ライフサイエンスコーパス: nicotinic

1 gest nicotine as a neuroprotective agent and nicotinic acetylcholine (ACh) receptors (nAChRs) as targ

2 Positive allosteric modulators (PAMs) of nicotinic acetylcholine (ACh) receptors (nAChRs) have po

3 nergic interneurons (CINs) and activation of nicotinic acetylcholine (ACh) receptors (nAChRs) in DA n

4 roca (HDB) and expresses both muscarinic and nicotinic acetylcholine (ACh) receptors.

5 te, GABAergic GABAA , muscarinic M1 , M2 and nicotinic acetylcholine (nACh; alpha4 beta2 subtype), no

6 evidence to indicate that the stimulation of nicotinic acetylcholine alpha7 receptors (nAChRa7s) can

7 kynurenic acid, an antagonist of both alpha7 nicotinic acetylcholine and N-methyl-D-aspartate recepto

8 tic and real single-channel data from muscle nicotinic acetylcholine channels.

9 Compared with neuronal nicotinic acetylcholine cholinergic receptors (nAChRs) a

10 is (MG) without detectable antibodies to the nicotinic acetylcholine receptor (AChR) or to muscle-spe

11 Two alpha4beta2 nicotinic acetylcholine receptor (alpha4beta2-nAChR) iso

12 (Abeta) accumulation in BMEC through Alpha7 nicotinic acetylcholine receptor (alpha7 nAChR).

13 SY5Y cells stably overexpressing the alpha-7 nicotinic acetylcholine receptor (alpha7-nAChR), a poten

14 ation in normal and cancer cells, the alpha7 nicotinic acetylcholine receptor (alpha7-nAChR), was mor

15 We hypothesized that agonism on alpha7 nicotinic acetylcholine receptor (alpha7nAChR) in fetal

16 Here, we show that ILC2s express the alpha7-nicotinic acetylcholine receptor (alpha7nAChR), which is

17 septal cholinergic fibers through the alpha7-nicotinic acetylcholine receptor (alpha7nAChR), whose ac

18 uced anti-shock effect via activating alpha7 nicotinic acetylcholine receptor (alpha7nAChR).

19 s16969968 that alters function of the alpha5 nicotinic acetylcholine receptor (CHRNA5) and noncoding

20 er cognitive processes that are modulated by nicotinic acetylcholine receptor (nAChR) activation by c

21 linical trials suggest that drugs that alter nicotinic acetylcholine receptor (nAChR) activity can af

22 hether extending plasma levels of the alpha7-nicotinic acetylcholine receptor (nAChR) agonist 3-(2,4-

23 Among them is epibatidine, a nicotinic acetylcholine receptor (nAChR) agonist that is

24 ation of nicotine or ABT-418, an alpha4beta2 nicotinic acetylcholine receptor (nAChR) agonist, normal

25 Nicotinic acetylcholine receptor (nAChR) agonists augmen

26 Conotoxin GeXIVA inhibits the alpha9alpha10 nicotinic acetylcholine receptor (nAChR) and is analgesi

27 These effects were blocked by the nicotinic acetylcholine receptor (nAChR) antagonist meca

28 alpha-Conotoxins, as nicotinic acetylcholine receptor (nAChR) antagonists, ar

29 The nicotinic acetylcholine receptor (nAChR) belongs to a su

30 The alpha7 nicotinic acetylcholine receptor (nAChR) belongs to the

31 t promote a desensitized state of the alpha7 nicotinic acetylcholine receptor (nAChR) have been assoc

32 associate with this soluble surrogate of the nicotinic acetylcholine receptor (nAChR) in a cooperativ

33 The nicotinic acetylcholine receptor (nAChR) is a major targ

34 The alpha4beta2 nicotinic acetylcholine receptor (nAChR) is important in

35 Although the Torpedo nicotinic acetylcholine receptor (nAChR) reconstituted i

36 y a critical role in the characterization of nicotinic acetylcholine receptor (nAChR) structure and f

37 Activation of the alpha3beta4 nicotinic acetylcholine receptor (nAChR) subtype has rec

38 ar domain (ECD) of the human neuronal alpha2 nicotinic acetylcholine receptor (nAChR) subunit in comp

39 The alpha9alpha10 nicotinic acetylcholine receptor (nAChR) was first ident

40 s for CHRNA7, the gene coding for the alpha7 nicotinic acetylcholine receptor (nAChR), and manifest a

41 CHRNA7, encoding for the alpha7 nicotinic acetylcholine receptor (nAChR), has been sugge

42 modulators (PAMs) acting on the human alpha7 nicotinic acetylcholine receptor (nAChR).

43 ed transcripts of several targets, including nicotinic acetylcholine receptor alpha 1 and alpha 2 sub

44 agus nerve regulation of splenic cholinergic nicotinic acetylcholine receptor alpha7 (nAChRa7) signal

45 RV fibrosis, RV inflammation, and RV alpha-7 nicotinic acetylcholine receptor and muscarinic acetylch

46 ters = primary outcome variables) as well as nicotinic acetylcholine receptor expression, muscle mass

47 CHRNA7, the alpha7-nicotinic acetylcholine receptor gene, has been associat

48 eta2 subunits are the most abundant class of nicotinic acetylcholine receptor in the brain.

49 Isoform-specific mechanisms of alpha3beta4*-nicotinic acetylcholine receptor modulation by the proto

50 rment of synaptic transmission targeting the nicotinic acetylcholine receptor of muscle.

51 f nicotine dependence and stimulation of the nicotinic acetylcholine receptor on the ability to inter

52 "spiroimidates") and their utility as alpha7 nicotinic acetylcholine receptor partial agonists are de

53 by KYNA via presynaptic inhibition of alpha7-nicotinic acetylcholine receptor signaling.

54 ommon variants near the apolipoprotein E and nicotinic acetylcholine receptor subunit alpha 5 genes a

55 active with ion channels of the ligand-gated nicotinic acetylcholine receptor superfamily (namely alp

56 In PAH RV samples, alpha-7 nicotinic acetylcholine receptor was increased and acety

57 Expression of nicotinic (alpha-7 nicotinic acetylcholine receptor) and muscarinic (muscar

58 f the anti-inflammatory alpha7-nAChR (alpha7-nicotinic acetylcholine receptor) was similar in young S

59 may, by increasing activation of the alpha7-nicotinic acetylcholine receptor, alter the development

60 MS stem from molecular defects in the muscle nicotinic acetylcholine receptor, but they can also be c

61 The alpha7 nicotinic acetylcholine receptor, encoded by the CHRNA7

62 ed tool to probe the ion channel pore of the nicotinic acetylcholine receptor, which is a prototypica

63 unique cell types expressing alpha8 subunit nicotinic acetylcholine receptor, while SPO and cOv are

64 te smoke (SS), or secondhand smoke, promoted nicotinic acetylcholine receptor-dependent exacerbation

65 clothianidin, but not imidacloprid, causes a nicotinic acetylcholine receptor-dependent rapid mitocho

66 ation of antiinflammatory effects via alpha7 nicotinic acetylcholine receptor-expressing splenic macr

67 Adult-type nicotinic acetylcholine receptors (AChRs) mediate signal

68 Nicotinic acetylcholine receptors (AChRs) switch on/off

69 d alpha3- and beta4-subunit-containing human nicotinic acetylcholine receptors (alpha3beta4*-nAChRs).

70 that resulted from local blockade of alpha7-nicotinic acetylcholine receptors (alpha7nAChR).

71 the integration of neural signals and alpha7 nicotinic acetylcholine receptors (alpha7nAChRs) on sple

72 Through deletion of beta2 subunits of nicotinic acetylcholine receptors (beta2-nAChRs) selecti

73 level of nonsmokers following stimulation of nicotinic acetylcholine receptors (familywise error-corr

74 Positive allosteric modulators (PAMs) of nicotinic acetylcholine receptors (nAChR) are important

75 tional regulation and synaptic clustering of nicotinic acetylcholine receptors (nAChR) during neurotr

76 ificant associations between variants in the nicotinic acetylcholine receptors (nAChR) subunits and n

77 nd murine monocytes by a mechanism involving nicotinic acetylcholine receptors (nAChR).

78 Nicotinic acetylcholine receptors (nAChRs) and gamma-ami

79 Neuronal nicotinic acetylcholine receptors (nAChRs) are promising

80 Nicotinic acetylcholine receptors (nAChRs) are the molec

81 Mesolimbic alpha6* nicotinic acetylcholine receptors (nAChRs) are thought t

82 alpha7 nicotinic acetylcholine receptors (nAChRs) are ubiquitou

83 The alpha7 nicotinic acetylcholine receptors (nAChRs) are uniquely

84 Nicotinic acetylcholine receptors (nAChRs) assemble in t

85 Nicotinic acetylcholine receptors (nAChRs) belong to the

86 Nicotinic acetylcholine receptors (nAChRs) binding to th

87 Neuronal nicotinic acetylcholine receptors (nAChRs) containing th

88 ives significant cholinergic innervation and nicotinic acetylcholine receptors (nAChRs) contribute gr

89 ng the most widely co-abused substances, and nicotinic acetylcholine receptors (nAChRs) contribute to

90 All nicotinic acetylcholine receptors (nAChRs) evolved from

91 andoxin and shows high binding affinity with nicotinic acetylcholine receptors (nAChRs) expressed on

92 menthol enhances nicotine-induced changes in nicotinic acetylcholine receptors (nAChRs) expressed on

93 anatomical localisation and function of the nicotinic acetylcholine receptors (nAChRs) formed by the

94 Antagonists of alpha9alpha10 nicotinic acetylcholine receptors (nAChRs) have been pro

95 The data suggest a complex interaction of nicotinic acetylcholine receptors (nAChRs) in regulating

96 X-12 over PhTX-343 for embryonic muscle-type nicotinic acetylcholine receptors (nAChRs) in TE671 cell

97 otine use induces functional upregulation of nicotinic acetylcholine receptors (nAChRs) in the mesoco

98 Study demonstrates that activation of nicotinic acetylcholine receptors (nAChRs) increases exc

99 Activation of nicotinic acetylcholine receptors (nAChRs) is associated

100 ulation of beta2 subunit-containing (beta2*) nicotinic acetylcholine receptors (nAChRs) is implicated

101 KEY POINTS: Neuronal nicotinic acetylcholine receptors (nAChRs) play a fundam

102 Blocking beta2 or alpha7 nicotinic acetylcholine receptors (nAChRs) prevents, res

103 actions, but very little is known about how nicotinic acetylcholine receptors (nAChRs) regulate LHb

104 ng the expression and clustering of neuronal nicotinic acetylcholine receptors (nAChRs) remain poorly

105 and impact of aging on presynaptic neuronal nicotinic acetylcholine receptors (nAChRs) within the ci

106 PG-PG interactions are modulated by nicotinic acetylcholine receptors (nAChRs), and our data

107 al homologs of the ligand-binding domains of nicotinic acetylcholine receptors (nAChRs), and they rep

108 d additive actions through a family of brain nicotinic acetylcholine receptors (nAChRs).

109 -, alpha3alpha5beta4-, and alpha7-containing nicotinic acetylcholine receptors (nAChRs).

110 ure to Abeta in model nerve cells expressing nicotinic acetylcholine receptors (nAChRs).

111 late-associated genes such as those encoding nicotinic acetylcholine receptors (nAChRs).

112 ting critical facets of brain maturation are nicotinic acetylcholine receptors (nAChRs).

113 It irreversibly inhibits nicotinic acetylcholine receptors and allosterically int

114 Using alpha4beta2 nicotinic acetylcholine receptors and the alpha4beta2-se

115 Nicotinic acetylcholine receptors are ligand-gated ion c

116 t on human voltage-gated calcium channels or nicotinic acetylcholine receptors at 5 muM.

117 Nicotinic acetylcholine receptors can be assembled from

118 pamine neurons receive cholinergic input via nicotinic acetylcholine receptors from the Kenyon cells;

119 ore, phosphomimetic Dok-7 mutants aggregated nicotinic acetylcholine receptors in C2C12 myotubes with

120 texts that predict alcohol, and suggest that nicotinic acetylcholine receptors in the NAc are critica

121 Inactivation of 42 genes, including the nicotinic acetylcholine receptors nAChRalpha1 and nAChRa

122 Up-regulation of nicotinic acetylcholine receptors normalized before day

123 sitivity and acute effects of stimulation of nicotinic acetylcholine receptors on behavioral and neur

124 survival in animal sepsis models via alpha7 nicotinic acetylcholine receptors on immunocompetent cel

125 r behaviour in animals through inhibition of nicotinic acetylcholine receptors present in the central

126 resting conformation, and in skeletal muscle nicotinic acetylcholine receptors there is an exponentia

127 sphorylation of the ER-resident chaperone of nicotinic acetylcholine receptors, RIC-3, leads to incre

128 As agonists of nicotinic acetylcholine receptors, they disturb acetylch

129 Lynx1, an endogenous inhibitor of nicotinic acetylcholine receptors, was previously shown

130 a genetic mutation in RIC3; a chaperone for nicotinic acetylcholine receptors.

131 s mediated by GABAA receptors in addition to nicotinic acetylcholine receptors.

132 sion to overcome imidacloprid binding to the nicotinic acetylcholine receptors.

133 ounds targeting the cannabinoid 1 and alpha7 nicotinic acetylcholine receptors.

134 control abilities.SIGNIFICANCE STATEMENT The nicotinic acetylcholine system plays a central role in n

135 Nicotinic acetylcholine, serotonin type 3, gamma-amminob

136 Nicotinic acetylcholinergic receptors (nAChR's) have bee

137 se brain slices, we found that ACh generated nicotinic ACh receptor (nAChR)-mediated depolarizing pot

138 l FFA3 suppresses Cl(-) secretion induced by nicotinic ACh receptor activation via a Gi/o pathway.

139 Furthermore, reducing nicotinic ACh receptor subunit expression in MBONs compr

140 ocation and function of presynaptic neuronal nicotinic ACh receptors (nAChRs) at the major inputs to

141 naptic function and pharmacology of neuronal nicotinic ACh receptors (nAChRs) in young adult and the

142 it striatal DA release through activation of nicotinic ACh receptors (nAChRs) on DA axonal projection

143 itter acetylcholine (ACh) activates calyceal nicotinic ACh receptors (nAChRs); however, it is unclear

144 Here we report that nicotinic acid (NA), an essential vitamin, inhibits glio

145 wo enzymes that sequentially convert NAD+ to nicotinic acid (NA), are up-regulated during CR.

146 thyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino)nicotinic acid (NEt-TMN) were synthesized and assessed f

147 unctionalized substituents introduced at the nicotinic acid 5-position are recognized by the sea urch

148 hat LarB carboxylates the pyridinium ring of nicotinic acid adenine dinucleotide (NaAD) and cleaves t

149 We also report that nicotinic acid adenine dinucleotide (NAAD), which was no

150 metabolites by phosphorylating nicotinamide/nicotinic acid adenine dinucleotide at the adenosine 3'-

151 Both products of AvrRxo1, 3'-NADP and 3'-nicotinic acid adenine dinucleotide phosphate (3'-NAADP)

152 Nicotinic acid adenine dinucleotide phosphate (NAADP) an

153 Nicotinic acid adenine dinucleotide phosphate (NAADP) is

154 Nicotinic acid adenine dinucleotide phosphate (NAADP) po

155 Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) st

156 Nicotinic acid adenine dinucleotide phosphate (NAADP), t

157 We have examined the possible role of nicotinic acid adenine dinucleotide phosphate (NAADP)-me

158 e-targeted calcium release channels gated by nicotinic acid adenine dinucleotide phosphate, as also a

159 ases the myocardial levels of 3 metabolites, nicotinic acid adenine dinucleotide, methylnicotinamide,

160 ve substituted at both the 5-position of the nicotinic acid and at the 8-adenosyl position was also r

161 nadC in B. bronchiseptica was influenced by nicotinic acid and by a NadQ family transcriptional repr

162 ct and superior pharmacokinetics to those of nicotinic acid and nicotinamide.

163 We hypothesize that the nicotinic acid derivative acipimox, an NAD(+) precursor,

164 thalpy of the OHN LBHB formed in crystalline nicotinic acid is only 7.7+/-0.5 kcal mol(-1) , suggesti

165 onucleotides nicotinamide mononucleotide and nicotinic acid mononucleotide (NAMN) and thus catalyze N

166 s of the two MtNadD substrates, i.e. ATP and nicotinic acid mononucleotide (NaMN).

167 A nicotinic acid mononucleotide derivative is tethered to

168 Here, we show the gene encoding nicotinic acid phosphoribosyltransferase (NAPRT), a seco

169 related to the consumption of peas (N-methyl nicotinic acid), apples (rhamnitol), and onions (N-acety

170 r NAD(+) precursors, such as nicotinamide or nicotinic acid, is dispensable.

171 , flufuran, gregatin B, hydroxysydonic acid, nicotinic acid, phomaligin A, spinulosin and terrein.

172 es pncA and pncB, for use of nicotinamide or nicotinic acid, respectively, for NAD synthesis.

173 onjugated with neuroactive carriers, namely, nicotinic acid, valproic acid, theophylline-7-acetic aci

174 improved by a more stable but still reactive nicotinic acid-derived tetrazine and by changing the key

175 rs a (SCS)Ni(II) pincer complex derived from nicotinic acid.

176 known to be auxotrophic for nicotinamide or nicotinic acid.

177 combinatorial effects of both muscarinic and nicotinic activation.

178 This indicates chronic exposure to nicotinic agonist as a potential pharmacological interve

179 or binding pose that differs from classical nicotinic agonists and antagonists and from the previous

180 cooperative fashion, not seen for classical nicotinic agonists and antagonists.

181 Expression of nicotinic (alpha-7 nicotinic acetylcholine receptor) and

182 tion of this projection elicits monosynaptic nicotinic and GABAergic currents in glomerular layer-pro

183 ly modulated by acetylcholine acting on both nicotinic and muscarinic acetylcholine receptors.

184 tween gamma and theta oscillations, and both nicotinic and muscarinic receptor activity contributed t

185 ne release, through distinct actions at both nicotinic and muscarinic receptors, triggers a processio

186 by the ascending cholinergic system through nicotinic and muscarinic receptors.

187 sensory and enteric neurons, which involves nicotinic and P2X receptors.

188 modeling of DPA docking to GABArho1, alpha7 nicotinic, and 5-HT3A receptors suggests that a hydropho

189 s of DPA on human homomeric GABArho1, alpha7 nicotinic, and 5-HT3A serotonin receptors expressed in X

190 d by nicotine withdrawal precipitated by the nicotinic antagonist mecamylamine.

191 s were worsened by mecamylamine, a selective nicotinic antagonist.

192 duced seizures, and validated TGFBR2 and the nicotinic antiinflammatory acetylcholine receptor nAChRa

193 l as corresponding kinase inhibitor, blocked nicotinic augmentation of AMPA/NMDA ratio.

194 city, we found that the deletion of Lynx1, a nicotinic "brake" for functional plasticity, doubled the

195 Nicotinic cholinergic activation induced proliferation o

196 y hypertensive rat and expand in response to nicotinic cholinergic activation.

197 A novel, inherited nicotinic cholinergic inflammatory effect exists in youn

198 Here we used the selective expression of the nicotinic cholinergic receptor alpha2 (Chrna2) in mice t

199 Muscarinic and nicotinic cholinergic receptors both contributed specifi

200 xpressed in the nervous system that modulate nicotinic cholinergic signaling, but their functions and

201 igestion (CHGA360-373) selectively inhibited nicotinic cholinergic stimulated catecholamine release f

202 provide evidence for the involvement of the nicotinic cholinergic system in alcohol withdrawal.

203 data support the notion that modulating the nicotinic cholinergic system might help to maintain long

204 Existing programs attempting to develop nicotinic drugs that might exert this apparent neuroprot

205 iring interneurons, BFc inputs elicited fast nicotinic EPSPs.

206 neurons have been shown to provide intrinsic nicotinic excitation of local GABAergic interneurons, wh

207 tation in NGF interneurons and a disynaptic, nicotinic excitation through cholinergic interneurons.

208 Maternal cigarette smoke, including prenatal nicotinic exposure (PNE), is responsible for sudden infa

209 Prenatal nicotinic exposure prolongs superior laryngeal C-fiber-m

210 y learned to discriminate 0.001 mg/kg of the nicotinic full agonist (+)-epibatidine ((+)-EPI).

211 eover, converging data are consistent with a nicotinic-GABAergic mechanism of multisensory integratio

212 Whether this novel route of nicotinic input constitutes a major output of cholinergi

213 We found that nicotinic-mediated dopamine release was blunted at highe

214 The frequency-dependence of disynaptic nicotinic modulation has led to the hypothesis that nACh

215 sting presynaptic GABA release in vivo using nicotinic modulators or an mGluR2 agonist.

216 icotinic receptors or biphasic GABAergic and nicotinic neurotransmission conveyed by GABA and ACh cor

217 teral DA neurons received mainly excitatory (nicotinic or glutamatergic) mediated cholinergic neurotr

218 imulation was rendered ineffective by either nicotinic or muscarinic receptor antagonists.

219 and elicit robust monosynaptic GABAergic and nicotinic postsynaptic currents.

220 ted orphan receptor gammat (RORgammat) and a nicotinic proinflammatory innate immune response.

221 ing homozygous variants of cholinergic gamma nicotinic receptor (CHRNG, 6 subjects) and endothelin co

222 The homomeric alpha7 nicotinic receptor (nAChR) is one of the most abundant n

223 f long-term depression by nicotine relied on nicotinic receptor activation and key regulators of NRG3

224 rular sensitivity to weak odor input whereas nicotinic receptor activation decreases sensitivity to s

225 and safety of 3 doses of ABT-126, an alpha7 nicotinic receptor agonist, for the treatment of cogniti

226 Genetic variation in nicotinic receptor alpha 5 (CHRNA5) has been associated

227 d a common polymorphism of the high-affinity nicotinic receptor alpha4beta2 (rs1044396 on the CHRNA4

228 f a common polymorphism of the high-affinity nicotinic receptor alpha4beta2 that is consistent across

229 nic (atropine, 0.1 mumol l(-1) , n = 6) or a nicotinic receptor antagonist (mecamylamine, 10 mumol l(

230 tion of carbamylcholine was prevented by the nicotinic receptor antagonist mecamylamine, inhibitors o

231 croinfusions of mecamylamine, a nonselective nicotinic receptor antagonist, highlight a major role fo

232 protective effect could also be induced by a nicotinic receptor antagonist, suggesting that xenobioti

233 premotor neurons that could be blocked by a nicotinic receptor antagonist.

234 evoked dopamine release, with muscarinic and nicotinic receptor antagonists causing suppression and a

235 tion of enteric neurons was inhibited by the nicotinic receptor antagonists hexamethonium and dihydro

236 we demonstrate that splenic injection of the nicotinic receptor blocker alpha-bungarotoxin increased

237 nt with previous analyses of N398-associated nicotinic receptor function.

238 The nicotinic receptor has been a model system for cell-surf

239 The same peptides significantly altered a nicotinic receptor induced behaviour in C. elegans and i

240 tor was described in landmark studies of the nicotinic receptor isolated from the electric organ of T

241 tive attention task in wild-type and alpha-9 nicotinic receptor knock-out (KO) mice.

242 Treatments were the alpha7 nicotinic receptor PAM JNJ-39393406 (100 mg b.i.d.) or p

243 cy and safety of ABT-126, a selective alpha7 nicotinic receptor partial agonist, in stable patients w

244 esting that xenobiotic exposure, rather than nicotinic receptor signaling, is responsible for program

245 on VFT that depends upon both muscarinic and nicotinic receptor stimulation, where the generation of

246 on VFT that depends upon both muscarinic and nicotinic receptor stimulation, where the generation of

247 dependent on NO generation and/or muscarinic/nicotinic receptor stimulation.

248 centrations of ethanol inhibit activity of a nicotinic receptor subtype that is expressed in brain ar

249 nsynonymous variant rs16969968 in the alpha5 nicotinic receptor subunit gene (CHRNA5) is the stronges

250 Here, we trained wild-type and alpha-9 nicotinic receptor subunit knock-out (KO) mice, which la

251 NIC) treatment or specific deletion of beta2 nicotinic receptor subunits in dopamine neurons mitigate

252 ale neuroimaging genetics study of the human nicotinic receptor system (two cohorts, males and female

253 To understand the impact of these nicotinic receptor variants in humans, we differentiated

254 her loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related gen

255 lographic structure of the human alpha4beta2 nicotinic receptor, the most abundant nicotinic subtype

256 ound healing via mitochondria stress through nicotinic receptor-dependent mechanisms.

257 ine; 100 nm) receptor blockers, but not by a nicotinic-receptor blocker (mecamylamine; 10 mum).

258 ed nicotine upregulation of alpha4beta2-type nicotinic receptors (alpha4beta2Rs) in live cells and ne

259 as a negative allosteric modulator of alpha7 nicotinic receptors (alpha7nAChRs).

260 As GABAA and nicotinic receptors (nAChR) belong to this family, we ex

261 two neurotransmitters activate two types of nicotinic receptors (nAChRs) (the homomeric alpha7 recep

262 Acetylcholine-activating pentameric nicotinic receptors (nAChRs) are an essential mode of ne

263 search shows that compounds acting at alpha7 nicotinic receptors (nAChRs) can reduce nicotine self-ad

264 mine release in the striatum via presynaptic nicotinic receptors (nAChRs) on dopamine axon terminals.

265 d/or receptor expression of beta2-containing nicotinic receptors alters presynaptic and postsynaptic

266 le Renshaw cell is more than halved when the nicotinic receptors are blocked, confirming that the two

267 the fields of pharmacology and neurobiology, nicotinic receptors are important therapeutic targets fo

268 alpha7-Nicotinic receptors are involved in the final maturation

269 an IC50 of 1.6 microM, an enhancer of alpha7 nicotinic receptors at relatively high concentrations of

270 tor activity attenuated, whereas blockade of nicotinic receptors augmented cue-induced invigoration o

271 an alpha-conotoxin that inhibits Drosophila nicotinic receptors but not its vertebrate counterparts.

272 current study found that ACh stimulation of nicotinic receptors comprised of alpha4 and beta2 subuni

273 The current study found that nicotinic receptors comprised of alpha4 and beta2 subuni

274 acetylcholine receptors, including neuronal nicotinic receptors comprising alpha4 and beta2 subunits

275 r antagonist, highlight a major role for the nicotinic receptors expressed in medial habenula and int

276 beta2-containing nicotinic receptors in dopamine neurons likely mediate t

277 bited acetylcholine responses of alpha4beta2 nicotinic receptors in vitro, as did full length ectodom

278 o be due, at least in part, to activation of nicotinic receptors on GABAergic NPY-neurogliaform inter

279 tually mediated by activation of presynaptic nicotinic receptors on nigrostriatal terminals that evok

280 y GABAergic currents mediated by presynaptic nicotinic receptors or biphasic GABAergic and nicotinic

281 Blocking nicotinic receptors primarily attenuated high-gamma osci

282 tion or a downregulation of beta2-containing nicotinic receptors protects the striatal network agains

283 Blockade of nicotinic receptors using mecamylamine (1 mg/kg) prevent

284 ometry, and the expression of muscarinic and nicotinic receptors was evaluated by flow cytometry or q

285 elease is (1) dependent of the activation of nicotinic receptors, (2) independent on the spontaneous

286 We show that nicotine, operating via nicotinic receptors, does protect these neurons against

287 stigmine can potentiate and inhibit neuronal nicotinic receptors, in addition to inhibiting the activ

288 ffects of KYNA on cannabinoid reward involve nicotinic receptors, in the present study we used rat an

289 Desensitization of nicotinic receptors, which is a prevailing mechanism for

290 ons with nicotine-via alpha2beta2-containing nicotinic receptors-to bypass innervation defects.

291 n the amniotic fluid is an agonist at alpha7-nicotinic receptors.

292 ding protein or the ligand-binding domain of nicotinic receptors.

293 o determine the stoichiometry of alpha3beta4 nicotinic receptors.

294 tudies identify Ash2l as a target induced by nicotinic stimulation that couples developmental nicotin

295 4beta2 nicotinic receptor, the most abundant nicotinic subtype in the brain.

296 earning, because selective deletion of beta2 nicotinic subunits in dopamine neurons reduced D2R-media

297 srupted premotor rhythms, as did blockade of nicotinic synapses in the motor nucleus (the putative lo

298 The nicotinic system plays an important role in cognitive co

299 is the first report of overdominance in the nicotinic system.

300 rplay is underpinned by marked remodeling of nicotinic systems, causing increased ventral tegmental a