ライフサイエンスコーパス: newly generated

1 adds a polyadenosine [poly(A)] tract to the newly generated 3' end.

2 NA exiting from RecC and loads RecA onto the newly generated 3'-ended single-stranded DNA during cont

3 inhibition of BACE would result in decreased newly generated Abeta and soluble APPbeta (sAPPbeta), wi

4 Newly generated actin free barbed ends at the front of m

5 In addition, spinal 5-HT(+) neurons were newly generated after a lesion and transiently increased

6 esent evidence that Pax2(+) interneurons are newly generated after a spinal lesion, whereas the gener

7 al propagation block, probably by preventing newly generated afterdischarges to travel backwards to t

8 This structure defines the positions of the newly generated amino and carboxyl groups following the

9 stant ALL cell lines and patients, including newly generated and previously published data sets avail

10 We use a comprehensive dataset of newly generated and publicly available sequence data to

11 mpendium and mining tool of high-dimensional newly generated and published miRNA expression profiles.

12 f graft composition on regeneration of host, newly generated, and mature transferred T cells, and und

13 Immunoprecipitation assays using a newly generated anti-16E5 antibody confirmed that 16E5 w

14 However, a newly generated anti-Clr-g mAb detected only residual Cl

15 ics in wastewater effluents, but residual or newly generated antibacterial properties of transformati

16 Using newly generated antibodies, we demonstrate that this PTE

17 Here, using our newly generated antibody raised against the entire C-ter

18 Using a newly generated antibody specific for zebrafish SynJ1, w

19 Using our newly generated APC conditional knock-out (cKO) mouse, w

20 Concentrations, kinetics, and amount of newly generated APP fragments were calculated.

21 In addition, the newly generated aptamer assembly is an excellent anticoa

22 Using a series of newly generated Ar reporter and Pten knock-out compound

23 provide proof-of-principle for the view that newly generated ASCs can acquire a mature PC phenotype t

24 A newly generated atlas is three-dimensional, allows the p

25 kNN-nearest and kNN-Kmeans, to partition the newly generated, attribute-enhanced graph.

26 previously tolerized T cell pool can buffer newly generated autoreactive T cells that might emerge.

27 In humans, up to 75% of newly generated B cells and about 30% of mature B cells

28 er treatment revealed that these clones were newly generated B cells and not self-reactive B cells th

29 ing is a mechanism of self-tolerance used in newly generated B cells.

30 y triggers severing and remains bound to the newly generated barbed ends.

31 Newly generated beta-like cells are epigenetically repro

32 However, newly generated Bim(+/-) naive CD4 T cells in middle-age

33 The newly generated cancer-specific aptamers hold great prom

34 y of stem cell engraftment and the number of newly generated cardiomyocytes and vascular cells, eithe

35 Using our newly generated CD11a-mYFP knock-in mice, we discovered

36 NOD stock also lacking ART2, but not in the newly generated CD38/P2X(7) double-KO line.

37 ration and (b) flow cytometry to analyze for newly generated CD4+ CD25(high) FOXP3+ Tregs in carboxyf

38 e the understanding of relationships between newly generated cells (marked with bromodeoxyuridine [Br

39 e, we extend upon these findings by ablating newly generated cells after the epileptogenic insult usi

40 Furthermore, some of the newly generated cells are capable of responding to lepti

41 pidermal stem cell behaviors and unravel how newly generated cells are integrated into pre-existing t

42 d the nestin-related filament transitin, and newly generated cells by using BrdU-birthdating.

43 th CRMP4 and GFAPdelta, markers specific for newly generated cells derived from the adult subventricu

44 ription factor A, and that a subset of these newly generated cells differentiate into AgRP neurons al

45 The newly generated cells followed the CNCC migration pathwa

46 progenitor proliferation and survival of the newly generated cells in the dentate gyrus (DG) and the

47 generation resulted in a decreased number of newly generated cells in the hippocampus.

48 ule cells in adulthood, the vast majority of newly generated cells in the intact mature rodent neocor

49 The number of newly generated cells in the subgranular zone/granule ce

50 ol rats, but the long-term survival of those newly generated cells is impaired relative normal contro

51 showed significant increases in survival of newly generated cells resulting from the wheel running.

52 In the hippocampus, newly generated cells undergo a step-wise progression of

53 n profile of maturation markers in surviving newly generated cells was altered.

54 idine [BrdU] labeling) and survival of these newly generated cells was evaluated at PD80.

55 Newly generated cells were detected by immunohistochemis

56 Proliferation and survival of newly generated cells were unchanged.

57 efits requiring long-lasting survival of the newly generated cells will depend on identifying ways to

58 tral canal proliferating cells with Ki67 and newly generated cells with bromodeoxyuridine incorporati

59 bone marrow (BM) produces a stable output of newly generated cells, but immunologic stress conditions

60 Using bromodeoxyuridine (BrdU) labeling of newly generated cells, double-labeling immunohistochemis

61 toneally for seven consecutive days to label newly generated cells.

62 Pulse chase experiments indicate that the newly-generated cells differentiate into N-beta-tubulin-

63 ition from FGF to retinoid signalling in the newly generated chick body axis.

64 These newly generated CIBER mice provide a novel tool for stud

65 Newly generated cinnamic acid from coumaric acid aglycon

66 otope-labeling, and dose-dependently reduced newly generated CNS Abeta.

67 Using newly generated conditional and constitutive C1ql3 knock

68 Using newly generated conditional knock-in and knockout mice,

69 Using newly generated constitutive and conditional knockout mi

70 We show that newly generated conventional CD69(+)Qa2(-) CD4 single-po

71 Additionally, survival of these newly generated cortical cells was affected by neonatal

72 r construct that allows for the isolation of newly generated cortical interneuron precursors.

73 -producing areas and (b) was co-localized in newly generated CR neurons.

74 ds can provide valuable tools to consolidate newly generated data with existing knowledge, and to dec

75 e transport modeling, based on published and newly generated data, is used to better understand the i

76 However, despite numerous flows of newly generated data, the precise mechanism with respect

77 using mathematical modeling of published and newly generated data, we have obtained estimates of adip

78 plied it to previously published (n = 5) and newly generated data.

79 The newly generated databases will provide a tool to explore

80 n divides distinct splice isoforms among the newly generated daughter genes, in this way reducing the

81 tivation are almost completely reversed in a newly generated dCK/TK1 double-knockout (DKO) mouse mode

82 res, density of polymorphic sites, number of newly generated deleterious mutations in one generation,

83 We applied our method to a set of newly generated deletion mutants in the dioecious plant

84 Newly generated dentate granule cells (GCs) are relevant

85 gs support the long-standing hypothesis that newly generated dentate granule cells are pro-epileptoge

86 the selective deletion of alpha-CaMKII from newly generated dentate granule cells led to an increase

87 impaired after deletion of alpha-CaMKII from newly generated dentate granule cells.

88 t of dendrite arbors and dendritic spines in newly generated dentate gyrus granule cell neurons of th

89 orchid phylogenies (including more than 400 newly generated DNA sequences), comparative phylogenetic

90 We conclude that apoptosis of newly generated donor-derived peripheral T cells after a

91 During the early stages of HR, the newly generated DSB ends are processed to yield long sin

92 wever, c-myc also translocated frequently to newly generated DSBs within a 35-Mb region downstream of

93 Here we show that newly generated embryonic day 17 (E17) RGCs are able to

94 acing the full complement of mitochondria in newly generated embryonic stem cell lines.

95 During blood vessel formation, newly generated endothelial cells rapidly expand into pr

96 ever, HNF1beta expression was not present in newly generated epithelial cell adhesion molecule (EpCAM

97 was validated with previously published and newly generated experimental data, and suggested new in

98 Rather, we provide evidence that newly generated FDCs also arise from the proliferation a

99 rotein fusions to the REL_DKK pair among the newly generated FokI nuclease domain variants appear to

100 ugh analysis of RNA-seq gene expression data newly generated for 448 cancer cell lines, combined with

101 ripheral position, while the same effect was newly generated for the index finger by the same postura

102 yophyllales, of which 43 transcriptomes were newly generated for this study, representing one of the

103 formed using the AMBER suite to validate the newly generated force field.

104 noclonal antibodies (MAbs), 14 of which were newly generated from 9 chronically infected subjects.

105 the membrane-retained 70-kDa CDCP1 fragment, newly generated from its full-length 135-kDa precursor t

106 Newly generated Gata3 hypomorphic mutant mice exhibited

107 Using newly generated GD/PD mouse lines of either sex [Gba mut

108 from other studies, akin to the way in which newly generated genomic information can be compared to d

109 revealed that females had significantly more newly generated glial cells but not more newly generated

110 Using newly generated glp1r-Cre mice crossed with fluorescent

111 eta-cell function in Gpr119(-/-) mice and in newly generated Gpr119(betacell-/-) mice.

112 Here, we examined GABAergic signaling to newly generated granule cells (GCs) of the adult mouse d

113 provides the first evidence that ablation of newly generated granule cells can be an effective therap

114 lar components, parvalbumin interneurons and newly generated granule cells in the hippocampus.

115 Newly generated granule cells may be uniquely vulnerable

116 brainstem responses, which suggests that the newly generated HCs may contribute to, or at least do no

117 Therefore, our data show that newly generated host Tregs can prevent chronic allograft

118 ions with polyclonal Abs were confirmed with newly generated human mAbs derived from DENV-immune indi

119 Interestingly, the newly generated human PrP(Sc) exhibits a distinct bioche

120 This work is the first report of a newly generated humanized transgenic mouse model enginee

121 e, along with true ICAM-1-deficient mice and newly generated ICAM-1-transgenic mice, have provided th

122 In wild-type and transgenic mice, we traced newly generated IgA-secreting cells at steady state and

123 cific S1pr1 knockout (B-S1pr1KO) mice, their newly generated immature B cells appeared in the blood a

124 Newly generated immature B cells are selected to enter t

125 gnal necessary for the efficient transfer of newly generated immature B cells from the bone marrow to

126 f INPs due to ectopic Prospero expression in newly generated immature INPs (imINPs), whereas the incr

127 re, we report that vChATs directly innervate newly generated immature neurons (NGIs) in the dorsal hi

128 e observed learning deficits were rescued as newly generated immature neurons repopulated the granule

129 brain structural plasticity consists of non-newly generated, "immature" neurons of the adult cerebra

130 lyst controls two stereocenters, one that is newly generated in a beta-migratory insertion and one th

131 or piggyBac element integrations and 12,500 newly generated insertions of the Minos transposon.

132 This early glutamatergic input onto newly generated interneurons in the OB was matched in ti

133 howed that mitral cells, the target cells of newly generated interneurons, receive reduced spontaneou

134 regated by recombination events, causing the newly generated intersubtype recombinants to undergo pur

135 Using newly generated knock-out mice lacking both RIM1alpha an

136 Using newly generated knockin reporter mice for Cbln2 and Cbln

137 The newly generated library of sphingolipid ions was then ap

138 In addition, the newly generated linkage map has allowed us to fine-map a

139 Finally, the newly generated linkage map was used to fine-map a QTL a

140 h preformed granule-associated mediators and newly generated lipid-derived mediators contributes to t

141 rm a comprehensive investigation using 3,059 newly generated low-depth whole-genome sequences from ei

142 0 and Hoxd10 are initially expressed in most newly generated lumbar motoneurons, but subsequently bec

143 In this study, using a newly generated mAb against human TIM-3, we examined TIM

144 gate Treml4 function, we took advantage of a newly generated mAb against Treml4 and engineered its H

145 evaluated Helios protein expression using a newly generated mAb and demonstrated that it is expresse

146 ilable genome-wide DNA methylation data with newly generated maps for chromatin accessibility and his

147 The MCC cell lines used include three newly generated MCV-infected cell lines and one MCV-nega

148 In this study, we show that newly generated memory B cells do not display active aut

149 RA, produced by newly generated mesodermal cells, provides feedback that

150 Using newly generated metabotropic glutamate receptor 5 (mGluR

151 nce presentation of exogenous Ag by limiting newly generated MHC class II molecules from forming stab

152 ctron microscopy reveal that the majority of newly generated MHC-II I-A(k)-HEL(46-61) complexes are e

153 We tracked the fate of newly generated micronuclei and found that they undergo

154 ing miR-29a/b-1 (miR-29a)-deficient mice and newly generated miR-29b-2/c (miR-29c)-deficient mice.

155 Several newly generated missense alleles carry amino acid substi

156 r the spatial resolution and distribution of newly generated mitochondrial tips following division.

157 these issues, we analyzed the phenotypes of newly generated MLL4 mutant mice, along with MLL3 mutant

158 We used newly generated MMTV-Cre105Ayn mice to inactivate p53 an

159 This newly generated moDC population and not the resident DCs

160 ion of the small GTP-binding protein Rnd2 in newly generated mouse cortical neurons before they initi

161 Capitalizing on a set of newly generated mouse models, we provide an integrated m

162 This newly generated mouse serves as a tool to study the func

163 Importantly, using a newly generated mouse strain expressing a kinase-inactiv

164 Using a newly generated mouse that expresses IFN-gammaR only on

165 tidergic nociceptors across the body using a newly generated Mrgprd(CreERT2) mouse line.

166 rodegeneration and synaptic damage between a newly generated mThy-1 alpha-synuclein E57K transgenic m

167 Recordings from newly generated mutant flies demonstrated that DmalphaG

168 The analysis of newly generated mutant mESCs revealed that DGCR8 is esse

169 The newly generated mutant mice displayed several striking b

170 We examined 3 existing and 12 newly generated mutations in the Drosophila type I recep

171 ediated by preactivated T cells, rather than newly generated myeloma-reactive T cells.

172 readth of myxozoan diversity, including four newly generated myxozoan assemblies, confirms that myxoz

173 e protease plasmepsin V, but the role of the newly generated N-terminal sequence in protein export is

174 Using phage display technology based on a newly generated naive human Fab library in phage display

175 Newly generated naive T cells derived from aged stem cel

176 Newly generated neural progenitors are exposed to FGF si

177 Newly generated neuroblasts from the subventricular zone

178 oglia hampered the survival and migration of newly generated neuroblasts through the RMS to the olfac

179 The diminished numbers of newly generated neurons (BrdU/NeuN co-localization) was

180 ex in cortical progenitors (Emx1-Cre) and in newly generated neurons (Nex1-Cre).

181 al neural progenitor cells (NPCs) and low in newly generated neurons (NGNs) and mature neurons (MNs).

182 ly to control the differentiation process of newly generated neurons and exert an important influence

183 was first reported as the co-association of newly generated neurons and their progenitors with both

184 Although newly generated neurons are able to migrate and preferen

185 procedure employed, can affect the number of newly generated neurons detected in the adult brain, thu

186 t not gliogenesis, and also on the number of newly generated neurons expressing ENK, OX, or melanin-c

187 l location, we also found populations of non-newly generated neurons in several subcortical regions (

188 g DISC1 in the maturation and integration of newly generated neurons in the adult mouse hippocampus.

189 reprogramming and subsequent survival of the newly generated neurons in the adult rodent brain.

190 th aging there is a decline in the number of newly generated neurons in the dentate gyrus of the hipp

191 Furthermore, short-term learning and newly generated neurons in the dentate gyrus were defici

192 d be traced starting only from 3 to 5 wk on, newly generated neurons in the OB received input from th

193 suggest common principles for incorporating newly generated neurons into a preexisting circuit.

194 Integration of newly generated neurons into adult cell assemblies is a

195 to image the addition of genetically labeled newly generated neurons into the brain of juvenile zebra

196 neurogenesis, we investigated whether these newly generated neurons might play a role in recovery.

197 for 8 weeks, resulting in a great number of newly generated neurons misplaced in the outer GCL in th

198 tent with a negative-feedback loop, in which newly generated neurons modulate cell division of SVZ st

199 Newly generated neurons must keep cell cycle components

200 reduced neurite outgrowth and the number of newly generated neurons only at nanomolar concentrations

201 enic mice, we determined that injury-induced newly generated neurons persisted over time and elaborat

202 unlike rodents, is largely endowed with non-newly generated neurons retaining immature features, sug

203 The number of newly generated neurons significantly declined only in t

204 ore newly generated glial cells but not more newly generated neurons than males, and treatment with W

205 neurogenic zones, whether and how it acts on newly generated neurons that integrate into the establis

206 indicating a more selective contribution of newly generated neurons to specific cognitive functions.

207 We investigated whether newly generated neurons were modulated by endogenous alp

208 Similar to newly generated neurons, these cells express the cytoske

209 required for the terminal differentiation of newly generated neurons, were both increased in the hipp

210 Motility is a universal property of newly generated neurons.

211 stream (RMS), which is a forebrain source of newly generated neurons.

212 ting cell rescue through the expression of a newly generated, non-self-reactive TCR.

213 Mechanistically, the newly generated NOXA interacted with Mcl-1 and displaced

214 guided by argonaute-mediated recognition of newly generated nucleotide overhangs when ssRNA is targe

215 Using newly generated null alleles, we demonstrate that polych

216 g lesion borders where at least a portion of newly generated oligodendrocytes (bromodeoxyuridine+) we

217 Although it is widely accepted that newly generated oligodendrocytes (OLs) produce myelin in

218 production in the adult CNS is initiated by newly generated oligodendrocytes (OLs), great interest r

219 siderable recovery, including immigration of newly generated or repaired neurons that became active d

220 and in vivo time-lapse imaging to show that newly generated OSNs form highly dynamic synapses and ar

221 The newly generated oxidized proteoforms are shown to posses

222 ulti-drug-resistant HIV-1 variants, that the newly generated P2-Crwn-THF moiety confers highly desira

223 l HIV-1 protease inhibitor (PI) containing a newly-generated P2-crown-tetrahydrofuranylurethane (Crwn

224 ng to FcgammaRIIa and FcgammaRIIIa with this newly generated panel of antibodies.

225 We propose that newly generated pDC mobilized from the bone marrow, rath

226 Here, making use of a newly generated Pdgfd knockout mouse, we reveal a functi

227 receptors, which preferentially destabilizes newly generated place fields.

228 Newly generated pMHC-II complexes are present in small c

229 ide to (R(s))-thiosulfinate which contains a newly generated polar group was also confirmed to be of

230 The large pre-B cells are newly generated pre-B cells that express pre-B-cell rece

231 later it inhibits the differentiation of the newly generated progenitor cells.

232 ys deliver a positive readout in the form of newly generated progeny phages by the bacterial host of

233 onine surrogate azido-nor-leucine (ANL) into newly generated proteins.

234 that there was no prevalence of disomy among newly generated [PSI (+)] strains in absence of strong s

235 Using newly generated pure Balb/C CAV1 null ((Balb/C)CAV1-/-)

236 Newly generated rabbit antibodies, respectively, against

237 the CA1 area of the rodent hippocampus using newly generated rabbit monoclonal antibodies and ErbB4-m

238 Using newly generated RANK Venus reporter mice, we identify di

239 Using newly generated recombinant antigen variant-expressing c

240 f Immunity, Licona-Limon et al. (2013) use a newly generated reporter mouse to demonstrate a role for

241 trigger receptivity; rather, the ability of newly generated RGCs to receive synapses is acquired at

242 herin activity to allow apical retraction in newly generated RGCs.

243 We tested the framework on newly generated RNA-seq and H3K27ac ChIP-seq profiles up

244 to regional cortical gene expression from a newly generated RNA-seq dataset and two additional gene

245 ation cues are required to guide and contain newly generated rodent subventricular zone (SVZ) neurobl

246 Notably, we observed that a newly generated Salmonella vaccine strain not only confe

247 d soluble APPbeta (sAPPbeta), with increased newly generated sAPPalpha.

248 This newly generated septal PG is initially shared by the dau

249 Finally, the newly generated sequences more closely resemble the low-

250 phages and pDC precursors were eliminated in newly generated SiglecH-diphtheria toxin receptor (DTR)-

251 main selectively assembles around one of the newly generated single strands in a manner that accounts

252 Immunoblot analyses using newly generated specific Cx47 antibodies revealed that o

253 type being due to variable efficiency of the newly generated splicing signal.

254 Evaluation of PREX2 expression in these newly generated stable cells revealed varying levels of

255 We then tested whether our newly generated, stage-specific transcriptional signatur

256 The organocatalyst controls the newly generated stereocenter six bonds away from the ste

257 with complementary stereochemistries at the newly generated stereogenic center and axially chiral al

258 fficiency and with full stereocontrol of the newly generated stereogenic center.

259 established that Cyp2a5-null mice, but not a newly generated strain of Cyp2g1-null mice, were resista

260 sors are particle-swapping loops rather than newly generated structural defects, and that coherent an

261 ly old populations, pocketed with occasional newly generated subclones that were the result of recent

262 Newly-generated synapse-like structures expressed glutam

263 Newly generated T cells are unable to respond to antigen

264 Recent thymic emigrants are newly generated T cells that need to undergo postthymic

265 In addition, HPC-derived newly generated T cells were able to mount a peptide-spe

266 of TK+ cells, anticipating the appearance of newly generated T cells.

267 Newly generated T-regs not only acquired T-reg phenotype

268 on and FOXP3 expression of both expanded and newly generated T-regs were higher in normal controls th

269 nd generated de novo from CD4+CD25- T cells (newly generated T-regs) increased constantly up to week

270 Affinity of newly generated TCR for peptide-MHC primarily sets the b

271 We have used a newly generated TCR-transgenic mouse to establish the ba

272 earing endogenous TCRbeta-chains can express newly generated TCRbeta molecules in adoptive hosts.

273 n by recruiting MRN (and other nucleases) to newly generated telomere ends.

274 as linked to the positioning of mtDNA to the newly generated tip.

275 vision, resulting in their distribution into newly generated tips in the mitochondrial network.

276 at preferential locations, including within newly generated tissue (the blastema), and along pre-exi

277 This explains how the structure of a newly generated tissue is coordinated with that of the o

278 s, and sebaceous glands were observed in the newly generated tissue.

279 We demonstrate here that our newly generated tools, including transgenic "MitoFish,"

280 tera: Tephritidae) is described here using a newly generated transcriptome dataset.

281 eny and diversification rate shifts using 31 newly generated transcriptomes and 88 other datasets cov

282 e IIS/TOR network across 66 amniotes with 18 newly generated transcriptomes from nonavian reptiles an

283 The nuclear genes from newly generated transcriptomes revealed a well-resolved

284 y superimpose the labeling patterns from our newly generated transgenic lines.

285 sed this issue in the olfactory system using newly generated transgenic mice that express channelrhod

286 Here, we describe a newly generated transgenic mouse in which the Gs DREADD

287 ter (WM) development and adult injury with a newly generated transgenic mouse overexpressing Sox17 in

288 orphology of various types of RGCs using the newly generated transgenic mouse rd1/Thy1-GFP, in which

289 By crossing SP-deficient mice with a newly generated transgenic mouse strain that expresses G

290 A newly generated transgenic prostate line expressing an M

291 Four of the PCTs that developed in the newly generated translocation reporter mice, designated

292 A newly generated UL32-null mutant was used to confirm tha

293 urther show that we need to hypothesize that newly generated uninfected cells are refractory to produ

294 uilibration, permitting the recycling of any newly generated unnatural atropisomer under progressivel

295 eletion of p53 in urothelial cells using the newly generated UPK II-Cre mice results in normal bladde

296 se findings illustrate the usefulness of the newly generated V2R mutant mice for elucidating and test

297 llowed the temporal dynamics of standing and newly generated variations in the evolving viral lineage

298 It appears that VpreB probes the fitness of newly generated VH domains of IgH chains for later pairi

299 By analysing 92 newly generated viral genome sequences from blood donors

300 nveloped viruses, by impeding the release of newly generated viral particles from the cell surface.