ライフサイエンスコーパス: nicotinamide riboside

1 nd was reversible on resupplying NAD(+) with nicotinamide riboside.

2 osphorylating nicotinamide mononucleotide to nicotinamide riboside.

3 Nicotinamide riboside, a form of vitamin B3, protects ag

4 In this issue, Belenky et al. report that nicotinamide riboside, a new NAD(+) precursor, regulates

5 ion on the development of steatosis in mice, nicotinamide riboside, a precursor of NAD(+) biosynthesi

6 ) precursors nicotinamide mononucleotide and nicotinamide riboside also increases NAD(+) levels in as

7 methotrexate, supplementation of a diet with nicotinamide riboside, an NAD precursor, replenished hep

8 y achieves stereoselective synthesis of beta-nicotinamide riboside and a series of related amide, est

9 n yeast and human cells, Nrk2 phosphorylates Nicotinamide Riboside and generates NAD+ through an alte

10 Here, we show that nicotinamide riboside and nicotinic acid riboside are au

11 Recently, we discovered that nicotinamide riboside and nicotinic acid riboside are bi

12 1 and Sdt1 are responsible for production of nicotinamide riboside and nicotinic acid riboside in cel

13 to be highly specific for phosphorylation of nicotinamide riboside and the cancer drug tiazofurin.

14 c precursors nicotinamide mononucleotide and nicotinamide riboside are reported to confer resistance

15 The nicotinamide riboside binding site overlaps that of the

16 under standard growth conditions, Nrt1, the nicotinamide riboside carrier, is the major AICAr transp

17 Nicotinamide riboside efficiently rescues NAD(+) synthes

18 Thus, like calorie restriction in the mouse, nicotinamide riboside elevates NAD(+) and increases Sir2

19 Nicotinamide riboside elevates NAD+ levels via the nicot

20 Supplementation of yeast cells with nicotinamide riboside extends replicative lifespan and i

21 idine hydrolase is 100-fold more active as a nicotinamide riboside hydrolase than as a uridine hydrol

22 ated by Sum1, Hst1, and Rfm1, fully restores nicotinamide riboside import and utilization when resupp

23 required for Nrk-independent utilization of nicotinamide riboside in yeast.

24 In eukaryotes, nicotinamide riboside is a newly discovered NAD(+) precu

25 Nicotinamide riboside is a recently discovered eukaryoti

26 vered as a nutrient in milk, suggesting that nicotinamide riboside is a useful compound for elevation

27 challenged experimentally and revealed that nicotinamide riboside is an unanticipated NAD+ precursor

28 ion, we have shown that exogenously supplied nicotinamide riboside is imported into yeast cells by a

29 The mechanism of action of nicotinamide riboside is totally dependent on increased

30 Here we show that nicotinamide riboside kinase 1 (NRK1) is necessary and r

31 cles the nicotinamide precursor, whereas the nicotinamide riboside kinase 2 (NMRK2) that phosphorylat

32 We found that Nicotinamide riboside kinase 2b (Nrk2b) cell autonomousl

33 We find that nicotinamide riboside kinase 2b-mediated NAD+ biosynthes

34 ion largely depends on uridine hydrolase and nicotinamide riboside kinase and that nicotinic acid rib

35 namide riboside elevates NAD+ levels via the nicotinamide riboside kinase pathway and by a pathway in

36 NAD(+) precursor converted to NAD(+) via the nicotinamide riboside kinase pathway and by nucleosidase

37 e phosphorylase is responsible for mammalian nicotinamide riboside kinase-independent nicotinamide ri

38 Nicotinamide riboside kinases from yeast and humans esse

39 d to nicotinamide mononucleotide by specific nicotinamide riboside kinases, Nrk1 and Nrk2.

40 Because current data suggest that nicotinamide riboside may be the only vitamin precursor

41 The adenosine moiety and the nicotinamide riboside moiety are both in the anti confor

42 The anti conformation of the nicotinamide riboside moiety is in accord with the prefe

43 rst time on the simultaneous quantitation of nicotinamide riboside, nicotinamide mononucleotide and N

44 iological assay, and intracellular levels of nicotinamide riboside, nicotinic acid riboside, and othe

45 Nicotinamide riboside, nicotinic acid riboside, O-ethyln

46 Administration of nicotinamide riboside (NmR) has been shown to ameliorate

47 Nicotinamide riboside (NmR) is a key pyridine metabolite

48 ryptophan, nicotinic acid, nicotinamide, and nicotinamide riboside (NmR), via multiple enzymatic step

49 ve, we treated prediabetic and T2D mice with nicotinamide riboside (NR) added to HFD.

50 Addition of NA or nicotinamide riboside (NR) allows a moved mother to main

51 -1 or supplementation with the NAD-precursor nicotinamide riboside (NR) ameliorates energetic derange

52 Nicotinamide and nicotinic acid as well as nicotinamide riboside (NR) and nicotinic acid riboside (

53 The activity of nicotinamide riboside (NR) in neuroprotective models and

54 ons of nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) in the amidated salvage pathw

55 Nicotinamide riboside (NR) is an endogenously produced k

56 Nicotinamide riboside (NR) is in wide use as an NAD(+) p

57 Additionally, deletion of SSY5 increases nicotinamide riboside (NR) levels and phosphate-responsi

58 Restoring NAD(+) pools with nicotinamide riboside (NR) prevents DNA damage and tumor

59 The gene for the nicotinamide riboside (NR) transporter (pnuC) was identi

60 the rate of liver regeneration, we supplied nicotinamide riboside (NR), an NAD precursor, in the dri

61 such as nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR), protects against metabolic d

62 arting from nicotinamide, nicotinic acid, or nicotinamide riboside (NR).

63 nicotinic acid (NA), nicotinamide (NAM) and nicotinamide riboside (NR).

64 s a pH-dependent facilitator with a K(m) for nicotinamide riboside of 22 microm.

65 assess the effects of the sirtuin activator, nicotinamide riboside, on NLRP3 inflammasome activation.

66 ide kinase 2 (NMRK2) that phosphorylates the nicotinamide riboside precursor is increased, to a highe

67 In this study, we discovered that exogenous nicotinamide riboside promotes Sir2-dependent repression

68 de, and the newly identified NAD+ precursor, nicotinamide riboside, reviewed herein, are responsible

69 Additionally, the two nicotinamide riboside salvage pathways contribute to NAD

70 D+ synthesis, we present prospects for human nicotinamide riboside supplementation and propose areas

71 Accordingly, we show that nicotinamide riboside supplementation in food attenuates

72 Nicotinamide riboside supplementation of yeast extends r

73 ibute to NAD(+) metabolism in the absence of nicotinamide-riboside supplementation.

74 The data show that nicotinamide riboside, the most energy-efficient among N

75 Nicotinamide riboside, the most recently discovered form

76 The ability of nicotinamide riboside to enhance life span does not depe

77 Nicotinamide riboside treatment also robustly increases

78 The molecular basis for nicotinamide riboside uptake was unknown in any eukaryot

79 eletion of a single gene, YOR071C, abrogates nicotinamide riboside uptake without altering nicotinic

80 icular fungi, suggesting a similar basis for nicotinamide riboside uptake.

81 ian nicotinamide riboside kinase-independent nicotinamide riboside utilization.

82 Secreted nicotinamide riboside was detected with a biological ass

83 Nicotinamide riboside was discovered as a nutrient in mi

84 on did not affect the bovine milk content of nicotinamide riboside, whereas UHT processing fully dest