ライフサイエンスコーパス: nicotinate

1 % polarization in the case of methyl-4,6-d2 -nicotinate.

2 in the presence of its ligands butyrate and nicotinate.

3 to a 1,6-dihydropyridine derived from methyl nicotinate.

4 cleotide (NMN) but shows specificity for the nicotinate.

5 te (K(m)(L-lactate) = 0.17 +/- 0.02 mM, K(m)(nicotinate) = 0.54 +/- 0.12 mM at -150 mV) than zSMCTn (

6 Tn (K(m)(L-lactate) = 1.81 +/- 0.19 mM, K(m)(nicotinate) = 23.68 +/- 4.88 mM).

7 An efficient synthesis of methyl nicotinates/6-halonicotinates by the domino isomerizatio

8 aMN) with ATP is coupled to the formation of nicotinate adenine dinucleotide (NaAD) and inorganic pyr

9 ensable downstream enzymes of NAD synthesis, nicotinate adenylyltransferase (NadD family) and NAD syn

10 The ability of a nicotinate analog to reduce NAH (disappearance of 2.067

11 g only two commercial building blocks, ethyl nicotinate and 2-iodoaniline.

12 ion occurred in the crystal lattice to yield nicotinate and alpha-ribazole-5'-phosphate.

13 complex of CobT with its reaction products, nicotinate and alpha-ribazole-5'-phosphate.

14 egrees C manifested elevated amino acids and nicotinate and depleted short chain fatty acids compared

15 LC method, capable of separating picolinate, nicotinate and isonicotinate, was developed and used in

16 ciation study of colon cancer and identified nicotinate and nicotinamide metabolism and transforming

17 Extensive changes in nicotinate and nicotinamide metabolism genes were corrob

18 ssess dual substrate specificity toward both nicotinate and nicotinamide mononucleotide substrates, w

19 The role of the NiaP transporter in both nicotinate and nicotinamide salvage was confirmed.

20 Here we characterized the effects of nicotinate and related modulators on the BvgS periplasmi

21 The remainder of the cavity binds the nicotinate and ribose-5'-phosphate moieties, which are n

22 carboxylates (MC) such as lactate, pyruvate, nicotinate, and butyrate.

23 at zSMCTe has a higher affinity for lactate, nicotinate, and pyruvate (K(m)(L-lactate) = 0.17 +/- 0.0

24 t of monocarboxylates such as propionate and nicotinate, and we show that SMCT may play a role in col

25 ologically relevant nicotinamides and methyl nicotinates are detailed.

26 The pH-dependence of nicotinate binding for rLb and Y30A was consistent with

27 GPR109A is a G-protein-coupled receptor for nicotinate but recognizes butyrate with low affinity.

28 ed to tert-butyl 4-(tert-butoxycarbonylamino)nicotinates by treatment with LDA in THF.

29 The crystal structures reveal that the nicotinate carboxylates of NaAD are recognized by intera

30 DMML is a key enzyme in bacterial nicotinate catabolism, catalyzing the last of nine enzym

31 Reduction potentials for the rLb and rLb-nicotinate derivatives were 29 +/- 2 mV (pH 5.40, 25.0 d

32 pounds were prepared through a triacetylated-nicotinate ester nucleoside, via coupling of either ethy

33 ich to minimal medium containing thiamin and nicotinate, growth is preceded by a considerable lag per

34 otinate hydrochloride to place 2.4 hydrazino nicotinate (Hn) chelating groups per peptide molecule.

35 nificantly upon administration of Ac3ManNBut-nicotinate hybrid, but not with Ac4ManNBut.

36 s were reacted with succinimidyl-4-hydrazino nicotinate hydrochloride to place 2.4 hydrazino nicotina

37 the bifunctional chelator molecule hydrazino nicotinate (HYNIC).

38 activity in response to modulators, notably nicotinate ions.

39 tion of the carboxylate functionality on the nicotinate ligand.

40 They demonstrate that the nicotinate moiety and phosphate do not appear to move si

41 Interestingly, the nicotinate moiety of NAMN is intercalated between highly

42 rance of the active site pocket, whereas the nicotinate moiety of NAMN is located deep inside.

43 ichiometric ATP hydrolysis with formation of nicotinate mononucleotide (NAMN) from nicotinic acid and

44 syltransferase (QAPRTase, EC 2.4.2.19) forms nicotinate mononucleotide (NAMN) from quinolinic acid (Q

45 with phosphoribosylpyrophosphate (PRPP) and nicotinate mononucleotide (NAMN) showed, surprisingly, t

46 e that transfers the phosphoribosyl group of nicotinate mononucleotide (NaMN) to phenol or p-cresol,

47 converge at the point where the reaction of nicotinate mononucleotide (NaMN) with ATP is coupled to

48 Nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazo

49 Nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazo

50 In such microbes, alpha-RP is synthesized by nicotinate mononucleotide (NaMN):DMB phosphoribosyltrans

51 Nicotinamide/nicotinate mononucleotide (NMN/ NaMN)adenylyltransferase

52 nvolved in the last steps of NAD biogenesis, nicotinate mononucleotide adenylyltransferase (NadD) and

53 This reaction is catalyzed by nicotinate mononucleotide adenylyltransferase (NMAT), wh

54 Bacterial nicotinate mononucleotide adenylyltransferase encoded by

55 Nicotinate mononucleotide adenylyltransferase NadD is an

56 The gene (ybeN) coding for nicotinate mononucleotide adenylyltransferase, an NAD(P)

57 o known as alpha-ribazole-5'-phosphate) from nicotinate mononucleotide and 5,6-dimethylbenzimidazole,

58 of ATP hydrolysis to drive the synthesis of nicotinate mononucleotide and pyrophosphate from nicotin

59 zyme catalyzes the reversible adenylation of nicotinate mononucleotide and shows product inhibition.

60 gene in yeast and catalyzes the formation of nicotinate mononucleotide from quinolinate and 5-phospho

61 The rate of adenylation of nicotinate mononucleotide is at least 20 times faster th

62 the structure of a complex with the product nicotinate mononucleotide suggests a mechanism for deami

63 The apparent Km for nicotinate mononucleotide was 680 microM; the apparent K

64 , the crystals containing DMB were soaked in nicotinate mononucleotide whereupon the physiological re

65 nosylcobinamide, 5, 6-dimethylbenzimidazole, nicotinate mononucleotide, and GTP.

66 oxylation reaction to form the NAD precursor nicotinate mononucleotide, carbon dioxide, and pyrophosp

67 ase, EC 2.4.2.19) catalyzes the formation of nicotinate mononucleotide, carbon dioxide, and pyrophosp

68 Nicotinate mononucleotide:5,6-dimethylbenzimidazole phos

69 ization of the cobalamin biosynthetic enzyme nicotinate-mononucleotide:5, 6-dimethylbenzimidazole pho

70 PncA is dispensable in the presence of nicotinate (Na), ruling it out as a viable antibacterial

71 amino acids, only genes for the synthesis of nicotinate, NAD+, NADP+ and coenzyme A were detected amo

72 ances in sugar, phospholipid, nucleotide and nicotinate/nicotinamide metabolism were noted.

73 s, phospholipids, ascorbate, nucleotides and nicotinate/nicotinamide.

74 reductase is inactive with LB3+ is bound to nicotinate or NO2-.

75 wnregulating the NAD+ salvage pathway enzyme nicotinate phosphoribosyltransferase (Naprt1), sensitizi

76 ared with those without renal-risk variants; nicotinate phosphoribosyltransferase also displayed gene

77 ow that increased dosage of NPT1, encoding a nicotinate phosphoribosyltransferase critical for the NA

78 We have determined the crystal structure of nicotinate phosphoribosyltransferase from Themoplasma ac

79 cells from black patients revealed that the nicotinate phosphoribosyltransferase gene, responsible f

80 d with loss of activity, suggesting that the nicotinate riboside moiety is recognized as a neutral zw

81 ing, the Leu44 side-chain interacts with the nicotinate ring by van der Waals contact.

82 nserved histidine residue interacts with the nicotinate ring, the Leu44 side-chain interacts with the

83 he VFT lobes prevent BvgS from responding to nicotinate, showing that BvgS shifts from kinase to phos

84 0 M, 25.0 +/- 0.1 degrees C), for binding of nicotinate to ferric rLb, H61A and Y30A were 1.4 +/- 0.3

85 1 and 6.7 +/- 0.2, respectively); binding of nicotinate to H61A was independent of pH.

86 active-site hydrogen bonds in the binding of nicotinate to recombinant ferric soybean leghaemoglobin

87 Na(+)-dependent nicotinate uptake by SMCT, however, was unaffected.

88 Extracellular nicotinate was depleted and metabolites of the deamidate

89 6-[2-(4,4-dimethylthiochroman-6-yl)-ethynyl]nicotinate), which is effective in the treatment of psor