ライフサイエンスコーパス: nitrosative

1 ung injury), immuno-histochemical (oxidative/nitrosative and blood-brain barrier markers) as well as

2 s reduced diabetes-induced retinal oxidative-nitrosative and endoplasmic reticulum stress and glial a

3 OPD, with these differences regulated by the nitrosative and oxidative free radicals and cytokines th

4 nd reactive oxygen species (ROS), generating nitrosative and oxidative stress conditions in the embry

5 onic infection phase, and that resistance to nitrosative and oxidative stress may be the mechanism of

6 Different markers of mitochondrial activity, nitrosative and oxidative stress, apoptosis, and inflamm

7 with a "renox guardian" to overcome abundant nitrosative and oxidative stresses encountered during th

8 ostnatal growth results in increased cardiac nitrosative and oxidative-stress and DNA damage, which c

9 Consistent with the underlying nitrosative and thiol-oxidative chemistry, growth inhibi

10 iptional network that responds to oxidative, nitrosative, and heat stresses in Mycobacterium tubercul

11 Here we show that NO accretion during the nitrosative burst promotes increasing S-nitrosylation of

12 orous proliferation, a substantial oxidative/nitrosative burst, and a proinflammatory cytokine respon

13 06), moderate proliferation, a low oxidative/nitrosative burst, and a regulatory/anti-inflammatory cy

14 h by depleting T(regs) through oxidative and nitrosative bursts, and suggest that As(2)O(3) could be

15 unrelated mechanisms, including hydrolysis, nitrosative chemistry, and deaminase enzymes.

16 nein suppresses Ang II-induced NOX-dependent nitrosative damage and cell death in both nondiabetic an

17 otection of the wound site against oxidative/nitrosative damage and prevention of hyaluronic acid deg

18 yclooxygenase type 2, and cellular oxidative/nitrosative damage are reduced when the TLR-4 pathway is

19 MCI could be important to determine whether nitrosative damage directly contributes to AD.

20 day for 2 weeks) also induced apoptosis and nitrosative damage in both diabetic and nondiabetic WT h

21 umber of studies reported that oxidative and nitrosative damage may be important in the pathogenesis

22 These findings suggest that nitrosative damage occurs early in the course of MCI, an

23 We concluded that the oxidative/nitrosative damage resulting from the testosterone-plus-

24 Collectively, these data suggested that nitrosative damage to proteins harbouring free or zinc-b

25 B. burgdorferi cells with DEA/NO resulted in nitrosative damage to several proteins, including the zi

26 tion, steatosis, and increased oxidative and nitrosative damage to the mitochondrion.

27 cardiomyocytes increased cardiac apoptosis, nitrosative damage, and membrane translocation of the ni

28 es_1165, that is implicated in the repair of nitrosative damage.

29 extracytoplasmic proteins are repaired after nitrosative damage.

30 2'-deoxyxanthosine and 2'-deoxyinosine from nitrosative deamination; 8-oxo-2'-deoxyguanosine from ox

31 celerate loss of heterozygocity by enhancing nitrosative DNA damage.

32 als, including those initiated by oxidative, nitrosative, genotoxic, oncogenic, thermal, inflammatory

33 Thus, all known products of nitrosative guanine deamination are consistent with the

34 cussed of the anisotropic DNA environment on nitrosative guanine deamination based on results of an a

35 oimine 10 emerges as the key intermediate in nitrosative guanine deamination in ds-DNA and ds-oligonu

36 that CHT inhibition is not due to oxidative-nitrosative inactivation of the protein and that decreas

37 ations in the hormonal milieu with oxidative/nitrosative/inflammatory damage to the prostate epitheli

38 t mechanisms governing Cdc25A in response to nitrosative insult.

39 f IL1R, IL17RA, S1P1, and S1P3 together with nitrosative markers in astrocytes within MS and EAE lesi

40 egulation of Bcl-2 phosphorylation is due to nitrosative modification of B56delta, which we identify

41 thiol(s) from further irreversible oxidative/nitrosative modification.

42 catalytic cysteine residues to oxidative and nitrosative modifications.

43 In Escherichia coli, nitrosative mutagenesis may occur during nitrate or nitr

44 The results suggest that nitrosative mutagenesis occurs during a shift from nitra

45 wo agents is more responsible for endogenous nitrosative mutagenesis.

46 The response to this nitrosative (NO-triggered) stress is controlled by the C

47 at a mild oxidative signal is converted to a nitrosative one due to the better redox signaling proper

48 ower cGMP concentration (P<0.001) and higher nitrosative/oxidative stress (P<0.05).

49 We identified increased nitrosative/oxidative stress and impaired microvascular

50 Thus, our data provide a direct link between nitrosative/oxidative stress and neurodegenerative disor

51 rt a pathway whereby basal and toxin-induced nitrosative/oxidative stress results in S-nitrosylation

52 ol by cyclic guanosine monophosphate (cGMP), nitrosative/oxidative stress, and brain natriuretic pept

53 , and nitrotyrosine expression, a measure of nitrosative/oxidative stress.

54 ive) and was related to increased myocardial nitrosative/oxidative stress.

55 generative disorders such as PD that involve nitrosative/oxidative stress.

56 e possible metal-dependent, O(2)-independent nitrosative pathway is the reaction of thiols with dinit

57 Several candidate nitrosative pathways involve the reaction of *NO with O(

58 The results suggest that the nitrosative pressure (NO burst) is higher in NE plants,

59 er to attenuation of the effects of NO or to nitrosative protein damage.

60 hich influences iron-dependent oxidative and nitrosative radical species generation.

61 de the cell, as opposed to cellular entry of nitrosative reactants from the extracellular compartment

62 n, indicating that the dominant oxidative or nitrosative reactions are not influenced by acidic pH.

63 involved in NO-generation suggested that the nitrosative status of leaves and roots was altered by Na

64 idative stress (8-hydroxy guanosine levels), nitrosative stress (nitrotyrosine formation), and apopto

65 bin III resulted in a reduction of pulmonary nitrosative stress (p = 0.002), airway obstruction (bron

66 Yet, how this nitrosative stress affects iNOS function in vivo is poor

67 crease in oxidative stress and minimal to no nitrosative stress after long-term alcohol feeding of an

68 ing of PBMCs and cardiac tissue leads to oxi/nitrosative stress and a proinflammatory phenotype.

69 GPI-15427 (20 microM) prevented oxidative-nitrosative stress and cell death in palmitate-exposed p

70 vel can trigger detrimental oxidative and/or nitrosative stress and damage events.

71 treatment of cancer cells with SNCEE induced nitrosative stress and decreased Cdc25A protein levels i

72 nce of the glucose stimulus, consistent with nitrosative stress and dysfunctional exocytosis, precedi

73 Oxidative/nitrosative stress and endothelial dysfunction are hypot

74 This link between placental nitrosative stress and exposure to fine particle air pol

75 on, diet-induced obesity increases lysosomal nitrosative stress and impairs autophagy in the liver, l

76 Low-dose arginine vasopressin reduced nitrosative stress and improved cardiopulmonary function

77 tochondrial biogenesis as well as decreasing nitrosative stress and inflammation, thereby attenuating

78 These findings suggest that oxidative/nitrosative stress and inflammatory stimuli may trigger

79 riptional repressor NsrR in response to both nitrosative stress and intracellular free iron concentra

80 aureus to maintain redox homeostasis during nitrosative stress and is essential for virulence.

81 f ischemia-reperfusion-induced oxidative and nitrosative stress and is therefore of potential therape

82 01 activation, contribute to increased oxido-nitrosative stress and lung protein nitration.

83 te numerous reports on the role of oxidative/nitrosative stress and mitochondrial dysfunction in hepa

84 ngs support an association between oxidative/nitrosative stress and SLE.

85 st that HboN may function in protection from nitrosative stress and that HboO may act as an oxygen tr

86 aA and crp deletion mutants are sensitive to nitrosative stress and the superoxide generator methyl v

87 aimed at eNMDARs may decrease Abeta-induced nitrosative stress and thus ameliorate neurotoxic damage

88 Oxidative and nitrosative stress are key to the pathogenesis of alcoho

89 the mechanisms by which NO and GSNO mediate nitrosative stress are not well understood.

90 mechanisms through which NO and GSNO mediate nitrosative stress as well as the cellular pathways of p

91 egulators that mediate adaptive responses to nitrosative stress but does not affect methionine requir

92 xidation end-products in spite of comparable nitrosative stress but likely reduced NOS3.

93 e ethanol-induced liver injury by decreasing nitrosative stress but not in a more chronic scenario wh

94 entral role in the response of Salmonella to nitrosative stress but requires precise regulation to av

95 defined physiological states before applying nitrosative stress by addition of S-nitrosoglutathione (

96 reus is capable of metabolically adapting to nitrosative stress by expressing an NO.-inducible L-lact

97 ) protein residues, indicating that reducing nitrosative stress by way of the L-citrulline/NO. pathwa

98 C development in the context of uncontrolled nitrosative stress can be blocked by pharmacologic inhib

99 These findings provide an example of how nitrosative stress can exert action at the atomic level.

100 bacteria, it can also protect itself against nitrosative stress caused by NO generated when nitrite a

101 A cmr mutant was better able to survive a nitrosative stress challenge but was attenuated in a mou

102 Nitrosative stress decreased the Cdc25A-bound fraction o

103 applied to measuring bacterial oxidative and nitrosative stress dynamics under different conditions i

104 ine abrogated the toxicity and the oxidative/nitrosative stress elicited by the induction of CYP2E1.

105 s a limited set of genes to combat oxidative/nitrosative stress encountered in its tick vector or mam

106 In contrast, LMW thiols diminish the nitrosative stress experienced by enzymes, such as gluta

107 Oxidative and nitrosative stress have been implicated in prostate carc

108 scherichia coli response to nitric oxide and nitrosative stress have suggested that additional transc

109 s shown to play a role in protection against nitrosative stress in addition to the previously identif

110 ces NO formation and increases oxidative and nitrosative stress in airway epithelial cells.

111 xygen or nitric oxide to combat oxidative or nitrosative stress in bacteria, archaea, and some protoz

112 upport accumulating evidence that implicates nitrosative stress in cardiac and muscle disease.

113 d by DNA damage caused by vascular oxidative-nitrosative stress in cerebral endothelial cells, which,

114 nd COX may mediate hormone-induced oxidative/nitrosative stress in epithelium.

115 Analysis of nitrosative stress in MCI could be important to determin

116 nitric oxide (NO) production, which promotes nitrosative stress in metabolic tissues such as liver an

117 receptors, interleukin (IL) 1R, IL17RA, and nitrosative stress in multiple sclerosis (MS) plaques, e

118 dendrites and Zn(II) release resulting from nitrosative stress in neurons.

119 e molecular mechanisms of protection against nitrosative stress in P. gingivalis and shows that the r

120 ate the status and contribution of oxidative/nitrosative stress in patients with SLE.

121 To understand the role of nitrosative stress in prostate cancer progression, we in

122 production of peroxynitrite which may cause nitrosative stress in pulmonary vasculature.

123 erns of PhoP-activated genes during moderate nitrosative stress in the innate host response.

124 nefit in ovine acute lung injury by reducing nitrosative stress in the lung and limiting the degree o

125 Increased oxidative-nitrosative stress in the microenvironment of cholinergi

126 have measured different molecular markers of nitrosative stress in three stably transfected cell line

127 he role of H2 in prevention of oxidative and nitrosative stress in UVB irradiated corneas, which may

128 ionylation reactions following oxidative and nitrosative stress in vitro and in vivo.

129 nced later in life through particle-mediated nitrosative stress incurred during fetal life.

130 Nitrosative stress induced a switch from a contractile t

131 utrophils displayed increased sensitivity to nitrosative stress induced apoptosis ex vivo and increas

132 We found that nitrosative stress induced by steady-state nitric oxide

133 lar granule neurons (CGNs) that oxidative or nitrosative stress induces an N-terminal cleavage of opt

134 eport that exposure of target HL-60 cells to nitrosative stress inhibited APLT, induced PS externaliz

135 host apart from protecting the bacilli from nitrosative stress inside the activated macrophages, con

136 ning aerobic respiration under conditions of nitrosative stress is a key factor for host colonisation

137 Increased oxidative/nitrosative stress is a major contributing factor to alc

138 These results suggest that increased nitrosative stress is critically important in promoting

139 Nitrosative stress is induced by pathophysiological leve

140 Additionally, our findings suggest that nitrosative stress is mediated principally via the S-nit

141 the relationship between S-nitrosylation and nitrosative stress is more complex.

142 ely modified under alcohol-induced oxidative/nitrosative stress is poorly understood.

143 One major marker of nitrosative stress is the formation of 3-Nitrotyrosine (

144 hanism behind polyamine-mediated rescue from nitrosative stress is unclear, but it is not attributabl

145 ed the hypothesis that cardiac oxidative and nitrosative stress leading to DNA damage and accelerated

146 Our findings show that nitrosative stress leads to dysfunctional ER stress sign

147 r histopathology, serum transaminase levels, nitrosative stress markers, and activities of oxidativel

148 were evaluated for serum levels of oxidative/nitrosative stress markers, including antibodies to malo

149 Oxidative/nitrosative stress may be important in the pathology of

150 AI scores suggests that markers of oxidative/nitrosative stress may be useful in evaluating the progr

151 ion, a situation possibly exacerbated by the nitrosative stress of concurrent inflammation.

152 rial dysfunction resulting from oxidative or nitrosative stress often acts as an initiating stimulus

153 for either nitric oxide-dependent oxidative/nitrosative stress or for the increased presence of the

154 first part of this review, the oxidative and nitrosative stress relation with cancer are described.

155 vement in iron mineralization, oxidative and nitrosative stress resistance and anaerobic ammonium oxi

156 to hmp are important for NO. detoxification, nitrosative stress resistance and Salmonella virulence.

157 that regulates expression of respiration and nitrosative stress resistance genes.

158 Staphylococcus aureus nitrosative stress resistance is due in part to flavohem

159 oduct was identified as a key facilitator of nitrosative stress resistance.

160 regulation which is especially important to nitrosative stress resistance.

161 to be directly involved in the oxidative and nitrosative stress response in E. coli.

162 (FDPs) play important roles in the microbial nitrosative stress response in low-oxygen environments b

163 sis revealed that rather than regulating the nitrosative stress response like Streptomyces coelicolor

164 ggesting that it plays a primary role in the nitrosative stress response.

165 he hybrid cluster protein and contributes to nitrosative stress responses.

166 to phosphorylate ULK1 at S317 in response to nitrosative stress resulted in increased autophagy: the

167 protein S-nitrosylation directly implicates nitrosative stress resulting from AniA-dependent nitric

168 Oxidative and nitrosative stress resulting in mitochondrial dysfunctio

169 , with their dysfunction under conditions of nitrosative stress serving as a mechanistic basis for in

170 aureus lacking SrrAB were more sensitive to nitrosative stress than hmp mutants, indicating that the

171 ichia coli display far greater resistance to nitrosative stress than the K-12 reference strain MG1655

172 Here we describe an adaptive response to nitrosative stress that allows S. aureus to replicate at

173 However, the potential for oxidative/nitrosative stress to elicit an autoimmune response or t

174 resented here reveal new genes important for nitrosative stress tolerance and demonstrate that methio

175 is particularly important for resistance to nitrosative stress under anaerobic conditions.

176 The present study aimed to target nitrosative stress using a naturally occurring Nos2 inhi

177 dings suggest that ENV-mediated induction of nitrosative stress via activation of TLR4 results in an

178 duction are coordinated with the response to nitrosative stress were revealed.

179 Salmonella experiences oxidative and nitrosative stress within host phagocytes, and CyaY-depe

180 hich serve to protect the microorganism from nitrosative stress within the intracellular environment.

181 levated temperature, and increased oxidative/nitrosative stress) and evade the immune response.

182 Aldosteronism may account for oxi/nitrosative stress, a proinflammatory phenotype, and was

183 These included nitrosative stress, accumulation of endoplasmic reticulu

184 xpression of genes associated with oxidative/nitrosative stress, anaerobic respiration and lactate me

185 luconate dehydratase-dependent growth during nitrosative stress, and a cyaY mutation reduces Salmonel

186 Since ammonia is known to induce oxidative/nitrosative stress, and antioxidants and nitric-oxide sy

187 e-induced endothelial cell oxidative stress, nitrosative stress, and apoptosis was determined by usin

188 in virulence, including cell wall stability, nitrosative stress, and extracellular capsule production

189 Hepatocellular damage, oxidative and nitrosative stress, and inflammation were also quantifie

190 s, causes impaired cell signaling, oxidative-nitrosative stress, and inflammation.

191 y decreased myocardial NOX-2 levels, reduced nitrosative stress, and lower matrix metalloproteinase-2

192 ical role for thioredoxin in protection from nitrosative stress, and suggest new approaches to manipu

193 enes required for defense against NO-induced nitrosative stress, and that diversification of signal p

194 Typhimurium growth during nitrosative stress, and the hcp-hcr locus plays a suppor

195 Nitrosative stress, as generated by ASN, can stimulate c

196 These changes occurred along with reduced nitrosative stress, as indicated by lower plasma levels

197 Emerging evidence suggests that oxidative/nitrosative stress, as occurs during aging, contributes

198 It protects various bacteria from nitrosative stress, but the mechanism is unknown.

199 , under aerobic conditions in the absence of nitrosative stress, elevated hmp expression increases S.

200 h in the human host, including oxidative and nitrosative stress, high temperature, hypoxia, and nutri

201 In the presence of nitrosative stress, Hmp-deficient Salmonella exhibits re

202 To defend itself against oxidative/nitrosative stress, M. tuberculosis expresses an NADH-de

203 misfolded proteins triggered by oxidative or nitrosative stress, or of mutated gene products.

204 ntributes to NO-dependent respiration during nitrosative stress, possibly conferring an advantage to

205 rfusion, LPS-induced inflammation, placental nitrosative stress, renal structural and functional alte

206 We now show that PABA/NO induces nitrosative stress, resulting in undetectable nitrosylat

207 Conditions associated with oxidative or nitrosative stress, such as myocardial ischemia and repe

208 d specifically induced following exposure to nitrosative stress, suggesting a previously unrecognized

209 s cancer cells are particularly sensitive to nitrosative stress, these data open another path for the

210 ogen Porphyromonas gingivalis must withstand nitrosative stress, which is particularly high in the or

211 sium (5K apoptotic conditions), oxidative or nitrosative stress-induced OPA1 cleavage caused by compl

212 iaminedichloroplatinum (II), suggesting that nitrosative stress-induced suppression of Cdc25A primed

213 rmed that this cis-acting motif mediates the nitrosative stress-inducible expression of cgb.

214 Our data suggest that nitrosative stress-mediated protein aggregation in neuro

215 jor positive regulatory factor that controls nitrosative stress-responsive expression of this gene.

216 Deletion of Fzf1p eliminated the nitrosative stress-specific transcriptional response, wh

217 ing NO production and reducing oxidative and nitrosative stress.

218 ade cerebral edema associated with oxidative-nitrosative stress.

219 P) exposed to agents that cause oxidative or nitrosative stress.

220 ssion, which led to increased sensitivity to nitrosative stress.

221 0893 (hcp) was abrogated in V2807 exposed to nitrosative stress.

222 by decreases in GSNOR activity, engendering nitrosative stress.

223 g species are produced in nodules leading to nitrosative stress.

224 gested that it was mediated by oxidative and nitrosative stress.

225 ide (NO) formation and greater oxidative and nitrosative stress.

226 lpha and PKC-beta and enhanced oxidative and nitrosative stress.

227 tion restores NO formation, while preventing nitrosative stress.

228 l fission and fusion induced by oxidative or nitrosative stress.

229 tiple AMPK-dependent pathways in response to nitrosative stress.

230 , such as elevated temperature and oxidative/nitrosative stress.

231 , thus protecting cells against oxidative or nitrosative stress.

232 ive disorders mediated, at least in part, by nitrosative stress.

233 which Campylobacter may survive host-derived nitrosative stress.

234 signaling, as well as in protection against nitrosative stress.

235 as a mediator of neurotoxicity triggered by nitrosative stress.

236 cts on S. Typhimurium survival during innate nitrosative stress.

237 denitrosylation thus allows cells to survive nitrosative stress.

238 trite (ASN), a model system used to generate nitrosative stress.

239 ing prolonged NO exposure or under oxidative/nitrosative stress.

240 mitochondrial oxidative stress, and promoted nitrosative stress.

241 nitrate, and HcpR2 regulates the response to nitrosative stress.

242 ssion, consistent with its role in mediating nitrosative stress.

243 that growth of C. jejuni with nitrite causes nitrosative stress.

244 ork is a key responder to this oxidative and nitrosative stress.

245 esponse to electron acceptor availability or nitrosative stress.

246 cible components of a robust defence against nitrosative stress.

247 e animals, suggesting elevated oxidative and nitrosative stress.

248 oter, which is also known to be sensitive to nitrosative stress.

249 bute to the pathophysiology of oxidative and nitrosative stress.

250 lyamines rescues growth of cad mutants under nitrosative stress.

251 ical role in defence of the bacillus against nitrosative stress.

252 the YjeB repressor is directly sensitive to nitrosative stress.

253 all of which are known to be upregulated by nitrosative stress.

254 d by sulfiredoxin following oxidative and/or nitrosative stress.

255 nct proteins in response to oxidative and/or nitrosative stress.

256 signaling events following oxidative and/or nitrosative stress.

257 mination is a major type of DNA damage under nitrosative stress.

258 environment and is exposed to oxidative and nitrosative stress.

259 nses that protect cells against oxidative or nitrosative stress.

260 hat methionine biosynthesis is a casualty of nitrosative stress.

261 adapt to metabolic limitations and oxidative/nitrosative stress.

262 's role in metabolism and in defense against nitrosative stress.

263 both thioredoxin genes during oxidative and nitrosative stress.

264 se NO mediate the primary response to NO and nitrosative stress.

265 clones that were induced > or = 4-fold upon nitrosative stress.

266 iratory capacity and decreased oxidative and nitrosative stress.

267 g laccase, urease and growth under oxidative/nitrosative stress.

268 n species, allowing the bacteria to face the nitrosative stress.

269 sylation, and protein nitration, alleviating nitrosative stress.

270 mocytoma cell (PC12) models of oxidative and nitrosative stress.

271 teraction enables H. pylori to survive under nitrosative stress.

272 ciated with reduced myocardial oxidative and nitrosative stress.

273 RS, FleRS and CrdRS) in H. pylori respond to nitrosative stress.

274 h, at least in part, by triggering oxidative/nitrosative stress.

275 and wild-type growth in bacteria undergoing nitrosative stress.

276 he metabolic stress imposed by oxidative and nitrosative stress.

277 the stringent response, sense oxidative and nitrosative stress.

278 ed uteroplacental hemodynamics and placental nitrosative stress.

279 e transcriptional responses to oxidative and nitrosative stress.

280 primarily as a cytotoxic response to excess nitrosative stress.

281 ential to protect neurons from oxidative and nitrosative stress.

282 nd kill nonreplicating M. tuberculosis under nitrosative stress.

283 ers in protecting neurons from oxidative and nitrosative stress.

284 expression of OXPHOS subunits; oxidative and nitrosative stress; and oxidative DNA damage.

285 These data identify a nitrosative-stress signaling pathway that engages ATM an

286 nd nitrogen species creates oxidative and/or nitrosative stresses in the failing heart and vascular t

287 on is an adaptive response to NO and related nitrosative stresses since Hmp levels are greatly elevat

288 ulosis SufB intein splicing to oxidative and nitrosative stresses when expressed in Escherichia coli.

289 staining, caspase-3 activity, oxidative and nitrosative stresses, and proinflammatory cytokine expre

290 the parental strain to several oxidative and nitrosative stresses, and sigL expression was not increa

291 TRPM7 channel activity causes oxidative and nitrosative stresses, producing cell rounding mediated b

292 ed a host of specialized mechanisms to evade nitrosative stresses, the cytochrome bd-I respiratory ox

293 ts C. neoformans from acidic, oxidative, and nitrosative stresses, which are encountered by the fungu

294 odulated by mild and transient oxidative and nitrosative stresses.

295 ritical for resistance to both oxidative and nitrosative stresses.

296 wn to be strongly inhibited by oxidative and nitrosative stresses.

297 transcriptional responses to these distinct nitrosative stresses.

298 otects bacterial cells against oxidative and nitrosative stresses.

299 ia into dormancy under extreme oxidative and nitrosative stresses.

300 nced susceptibility of CGNs to oxidative and nitrosative stressors.