ライフサイエンスコーパス: nitrosative stress

1 ing NO production and reducing oxidative and nitrosative stress.

2 mitochondrial oxidative stress, and promoted nitrosative stress.

3 ide (NO) formation and greater oxidative and nitrosative stress.

4 gested that it was mediated by oxidative and nitrosative stress.

5 lpha and PKC-beta and enhanced oxidative and nitrosative stress.

6 tion restores NO formation, while preventing nitrosative stress.

7 l fission and fusion induced by oxidative or nitrosative stress.

8 tiple AMPK-dependent pathways in response to nitrosative stress.

9 , such as elevated temperature and oxidative/nitrosative stress.

10 ive disorders mediated, at least in part, by nitrosative stress.

11 , thus protecting cells against oxidative or nitrosative stress.

12 which Campylobacter may survive host-derived nitrosative stress.

13 signaling, as well as in protection against nitrosative stress.

14 as a mediator of neurotoxicity triggered by nitrosative stress.

15 cts on S. Typhimurium survival during innate nitrosative stress.

16 denitrosylation thus allows cells to survive nitrosative stress.

17 trite (ASN), a model system used to generate nitrosative stress.

18 ing prolonged NO exposure or under oxidative/nitrosative stress.

19 ssion, consistent with its role in mediating nitrosative stress.

20 that growth of C. jejuni with nitrite causes nitrosative stress.

21 nitrate, and HcpR2 regulates the response to nitrosative stress.

22 ork is a key responder to this oxidative and nitrosative stress.

23 cible components of a robust defence against nitrosative stress.

24 e animals, suggesting elevated oxidative and nitrosative stress.

25 oter, which is also known to be sensitive to nitrosative stress.

26 bute to the pathophysiology of oxidative and nitrosative stress.

27 lyamines rescues growth of cad mutants under nitrosative stress.

28 ical role in defence of the bacillus against nitrosative stress.

29 iratory capacity and decreased oxidative and nitrosative stress.

30 esponse to electron acceptor availability or nitrosative stress.

31 the YjeB repressor is directly sensitive to nitrosative stress.

32 all of which are known to be upregulated by nitrosative stress.

33 d by sulfiredoxin following oxidative and/or nitrosative stress.

34 nct proteins in response to oxidative and/or nitrosative stress.

35 signaling events following oxidative and/or nitrosative stress.

36 mination is a major type of DNA damage under nitrosative stress.

37 environment and is exposed to oxidative and nitrosative stress.

38 nses that protect cells against oxidative or nitrosative stress.

39 hat methionine biosynthesis is a casualty of nitrosative stress.

40 adapt to metabolic limitations and oxidative/nitrosative stress.

41 's role in metabolism and in defense against nitrosative stress.

42 both thioredoxin genes during oxidative and nitrosative stress.

43 se NO mediate the primary response to NO and nitrosative stress.

44 clones that were induced > or = 4-fold upon nitrosative stress.

45 idative stress, suggesting an involvement of nitrosative stress.

46 g of these cells and transduced by oxidative/nitrosative stress.

47 itrotyrosine labeling, a marker of oxidative/nitrosative stress.

48 tion, and are cleared actively to ameliorate nitrosative stress.

49 s of the balance between local oxidative and nitrosative stress.

50 divalent cations and transduced by oxidative/nitrosative stress.

51 erlying mechanism is related to oxidative or nitrosative stress.

52 g laccase, urease and growth under oxidative/nitrosative stress.

53 ome serves as a defense against oxidative or nitrosative stress.

54 n species, allowing the bacteria to face the nitrosative stress.

55 eases that have been related to oxidative or nitrosative stress.

56 lso produced in the brain after oxidative or nitrosative stress.

57 ability of iNOS to form N(2)O(3) and elicit nitrosative stress.

58 al for SNO homeostasis, and protects against nitrosative stress.

59 lobin protects Saccharomyces cerevisiae from nitrosative stress.

60 sylation, and protein nitration, alleviating nitrosative stress.

61 mocytoma cell (PC12) models of oxidative and nitrosative stress.

62 teraction enables H. pylori to survive under nitrosative stress.

63 ciated with reduced myocardial oxidative and nitrosative stress.

64 RS, FleRS and CrdRS) in H. pylori respond to nitrosative stress.

65 h, at least in part, by triggering oxidative/nitrosative stress.

66 and wild-type growth in bacteria undergoing nitrosative stress.

67 he metabolic stress imposed by oxidative and nitrosative stress.

68 the stringent response, sense oxidative and nitrosative stress.

69 ed uteroplacental hemodynamics and placental nitrosative stress.

70 e transcriptional responses to oxidative and nitrosative stress.

71 primarily as a cytotoxic response to excess nitrosative stress.

72 ential to protect neurons from oxidative and nitrosative stress.

73 nd kill nonreplicating M. tuberculosis under nitrosative stress.

74 ssion, which led to increased sensitivity to nitrosative stress.

75 ers in protecting neurons from oxidative and nitrosative stress.

76 ade cerebral edema associated with oxidative-nitrosative stress.

77 P) exposed to agents that cause oxidative or nitrosative stress.

78 by decreases in GSNOR activity, engendering nitrosative stress.

79 0893 (hcp) was abrogated in V2807 exposed to nitrosative stress.

80 g species are produced in nodules leading to nitrosative stress.

81 odulated by mild and transient oxidative and nitrosative stresses.

82 ritical for resistance to both oxidative and nitrosative stresses.

83 wn to be strongly inhibited by oxidative and nitrosative stresses.

84 transcriptional responses to these distinct nitrosative stresses.

85 otects bacterial cells against oxidative and nitrosative stresses.

86 ia into dormancy under extreme oxidative and nitrosative stresses.

87 Aldosteronism may account for oxi/nitrosative stress, a proinflammatory phenotype, and was

88 These included nitrosative stress, accumulation of endoplasmic reticulu

89 Yet, how this nitrosative stress affects iNOS function in vivo is poor

90 crease in oxidative stress and minimal to no nitrosative stress after long-term alcohol feeding of an

91 xpression of genes associated with oxidative/nitrosative stress, anaerobic respiration and lactate me

92 ing of PBMCs and cardiac tissue leads to oxi/nitrosative stress and a proinflammatory phenotype.

93 GPI-15427 (20 microM) prevented oxidative-nitrosative stress and cell death in palmitate-exposed p

94 vel can trigger detrimental oxidative and/or nitrosative stress and damage events.

95 treatment of cancer cells with SNCEE induced nitrosative stress and decreased Cdc25A protein levels i

96 nce of the glucose stimulus, consistent with nitrosative stress and dysfunctional exocytosis, precedi

97 Oxidative/nitrosative stress and endothelial dysfunction are hypot

98 XY neurons were more sensitive to nitrosative stress and excitotoxicity versus XX neurons.

99 This link between placental nitrosative stress and exposure to fine particle air pol

100 on, diet-induced obesity increases lysosomal nitrosative stress and impairs autophagy in the liver, l

101 Low-dose arginine vasopressin reduced nitrosative stress and improved cardiopulmonary function

102 tochondrial biogenesis as well as decreasing nitrosative stress and inflammation, thereby attenuating

103 These findings suggest that oxidative/nitrosative stress and inflammatory stimuli may trigger

104 riptional repressor NsrR in response to both nitrosative stress and intracellular free iron concentra

105 aureus to maintain redox homeostasis during nitrosative stress and is essential for virulence.

106 f ischemia-reperfusion-induced oxidative and nitrosative stress and is therefore of potential therape

107 01 activation, contribute to increased oxido-nitrosative stress and lung protein nitration.

108 te numerous reports on the role of oxidative/nitrosative stress and mitochondrial dysfunction in hepa

109 tase inhibition counteracts diabetes-induced nitrosative stress and PARP activation in sciatic nerve

110 ase inhibition on diabetes-induced oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP

111 ngs support an association between oxidative/nitrosative stress and SLE.

112 s show similar gender-dependent responses to nitrosative stress and staurosporine-induced apoptosis.

113 st that HboN may function in protection from nitrosative stress and that HboO may act as an oxygen tr

114 aA and crp deletion mutants are sensitive to nitrosative stress and the superoxide generator methyl v

115 uld prove exciting in reducing oxidative and nitrosative stress and thereby suppressing the developme

116 aimed at eNMDARs may decrease Abeta-induced nitrosative stress and thus ameliorate neurotoxic damage

117 levated temperature, and increased oxidative/nitrosative stress) and evade the immune response.

118 luconate dehydratase-dependent growth during nitrosative stress, and a cyaY mutation reduces Salmonel

119 Since ammonia is known to induce oxidative/nitrosative stress, and antioxidants and nitric-oxide sy

120 e-induced endothelial cell oxidative stress, nitrosative stress, and apoptosis was determined by usin

121 s in cellular responses to oxidative stress, nitrosative stress, and changes in the overall thiol-dis

122 in virulence, including cell wall stability, nitrosative stress, and extracellular capsule production

123 Hepatocellular damage, oxidative and nitrosative stress, and inflammation were also quantifie

124 s, causes impaired cell signaling, oxidative-nitrosative stress, and inflammation.

125 y decreased myocardial NOX-2 levels, reduced nitrosative stress, and lower matrix metalloproteinase-2

126 ical role for thioredoxin in protection from nitrosative stress, and suggest new approaches to manipu

127 enes required for defense against NO-induced nitrosative stress, and that diversification of signal p

128 Typhimurium growth during nitrosative stress, and the hcp-hcr locus plays a suppor

129 staining, caspase-3 activity, oxidative and nitrosative stresses, and proinflammatory cytokine expre

130 the parental strain to several oxidative and nitrosative stresses, and sigL expression was not increa

131 expression of OXPHOS subunits; oxidative and nitrosative stress; and oxidative DNA damage.

132 nerve function and biochemical indicators of nitrosative stress annually for 3 years in 37 patients w

133 t prevalent movement disorder, oxidative and nitrosative stress are believed to contribute to disease

134 Oxidative and nitrosative stress are key to the pathogenesis of alcoho

135 the mechanisms by which NO and GSNO mediate nitrosative stress are not well understood.

136 mechanisms through which NO and GSNO mediate nitrosative stress as well as the cellular pathways of p

137 Nitrosative stress, as generated by ASN, can stimulate c

138 These changes occurred along with reduced nitrosative stress, as indicated by lower plasma levels

139 Emerging evidence suggests that oxidative/nitrosative stress, as occurs during aging, contributes

140 explore the biochemical origin of oxidative/nitrosative stress associated with secondary SCI, we stu

141 resent a previously unsuspected link between nitrosative stress, atherosclerosis, and inflammation.

142 egulators that mediate adaptive responses to nitrosative stress but does not affect methionine requir

143 xidation end-products in spite of comparable nitrosative stress but likely reduced NOS3.

144 e ethanol-induced liver injury by decreasing nitrosative stress but not in a more chronic scenario wh

145 entral role in the response of Salmonella to nitrosative stress but requires precise regulation to av

146 It protects various bacteria from nitrosative stress, but the mechanism is unknown.

147 n shown to gate in response to oxidative and nitrosative stresses, but the mechanism through which TR

148 defined physiological states before applying nitrosative stress by addition of S-nitrosoglutathione (

149 reus is capable of metabolically adapting to nitrosative stress by expressing an NO.-inducible L-lact

150 ) protein residues, indicating that reducing nitrosative stress by way of the L-citrulline/NO. pathwa

151 C development in the context of uncontrolled nitrosative stress can be blocked by pharmacologic inhib

152 These findings provide an example of how nitrosative stress can exert action at the atomic level.

153 Nitrosative stress can occur when reactive nitric oxide

154 bacteria, it can also protect itself against nitrosative stress caused by NO generated when nitrite a

155 A cmr mutant was better able to survive a nitrosative stress challenge but was attenuated in a mou

156 Nitrosative stress decreased the Cdc25A-bound fraction o

157 applied to measuring bacterial oxidative and nitrosative stress dynamics under different conditions i

158 , under aerobic conditions in the absence of nitrosative stress, elevated hmp expression increases S.

159 ine abrogated the toxicity and the oxidative/nitrosative stress elicited by the induction of CYP2E1.

160 reactions involving NO and S-nitrosothiols (nitrosative stress), emphasizing a versatile role for th

161 s a limited set of genes to combat oxidative/nitrosative stress encountered in its tick vector or mam

162 In contrast, LMW thiols diminish the nitrosative stress experienced by enzymes, such as gluta

163 Oxidative and nitrosative stress have been implicated in prostate carc

164 scherichia coli response to nitric oxide and nitrosative stress have suggested that additional transc

165 h in the human host, including oxidative and nitrosative stress, high temperature, hypoxia, and nutri

166 In the presence of nitrosative stress, Hmp-deficient Salmonella exhibits re

167 s shown to play a role in protection against nitrosative stress in addition to the previously identif

168 ces NO formation and increases oxidative and nitrosative stress in airway epithelial cells.

169 We examined the role of nitrosative stress in allograft destruction.

170 xygen or nitric oxide to combat oxidative or nitrosative stress in bacteria, archaea, and some protoz

171 upport accumulating evidence that implicates nitrosative stress in cardiac and muscle disease.

172 d by DNA damage caused by vascular oxidative-nitrosative stress in cerebral endothelial cells, which,

173 In conclusion, nitrosative stress in early diabetes is associated with

174 nd COX may mediate hormone-induced oxidative/nitrosative stress in epithelium.

175 ve mechanisms, and (3) establish a model for nitrosative stress in mammalian cells.

176 Analysis of nitrosative stress in MCI could be important to determin

177 nitric oxide (NO) production, which promotes nitrosative stress in metabolic tissues such as liver an

178 receptors, interleukin (IL) 1R, IL17RA, and nitrosative stress in multiple sclerosis (MS) plaques, e

179 dendrites and Zn(II) release resulting from nitrosative stress in neurons.

180 e molecular mechanisms of protection against nitrosative stress in P. gingivalis and shows that the r

181 ate the status and contribution of oxidative/nitrosative stress in patients with SLE.

182 racellular Ca2+, the appearance of oxidative/nitrosative stress in PBMCs and invading inflammatory ce

183 To understand the role of nitrosative stress in prostate cancer progression, we in

184 production of peroxynitrite which may cause nitrosative stress in pulmonary vasculature.

185 e data support a role for both oxidative and nitrosative stress in rejection and the immunoregulatory

186 ), work in concert to maintain oxidative and nitrosative stress in the injured cord tissue.

187 erns of PhoP-activated genes during moderate nitrosative stress in the innate host response.

188 nefit in ovine acute lung injury by reducing nitrosative stress in the lung and limiting the degree o

189 Increased oxidative-nitrosative stress in the microenvironment of cholinergi

190 The role of oxidative and nitrosative stress in the nephropathy in ZDF was studied

191 have measured different molecular markers of nitrosative stress in three stably transfected cell line

192 This study evaluated the role for nitrosative stress in two animal models of type 1 diabet

193 he role of H2 in prevention of oxidative and nitrosative stress in UVB irradiated corneas, which may

194 ionylation reactions following oxidative and nitrosative stress in vitro and in vivo.

195 nd nitrogen species creates oxidative and/or nitrosative stresses in the failing heart and vascular t

196 nced later in life through particle-mediated nitrosative stress incurred during fetal life.

197 Nitrosative stress induced a switch from a contractile t

198 utrophils displayed increased sensitivity to nitrosative stress induced apoptosis ex vivo and increas

199 We found that nitrosative stress induced by steady-state nitric oxide

200 We also show that oxidative/nitrosative stress-induced gating can be inhibited by ph

201 sium (5K apoptotic conditions), oxidative or nitrosative stress-induced OPA1 cleavage caused by compl

202 iaminedichloroplatinum (II), suggesting that nitrosative stress-induced suppression of Cdc25A primed

203 ost consistent with a model of oxidative and nitrosative stress-induced TRPM2 activation in which mit

204 lar granule neurons (CGNs) that oxidative or nitrosative stress induces an N-terminal cleavage of opt

205 rmed that this cis-acting motif mediates the nitrosative stress-inducible expression of cgb.

206 stress induction, and Yap4 is necessary for nitrosative stress induction of the thioredoxin genes in

207 eport that exposure of target HL-60 cells to nitrosative stress inhibited APLT, induced PS externaliz

208 host apart from protecting the bacilli from nitrosative stress inside the activated macrophages, con

209 ning aerobic respiration under conditions of nitrosative stress is a key factor for host colonisation

210 Increased oxidative/nitrosative stress is a major contributing factor to alc

211 These results suggest that increased nitrosative stress is critically important in promoting

212 Nitrosative stress is induced by pathophysiological leve

213 Inhibition of DNA replication during nitrosative stress is invariably accompanied by zinc mob

214 etic analysis indicated that protection from nitrosative stress is likely to be a conserved function

215 Additionally, our findings suggest that nitrosative stress is mediated principally via the S-nit

216 the relationship between S-nitrosylation and nitrosative stress is more complex.

217 ely modified under alcohol-induced oxidative/nitrosative stress is poorly understood.

218 that the cellular response to oxidative and nitrosative stress is primarily regulated at the level o

219 suggesting ALDO/salt induction of oxidative/nitrosative stress is responsible for the appearance of

220 One major marker of nitrosative stress is the formation of 3-Nitrotyrosine (

221 hanism behind polyamine-mediated rescue from nitrosative stress is unclear, but it is not attributabl

222 ed the hypothesis that cardiac oxidative and nitrosative stress leading to DNA damage and accelerated

223 Our findings show that nitrosative stress leads to dysfunctional ER stress sign

224 Here we show both in vitro and in vivo that nitrosative stress leads to S-nitrosylation of wild-type

225 To defend itself against oxidative/nitrosative stress, M. tuberculosis expresses an NADH-de

226 r histopathology, serum transaminase levels, nitrosative stress markers, and activities of oxidativel

227 were evaluated for serum levels of oxidative/nitrosative stress markers, including antibodies to malo

228 Oxidative/nitrosative stress may be important in the pathology of

229 AI scores suggests that markers of oxidative/nitrosative stress may be useful in evaluating the progr

230 Nitrosative stress may develop when scavengers are deple

231 Our data suggest that nitrosative stress-mediated protein aggregation in neuro

232 sfunction, excitotoxic insult, oxidative and nitrosative stress, mitochondrial injury, synaptic failu

233 thogens elaborate enzymatic defenses against nitrosative stress mounted by the host.

234 idative stress (8-hydroxy guanosine levels), nitrosative stress (nitrotyrosine formation), and apopto

235 ion, a situation possibly exacerbated by the nitrosative stress of concurrent inflammation.

236 rial dysfunction resulting from oxidative or nitrosative stress often acts as an initiating stimulus

237 for either nitric oxide-dependent oxidative/nitrosative stress or for the increased presence of the

238 misfolded proteins triggered by oxidative or nitrosative stress, or of mutated gene products.

239 bin III resulted in a reduction of pulmonary nitrosative stress (p = 0.002), airway obstruction (bron

240 , demonstrating a link between oxidative and nitrosative stress pathways.

241 Oxidative and nitrosative stress play a key role in the pathogenesis o

242 Oxidative and nitrosative stresses play an important role in progressi

243 In conclusion, nitrosative stress plays a major role in DN in, at least

244 ntributes to NO-dependent respiration during nitrosative stress, possibly conferring an advantage to

245 Oxidative and nitrosative stress predates the nephropathy, which is im

246 Nitrosative stress produced by cytokines predisposes to

247 TRPM7 channel activity causes oxidative and nitrosative stresses, producing cell rounding mediated b

248 Hrb/FprA is fully capable of functioning in nitrosative stress protection in M. thermoacetica.

249 first part of this review, the oxidative and nitrosative stress relation with cancer are described.

250 rfusion, LPS-induced inflammation, placental nitrosative stress, renal structural and functional alte

251 gating by ADP-ribose and both oxidative and nitrosative stresses requires an intact ADP-ribose bindi

252 vement in iron mineralization, oxidative and nitrosative stress resistance and anaerobic ammonium oxi

253 to hmp are important for NO. detoxification, nitrosative stress resistance and Salmonella virulence.

254 that regulates expression of respiration and nitrosative stress resistance genes.

255 Staphylococcus aureus nitrosative stress resistance is due in part to flavohem

256 oduct was identified as a key facilitator of nitrosative stress resistance.

257 regulation which is especially important to nitrosative stress resistance.

258 to be directly involved in the oxidative and nitrosative stress response in E. coli.

259 (FDPs) play important roles in the microbial nitrosative stress response in low-oxygen environments b

260 sis revealed that rather than regulating the nitrosative stress response like Streptomyces coelicolor

261 ggesting that it plays a primary role in the nitrosative stress response.

262 as been implicated in both the oxidative and nitrosative stress responses in Saccharomyces cerevisiae

263 he hybrid cluster protein and contributes to nitrosative stress responses.

264 jor positive regulatory factor that controls nitrosative stress-responsive expression of this gene.

265 ed for the first time a novel NssR-dependent nitrosative stress-responsive regulon.

266 to phosphorylate ULK1 at S317 in response to nitrosative stress resulted in increased autophagy: the

267 Removal of nitrosative stress resulted in the coalescence of small

268 protein S-nitrosylation directly implicates nitrosative stress resulting from AniA-dependent nitric

269 Oxidative and nitrosative stress resulting in mitochondrial dysfunctio

270 We now show that PABA/NO induces nitrosative stress, resulting in undetectable nitrosylat

271 , with their dysfunction under conditions of nitrosative stress serving as a mechanistic basis for in

272 These data identify a nitrosative-stress signaling pathway that engages ATM an

273 on is an adaptive response to NO and related nitrosative stresses since Hmp levels are greatly elevat

274 Deletion of Fzf1p eliminated the nitrosative stress-specific transcriptional response, wh

275 Conditions associated with oxidative or nitrosative stress, such as myocardial ischemia and repe

276 d specifically induced following exposure to nitrosative stress, suggesting a previously unrecognized

277 aureus lacking SrrAB were more sensitive to nitrosative stress than hmp mutants, indicating that the

278 ichia coli display far greater resistance to nitrosative stress than the K-12 reference strain MG1655

279 Here we describe an adaptive response to nitrosative stress that allows S. aureus to replicate at

280 Nitrosative stress, that is, enhanced peroxynitrite form

281 its in mitochondrial function, oxidative and nitrosative stress, the accumulation of aberrant or misf

282 ed a host of specialized mechanisms to evade nitrosative stresses, the cytochrome bd-I respiratory ox

283 s cancer cells are particularly sensitive to nitrosative stress, these data open another path for the

284 However, the potential for oxidative/nitrosative stress to elicit an autoimmune response or t

285 resented here reveal new genes important for nitrosative stress tolerance and demonstrate that methio

286 is particularly important for resistance to nitrosative stress under anaerobic conditions.

287 mation of N(2)O), thereby protecting against nitrosative stress under both aerobic and anaerobic cond

288 The present study aimed to target nitrosative stress using a naturally occurring Nos2 inhi

289 dings suggest that ENV-mediated induction of nitrosative stress via activation of TLR4 results in an

290 only the flavohemoglobin gene was induced by nitrosative stress via both a ResDE-dependent mechanism

291 ble nitric-oxide synthase (iNOS) to generate nitrosative stress was investigated in the murine macrop

292 and biochemical parameters of oxidative and nitrosative stress were evaluated at 8 and 22 wk of age

293 duction are coordinated with the response to nitrosative stress were revealed.

294 al detection of 3-nitrotyrosine, a marker of nitrosative stress, were performed in inflated-fixed lun

295 ulosis SufB intein splicing to oxidative and nitrosative stresses when expressed in Escherichia coli.

296 ogen Porphyromonas gingivalis must withstand nitrosative stress, which is particularly high in the or

297 ts C. neoformans from acidic, oxidative, and nitrosative stresses, which are encountered by the fungu

298 s" will, in turn, mediate both oxidative and nitrosative stresses, which form the basis of the cytoto

299 Salmonella experiences oxidative and nitrosative stress within host phagocytes, and CyaY-depe

300 hich serve to protect the microorganism from nitrosative stress within the intracellular environment.