ライフサイエンスコーパス: nitro group

1 he 4-nitro group of CB1954 rather than the 2-nitro group.

2 nd geometry to within 2.8 A of the inhibitor nitro group.

3 the hemin which stabilizes the highly polar nitro group.

4 ono-NP is dependent upon the position of the nitro group.

5 beta- and delta-carbons with respect to the nitro group.

6 l group with evidence for ion pairing at the nitro group.

7 ization onto the secondary aromatic ring and nitro group.

8 the product resulting from reduction of the nitro group.

9 Previously reported representatives bear a 3-nitro group.

10 ammonium cation and the oxygen atoms of the nitro group.

11 amed dZ, the electron withdrawing unit was a nitro group.

12 ional interlobe interactions mediated by the nitro group.

13 tivating groups including acetyl, cyano, and nitro groups.

14 ups, including methoxy, alcohol, ketone, and nitro groups.

15 s, including methoxy, alcohol, aldehyde, and nitro groups.

16 tert-butyldiphenylsilyl ether, and aliphatic nitro groups.

17 which favour the preferential adsorption of nitro groups.

18 hance selectivity toward analytes containing nitro groups.

19 ino groups present will have originally been nitro groups.

20 nyl, cyclopropyl, pyridyl, aryl, benzyl, and nitro groups.

21 lopenta[b]indolines with versatile vinyl and nitro-groups.

22 ence involving (1) reduction of the aromatic nitro group, (2) condensation of the aniline or hydroxyl

23 to bind at both active sites with only the 2-nitro group able to participate in hydride transfer from

24 ce of other reactive functionality including nitro groups, alkenes, and halogens.

25 leavages on the fatty acid backbone near the nitro group, allowing its localization within the FA aky

26 Previously, it was discovered that a 3-nitro group and a 9-methoxy group afforded enhanced biol

27 exploration of the chemical potential of the nitro group and a putative reaction mechanism are discus

28 ed dipole stacking interaction between the 5-nitro group and base 3' to the templating lesion explain

29 ituted OPE by electrochemically reducing the nitro group and by varying the pH of the electrolyte.

30 ignificant directing interaction between the nitro group and the incoming nucleophilic palladium cata

31 tter are more acceptable pharmacophores than nitro groups and also tend to increase the water solubil

32 des were treated with Pd/C, H2 to reduce the nitro groups and cyclized with nitrous acid, and the cor

33 ch polymorphs are the interactions among the nitro groups and phenyl rings of those crystals.

34 separately reduced both the para- and ortho-nitro groups and produced glycosylated products that acc

35 the XPS peak of the N 1s electrons of the NT nitro groups and the DPV peak of electroreduction of the

36 ry nitrogen-15 isotope effect ((15)k) in the nitro group, and (for the monoester and diester) the sec

37 e spectra indicated irreversible loss of the nitro group, and a dramatic but reversible decrease in R

38 phenyl-alpha-d-mannopyranoside, reducing its nitro group, and reacting it with thiophosgene to produc

39 hows functional group tolerance for alkenes, nitro groups, and aryl halides, including aryl iodides.

40 rray of functional groups, including esters, nitro groups, and enolizable ketones.

41 The process tolerates nitro groups, and it efficiently generates sterically hi

42 particular, the reaction between Ti and the nitro group appears to prevent short circuits resulting

43 All nitro groups are electronically isolated and thus are re

44 By implementation of both the azido and nitro group as sulfide-reactive functionalities on the s

45 ction of multiple bonds, azides, imines, and nitro groups, as well as benzyl group and allyl group de

46 d symmetric etioheme I modified with a bulky nitro group at a single meso position.

47 minor isomers are shown to place their bulky nitro group at the canonical delta-meso (8%) and alpha-m

48 etermine that the hemin is oriented with the nitro group at the canonical gamma-meso position of nati

49 he comparable population of the isomers with nitro groups at the hydrophobic alpha- and delta-meso po

50 stacked head-to-tail, with the plane of the nitro group being tilted above the plane of the benzene

51 gest that 1,3-disiloxanediols bind weakly to nitro groups but are strongly activating for catalysis.

52 e replacement of the potentially genotoxic 3-nitro group by 3-chloro and 3-fluoro substituents, resul

53 The direct substitution of a nitro group by a hydroxide represents the most favorable

54 followed by nucleophilic attack on the TBNS nitro group by Cys-215 of PTP1B to form a reversible, co

55 The displacement of the aromatic nitro group by dioxygenases has only recently been descr

56 Photoexcitation of nitro groups by a high-energy laser is not required; the

57 Selective reduction of the nitro group can be accomplished.

58 sibly because their less sterically hindered nitro groups can be released more easily as nitrite and

59 reactive and the least selective: all three nitro groups can be substituted using an excess of thiol

60 tivity to afford products with the vinyl and nitro groups cis to each other is observed with a 4-subs

61 ing of NS1 and in local solvation around NS1 nitro group, consistent with changes of NS1 fluorescence

62 is carried out in an (16)O2 atmosphere, CAM nitro groups contain both (18)O and (16)O, suggesting th

63 For the first time both nitro group containing aryl/heteroaryl iodides and bromi

64 intensities of NAB modes associated with the nitro group decreased significantly, and the XPS indicat

65 avior between pyrrolidines with or without a nitro group, demonstrating the strong nitro-group-depend

66 amine group to one of the two O atoms in the nitro group denotes the most accessible route in the uni

67 hout a nitro group, demonstrating the strong nitro-group-dependent periselectivity.

68 ks above the FMN, and in active site B the 4-nitro group does, explaining why reduction of either nit

69 The elimination of the nitro group during lactone formation is a previously unr

70 s afforded products of substitution of the p-nitro group exclusively.

71 n with 2,3-dimethoxy-8,9-methylenedioxy or 3-nitro groups exerted strong effects on antiproliferative

72 Indium-mediated reduction of the nitro group followed by acylation of the resulting amine

73 Mild reduction of the nitro group followed by an acid-mediated cyclodehydratio

74 Reduction of the nitro group followed by derivatization of the so formed

75 Subsequent reduction of the nitro group followed by hydrolysis of the oxazoline ring

76 ams can be obtained via hydrogenation of the nitro group followed by in situ cyclization.

77 Catalytic reduction of the nitro group followed by reaction with NBS resulted in th

78 ds 6 and 7 respectively, by reduction of the nitro groups followed by diazotization of the amines.

79 tance of certain molecular fragments, such a nitro groups, for the outcome of a mutagenicity study.

80 acids as inexpensive, readily available, and nitro group-free aminating reagents.

81 onsistent with a random removal of the first nitro group from either the terminal (C-1 and C-3) posit

82 C monooxygenase catalyzes the removal of the nitro group from MNC to form 2-hydroxy-5-methylquinone.

83 regioselectivity for removal of the central nitro group from NG and that transforms TNT but did not

84 e, a 2.4-fold selectivity for removal of the nitro group from the C-2 position of 1,2-DNG was also de

85 that removes either the terminal or central nitro groups from NG and that reduces 2-cyclohexen-1-one

86 0.9), compounds containing halogen atoms or nitro groups gave a lower predicted ESI response.

87 e 4-nitro group of CB1954, rather than the 2-nitro group, giving the more cytotoxic reduction product

88 The experiments indicated that the nitro group has influence on regioselectivity of the rea

89 e predicted to catalyze the formation of the nitro group, have also been identified.

90 now show the typical activity of Au(0)NPs in nitro group hydrogenation.

91 Reduction of the nitro group in 13 to an amine, followed by reductive ami

92 hesized incorporating a strategically placed nitro group in a position para to the benzylic carbon fo

93 g macrocycle ring-opening and insertion of a nitro group in one of the four aromatic rings.

94 (15(V/K) refers to the nitro group in p-nitrophenyl sulfate).

95 migration and that the presence of an ortho nitro group in the aminating agent plays a critical role

96 Compound 4 is the isomer that has the nitro group in the best orientation at the es transporte

97 ample with the strongly electron-withdrawing nitro group in the gamma position.

98 gen in the quinoline ring and a halogen or a nitro group in the indole ring have enhanced antiplasmod

99 from energetically favorable stacking of the nitro group in with pi-electrons of the adjacent base.

100 te of DprE1 may trigger the reduction of the nitro groups in a manner similar to the von Richter reac

101 additional interactions of the hydroxyl and nitro groups in pNCS with Asp-356, Gln-357, Arg-404, and

102 om the separate reduction of the quinone and nitro groups in the molecules.

103 Chemoselective reduction of nitro groups in the presence of activated heteroaryl hal

104 (cyano-dZ) having a cyano group instead of a nitro group, including its synthesis, pK(a), rates of ac

105 ecreasing as the number of bonds between the nitro groups increases, except for the 1,5-dinitronaphth

106 The oxygens of the substrate nitro group interact both with amino acid residues and w

107 Introduction of a para-nitro group into the benzene ring of the diene enabled s

108 reaction with nitric acid to insert aromatic nitro-groups into the benzene rings, followed by treatme

109 This AAD process only occurred when a nitro group is bonded to the 4-position of the initial e

110 The nitro group is easily reduced with hydrogen over a Raney

111 of the biological results suggests that the nitro group is important for Top1 inhibition and the met

112 esized in this study are examples, where the nitro group is introduced into the fjord region, for whi

113 ced potency compared to NH-3, indicating the nitro group is not required for antagonism.

114 oup does, explaining why reduction of either nitro group is observed.

115 with protoheme or mesoheme, we show that the nitro group is on the 4-vinyl.

116 the derivatives 12-14 in which the aromatic nitro group is replaced by amine, guanidine, or sulfonam

117 The nitro group is required for both activities in all compo

118 The nitro group is spontaneously eliminated as nitrite conco

119 (15)N nitro group labeled RDX ((15)N-[RDX], 50 atom %) was spi

120 Polynitrocalix[4]arenes with reducible nitro groups located at the upper rim represent molecule

121 ystematically prepared using combinations of nitro groups, methoxy groups, and hydrogen atoms in an e

122 ible binding orientations, and the reducible nitro group must be located para to the mustard.

123 osine (3-NT) from Tyrosine (Tyr) by adding a nitro group (-NO2) with nitrating agents.

124 s no hydrogen-bonding partners for the polar nitro group of 4-NBP within the hydrophobic active site.

125 n aryl-amine precursor (NH2-CAM) to the aryl-nitro group of CAM catalyzed by the non-heme diiron clus

126 n increase in selectivity for reducing the 4-nitro group of CB1954 rather than the 2-nitro group.

127 st active mutant is also selective for the 4-nitro group of CB1954, rather than the 2-nitro group, gi

128 imer complex via interactions with the ortho nitro group of CDNB or FDNB and provide insight into the

129 ic nucleophilic substitution reaction of the nitro group of meso-nitroporphyrins with azide and vario

130 ew TS devoid of hydrogen bonding between the nitro group of nitrostyrene and carboxylic acid of proli

131 acking interactions with C13 and C15 and the nitro group of X14 is pointing out of the major groove.

132 In solution, the electron-withdrawing nitro groups of both compounds establish a resonance equ

133 The nitro groups of energetic compounds are readily reduced

134 It also reduced the nitro groups of Nit(V), forming p-aminophenyl arsenate (

135 ineNO- group was added para and ortho to the nitro groups of the dinitrophenyl ring.

136 In each site, the nitro groups of the prodrug make direct H-bond contacts

137 ration (i.e., the irreversible addition of a nitro group) of the Alzheimer-related peptide amyloid-be

138 Arylation occurs ortho to the nitro group offering a synthetic route to polyfluorinate

139 In order to assess the role of the nitro group on base stacking interaction, sequences were

140 f 3, which contained an electron-withdrawing nitro group on the phenyl ring, produced a single diaste

141 se labile stereogenic center adjacent to the nitro group on the piperidinone ring, while the undesire

142 Modeling studies showed that the nitro group on the pyrene ring at the 8-position can pro

143 1,6-ANP and Gua-C8-1,8-ANP), which contain a nitro group on the pyrene ring covalently linked to the

144 Unique features include stacking of the nitro group on Z with the adjacent nucleobase ring in th

145 G:C pairs, perhaps to accommodate the large nitro group on Z.

146 Electron-withdrawing substituents such as nitro groups on the phenyl ring cause higher quantum yie

147 onating (hydroxyl) and electron-withdrawing (nitro) groups on the phenyl ring of Phe to affect the in

148 henols showed an exponential decay, with the nitro-group on the aromatic ring found to control the fo

149 o the electrochemical reduction of the three nitro-groups on the TNT molecule.

150 9 was synthesized by (18)F displacement of a nitro group or an iodonium ylide.

151 e single phenyl ring were either an ester, a nitro group, or a sulfonamide group.

152 ributions of the pi-electrons present in the nitro group, other physical parameters such as solvation

153 ronaphthalene, steric interactions force the nitro groups out of the plane of the naphthalene ring, d

154 uperior selectivity for hydrogenation of the nitro group, outperforming both conventional Pd nanopart

155 hydride induce nonenzymatic reduction of the nitro groups present in these compounds to the correspon

156 yl and ethyl esters, enolizable ketones, and nitro groups provided that cesium carbonate is employed

157 imination occurred, leading to the selective nitro group reduction reaction on the syn-alpha-amino es

158 with 2 equiv of the acrylamides, followed by nitro group reduction, afforded the desired amino-polyes

159 elopment for H2S detection include azide and nitro group reduction, nucleophilic attack, and CuS prec

160 zoate followed by catalytic reduction of the nitro group, reductive coupling with 2-acetamido-6-formy

161 by a [3 + 2] cycloaddition/extrusion of the nitro group/regioselective 6-endo cyclization domino seq

162 The olefinic nitro group renders these derivatives electrophilic at t

163 rally identical to CT325 except for an inert nitro group replacing the reactive nitroso group.

164 Chemical reduction of the nitro group resulted in rapid expulsion of the cytotoxic

165 This reaction proceeds via reduction of the nitro group, resulting in in situ imine formation follow

166 4 and 6 with a benzylic nitrogen para to the nitro group showed little selective cytotoxicity despite

167 s 3 and 5 with a benzylic oxygen para to the nitro group showed potent selective cytotoxicity in nitr

168 Here we demonstrate that incorporation of a nitro group significantly stabilizes the LUMO, and hence

169 In active site A the 2-nitro group stacks above the FMN, and in active site B t

170 ester], a derivative of aspirin containing a nitro group that releases nitric oxide in a sustained fa

171 s the main chain nitrogen of Thr41 and the 4-nitro group the Lys14 side chain.

172 ives electrophilic at the carbon beta to the nitro group, thus competent for Michael addition reactio

173 sistent with the 4e-, 4H+ reduction of the 7-nitro group to a hydroxylamine species; the second more

174 aromatic ring using an electron-withdrawing nitro group to activate that fluorine.

175 Reduction of the nitro group to an amino group yields 12, which is treate

176 iring bioreductive activation of an aromatic nitro group to exert an antitubercular effect.

177 ociated ion channel that is used to target a nitro group to redox-mediated regulatory sites on the re

178 by electrochemical reduction of the terminal nitro groups to amines.

179 thionite is added subsequently to reduce the nitro groups to amines; in theory, the only amino groups

180 orating the pores vary from polar cyano- and nitro- groups to nonpolar alkyl groups.

181 atment with sodium borohydride to reduce the nitro-groups to primary amines.

182 ubstrates (e.g., those containing esters and nitro groups) to be utilized in our amination protocols.

183 g electron withdrawing substituents, such as nitro groups, to superoxide-driven nucleophilic attack.

184 A denitration step renders the nitro group "traceless" and delivers secondary, tertiary

185 yield of O(6)-BG following reduction of the nitro group trigger.

186 on of a nitronate or by equilibration of the nitro group under thermodynamic control.

187 at have a 4-formyl-benzamido group where the nitro group used to be.

188 achieved via reductive deoxygenation of the nitro groups using a slight excess of triphenylphosphine

189 for the chemoselective reduction of aromatic nitro groups using samarium(0) metal in the presence of

190 1,2-DNG, a 1.3-fold selectivity for the C-1 nitro group was determined.

191 dazole derivatives directed by a manipulable nitro group was developed.

192 The mechanism of release of the nitro group was unknown.

193 g a bioisosteric carboxylate in place of the nitro group, was examined.

194 Analogues lacking the nitro group were not cytotoxic.

195 Two independent pairs of equivalent nitro groups were identified whose reduction potential d

196 nating diphenylamino or electron-withdrawing nitro groups were synthesized as well as their linear an

197 as esters, enolizable ketones, nitriles, and nitro groups, were tolerated by the combination of hydro

198 ibited by the large electron affinity of the nitro group, while CID efficiency remains unaffected by

199 on of an alkyl radical by abstraction of the nitro group with a stannyl radical.

200 troarenes at a position ortho or para to the nitro group with formation of anionic sigma(H) adducts.

201 uorine and chlorine may substitute for the 3-nitro group with minimal loss of Top1 poisoning activity

202 intermediates, followed by reduction of the nitro group with Raney Ni.

203 id derivatives, followed by reduction of the nitro group with tin chloride, generated a resin-bound o