ライフサイエンスコーパス: nicotinic receptor

1 plasma cholinesterases; cerebrum muscarinic, nicotinic receptors).

2 entially, although they operate via the same nicotinic receptor.

3 blem in the case of activation of the muscle nicotinic receptor.

4 mbers of the superfamily, such as the muscle nicotinic receptor.

5 hen combined with transmembrane spans of the nicotinic receptor.

6 ptors and in particular the homomeric alpha7 nicotinic receptor.

7 at c-fos induction was mediated by a central nicotinic receptor.

8 otentiation (LTP) in a manner dependent upon nicotinic receptors.

9 g cells (c-ACs) at rest by the activation of nicotinic receptors.

10 d picomolar binding affinity for alpha4beta2 nicotinic receptors.

11 activating alpha7 and non-alpha7 classes of nicotinic receptors.

12 e and long-lasting up-regulation of neuronal nicotinic receptors.

13 ane proteins forming tight associations with nicotinic receptors.

14 adrenergic splenic nerve via the alpha7nAChR nicotinic receptors.

15 hyl-D-aspartate (NMDA) and cholinergic alpha nicotinic receptors.

16 annel results reported for normal and mutant nicotinic receptors.

17 P1 cells stably transfected with alpha4beta2 nicotinic receptors.

18 depolarizes 5-HT(3A)R-expressing neurons via nicotinic receptors.

19 develop drugs that target specific types of nicotinic receptors.

20 postsynaptically by acetylcholine acting on nicotinic receptors.

21 ement after clozapine was mediated by alpha7 nicotinic receptors.

22 e for deficiencies in expression of alpha(7)-nicotinic receptors.

23 be the molecular determinants of agonists on nicotinic receptors.

24 gger of rapid and efficient gating of muscle nicotinic receptors.

25 harmacological antagonists of alpha9/alpha10 nicotinic receptors.

26 n the amniotic fluid is an agonist at alpha7-nicotinic receptors.

27 ding protein or the ligand-binding domain of nicotinic receptors.

28 o determine the stoichiometry of alpha3beta4 nicotinic receptors.

29 h beta-amyloid in its agonist-like action on nicotinic receptors.

30 ent disynaptic neurotransmission mediated by nicotinic receptors.

31 at CSE is an effective reinforcer acting via nicotinic receptors.

32 elease is (1) dependent of the activation of nicotinic receptors, (2) independent on the spontaneous

33 eines display agonist activity on the alpha7 nicotinic receptor, a homomeric receptor with sequences

34 itis elegans muscle contains seven different nicotinic receptor (AChR) subunits, five of which have b

35 Accessory subunits in heteromeric nicotinic receptors (AChRs) do not take part in forming

36 for acetylcholine in adult-type muscle mouse nicotinic receptors (AChRs) having mutations of agonist

37 f long-term depression by nicotine relied on nicotinic receptor activation and key regulators of NRG3

38 xamined the link between both muscarinic and nicotinic receptor activation and nitric oxide productio

39 rular sensitivity to weak odor input whereas nicotinic receptor activation decreases sensitivity to s

40 cs at the growth cone are mediated by alpha7 nicotinic receptor activation of a Galphaq and IP3 recep

41 nd decaying disynaptic component mediated by nicotinic receptor activation.

42 er retina in response to muscarinic (but not nicotinic) receptor activation.

43 found that RJR-2403, a selective alpha4beta2 nicotinic receptor agonist, also enhanced discrimination

44 and safety of 3 doses of ABT-126, an alpha7 nicotinic receptor agonist, for the treatment of cogniti

45 gues of the diamine part of two known alpha7 nicotinic receptor agonists and construct libraries of v

46 to TBI-induced cognitive impairment and that nicotinic receptor agonists can reverse alpha7 binding d

47 l rationale for the clinical study of alpha7-nicotinic receptor agonists to improve neurocognition.

48 es of cholinergic pesticide: neonicotinoids (nicotinic receptor agonists) and organophosphate miticid

49 licating the development of subtype-specific nicotinic receptor agonists.

50 Genetic variation in nicotinic receptor alpha 5 (CHRNA5) has been associated

51 or the restricted expression patterns of the nicotinic receptor alpha3 and beta4 subunit genes.

52 d a common polymorphism of the high-affinity nicotinic receptor alpha4beta2 (rs1044396 on the CHRNA4

53 f a common polymorphism of the high-affinity nicotinic receptor alpha4beta2 that is consistent across

54 ed nicotine upregulation of alpha4beta2-type nicotinic receptors (alpha4beta2Rs) in live cells and ne

55 artic acid-to-asparagine substitution in the nicotinic receptor alpha5 subunit at amino acid position

56 ddition to alpha4beta2 and alpha3-containing nicotinic receptors, alpha6-containing receptors are pre

57 (IIIB) on the expression and function of the nicotinic receptor alpha7 (alpha7-nAChR).

58 The alpha7 nicotinic receptor (alpha7) plays an important role in n

59 as a negative allosteric modulator of alpha7 nicotinic receptors (alpha7nAChRs).

60 d/or receptor expression of beta2-containing nicotinic receptors alters presynaptic and postsynaptic

61 a-bungarotoxin-sensitive (presumably alpha7) nicotinic receptors, although nicotine had no effect on

62 hisms (SNPs) in 58 genes within the neuronal nicotinic receptor and dopamine systems to investigate t

63 unds revealed eight inhibitors of the alpha7 nicotinic receptor and three positive allosteric modulat

64 sis and amnesia, by inhibiting glutamate and nicotinic receptors and activating potassium 'leak' chan

65 one-reward associability through alpha4beta2 nicotinic receptors and by enhancing attention to the li

66 ist methyllycaconitine (MLA) to block alpha7 nicotinic receptors and dihydro-beta-erythrodine (DHbeta

67 ining structure and ligand interactions with nicotinic receptors and related pentameric ligand-gated

68 onicotinoids, exhibit specificity for insect nicotinic receptors and selective toxicity as insecticid

69 as implications for rational drug design for nicotinic receptors and sheds light on mechanisms of all

70 reward signaling through alpha(6)-containing nicotinic receptors and suggest that PKCepsilon could be

71 entiation with retinoic acid, expresses both nicotinic receptors and the receptor for BDNF, TrkB.

72 o have an agonist-like action on presynaptic nicotinic receptors and to augment long-term potentiatio

73 These authors show a critical link between nicotinic receptors and TRP channels, which may represen

74 lease was sensitive to antagonists of alpha7 nicotinic receptors and was absent in mice harboring a n

75 lso GTS-21) selectively activates the alpha7 nicotinic receptor, and in acute administration studies,

76 eurotransmission was not altered by blocking nicotinic receptors, and many of these GABAergic neurons

77 that LYNX2 can bind to and modulate neuronal nicotinic receptors, and that loss of Lynx2 alters the a

78 nic (atropine, 0.1 mumol l(-1) , n = 6) or a nicotinic receptor antagonist (mecamylamine, 10 mumol l(

79 Studies using the radio-labeled nicotinic receptor antagonist [(125)I]-alpha-bungarotoxi

80 g, IP) in combination with either the alpha7 nicotinic receptor antagonist alpha-bungarotoxin or the

81 gonist alpha-bungarotoxin or the alpha4beta2 nicotinic receptor antagonist di-hydro-beta-erythroidine

82 tion of carbamylcholine was prevented by the nicotinic receptor antagonist mecamylamine, inhibitors o

83 In contrast, the nicotinic receptor antagonist, hexamethonium, and the N-

84 croinfusions of mecamylamine, a nonselective nicotinic receptor antagonist, highlight a major role fo

85 protective effect could also be induced by a nicotinic receptor antagonist, suggesting that xenobioti

86 premotor neurons that could be blocked by a nicotinic receptor antagonist.

87 , 0.75, or 2.25 mg/kg, intraperitoneally), a nicotinic receptor antagonist.

88 evoked dopamine release, with muscarinic and nicotinic receptor antagonists causing suppression and a

89 tion of enteric neurons was inhibited by the nicotinic receptor antagonists hexamethonium and dihydro

90 le Renshaw cell is more than halved when the nicotinic receptors are blocked, confirming that the two

91 demonstrate that nicotine and activation of nicotinic receptors are critical factors in the developm

92 Nicotinic receptors are critical in the induction of ges

93 the fields of pharmacology and neurobiology, nicotinic receptors are important therapeutic targets fo

94 the flip conformational state of glycine and nicotinic receptors are in disaccord with REFERs, since

95 alpha7-Nicotinic receptors are involved in the final maturation

96 for the study of cocaine dependence because nicotinic receptors are thought to be involved in genera

97 Heteropentameric neuronal nicotinic receptors assemble so that the canonical acety

98 an IC50 of 1.6 microM, an enhancer of alpha7 nicotinic receptors at relatively high concentrations of

99 inetics of the EPSCs mediated by heteromeric nicotinic receptors at the motoneuron-Renshaw cell (MN-R

100 tor activity attenuated, whereas blockade of nicotinic receptors augmented cue-induced invigoration o

101 Behavioral impairment following nicotinic receptor blockade may not be due to the inabil

102 This is similar to published effects of nicotinic receptor blockade or desensitization, and is m

103 tected DA release evoked electrically during nicotinic receptor blockade or optogenetically by light

104 we demonstrate that splenic injection of the nicotinic receptor blocker alpha-bungarotoxin increased

105 ravalent dendrimers incorporating the alpha7-nicotinic receptor blocker alpha-conotoxin ImI (alpha-Im

106 ine; 100 nm) receptor blockers, but not by a nicotinic-receptor blocker (mecamylamine; 10 mum).

107 an alpha-conotoxin that inhibits Drosophila nicotinic receptors but not its vertebrate counterparts.

108 from HEK-expressed human recombinant muscle nicotinic receptors by choline and by tetramethylammoniu

109 Activation of cortical nicotinic receptors by cholinergic axons from the basal

110 PNU-120596 enhance agonist-evoked gating of nicotinic receptors by eliciting conformational effects

111 on were attenuated by blockade of peripheral nicotinic receptors by hexamethonium (3 mg/kg, i.v.).

112 xtracellular ligand binding domain of alpha7 nicotinic receptors carrying the L247T mutation.

113 her loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related gen

114 ariation in the cluster of physically linked nicotinic receptors, CHRNA5-CHRNA3-CHRNB4, and the risk

115 ing homozygous variants of cholinergic gamma nicotinic receptor (CHRNG, 6 subjects) and endothelin co

116 to the neuron while stabilizing postsynaptic nicotinic receptor clusters under the release sites.

117 current study found that ACh stimulation of nicotinic receptors comprised of alpha4 and beta2 subuni

118 The current study found that nicotinic receptors comprised of alpha4 and beta2 subuni

119 acetylcholine receptors, including neuronal nicotinic receptors comprising alpha4 and beta2 subunits

120 Nicotinic receptors containing alpha4, alpha6, beta2, an

121 gonists and also by a specific antagonist of nicotinic receptors containing beta2 subunits.

122 Acting mainly through nicotinic receptors containing the alpha4 and beta2 subu

123 To examine the role of nicotinic receptors containing the alpha4 subunit (alpha

124 These data suggest that alpha7-nicotinic-receptors contribute strongly to olfactory dis

125 Ca(2+)-permeable postsynaptic alpha9alpha10 nicotinic receptors coupled to the opening of hyperpolar

126 ound healing via mitochondria stress through nicotinic receptor-dependent mechanisms.

127 the relative contribution of muscarinic and nicotinic receptors depends on task difficulty.

128 We show that nicotine, operating via nicotinic receptors, does protect these neurons against

129 Neuronal alpha7 nicotinic receptors elicit rapid cation influx in respon

130 harmacological ablation of the alpha9alpha10 nicotinic receptor elicits an increase in the discharge

131 r antagonist, highlight a major role for the nicotinic receptors expressed in medial habenula and int

132 of varenicline at a variety of rat neuronal nicotinic receptors expressed in Xenopus laevis oocytes

133 Brain inflammation, changes in nicotinic receptor expression and cortical tissue sparin

134 he post-transcriptional regulation of alpha7 nicotinic receptor expression.

135 ligand specificities resembling those of the nicotinic receptor for agonists and antagonists.

136 odulator at the alpha(4)beta(2) and alpha(7) nicotinic receptors, for the treatment of these impairme

137 f side chains at homologous positions in the nicotinic receptor from the motor end plate decreases un

138 Previous studies indicate lynx1 inhibits nicotinic receptor function and limits neuronal plastici

139 estigate the mechanism of action of lynx1 on nicotinic receptor function, through the generation of l

140 nt with previous analyses of N398-associated nicotinic receptor function.

141 ce carrying the null mutation for the alpha7 nicotinic receptor gene (Chrna7).

142 ssociation was a synonymous 15q25 SNP in the nicotinic receptor gene CHRNA3 (rs1051730[A], beta = 1.0

143 ociations were observed at the chromosome 15 nicotinic receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) p

144 This study tested whether variants in the nicotinic receptor gene cluster CHRNA5-CHRNA3-CHRNB4 pre

145 method to correlated SNPs in the cholinergic nicotinic receptor gene cluster CHRNA5-CHRNA3-CHRNB4, in

146 at at least two independent variants in this nicotinic receptor gene cluster contribute to the develo

147 The cluster of human neuronal nicotinic receptor genes (CHRNA5/A3/B4) (15q25.1) has be

148 ion in risk for nicotine dependence in these nicotinic receptor genes has not been studied.

149 C1, COMT, neuregulin, dysbindin, and alpha-7 nicotinic receptor genes, appear to affect quantitative

150 The nicotinic receptor has become the founding father of a b

151 The nicotinic receptor has been a model system for cell-surf

152 These data indicate that activation of nicotinic receptors has effects upon the BDNF-TrkB pathw

153 in, which binds to alpha7 subunit containing nicotinic receptors, have demonstrated that mouse strain

154 of WT, Nrg1 heterozygous animals and alpha7 nicotinic receptor heterozygous mice reveals that the su

155 se-response curves for homopentameric alpha7 nicotinic receptors illustrate this relationship for bot

156 a nicotinic agonist that activates alpha(7)-nicotinic receptors, improved clinical ratings of negati

157 ied variants in 30 candidate genes including nicotinic receptors in 200 sib pairs selected from the M

158 siderably in the number of alpha7-containing nicotinic receptors in brain.

159 rawal period and measured levels of neuronal nicotinic receptors in cortex, striatum, and hippocampus

160 dministration, indicating the involvement of nicotinic receptors in CSE reinforcement.

161 beta2-containing nicotinic receptors in dopamine neurons likely mediate t

162 found that, both during acute activation of nicotinic receptors in the adolescent mPFC as well as im

163 Usually nicotinic receptors in the central nervous system only i

164 Cholinergic activation of nicotinic receptors in the cortex plays a critical role

165 assessed the roles of alpha7 and alpha4beta2 nicotinic receptors in the dorsal hippocampus for memory

166 Furthermore, despite the rich endowment of nicotinic receptors in the visual cortex there was no ch

167 bited acetylcholine responses of alpha4beta2 nicotinic receptors in vitro, as did full length ectodom

168 stigmine can potentiate and inhibit neuronal nicotinic receptors, in addition to inhibiting the activ

169 ffects of KYNA on cannabinoid reward involve nicotinic receptors, in the present study we used rat an

170 The same peptides significantly altered a nicotinic receptor induced behaviour in C. elegans and i

171 a-erythrodine (DHbetaE) to block alpha4beta2 nicotinic receptors into the basolateral amygdala and th

172 The alpha7 subtype of nicotinic receptor is highly expressed in the hippocampu

173 y impacts cortical function, and the loss of nicotinic receptors is a hallmark of aging and neurodege

174 e extracellular ligand-binding domain of the nicotinic receptor, is similarly sensitive to neonicotin

175 tor was described in landmark studies of the nicotinic receptor isolated from the electric organ of T

176 partial agonist at some heteromeric neuronal nicotinic receptors, it is a full agonist at the homomer

177 al role in a number of pioneering studies of nicotinic receptors, its functional role in native recep

178 tive attention task in wild-type and alpha-9 nicotinic receptor knock-out (KO) mice.

179 ere obtained to ascertain hippocampal alpha7 nicotinic receptor levels.

180 y synthesized for the generation of neuronal nicotinic receptor ligands.

181 novel mutations in the alpha subunit of the nicotinic receptor linked to myasthenia gravis.

182 ogic or pharmacological subtypes of neuronal nicotinic receptors may be present in neurons.

183 odel simulations suggest that muscarinic and nicotinic receptors may serve complementary roles in reg

184 terneurons via a remarkably slow, non-alpha7 nicotinic receptor-mediated conductance.

185 cholinergic signaling at both muscarinic and nicotinic receptors mediates action selection based on P

186 ermeability of the alpha9alpha10 cholinergic nicotinic receptor might have evolved together with othe

187 ulator of the (alpha4beta2)(2)alpha5 type of nicotinic receptor might have therapeutic potential in N

188 atment with the cholinesterase inhibitor and nicotinic receptor modulator, galantamine, on the cerebr

189 inery is the underlying mechanism for alpha7 nicotinic receptor (nAChR) desensitization.

190 riants in the alpha5 subunit of the neuronal nicotinic receptor (nAChR) influence both ethanol and ni

191 The homomeric alpha7 nicotinic receptor (nAChR) is one of the most abundant n

192 ked with high penetrance to several distinct nicotinic receptor (nAChR) mutations.

193 As GABAA and nicotinic receptors (nAChR) belong to this family, we ex

194 two neurotransmitters activate two types of nicotinic receptors (nAChRs) (the homomeric alpha7 recep

195 Acetylcholine-activating pentameric nicotinic receptors (nAChRs) are an essential mode of ne

196 Nicotinic receptors (nAChRs) are important modulators of

197 search shows that compounds acting at alpha7 nicotinic receptors (nAChRs) can reduce nicotine self-ad

198 Nicotine-induced up-regulation of neuronal nicotinic receptors (nAChRs) has been known and studied

199 Transient expression of alpha4beta2 nicotinic receptors (nAChRs) in Neuro-2a cells induced t

200 mine release in the striatum via presynaptic nicotinic receptors (nAChRs) on dopamine axon terminals.

201 Recent studies suggest that the neuronal nicotinic receptors (nAChRs) present in the habenulo-int

202 rents via tyrosine phosphorylation of alpha7 nicotinic receptors (nAChRs) through src tyrosine kinase

203 or addictive substance in tobacco, activates nicotinic receptors (nAChRs) to initiate a series of ada

204 ffects of striatal ACh acting at presynaptic nicotinic receptors (nAChRs) were antagonized.

205 otine alters the trafficking and assembly of nicotinic receptors (nAChRs), leading to their up-regula

206 Acetylcholine, acting on presynaptic nicotinic receptors (nAChRs), modulates the release of n

207 me of those involved in the flight response, nicotinic receptors not only modulate the signal, they a

208 uate or eliminate any desensitization of the nicotinic receptors occurring during the repeated applic

209 triggers dopamine release via activation of nicotinic receptors on dopamine axons.

210 o be due, at least in part, to activation of nicotinic receptors on GABAergic NPY-neurogliaform inter

211 tually mediated by activation of presynaptic nicotinic receptors on nigrostriatal terminals that evok

212 otine withdrawal, for example, by activating nicotinic receptors on somatostatin interneurons, may be

213 ll as the contribution of the muscarinic and nicotinic receptors on SSA.

214 mocortical (TC) synapse, where activation of nicotinic receptors on TC terminals have been shown to e

215 g for nearly all odor sets, whereas blocking nicotinic receptors only affects performance for percept

216 y GABAergic currents mediated by presynaptic nicotinic receptors or biphasic GABAergic and nicotinic

217 ow that incorporation of beta3 into neuronal nicotinic receptors other than alpha3beta4 has a powerfu

218 Treatments were the alpha7 nicotinic receptor PAM JNJ-39393406 (100 mg b.i.d.) or p

219 Varenicline acts as a nicotinic receptor partial agonist or antagonist dependi

220 cy and safety of ABT-126, a selective alpha7 nicotinic receptor partial agonist, in stable patients w

221 s conducted to test the effects of an alpha7 nicotinic receptor partial agonist, TC-5619, on cognitiv

222 the potential benefits of TC-5619 and alpha7 nicotinic receptor partial agonists for cognitive dysfun

223 , specific assembly of beta3 and alpha6 into nicotinic receptor pentamers of various subunit composit

224 ing selectivity differences for the specific nicotinic receptor populations expressed in GABAergic ne

225 Blocking nicotinic receptors primarily attenuated high-gamma osci

226 5(GFP) neurons in the IP, suggesting a mixed nicotinic receptor profile in these cells.

227 tion or a downregulation of beta2-containing nicotinic receptors protects the striatal network agains

228 ciated with maternal genotype for the alpha5 nicotinic receptor (rs16969968) (P < .001 for interactio

229 esting that xenobiotic exposure, rather than nicotinic receptor signaling, is responsible for program

230 Stimulation of nicotinic receptors, specifically the alpha7 subtype, im

231 on VFT that depends upon both muscarinic and nicotinic receptor stimulation, where the generation of

232 on VFT that depends upon both muscarinic and nicotinic receptor stimulation, where the generation of

233 dependent on NO generation and/or muscarinic/nicotinic receptor stimulation.

234 Our studies on the nicotinic receptor structure in the neonicotinoid-bound

235 cted based on the torpedo neuromuscular-like nicotinic receptor structure.

236 rhythm generation occur in cerebellum during nicotinic receptor subtype activation.

237 erebellar alpha(4)beta(2), but not alpha(7), nicotinic receptor subtype in the mediation via nicotine

238 centrations of ethanol inhibit activity of a nicotinic receptor subtype that is expressed in brain ar

239 ts to form the major ganglionic postsynaptic nicotinic receptor subtype.

240 A major standing question is which nicotinic receptor subtypes and which areas of the brain

241 ological disorders, how and whether specific nicotinic receptor subtypes are involved is unknown.

242 accessible for study, up to three different nicotinic receptor subtypes mediate the signal.

243 ole-cell current responses generated by both nicotinic receptor subtypes present on CG neurons (alpha

244 xhibited reduced agonist activity across all nicotinic receptor subtypes tested.

245 umber of stoichiometries to generate several nicotinic receptor subtypes that have distinct pharmacol

246 o detectable effects on muscle or ganglionic nicotinic receptor subtypes, indicating a marked selecti

247 for Renshaw cells (calbindin and cholinergic nicotinic receptor subunit alpha2 [Chrna2]), two general

248 nsynonymous variant rs16969968 in the alpha5 nicotinic receptor subunit gene (CHRNA5) is the stronges

249 s from an SNP representing CHRNB3, the beta3 nicotinic receptor subunit gene (P = 9.4 x 10(-5)).

250 came from a non-synonymous SNP in the alpha5 nicotinic receptor subunit gene CHRNA5 (P = 6.4 x 10(-4)

251 D, and it includes the alpha5 and the alpha3 nicotinic receptor subunit genes (CHRNA5 and CHRNA3).

252 Here, we trained wild-type and alpha-9 nicotinic receptor subunit knock-out (KO) mice, which la

253 with reduced levels of alpha(6) and beta(3) nicotinic receptor subunit mRNA in the ventral midbrain

254 of individual genes, CHRNA7, which encodes a nicotinic receptor subunit previously implicated in neur

255 lective alpha-conotoxins in combination with nicotinic receptor subunit-deficient mice to characteriz

256 acetylcholine receptors that contain alpha7 nicotinic receptor subunits (alpha7-nAChRs).

257 this problem, we developed mice whose alpha4 nicotinic receptor subunits are replaced by normally fun

258 The alpha9 and alpha10 cholinergic nicotinic receptor subunits assemble to form the recepto

259 hromosome 15 encompassing genes encoding the nicotinic receptor subunits CHRNA5, CHRNA3 and CHRNB4.

260 the habenulo-interpeduncular system and the nicotinic receptor subunits expressed therein, in nicoti

261 NIC) treatment or specific deletion of beta2 nicotinic receptor subunits in dopamine neurons mitigate

262 f sequential expression of alpha5 and alpha7 nicotinic receptor subunits in oral keratinocytes expose

263 wal in mice lacking the alpha2 or the alpha5 nicotinic receptor subunits, which are highly expressed

264 ctions and differential use of fast and slow nicotinic receptors suggests a mechanism that can implem

265 (PDB) code 2VL0], a bacterial member of the nicotinic receptor superfamily of ion channels where fiv

266 Among ion channels, only the nicotinic-receptor superfamily has evolved to generate b

267 nel conformation of different members of the nicotinic-receptor superfamily.

268 el in a crystal, at least in the case of the nicotinic-receptor superfamily.

269 ale neuroimaging genetics study of the human nicotinic receptor system (two cohorts, males and female

270 aired spatial learning, while activating the nicotinic receptor system counteracts the effects of AT(

271 Nicotinic receptor systems have been shown to be importa

272 ubunit, an "accessory" subunit of pentameric nicotinic receptors, that has been shown to play a role

273 lographic structure of the human alpha4beta2 nicotinic receptor, the most abundant nicotinic subtype

274 ensitive to blockade of action potentials or nicotinic receptors; the effects of Abeta (but not its p

275 liary ganglion is mediated by two classes of nicotinic receptors: those containing alpha3 subunits [a

276 supplementation is acting through the alpha7 nicotinic receptor to improve sensory inhibition.

277 Like clozapine, olanzapine acts via alpha7 nicotinic receptors to elicit improved inhibitory proces

278 ons with nicotine-via alpha2beta2-containing nicotinic receptors-to bypass innervation defects.

279 CSE to have similar affinities for different nicotinic receptor types.

280 Our data suggest that nicotinic receptor up-regulation is subtype-specific suc

281 red for rapid and efficient gating of muscle nicotinic receptors using a structural model of the Torp

282 Blockade of nicotinic receptors using mecamylamine (1 mg/kg) prevent

283 To understand the impact of these nicotinic receptor variants in humans, we differentiated

284 cult, with one recent success in identifying nicotinic receptor variants that affect risk for nicotin

285 ometry, and the expression of muscarinic and nicotinic receptors was evaluated by flow cytometry or q

286 , which selectively desensitizes alpha4beta2 nicotinic receptors, was shown to significantly reduce a

287 For the nicotinic receptor we observed barriers to ion transloca

288 surrogate of the extracellular domain of the nicotinic receptor, we combined site-directed labeling w

289 Summarizing recent data for nicotinic receptors, we explain how such effects could l

290 lying the conformational wave hypothesis for nicotinic receptors, we note that interpretations may be

291 rotoxins tightly bound to the coated Torpedo nicotinic receptor were eluted with methanol, and the ch

292 both alpha4beta2- and alpha3beta4-containing nicotinic receptors were able to reduce nicotine-evoked

293 alpha-bungarotoxin binding sites (indicating nicotinic receptors) were found throughout the pTRG area

294 otonated and selective for insects and their nicotinic receptors, whereas nicotinoids such as nicotin

295 holine is a selective agonist for the alpha7 nicotinic receptor which appears in development before a

296 tors could become desensitized, particularly nicotinic receptors which function as calcium channels.

297 Desensitization of nicotinic receptors, which is a prevailing mechanism for

298 intracellular pools of assembled, functional nicotinic receptors, which may provide them with the abi

299 In contrast to all nicotinic receptors, which serve excitatory neurotransmi

300 identity to the extracellular domain of the nicotinic receptor, yet these soluble proteins have thei