ライフサイエンスコーパス: nicotinamide mononucleotide

1 Human milk was the richest source of nicotinamide mononucleotide.

2 enzymatic activity and of the NAMPT product nicotinamide mononucleotide.

3 hritic mice, a result that was reversed with nicotinamide mononucleotide.

4 namidase and instead convert nicotinamide to nicotinamide mononucleotide.

5 times faster than the rate of adenylation of nicotinamide mononucleotide.

6 n indicated that three yeast enzymes possess nicotinamide mononucleotide 5'-nucleotidase activity in

7 ate-trapping mutant P4 enzyme complexed with nicotinamide mononucleotide, 5'-AMP, 3'-AMP, and 2'-AMP.

8 Notably, all Listeria genomes lack CobT, the nicotinamide mononucleotide:5,6-dimethylbenzimidazole (D

9 target of Hiw: the NAD+ biosynthetic enzyme nicotinamide mononucleotide adenyltransferase (Nmnat), w

10 nsertion site in the first intron of Nmnat2 (Nicotinamide mononucleotide adenyltransferase 2).

11 ed expression of the NAD synthesizing enzyme nicotinamide mononucleotide adenylyl transferase 1 (Nmna

12 ne dinucleotide (NAD(+)) biosynthetic enzyme nicotinamide mononucleotide adenylyl transferase 1 (Nmna

13 generation (Wld(S)) encodes a chimeric Ube4b/nicotinamide mononucleotide adenylyl transferase 1 (Nmna

14 ed in Wld(S) mutant mice by expression of an nicotinamide mononucleotide adenylyl transferase 1 (Nmna

15 ide adenine dinucleotide-synthesizing enzyme nicotinamide mononucleotide adenylyl transferase 1.

16 Nicotinamide mononucleotide adenylyl transferase 2 (NMNA

17 Nicotinamide mononucleotide adenylyl transferase 2 (NMNA

18 onal maintenance and protective function for nicotinamide mononucleotide adenylyl transferases (NMNAT

19 Nicotinamide mononucleotide adenylyltransferase (NMNAT)

20 Recent studies on the NAD synthesis enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT)

21 uncovered protective effects of NAD synthase nicotinamide mononucleotide adenylyltransferase (NMNAT)

22 gulation of NAD biosynthesis, (ii) a central nicotinamide mononucleotide adenylyltransferase (NMNAT)

23 Overexpression of nicotinamide mononucleotide adenylyltransferase (Nmnat),

24 ence of Pof1 indicates that it is a putative nicotinamide mononucleotide adenylyltransferase (NMNAT).

25 an axonal protective function of Wld(S) and nicotinamide mononucleotide adenylyltransferase (Nmnat).

26 protein sequences are identical to the human nicotinamide mononucleotide adenylyltransferase (NMNAT).

27 encoding the nuclear NAD(+) synthesis enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT1)

28 adenine dinucleotide (NAD) synthetic enzyme, nicotinamide mononucleotide adenylyltransferase (Nmnat1)

29 namide phosphoribosyltransferase (NAMPT) and nicotinamide mononucleotide adenylyltransferase 1 (NMNAT

30 contains the full-length coding sequence of nicotinamide mononucleotide adenylyltransferase 1 (Nmnat

31 studies demonstrated that overexpression of nicotinamide mononucleotide adenylyltransferase 1 (Nmnat

32 The NAD-synthesizing enzyme nicotinamide mononucleotide adenylyltransferase 2 (NMNAT

33 that the mRNA and protein levels of NMNAT2 (nicotinamide mononucleotide adenylyltransferase 2), a re

34 we show that NAD(+), the metabolite of WldS/nicotinamide mononucleotide adenylyltransferase enzymati

35 ebrates, including inhibition by both NMNAT (nicotinamide mononucleotide adenylyltransferase) express

36 CA9 locus and encodes the nuclear isoform of nicotinamide mononucleotide adenylyltransferase, a rate-

37 Nicotinamide mononucleotide adenylytransferase (NMNAT) i

38 awed tissue was minimized by the addition of nicotinamide mononucleotide, an inhibitor of NAD(+) glyc

39 ral membrane protein (PnuC) in the import of nicotinamide mononucleotide, an NAD precursor.

40 Nicotinamide adenylyl transferase condenses nicotinamide mononucleotide and (tz) ATP to yield N(tz)

41 neous quantitation of nicotinamide riboside, nicotinamide mononucleotide and NAD in milk by means of

42 Supplementation with the NAD(+) precursors nicotinamide mononucleotide and nicotinamide riboside al

43 The NAD biosynthetic precursors nicotinamide mononucleotide and nicotinamide riboside ar

44 -IA, can dephosphorylate the mononucleotides nicotinamide mononucleotide and nicotinic acid mononucle

45 mononucleotides, adenosine monophosphate and nicotinamide mononucleotide, and are present as oxidized

46 es, including nicotinic acid mononucleotide, nicotinamide mononucleotide, and NmR, can also delay axo

47 CobT used nicotinamide mononucleotide as a ribose phosphate donor.

48 overed NAD(+) precursor that is converted to nicotinamide mononucleotide by specific nicotinamide rib

49 ach chain; the C-terminal domain harbors the nicotinamide mononucleotide deamidase activity, and the

50 CinA was shown to have both nicotinamide mononucleotide deamidase and ADP-ribose pyr

51 m of vitamin B3, and its phosphorylated form nicotinamide mononucleotide, have been shown to be poten

52 imiting enzyme that converts nicotinamide to nicotinamide mononucleotide in the NAD biosynthetic path

53 side chains comprise a binding site for the nicotinamide mononucleotide moiety of NAD(+).

54 and is likely to interact directly with the nicotinamide mononucleotide moiety of NAD(+).

55 ntly identified neuronal maintenance factor, nicotinamide mononucleotide (NAD) adenylyl transferase (

56 as NAD, nicotinic acid adenine dinucleotide, nicotinamide mononucleotide, nicotinic acid, or nicotina

57 Nicotinamide mononucleotide (NMN) adenylyltransferase 2

58 .2.12) catalyzes the reversible synthesis of nicotinamide mononucleotide (NMN) and inorganic pyrophos

59 pathways including striking accumulations of nicotinamide mononucleotide (NMN) and nicotinamide ribos

60 f extracellular NAD(+) or NAD(+) precursors, nicotinamide mononucleotide (NMN) and NR, can reverse th

61 reversible adenylation of both NaMN and the nicotinamide mononucleotide (NMN) but shows specificity

62 enterica can obtain pyridine from exogenous nicotinamide mononucleotide (NMN) by three routes.

63 We have shown that the NAD(+) precursor, nicotinamide mononucleotide (NMN) can reverse some of th

64 inic acid mononucleotide (NaMN) and mediates nicotinamide mononucleotide (NMN) catabolism, thereby co

65 d the TS structure for pyrophosphorolysis of nicotinamide mononucleotide (NMN) from kinetic isotope e

66 t specifically bind riboflavin (Rb) and beta-nicotinamide mononucleotide (NMN) have been isolated by

67 treatment of mice with the NAD(+) precursor nicotinamide mononucleotide (NMN) increases BubR1 abunda

68 phate and the nicotinamide nucleoside of the nicotinamide mononucleotide (NMN) leaving group are orie

69 In this route, the amidation of NaMN to nicotinamide mononucleotide (NMN) occurs before the aden

70 plementation with NAD(+) precursors, such as nicotinamide mononucleotide (NMN) or nicotinamide ribosi

71 t be mimicked by the Nampt enzymatic product nicotinamide mononucleotide (NMN), was not blocked by th

72 cannot be compensated for by an alternative nicotinamide mononucleotide (NMN)-preferring adenylyltra

73 milation of NmR, converting it internally to nicotinamide mononucleotide (NMN).

74 require high (millimolar) concentrations of nicotinamide mononucleotide or NAMN for efficient cataly

75 The flexibility of the nicotinamide mononucleotide portion of NADPH may be nece

76 In addition, utilization of extracellular nicotinamide mononucleotide requires prior conversion to

77 The NAD(+) precursor nicotinamide mononucleotide restored the cellular NAD(+)

78 trate specificity toward both nicotinate and nicotinamide mononucleotide substrates, which is consist

79 precursors nicotinamide, nicotinic acid, or nicotinamide mononucleotide, the Ca(2+) content of thaps

80 Following deadenylation with nicotinamide mononucleotide, the purified fragment could

81 (+) utilization pathway by dephosphorylating nicotinamide mononucleotide to nicotinamide riboside.

82 es, but not by NADH, NADPH, or NMNH (reduced nicotinamide mononucleotide), was isolated from bovine k