here we present new hydrogen self-diffusion coefficients in natural oliv

122 can leverage molecular data sets to develop new hypotheses for disease mechanisms, identify new dise

123 n protein or PrP(C) The current work tests a new hypothesis that sialylation determines the fate of p

124 We also reported the frequency of new immune patterns of response and progression.

125 P on the epithelium and granulopoiesis, this new immunomodulatory role could explain the protection c

126 ove computational efficiency, we describe an new importance sampling scheme to perform model inferenc

127 scovered five novel heart rate loci, and one new independent low-frequency non-synonymous variant in

128 Microarray methods provided new information in 47% of the sensitized children in com

129 signaling during morphogenesis, and provides new insight into PCP-related disorders in humans.

130 wledge on novel sRNAs but would also give us new insight into sRNA degradation.

131 Our findings provide new insight on the microscopic mechanisms of atomic deso

132 These studies have yielded not only new insights but also a plethora of experimental approac

133 ng flavin-dependent halogenases and provides new insights into a potentially unique reaction mechanis

134 ce of an additional binding site and provide new insights into GB1:IgG complex structure that amend a

135 Our results provide new insights into genetic histories of Siberian and Nort

136 These findings provide new insights into how chromatin regulation modulates sto

137 Furthermore, our data provide new insights into microtubule regulation during axonal m

138 tential for "big data" techniques to provide new insights into movement behaviour when applied to lar

139 Taken together, these results provide new insights into regulatory mechanisms of seed vigor an

140 n of these virulence-associated PKs provides new insights into T. brucei-host interaction and reveals

141 d resequencing of tumor genomes in providing new insights into the contribution of mutagenic exposure

142 5-linkages at different positions, providing new insights into the effects of these modifications and

143 Collectively, these findings provide new insights into the inhibitory effect of SFN on HCC tu

144 ially causal of sero-negative RA and provide new insights into the pathogenesis of the disorder.

145 tivating NK cell receptor KIR2DS1, providing new insights into the underlying mechanisms involved in

146 oparticles (NPs) with electrodes can provide new insights into their electrocatalytic behavior, mass

147 have demonstrated that DeBooster may provide new insights into understanding the regulatory functions

148 Collectively, our data provides new insights to understand the evolutionary relationship

149 baseline and 24 h CTs, with dIVH defined as new intraventricular haemorrhage (IVH) on the latter sca

150 -friendliness, these properties could enable new kinds of electrically driven entirely soft robots.Th

151 tected and only 8.9% have strict protection, new large-scale conservation efforts to protect intact f

152 A new, largely complete eusauropod dinosaur with cranial a

153 e, accessing probe compounds, and generating new leads that yield manufactured cells with improved pr

154 This not only sheds new light on how efficient nature is in preventing biolo

155 ublished in Nature, Brown et al. (2017) shed new light on how the skin handles the activation of onco

156 ation of inflammation mediators and shedding new light on the role of fibroblasts in chronic inflamma

157 These data establish a new link between the pluripotency factor NANOG and autop

158 ly, our results establish the utility of the new live-imaging tools for the study of molecular-neural

159 emorrhage were all significant predictors of new MA development (P = 0.04, 0.01, 0.04, 0.004, 0.01, r

160 e rate of microearthquakes in the intraplate New Madrid Seismic Zone at annual and multi-annual times

161 ring their frequency in the circulation is a new marker of response to ART when effects on viremia an

162 This new material is related to the active species of industr

163 New materials with high selectivities for CO2 adsorption

164 We describe new mechanisms of coding and noncoding alteration and id

165 ess has been made on the characterization of new members of this family of signals.

166 Taken together, our studies uncover a new metastasis-promoting pathway in Ewing Sarcoma, with

167 We developed a new method (called REPPS) for incorporating experimental

168 Here, a new method for stabilizing the photoluminescence and cha

169 The new method utilizes gold coated magnetic nanoparticles t

170 d using mobile phone microscopy, achieving a new milestone for tele-medicine technologies.

171 reduced under mild conditions by using this new Mn catalyst.

172 Here we propose a new model for how these proteins can initiate autoimmuni

173 We emphasize tools that offer new modes of control and could realistically contribute

174 This Communication describes a new molecular design that yields ultranarrowband organic

175 metabolomics methods have already identified new molecular markers and metabolomic signatures of card

176 IDIF treatment and eventually for designing new molecules toward AD therapeutic drugs.

177 New mosquito control strategies are vitally needed to ad

178 s in LPS-induced endotoxemia, we developed a new mouse model, PMN(DTR) mice, in which injection of di

179 We developed a new multivariable linear model for GFR using statistical

180 mutants (sgb10-sgb13) identified, sgb11 is a new mutant allele of ESKIMO1 (ESK1), which encodes a pla

181 5-dihydro-1H-imidazol-3-oxide- 1-oxyl (3), a new nitronyl nitroxide containing a multifunctional fram

182 ory of currently held items to make room for new ones.

183 New onset AF was associated with increased risk of all o

184 New-onset atrial fibrillation was subclinical or went un

185 s with anti-inflammatory effects and risk of new-onset depression and anxiety among adult patients ad

186 hemical versatility for adaptation will open new opportunities for applications built upon diverse me

187 The properties of graphene open new opportunities for the fabrication of composites exhi

188 ion of short RNA regions which could open up new opportunities in transcriptome analysis, virology, a

189 ditions of the Mongol invasion, do not offer new or different climatic data, and are supported by ana

190 x diseases renewed opportunities to discover new or repurpose existing compounds and expedite treatme

191 tches of genomic DNA enables the creation of new organisms with customized functions.

192 nage this energy stress for proliferation in new osmotic states.

193 at are centralized around the development of new oxide compositions capable of featuring simultaneous

194 g and illustrate the potential of developing new PAI-1- and CCL5-targeting therapy for patients with

195 Several new pairs were applied in a multimolecular FRET based se

196 Our strategy thus enables a new paradigm for using air-stable molecular dopants to i

197 The objective is to find a new pathway for significant reduction in CO2 capture ene

198 ed during photodegradation of SDs, whereas a new pathway yielding oxidation of the benzene ring after

199 New patterns were encountered in 31% of patients, emphas

200 observation and, to our knowledge, brings a new perspective to molecular-scale understanding of neur

201 Our work opens new perspectives for PAM in biomedical sciences.Photoaco

202 n ordered and disordered solids and provides new perspectives on electron-precise dianionic diboranes

203 roceeds through nucleation and growth of the new phase in corners of the nanocubes.

204 restricted by the nucleation and growth of a new phase.

205 ng fermionic optical lattice clocks to probe new phases of matter.

206 Occurrence of new photoproducts derived from desulfonation and/or deni

207 es of freedom, making it possible to explore new physical phenomena and to foresee novel applications

208 ane based off surface matrix may present the new platform to sensitively measure biomarkers electroch

209 we address the high-pressure synthesis of a new polar and antiferromagnetic corundum derivative Mn2M

210 A new polymer acceptor, naphthodiperylenetetraimide-vinyle

211 revealed several emerging issues, including new populations at risk because of travel or relocation,

212 gents have been recently developed and offer new possibilities (pomalidomide, carfilzomib and ixazomi

213 It also suggests new possibilities for discovering BACE-1-targeted compou

214 tering its charge distribution, thus opening new possible roles for betaS in Parkinson's and other ne

215 y within the glomerulus, thus representing a new potential glomerulus-specific targeted intervention.

216 pecific inhibition of HIFs might represent a new powerful treatment strategy.

217 ught to establish the effect of MABp1 with a new primary endpoint in patients with advanced colorecta

218 is the driving force behind the creation of new prochlorosin structures and represents an intriguing

219 oding RNAs, and even supporting evolution of new protein-coding genes.

220 en copied as RNA and exported to manufacture new proteins.

221 Here, we summarize new quantitative paradigms for assessing the self, drawn

222 k oak and holm oak outer bark, which unveils new regulatory candidate genes of phellem development.

223 identify drug-target interactions, opening a new research direction in target identification.

224 New research documents this process in a bacterial syste

225 New research has demonstrated a causal association betwe

226 be subducted into the mantle as "slabs" and new rock to be generated by volcanism.

227 Our findings reveal an unexpected new role for NKG2D in the regulation of B1a cell develop

228 his direct interaction with actin suggests a new role of SPARC during tissue remodeling.

229 nto subunits and are presumably recycled for new rounds of translation.

230 Recent advances in optogenetics have opened new routes to drug discovery, particularly in neuroscien

231 emains largely unscathed by the onslaught of new scientific insights.

232 genome editing techniques enable a radically new set of approaches to limit evolution.

233 knowledge fitting (ProFit) algorithm, with a new simulated basis set consisting of macromolecules and

234 New single-component effector CRISPR systems are emergin

235 levated CO2 might increase turnover rates of new soil C.

236 ation of their properties can illuminate how new species evolve.

237 her resting astrocyte Ca(2+) can adjust to a new steady-state level, with an impact on surrounding br

238 d how aging promotes CVD in order to develop new strategies to confront this challenge.

239 s proliferation, this approach could offer a new strategy for the development of HIV inhibitors.

240 phosphine borane compounds offer a promising new strategy for the reversible immobilization of amino

241 In conclusion, the new strategy, called PRES (Personalized REgimen Selectio

242 f N-pentafluorophenylbenzamides, providing a new structural lead for ligand design.

243 A new study seeks to overcome this problem by sampling mor

244 A new study suggests that the lateral hypothalamus may als

245 In this new study, we investigated the interaction of protein ph

246 2 in the T. brucei bloodstream form provides new support for the presence of an active pyruvate dehyd

247 toperative conditions they will encounter as new surgical interns.

248 nists relieve depressive symptoms by forming new synapses resulting in increased excitatory drive.

249 This study offers new synthetic biology tools to program spatial structure

250 ccurately models human NBL and establishes a new system with potential to study early stages of NBL o

251 nd alternative payment methods evolve, these new systems of care must continue to serve the needs of

252 toration of let-7 expression could provide a new target for an anti-inflammatory approach in diabetic

253 S that thwarted past efforts, and armed with new technologies and directions, the field is experienci

254 Based on the same knowledge but thanks to new technologies, such hospitals have now been built dow

255 The target article highlights the utility of new technology to study sign language and gesture.

256 S-TBPTTL)4 , and the enone 1,2-addition of a new TEMPO carbamate methyl carbanion.

257 In this study, we generated a new Tg(mrc1a:egfp)(y251) transgenic zebrafish that uses

258 anulocytes and endothelial cells may lead to new therapeutic approaches to improve blood vessel regen

259 isms that result in LSC survival and develop new therapeutic approaches.

260 CT-P10 might represent a new therapeutic option for advanced-stage follicular lym

261 alf-life is an important issue in developing new therapeutic proteins and expanding applications of e

262 -like growth factor I receptor (IGF-IR) is a new therapeutic strategy to attenuate the underlying aut

263 angiogenesis and point to its potential as a new therapeutic target for angiogenesis-related diseases

264 tic galanin-opioid interactions and offers a new therapeutic target for the treatment of opioid use d

265 es for the stratification and development of new therapeutics for depression, and the next steps that

266 other biological processes, and discovery of new therapeutics.

267 iseases, diagnostic rates and development of new therapies are still limited by a lack of knowledge o

268 ite to introduce analytical chemists who are new to the open-source movement to best practices and co

269 PPiSeq is therefore a powerful new tool for large-scale investigations of dynamic PPIs.

270 s modulated by exogenous lipids, providing a new tool for studying nonlytic exocytosis.

271 brain's vast synaptic networks will require new tools for high-throughput structural and molecular p

272 e results demonstrate the usefulness of this new transgenic hepatitis B model.

273 Trial designs for new transplant immunosuppression must be intelligently r

274 nderlie restless legs syndrome could lead to new treatment options.

275 e modulatory therapies such that approval of new treatments can be linked to the approval of new diag

276 into beneficial LoF mutations and potential new treatments.

277 us-level sequencing effort that represents a new type of model system driven not only by genetic trac

278 Our results suggest that DISARM is a new type of multi-gene restriction-modification module,

279 These findings suggest a new type of neuron-astrocyte communication, based on the

280 We also uncovered a new type of oscillation during recovery from H2O2 challe

281 The fabrication of a new type of solar cell encapsulation architecture compri

282 Here, we propose a new unbiased method to identify canonical and non-canoni

283 ir neighboring mesenchymal partners provides new understanding of how different cell types are mainta

284 ndidate antiviral drugs, and the efficacy of new vaccines.

285 y to slow deforestation rates and to avert a new wave of global extinctions.

286 More generally, a new wave of quantitative single-cell studies has begun t

287 Darwinian evolution but also extend them in new ways and then by assessing the principal causal inte

288 viruses to respond to endogenous stimuli in new ways as well as to exogenous stimuli, such as temper

289 New work on innate escape behavior shows that mice spont

290 cology and molecular and cellular biology of New World arenaviruses, as well as a discussion of the c

291 over 18,000 y ago and eventually peopled the New World they encountered a new environment with extrem

292 regenerate within about a week, forming two new worms.

293 ce the 1990s, tuberculosis (TB) incidence in New York City (NYC) and the United States (US) has flatt

294 eft ventricular ejection fraction </=35% and New York Heart Association class II to III were randomly

295 lthough it is typically not considered among New York Heart Association class IV (NYHA IV) heart fail

296 inpatient and ambulatory surgery settings in New York State.

297 ge patients admitted to ICU in Australia and New Zealand have a high mortality rate.

298 ective study of data from the Australian and New Zealand Intensive Care Society Adult Patient Databas

299 a honey is a product produced essentially in New Zealand, and has been widely recognised for its anti

300 was a regional perinatal center in Hamilton, New Zealand.