ライフサイエンスコーパス: nitrosate

1 dines hydrolyzed much more rapidly than they nitrosated.

2 s) in carboxymethyl-bovine serum albumin was nitrosated.

3 Reduced Trx (rTrx) was nitrosated 2.7-times faster than oxidized Trx (oTrx), an

4 NO and NO-related reactive nitrogen species nitrosate 4,5-diaminofluorescein to yield the highly flu

5 diffusion limits and the true nature of the nitrosating agent for nitrous acid initiated reactions.

6 The endogenous nitrosating agent N2O3 (dinitrogen trioxide, nitrous anh

7 autoxidation of nitric oxide (NO.) forms the nitrosating agent N2O3, which can directly damage DNA by

8 loride presumably by anion scavenging of the nitrosating agent nitrous anhydride, N2O3.

9 ptional responses of Escherichia coli to the nitrosating agent S-nitrosoglutathione (GSNO) in both ae

10 Thus, GSNO (a nitrosating agent) and NO have distinct cellular effects

11 rase (NA) reaction in which N2O3, a potent S-nitrosating agent, is produced through the reaction of N

12 Here we used a mitochondria-selective S-nitrosating agent, MitoSNO, to determine how mitochondri

13 roducing NO, also produces the highly potent nitrosating agent, nitrosyliodide.

14 of phosphate may be due to reaction with the nitrosating agent, nitrous anhydride (N2O3), formed by o

15 known to be up-regulated by nitric oxide and nitrosating agents (e.g. hmp and norVW) were unaffected.

16 satable drugs (NSDs) can, in the presence of nitrosating agents and highly acidic conditions, form N-

17 Nitric oxide and nitrosating agents exert powerful antimicrobial effects

18 apsulated within the tube NO+ species act as nitrosating agents for secondary amides.

19 endent mechanism leading to formation of the nitrosating agents N(2)O(3) and/or N(2)O(4).

20 A wide variety of nitric oxide donors and S-nitrosating agents protect the ischemic myocardium from

21 oxide reacts with oxygen to form endogenous nitrosating agents such as N2O3.

22 structural gene hmp is upregulated by NO and nitrosating agents; (ii) purified Hmp binds NO avidly, b

23 Although S-nitrosated albumin has been considered the major species

24 exes in plasma previously considered to be S-nitrosated albumin were <10 nM after elimination of nitr

25 Moreover, oxidized and nitrosated amino acids are suspected to promote various

26 ined significantly greater concentrations of nitrosated and chlorinated IgG compared with ostearthrit

27 asorelaxation activity as that observed with nitrosated bovine serum albumin.

28 When hTrx was partially S-nitrosated by preincubation with S-nitrosoglutathione, i

29 a viable alternative to polyDADMAC to avoid nitrosated byproduct formation during chloramination.

30 ons drawn are as follows: (i) Nitrite showed nitrosating capacity on Tau.

31 The nitrosated carboxymethyl-bovine serum albumin exhibited

32 which nitrosation of nitrosothiol produces a nitrosated cation that, in turn, reacts with a second ni

33 Here we report on the presence of nitrosated compounds in plasma and erythrocytes of rats,

34 ursor protein processing and secretion are S-nitrosated, correlating with increased amyloid formation

35 d met forms of Hb A(0) and Hb S, and their S-nitrosated counterparts, is presented.

36 Labeling S-nitrosated cysteines with a biotin tag enabled us to rev

37 The nitrosated disulfide acts as a source of nitrosonium for

38 reacts with a second nitrosothiol to produce nitrosated disulfide and the NO dimer.

39 ce of a 1-, 20-, 100-, or 200-fold excess of nitrosating equivalents removes 0.6 +/- 0.2, 3.2 +/- 0.4

40 copper complex with NO indicated that the N-nitrosated fluorescein ligand (FL(5)-NO) is the species

41 Cu(I) with concomitant dissociation of the N-nitrosated fluorophore ligand from copper.

42 m the thiol, disulfide, sulfinic acid, and S-nitrosated forms of cysteine while displaying an accepta

43 d SNO-Hb, the oxygen binding properties of S-nitrosated forms of normal and sickle cell Hb were inves

44 No nitrosated forms of the enzyme were observed.

45 by inducible NOS (iNOS) causes buildup of S-nitrosated GAPDH (SNO-GAPDH) in cells, which then inhibi

46 Previously, we have shown that S-nitrosated GC1 (SNO-GC1) is desensitized to NO stimulati

47 Nitrosated Gly-Trp exhibited dose-dependent vasorelaxati

48 rom heme groups to form nitroxyl anions or S-nitrosated Hb at low ratios of NO to Hb.

49 otein also produce an allosteric effect on S-nitrosated Hb.

50 S-Nitrosated hemoglobin (SNO-Hb) is of interest because of

51 S-Nitrosated hemoglobin is remarkably stable and can be cy

52 of GSNO supporting the hypothesis that GSNO nitrosates homocysteine, thereby withdrawing this interm

53 d for carbon capture, but amine solvents can nitrosate in the desorber, forming potentially carcinoge

54 Cys(101), in contrast, is S-nitrosated in a single step but is subject to negative c

55 Cys(47) of GSTP1-1 is S-nitrosated in two steps, with the chemical step limited

56 The nitrosated iNOS crystal structure revealed an unexpected

57 , recent evidence suggests that Hb that is S-nitrosated may act as an NO donor and vasodilator.

58 avenger compounds suggested that the salient nitrosating mechanism was the NO/O(2) reaction leading t

59 Identification of the nitrosated non-cysteine residue(s) was studied using 16

60 sated selectively on Cys62, whereas oTrx was nitrosated only on Cys73.

61 oth the disappearance of NO and formation of nitrosated product from DAF in aerobic aqueous buffer fo

62 P-based compounds formed oxygenated and not nitrosated products.

63 Cellular S-nitrosated protein abundance changed as expected, with c

64 The most abundant S-nitrosated protein in the resting endothelial cell is GA

65 Quantifying S-nitrosated protein thiols now allows determination of mo

66 of thioredoxin, providing three views of the nitrosated protein.

67 NO2(-) may act by S-nitrosating protein thiols, thereby altering protein act

68 Detection of nitrosated proteins (i.e., S-nitrosoalbumin) was also po

69 en we used this methodology, we found that S-nitrosated proteins can form within endothelial cells fr

70 enrich and annotate hundreds of endogenous S-nitrosated proteins.

71 d p120 identified cysteine 579 as the main S-nitrosated residue in the region that putatively interac

72 aster than oxidized Trx (oTrx), and rTrx was nitrosated selectively on Cys62, whereas oTrx was nitros

73 idation of NO (cyanometHb), and Hb that is S-nitrosated (SNO-Hb and SNO-cyanometHb) on HPV, expired N

74 n assessing the significance of formation of nitrosated species is the limited reliability of availab

75 n 8.8-fold increased affinity of MPO-derived nitrosating species for IQ.

76 The quintessential nitrosating species produced during NO autoxidation is N

77 boronate-based probes, nitric oxide-derived nitrosating species with 4,5-diaminofluorescein, and hyd

78 regulation by NO to one of adaptation during nitrosated stress.

79 y be stabilized by binding to hemoglobin, by nitrosating thiol-containing plasma molecules, or by con

80 sults in cleavage of the amine moiety, which nitrosates to give N-nitrosopyrrolidine.

81 -based method for the direct analysis of the nitrosated Trx.

82 the mitochondrial matrix were selectively S-nitrosated under these conditions, potentially contribut

83 mides (R = MeO, Me, H, CF(3), and NO(2)) was nitrosated using a standardized solution of N(2)O(4) in

84 Increased formation of S-nitrosated YC (YCysNO) was detected in the MPO/H(2)O(2)/