ライフサイエンスコーパス: nitroreductase

1 catalytic activity of a dehalogenase into a nitroreductase.

2 nicotinamide adenine dinucleotide dependent nitroreductase.

3 ophenylcyclophosphamide analogues by E. coli nitroreductase.

4 on mutations in genes encoding RdxA and FrxA nitroreductases.

5 omatid parasites, this is mediated by type I nitroreductases.

6 ical state commonly seen in oxygen-sensitive nitroreductases.

7 s, which we annotated as rdxAB, encoding two nitroreductases.

8 Nitroreductase A catalyzes the divalent reduction of nit

9 In this paper, nitroreductase A is induced in Escherichia coli by expos

10 Nitroreductase A thus appears to be a member of the soxR

11 ing a mutational defect in the gene encoding nitroreductase A, but it was approximately 3-fold induce

12 irected enzyme prodrug therapy using E. coli nitroreductase, a series of nitrobenzylphosphoramide mus

13 d dosS and dosT genes encoding DosR kinases, nitroreductases (acg; Rv3131), diacylglycerol acyltransf

14 Nitroreductase activity declined 80% after the control d

15 deiodinase activity and leads to significant nitroreductase activity that supports full reduction to

16 Nitroreductase activity was only slightly induced by par

17 he >30-fold improvement of prodrug activator nitroreductase activity with an UAA over that of the nat

18 to either non-oxygen-dependent variations in nitroreductase activity, drug metabolism, and/or actual

19 ng equivalents from NAD(P)H, nor demonstrate nitroreductase activity.

20 rvations are not due to tissue variations in nitroreductase activity.

21 first time, the activity of a mycobacterial nitroreductase against 1 analogs, highlighting the diffe

22 mustard analogues were activated by E. coli nitroreductase, an enzyme explored in GDEPT.

23 ing was achieved by expressing the bacterial nitroreductase, an enzyme that catalyzes its substrate i

24 lved in the breakdown of explosives, such as nitroreductase and cytochrome P450, have been introduced

25 cteria, and to assay for beta-glucuronidase, nitroreductase, and glycocholic acid hydroxylase.

26 alysis of large gene families encoding USPs, nitroreductases, and DGATs demonstrates a mosaic distrib

27 Bacterial nitroreductases are NAD(P)H-dependent flavoenzymes which

28 r of the same structural superfamily as many nitroreductases but does not directly consume reducing e

29 Nitroreductase catalyzes the reduction of TNT to hydroxy

30 ne deaminase/5-fluorocytosine (yCD/5-FC) and nitroreductase/CB1954 (NTR/CB1954) have been used for st

31 a replication-defective adenovirus encoding nitroreductase (CTL102) in patients with liver tumors.

32 te oxidase (PPOX), and deazaflavin-dependent nitroreductase (DDN) families.

33 tb mutants lacking the deazaflavin-dependent nitroreductase (Ddn) retained anaerobic sensitivity to s

34 found that Rv3547 is a deazaflavin-dependent nitroreductase (Ddn) that converts PA-824 into three pri

35 The monomers of the nitroreductase dimer adopt an alpha+beta fold and togeth

36 the monomeric protein resembles a classical nitroreductase dimer but with one active site deleted an

37 In metronidazole-treated myl7:nitroreductase embryos, myocardial cells were targeted f

38 The E. coli nitroreductase enzyme (NTR) has been widely used in suic

39 The crystal structure of the nitroreductase enzyme from Enterobacter cloacae has been

40 transgenic lines that expressed the E. coli nitroreductase enzyme fused to EGFP (NTR-EGFP) in only r

41 enes to regulate expression of the bacterial nitroreductase enzyme in combination with the pro-drug C

42 nce similarity to an FMN-dependent family of nitroreductase enzymes.

43 ile of glutathione S-transferases (GSTs) and nitroreductases enzymes.

44 howed 167 500x selective cytotoxicity toward nitroreductase-expressing V79 cells with an IC(50) as lo

45 Dose-related increases in tumoral nitroreductase expression measured by immunohistochemica

46 The high level of nitroreductase expression observed at 1 to 5 x 10(11) vi

47 enoviral vectors showed cancer cell-specific nitroreductase expression.

48 e NADH/flavin mononucleotide (FMN)-dependent nitroreductase family, and we propose that it is involve

49 ne groups (regulators, kinases, USPs, DGATs, nitroreductases, ferredoxins, heat shock proteins, and t

50 as the first protein known to repurpose the nitroreductase fold solely for protein-protein interacti

51 on at 2.2 A resolution, revealing a modified nitroreductase fold with surprising homology to MMACHC d

52 The oxygen-insensitive nitroreductase from Enterobacter cloacae (NR) catalyzes

53 fundamental differences in the activities of nitroreductases from epsilonproteobacteria.

54 at H. pylori strains differ in regulation of nitroreductase gene expression.

55 Placing the nitroreductase gene under the control of the telomerase

56 tissue-specific cell death using a bacterial nitroreductase gene under UAS control.

57 d that plants transformed with the bacterial nitroreductase gene, nfsI have increased ability to tole

58 KEY MESSAGE: Expression of the bacterial nitroreductase gene, nfsI, in tobacco plastids conferred

59 The relative importance of the frxA and rdxA nitroreductase genes of Helicobacter pylori in metronida

60 Natural and engineered nitroreductases have rarely supported full reduction of

61 ey could be used in combination with E. coli nitroreductase in enzyme prodrug therapy.

62 toxic effects of TNT, we expressed bacterial nitroreductase in tobacco plants.

63 HyCL-2 can image exogenous nitroreductase in vitro and in vivo in living mice, and

64 Escherichia coli nitroreductase is a flavoprotein that reduces a variety

65 Nitroreductase is a member of a group of enzymes that re

66 chemical basis for the recent finding that a nitroreductase is a member of the soxRS oxidative defens

67 eishmania major, expresses an FMN-containing nitroreductase (LmNTR) that metabolizes a wide range of

68 To investigate this, we applied the nitroreductase/metronidazole zebrafish model of podocyte

69 uctase and the non-bifurcating flavoproteins nitroreductase, NADH oxidase, and flavodoxin.

70 MarA upregulation of the oxygen-insensitive nitroreductase nfnB gene.

71 e repression of the gene nfnB coding for the nitroreductase NfnB was responsible for the natural resi

72 N137 directly represses the synthesis of the nitroreductase NfsA, which catalyzes the reduction of th

73 The enzyme nitroreductase, NfsB, from Escherichia coli has entered

74 ilization of a maltose binding protein (MBP) nitroreductase (NR) fusion (MBP-NR) onto an electrode mo

75 Our work suggests that expression of nitroreductase (NR) in plants suitable for phytoremediat

76 onucleotide cofactor of Enterobacter cloacae nitroreductase (NR), determined under a variety of solut

77 Nitroreductases (Nrs) play important roles in redox syst

78 Nitroreductase (NTR) activities have been known for deca

79 roup showed potent selective cytotoxicity in nitroreductase (NTR) expressing cells, while analogues 4

80 ple of suicide gene therapy is the bacterial nitroreductase (NTR) gene, which bioactivates the prodru

81 Escherichia coli nitroreductase (NTR) is a flavoprotein that reduces a va

82 Bacterial Nitroreductase (NTR) is used to catalyze the reduction o

83 ompounds are excellent substrates for type I nitroreductase (NTR) located in the mitochondrion of try

84 ters, we found much higher expression of the nitroreductase (NTR) protein in the E. coli host compare

85 tein) reporter fused to the Escherichia coli nitroreductase (NTR) selection enzyme.

86 ally diverse flavin mononucleotide-dependent nitroreductase (NTR) superfamily (>24,000 sequences from

87 aevis expressing the Escherichia coli enzyme nitroreductase (NTR) under the control of the rod-specif

88 hondrially localized, bacterial-like, type I nitroreductase (NTR), and that down-regulation of this e

89 oCy5S), which is reduced by Escherichia coli nitroreductase (NTR), resulting in a near-infrared fluor

90 cil phosphoribosyltransferase (yCD:UPRT) and nitroreductase (NTR).

91 dinase based on the coordinates of the minor nitroreductase of Escherichia coli indicates that a Cys

92 te the presence of the nimA gene, encoding a nitroreductase previously shown to mediate resistance to

93 ing activation by a parasite specific type I nitroreductase, produce metabolites that promote formati

94 -NBA is predominantly activated by cytosolic nitroreductases rather than microsomal POR.

95 Using a modified nitroreductase scaffold tailored to bind cobalamin and g

96 de gene therapy vectors expressing bacterial nitroreductase sensitize human cancer cells to the pro-d

97 Transgenic plants expressing nitroreductase show a striking increase in ability to to

98 tion and fusion from a classical homodimeric nitroreductase such that the monomeric protein resembles

99 Many functioned as type I nitroreductase (TbNTR) or cytochrome P450 reductase (TbC

100 ted within the parasite by the mitochondrial nitroreductase TcNTR-1, leading to the generation of rea

101 tations in the gene encoding a mitochondrial nitroreductase (TcNTR) can give rise to distinct drug-re

102 y parasites via an enzyme, distinct from the nitroreductase that activates fexinidazole.

103 ains: type I, in which frxA (which encodes a nitroreductase that contributes to Mtz susceptibility) i

104 o mutation in rdxA (HP0954), which encodes a nitroreductase that converts Mtz from prodrug to bacteri

105 th pyridoxal 5'-phosphate synthases and aryl nitroreductases, these proteins form a large and versati

106 The use of the bacterial enzyme nitroreductase to activate CB1954 (5-(aziridin-1-yl)-2,4

107 Nitrofurazone is reduced by cellular nitroreductases to form N(2)-deoxyguanine (N(2)-dG) addu

108 as well as an ABC transporter and a probable nitroreductase, were highly induced by TNT exposure.

109 (pod::NTR-mCherry) by expressing a bacterial nitroreductase, which converts metronidazole to a cytoto

110 elong to an unusual superfamily of classical nitroreductases, which may have a role for bacteria with

111 hemiLuminescent Probe 2 (HyCL-2) responds to nitroreductase with approximately 170-fold increase in l

112 ll analogues were good substrates of E. coli nitroreductase with half-lives between 2.9 and 11.9 min