ライフサイエンスコーパス: newly generated

1 adds a polyadenosine [poly(A)] tract to the newly generated 3' end.

2 NA exiting from RecC and loads RecA onto the newly generated 3'-ended single-stranded DNA during cont

3 inhibition of BACE would result in decreased newly generated Abeta and soluble APPbeta (sAPPbeta), wi

4 In addition, spinal 5-HT(+) neurons were newly generated after a lesion and transiently increased

5 esent evidence that Pax2(+) interneurons are newly generated after a spinal lesion, whereas the gener

6 al propagation block, probably by preventing newly generated afterdischarges to travel backwards to t

7 Thus, our newly generated allele provides novel biological insight

8 This structure defines the positions of the newly generated amino and carboxyl groups following the

9 findings establish clear differences between newly generated and pre-existing memory B cells, highlig

10 stant ALL cell lines and patients, including newly generated and previously published data sets avail

11 We use a comprehensive dataset of newly generated and publicly available sequence data to

12 mpendium and mining tool of high-dimensional newly generated and published miRNA expression profiles.

13 f graft composition on regeneration of host, newly generated, and mature transferred T cells, and und

14 Immunoprecipitation assays using a newly generated anti-16E5 antibody confirmed that 16E5 w

15 However, a newly generated anti-Clr-g mAb detected only residual Cl

16 ics in wastewater effluents, but residual or newly generated antibacterial properties of transformati

17 Here, using our newly generated antibody raised against the entire C-ter

18 Using our newly generated APC conditional knock-out (cKO) mouse, w

19 Concentrations, kinetics, and amount of newly generated APP fragments were calculated.

20 iven, invasive gastric cancer in vivo, using newly generated Aqp5-creERT2 mouse models.

21 Using a series of newly generated Ar reporter and Pten knock-out compound

22 ated from these compartments and loaded into newly generated Argonaute 2 protein complexes weeks afte

23 provide proof-of-principle for the view that newly generated ASCs can acquire a mature PC phenotype t

24 A newly generated atlas is three-dimensional, allows the p

25 kNN-nearest and kNN-Kmeans, to partition the newly generated, attribute-enhanced graph.

26 In humans, up to 75% of newly generated B cells and about 30% of mature B cells

27 er treatment revealed that these clones were newly generated B cells and not self-reactive B cells th

28 ing is a mechanism of self-tolerance used in newly generated B cells.

29 y triggers severing and remains bound to the newly generated barbed ends.

30 o an elevated IAPP over insulin ratio in the newly generated beta cells.

31 Newly generated beta-like cells are epigenetically repro

32 However, newly generated Bim(+/-) naive CD4 T cells in middle-age

33 Using our newly generated CD11a-mYFP knock-in mice, we discovered

34 NOD stock also lacking ART2, but not in the newly generated CD38/P2X(7) double-KO line.

35 ration and (b) flow cytometry to analyze for newly generated CD4+ CD25(high) FOXP3+ Tregs in carboxyf

36 e the understanding of relationships between newly generated cells (marked with bromodeoxyuridine [Br

37 e, we extend upon these findings by ablating newly generated cells after the epileptogenic insult usi

38 Furthermore, some of the newly generated cells are capable of responding to lepti

39 pidermal stem cell behaviors and unravel how newly generated cells are integrated into pre-existing t

40 ription factor A, and that a subset of these newly generated cells differentiate into AgRP neurons al

41 The dispersion of newly generated cells in the neurogenic zone is restrict

42 n profile of maturation markers in surviving newly generated cells was altered.

43 Newly generated cells were detected by immunohistochemis

44 Proliferation and survival of newly generated cells were unchanged.

45 tral canal proliferating cells with Ki67 and newly generated cells with bromodeoxyuridine incorporati

46 bone marrow (BM) produces a stable output of newly generated cells, but immunologic stress conditions

47 toneally for seven consecutive days to label newly generated cells.

48 Pulse chase experiments indicate that the newly-generated cells differentiate into N-beta-tubulin-

49 of 6.1 inside CG using ClopHensorN(Q69M), a newly generated CG-specific pH indicator.

50 synteny conservation across centromeres with newly generated chromosome-level genome assemblies sugge

51 These newly generated CIBER mice provide a novel tool for stud

52 Newly generated cinnamic acid from coumaric acid aglycon

53 Mechanistically, newly generated, circulating neutrophils have lower Ly6G

54 otope-labeling, and dose-dependently reduced newly generated CNS Abeta.

55 Screening of the biological activity of the newly generated compounds leads to the identification of

56 Using newly generated conditional and constitutive C1ql3 knock

57 Using newly generated conditional knock-in and knockout mice,

58 Using newly generated conditional knockin mice that enable gen

59 Using newly generated constitutive and conditional knockout mi

60 We show that newly generated conventional CD69(+)Qa2(-) CD4 single-po

61 r construct that allows for the isolation of newly generated cortical interneuron precursors.

62 generated from tomato plants, combined with newly generated data from N. benthamiana leaves infiltra

63 ds can provide valuable tools to consolidate newly generated data with existing knowledge, and to dec

64 e transport modeling, based on published and newly generated data, is used to better understand the i

65 However, despite numerous flows of newly generated data, the precise mechanism with respect

66 using mathematical modeling of published and newly generated data, we have obtained estimates of adip

67 plied it to previously published (n = 5) and newly generated data.

68 The newly generated databases will provide a tool to explore

69 n divides distinct splice isoforms among the newly generated daughter genes, in this way reducing the

70 tivation are almost completely reversed in a newly generated dCK/TK1 double-knockout (DKO) mouse mode

71 res, density of polymorphic sites, number of newly generated deleterious mutations in one generation,

72 We applied our method to a set of newly generated deletion mutants in the dioecious plant

73 Using a newly generated Dennd5b(-/-) mouse, we demonstrate an es

74 Newly generated dentate granule cells (GCs) are relevant

75 gs support the long-standing hypothesis that newly generated dentate granule cells are pro-epileptoge

76 study reveal that the dynamic dispersion of newly generated dentate granule cells in the neurogenic

77 the selective deletion of alpha-CaMKII from newly generated dentate granule cells led to an increase

78 impaired after deletion of alpha-CaMKII from newly generated dentate granule cells.

79 t of dendrite arbors and dendritic spines in newly generated dentate gyrus granule cell neurons of th

80 The process of circuit integration of newly-generated dentate granule cells of the hippocampus

81 orchid phylogenies (including more than 400 newly generated DNA sequences), comparative phylogenetic

82 We apply PhEMD to a newly generated drug-screen dataset and demonstrate that

83 During the early stages of HR, the newly generated DSB ends are processed to yield long sin

84 wever, c-myc also translocated frequently to newly generated DSBs within a 35-Mb region downstream of

85 During blood vessel formation, newly generated endothelial cells rapidly expand into pr

86 ever, HNF1beta expression was not present in newly generated epithelial cell adhesion molecule (EpCAM

87 t of 566 high-coverage exomes, including 266 newly generated exomes, from 14 populations of rainfores

88 was validated with previously published and newly generated experimental data, and suggested new in

89 Rather, we provide evidence that newly generated FDCs also arise from the proliferation a

90 rotein fusions to the REL_DKK pair among the newly generated FokI nuclease domain variants appear to

91 ugh analysis of RNA-seq gene expression data newly generated for 448 cancer cell lines, combined with

92 ripheral position, while the same effect was newly generated for the index finger by the same postura

93 yophyllales, of which 43 transcriptomes were newly generated for this study, representing one of the

94 noclonal antibodies (MAbs), 14 of which were newly generated from 9 chronically infected subjects.

95 the membrane-retained 70-kDa CDCP1 fragment, newly generated from its full-length 135-kDa precursor t

96 Newly generated Gata3 hypomorphic mutant mice exhibited

97 Using newly generated GD/PD mouse lines of either sex [Gba mut

98 from other studies, akin to the way in which newly generated genomic information can be compared to d

99 revealed that females had significantly more newly generated glial cells but not more newly generated

100 Using newly generated glp1r-Cre mice crossed with fluorescent

101 eta-cell function in Gpr119(-/-) mice and in newly generated Gpr119(betacell-/-) mice.

102 provides the first evidence that ablation of newly generated granule cells can be an effective therap

103 lar components, parvalbumin interneurons and newly generated granule cells in the hippocampus.

104 Newly-generated hair cells presented in three cochlear t

105 brainstem responses, which suggests that the newly generated HCs may contribute to, or at least do no

106 Retraining National Early Warning Score with newly generated hospital-specific coefficients improved

107 Therefore, our data show that newly generated host Tregs can prevent chronic allograft

108 Here, using a newly generated Hoxa11-CreER(T2) lineage-tracing system,

109 ions with polyclonal Abs were confirmed with newly generated human mAbs derived from DENV-immune indi

110 Interestingly, the newly generated human PrP(Sc) exhibits a distinct bioche

111 This work is the first report of a newly generated humanized transgenic mouse model enginee

112 e, along with true ICAM-1-deficient mice and newly generated ICAM-1-transgenic mice, have provided th

113 In wild-type and transgenic mice, we traced newly generated IgA-secreting cells at steady state and

114 cific S1pr1 knockout (B-S1pr1KO) mice, their newly generated immature B cells appeared in the blood a

115 Newly generated immature B cells are selected to enter t

116 gnal necessary for the efficient transfer of newly generated immature B cells from the bone marrow to

117 f INPs due to ectopic Prospero expression in newly generated immature INPs (imINPs), whereas the incr

118 re, we report that vChATs directly innervate newly generated immature neurons (NGIs) in the dorsal hi

119 e observed learning deficits were rescued as newly generated immature neurons repopulated the granule

120 brain structural plasticity consists of non-newly generated, "immature" neurons of the adult cerebra

121 lyst controls two stereocenters, one that is newly generated in a beta-migratory insertion and one th

122 or piggyBac element integrations and 12,500 newly generated insertions of the Minos transposon.

123 This early glutamatergic input onto newly generated interneurons in the OB was matched in ti

124 howed that mitral cells, the target cells of newly generated interneurons, receive reduced spontaneou

125 regated by recombination events, causing the newly generated intersubtype recombinants to undergo pur

126 -MS/MS) analyses on brain homogenates of our newly generated knockin mouse expressing a FLAG-tagged v

127 Using newly generated knockin reporter mice for Cbln2 and Cbln

128 The newly generated library of sphingolipid ions was then ap

129 In addition, the newly generated linkage map has allowed us to fine-map a

130 Finally, the newly generated linkage map was used to fine-map a QTL a

131 h preformed granule-associated mediators and newly generated lipid-derived mediators contributes to t

132 rm a comprehensive investigation using 3,059 newly generated low-depth whole-genome sequences from ei

133 nter-gatherers and farmers, together with 40 newly generated, low-coverage genomes.

134 gate Treml4 function, we took advantage of a newly generated mAb against Treml4 and engineered its H

135 evaluated Helios protein expression using a newly generated mAb and demonstrated that it is expresse

136 ilable genome-wide DNA methylation data with newly generated maps for chromatin accessibility and his

137 rdelino to a published cancer dataset and to newly generated matched scRNA-seq and exome-seq data fro

138 The MCC cell lines used include three newly generated MCV-infected cell lines and one MCV-nega

139 learned classifications of these states onto newly generated MD simulations.

140 cells recognizing conserved epitopes and the newly generated memory B cells directed toward H7 strain

141 In this study, we show that newly generated memory B cells do not display active aut

142 RA, produced by newly generated mesodermal cells, provides feedback that

143 nce presentation of exogenous Ag by limiting newly generated MHC class II molecules from forming stab

144 ctron microscopy reveal that the majority of newly generated MHC-II I-A(k)-HEL(46-61) complexes are e

145 meningitis virus infection were augmented in newly generated mice lacking LIFR in either CD11c(+) or

146 Our newly generated mice, overexpressing mutant G2019S-LRRK2

147 d that abnormal LD morphology occurs because newly generated micro-LDs fail to dissociate from the ER

148 ed microRNA and mRNA transcriptome data from newly generated microarray data on IHs with publicly ava

149 ter 14 d, the brain had a full complement of newly generated microglia.

150 We tracked the fate of newly generated micronuclei and found that they undergo

151 ing miR-29a/b-1 (miR-29a)-deficient mice and newly generated miR-29b-2/c (miR-29c)-deficient mice.

152 Several newly generated missense alleles carry amino acid substi

153 r the spatial resolution and distribution of newly generated mitochondrial tips following division.

154 these issues, we analyzed the phenotypes of newly generated MLL4 mutant mice, along with MLL3 mutant

155 We used newly generated MMTV-Cre105Ayn mice to inactivate p53 an

156 This newly generated moDC population and not the resident DCs

157 structed structure of AAV5 in complex with a newly generated monoclonal antibody, HL2476, at 3.1- ang

158 ascades in prostate tumorigenesis by using a newly generated mouse model in which both murine Met tra

159 Capitalizing on a set of newly generated mouse models, we provide an integrated m

160 beta-catenin in prostate tumorigenesis using newly generated mouse models.

161 hearing loss by screening a large cohort of newly generated mouse mutants using a sensitive electrop

162 This newly generated mouse serves as a tool to study the func

163 Importantly, using a newly generated mouse strain expressing a kinase-inactiv

164 Using a newly generated mouse that expresses IFN-gammaR only on

165 tidergic nociceptors across the body using a newly generated Mrgprd(CreERT2) mouse line.

166 rodegeneration and synaptic damage between a newly generated mThy-1 alpha-synuclein E57K transgenic m

167 Recordings from newly generated mutant flies demonstrated that DmalphaG

168 The analysis of newly generated mutant mESCs revealed that DGCR8 is esse

169 The newly generated mutant mice displayed several striking b

170 ediated by preactivated T cells, rather than newly generated myeloma-reactive T cells.

171 readth of myxozoan diversity, including four newly generated myxozoan assemblies, confirms that myxoz

172 Through an analysis of 49 newly generated MYXV genome sequences isolated in Austra

173 e protease plasmepsin V, but the role of the newly generated N-terminal sequence in protein export is

174 The contribution of newly generated NAP acids was mainly from higher-order o

175 Newly generated neural progenitors are exposed to FGF si

176 Newly generated neuroblasts from the subventricular zone

177 wed a highly significant correlation between newly generated neuroblasts in the DG and cognition defi

178 oglia hampered the survival and migration of newly generated neuroblasts through the RMS to the olfac

179 The diminished numbers of newly generated neurons (BrdU/NeuN co-localization) was

180 ex in cortical progenitors (Emx1-Cre) and in newly generated neurons (Nex1-Cre).

181 ly to control the differentiation process of newly generated neurons and exert an important influence

182 was first reported as the co-association of newly generated neurons and their progenitors with both

183 t not gliogenesis, and also on the number of newly generated neurons expressing ENK, OX, or melanin-c

184 vidence of aberrant functional maturation of newly generated neurons following stroke.

185 and the olfactory bulb, the region to which newly generated neurons from the sub-ependymal zone migr

186 l location, we also found populations of non-newly generated neurons in several subcortical regions (

187 reprogramming and subsequent survival of the newly generated neurons in the adult rodent brain.

188 Furthermore, short-term learning and newly generated neurons in the dentate gyrus were defici

189 ematically analyze the dynamic dispersion of newly generated neurons in the neurogenic zone and obser

190 d be traced starting only from 3 to 5 wk on, newly generated neurons in the OB received input from th

191 suggest common principles for incorporating newly generated neurons into a preexisting circuit.

192 Integration of newly generated neurons into adult cell assemblies is a

193 to image the addition of genetically labeled newly generated neurons into the brain of juvenile zebra

194 neurogenesis, we investigated whether these newly generated neurons might play a role in recovery.

195 for 8 weeks, resulting in a great number of newly generated neurons misplaced in the outer GCL in th

196 tent with a negative-feedback loop, in which newly generated neurons modulate cell division of SVZ st

197 Newly generated neurons must keep cell cycle components

198 reduced neurite outgrowth and the number of newly generated neurons only at nanomolar concentrations

199 enic mice, we determined that injury-induced newly generated neurons persisted over time and elaborat

200 s known regarding the initial development of newly generated neurons prior to circuit integration and

201 unlike rodents, is largely endowed with non-newly generated neurons retaining immature features, sug

202 Whole-cell recordings of adjacent newly generated neurons reveal that they are coupled via

203 The number of newly generated neurons significantly declined only in t

204 ore newly generated glial cells but not more newly generated neurons than males, and treatment with W

205 neurogenic zones, whether and how it acts on newly generated neurons that integrate into the establis

206 We investigated whether newly generated neurons were modulated by endogenous alp

207 Similar to newly generated neurons, these cells express the cytoske

208 required for the terminal differentiation of newly generated neurons, were both increased in the hipp

209 stream (RMS), which is a forebrain source of newly generated neurons.

210 ting cell rescue through the expression of a newly generated, non-self-reactive TCR.

211 Mechanistically, the newly generated NOXA interacted with Mcl-1 and displaced

212 guided by argonaute-mediated recognition of newly generated nucleotide overhangs when ssRNA is targe

213 Using newly generated null alleles, we demonstrate that polych

214 g lesion borders where at least a portion of newly generated oligodendrocytes (bromodeoxyuridine+) we

215 Although it is widely accepted that newly generated oligodendrocytes (OLs) produce myelin in

216 production in the adult CNS is initiated by newly generated oligodendrocytes (OLs), great interest r

217 siderable recovery, including immigration of newly generated or repaired neurons that became active d

218 and in vivo time-lapse imaging to show that newly generated OSNs form highly dynamic synapses and ar

219 The newly generated oxidized proteoforms are shown to posses

220 ulti-drug-resistant HIV-1 variants, that the newly generated P2-Crwn-THF moiety confers highly desira

221 l HIV-1 protease inhibitor (PI) containing a newly-generated P2-crown-tetrahydrofuranylurethane (Crwn

222 ng to FcgammaRIIa and FcgammaRIIIa with this newly generated panel of antibodies.

223 We propose that newly generated pDC mobilized from the bone marrow, rath

224 Here, making use of a newly generated Pdgfd knockout mouse, we reveal a functi

225 receptors, which preferentially destabilizes newly generated place fields.

226 Newly generated pMHC-II complexes are present in small c

227 ide to (R(s))-thiosulfinate which contains a newly generated polar group was also confirmed to be of

228 ys deliver a positive readout in the form of newly generated progeny phages by the bacterial host of

229 onine surrogate azido-nor-leucine (ANL) into newly generated proteins.

230 that there was no prevalence of disomy among newly generated [PSI (+)] strains in absence of strong s

231 Using newly generated pure Balb/C CAV1 null ((Balb/C)CAV1-/-)

232 Newly generated rabbit antibodies, respectively, against

233 Using newly generated RANK Venus reporter mice, we identify di

234 Using newly generated recombinant antigen variant-expressing c

235 f Immunity, Licona-Limon et al. (2013) use a newly generated reporter mouse to demonstrate a role for

236 herin activity to allow apical retraction in newly generated RGCs.

237 We tested the framework on newly generated RNA-seq and H3K27ac ChIP-seq profiles up

238 to regional cortical gene expression from a newly generated RNA-seq dataset and two additional gene

239 ation cues are required to guide and contain newly generated rodent subventricular zone (SVZ) neurobl

240 Notably, we observed that a newly generated Salmonella vaccine strain not only confe

241 d soluble APPbeta (sAPPbeta), with increased newly generated sAPPalpha.

242 n Markov Models (HMMs), also included are 13 newly generated SCG-set HMMs for different lineages and

243 Finally, the newly generated sequences more closely resemble the low-

244 phages and pDC precursors were eliminated in newly generated SiglecH-diphtheria toxin receptor (DTR)-

245 Using newly generated single-cell 5mCpG sequencing data, we sh

246 An analysis of a newly generated single-cell RNA sequencing dataset on hu

247 Newly generated SP cells exhibit greater capacity for sp

248 Immunoblot analyses using newly generated specific Cx47 antibodies revealed that o

249 e, we used a large data set of published and newly generated sRNA sequencing data (1333 sRNA-seq libr

250 Evaluation of PREX2 expression in these newly generated stable cells revealed varying levels of

251 We then tested whether our newly generated, stage-specific transcriptional signatur

252 The organocatalyst controls the newly generated stereocenter six bonds away from the ste

253 fficiency and with full stereocontrol of the newly generated stereogenic center.

254 established that Cyp2a5-null mice, but not a newly generated strain of Cyp2g1-null mice, were resista

255 The newly generated strains harboring chromosome translocati

256 sors are particle-swapping loops rather than newly generated structural defects, and that coherent an

257 ly old populations, pocketed with occasional newly generated subclones that were the result of recent

258 energy/tension that drives the reduction of newly generated surface areas created upon damage by sha

259 Newly-generated synapse-like structures expressed glutam

260 Newly generated T cells are unable to respond to antigen

261 Recent thymic emigrants are newly generated T cells that need to undergo postthymic

262 of TK+ cells, anticipating the appearance of newly generated T cells.

263 Here, using a newly generated, tagged Gli3 knock-in mouse (Gli3(TAP) )

264 , we inferred a Brassicaceae phylogeny using newly generated targeted enrichment sequence data of 182

265 Affinity of newly generated TCR for peptide-MHC primarily sets the b

266 earing endogenous TCRbeta-chains can express newly generated TCRbeta molecules in adoptive hosts.

267 ribution data of 1719 genera combined with a newly generated time-calibrated mega-phylogenetic tree.

268 as linked to the positioning of mtDNA to the newly generated tip.

269 vision, resulting in their distribution into newly generated tips in the mitochondrial network.

270 at preferential locations, including within newly generated tissue (the blastema), and along pre-exi

271 This explains how the structure of a newly generated tissue is coordinated with that of the o

272 s, and sebaceous glands were observed in the newly generated tissue.

273 finding which we were able to replicate in a newly generated Tmem106b CRISPR/cas9 knock-out mouse mod

274 We demonstrate here that our newly generated tools, including transgenic "MitoFish,"

275 tera: Tephritidae) is described here using a newly generated transcriptome dataset.

276 eny and diversification rate shifts using 31 newly generated transcriptomes and 88 other datasets cov

277 e IIS/TOR network across 66 amniotes with 18 newly generated transcriptomes from nonavian reptiles an

278 The nuclear genes from newly generated transcriptomes revealed a well-resolved

279 By using a newly generated transgenic line of P. falciparum (PfGCaM

280 y superimpose the labeling patterns from our newly generated transgenic lines.

281 sed this issue in the olfactory system using newly generated transgenic mice that express channelrhod

282 Using a newly generated transgenic mouse in which PSCs are speci

283 Here, we describe a newly generated transgenic mouse in which the Gs DREADD

284 ter (WM) development and adult injury with a newly generated transgenic mouse overexpressing Sox17 in

285 orphology of various types of RGCs using the newly generated transgenic mouse rd1/Thy1-GFP, in which

286 By crossing SP-deficient mice with a newly generated transgenic mouse strain that expresses G

287 A newly generated transgenic prostate line expressing an M

288 im3(+) CD8(+) T cells, suggesting that these newly generated transitional cells play a critical role

289 Four of the PCTs that developed in the newly generated translocation reporter mice, designated

290 A newly generated UL32-null mutant was used to confirm tha

291 uilibration, permitting the recycling of any newly generated unnatural atropisomer under progressivel

292 eletion of p53 in urothelial cells using the newly generated UPK II-Cre mice results in normal bladde

293 se findings illustrate the usefulness of the newly generated V2R mutant mice for elucidating and test

294 llowed the temporal dynamics of standing and newly generated variations in the evolving viral lineage

295 It appears that VpreB probes the fitness of newly generated VH domains of IgH chains for later pairi

296 By analysing 92 newly generated viral genome sequences from blood donors

297 nveloped viruses, by impeding the release of newly generated viral particles from the cell surface.

298 Using these newly generated viruses allowed us to examine the expres

299 53 candidate odorant receptors (ORs) using a newly generated whole-genome dataset for B. minax.

300 In this study, we used a newly generated zebrafish reporter to screen over 8000 s