ライフサイエンスコーパス: nitrosylation

1 ing that Cys931 is the predominant site of S-nitrosylation.

2 -l-glutathione, a NO donor, triggered LKB1 S-nitrosylation.

3 and sufficient for iNOS-S100A8/A9-mediated S-nitrosylation.

4 EC insulin transport by enhancing protein S-nitrosylation.

5 assembly of the NLRP3 inflammasome via thiol nitrosylation.

6 sialic acid intake reduced ROS and protein S-nitrosylation.

7 receptor-dependent NO formation and GluA1 S-nitrosylation.

8 the posttranslational level by NO through S-nitrosylation.

9 SNOR(-/-)), a denitrosylase that regulates S-nitrosylation.

10 on, FAK influences TrxR activity and actin S-nitrosylation.

11 succeeded by a reciprocal enhancement of p65 nitrosylation.

12 use aortic endothelial cells induced Panx1 S-nitrosylation.

13 ranscriptional activity of TonEBP/NFAT5 by S-nitrosylation.

14 Syntaxin 4 as a target of modification by S-nitrosylation.

15 carbonyls, protein nitration, and protein S-nitrosylation.

16 greatly enhanced in mice lacking betaCys93 S-nitrosylation.

17 leading to dysregulation of total cellular S-nitrosylation.

18 ed by nitric oxide on cysteine residues by S-nitrosylation.

19 mutating cysteine-150 of GAPDH, its site of nitrosylation.

20 force for experimentally observed reductive nitrosylation.

21 nction GSNOR1 mutant defective in protein de-nitrosylation.

22 inhibited auxin transport probably through S-nitrosylation.

23 ma transcriptional activity by NO-mediated S-nitrosylation.

24 ine residues in a chemical reaction called S-nitrosylation.

25 would be manifest in increased myocardial S-nitrosylation, a posttranslational modification increasi

26 toxic effects at least in part via protein S-nitrosylation, a reaction that covalently attaches NO to

27 logical activity of NO is also mediated by S-nitrosylation, a well-known redox-based posttranslationa

28 S-Nitrosylation accelerates actin filament turnover, which

29 osoglutahione reductase, Tyr-nitration and S-nitrosylation along with the expression of genes involve

30 Nitrosylation also significantly reduced subsequent CaMK

31 vestigate the extent of endogenous heme iron nitrosylation an experimental in vitro model that mimics

32 w that deletion of ADH6 increases cellular S-nitrosylation and alters CoA metabolism.

33 sidue is governed by the equilibrium between nitrosylation and denitrosylation reactions.

34 l to investigate the molecular mechanisms of nitrosylation and denitrosylation using a combination of

35 In mice, GSNOR deficiency causes S-nitrosylation and depletion of the DNA repair protein O6

36 RyR2 S-nitrosylation and diastolic Ca2+ leak were larger in mGC

37 ich was followed by generation of NO and the nitrosylation and dissociation of beta-catenin from VE-c

38 which potently and selectively blocks GAPDH nitrosylation and GAPDH-Siah binding, prevents these act

39 GSNO was found to trigger both GAPDH nitrosylation and glutathionylation, although nitrosylat

40 Our results suggest that S-nitrosylation and GSNOR1-mediated de-nitrosylation contr

41 Increases in S-nitrosylation and inactivation of the neuroprotective ub

42 us small-molecule NO donors promote the AR S-nitrosylation and inhibit growth of castration-resistant

43 mutagenesis of IRE1alpha(Cys931) prevented S-nitrosylation and inhibition of its ribonuclease activit

44 lation, phosphorylation, methylthiolation, S-nitrosylation and nitration) in a natural microbial comm

45 ition or genetic ablation of iNOS inhibits S-nitrosylation and nuclear translocation of CLIC4.

46 14), suggesting molecular cross-talk between nitrosylation and phosphorylation of RyR2.

47 reveal an elusive parallel between protein S-nitrosylation and phosphorylation, namely, stimulus-depe

48 difications of Cys residues, in particular S-nitrosylation and S-oxidation.

49 subjected to two competing modifications: S-nitrosylation and S-sulfhydration, which are naturally o

50 ht-evoked NO production leads to extensive S-nitrosylation and that this process is a significant pos

51 over, mechanisms underlying site-selective S-nitrosylation and the potential role of specific sequenc

52 s acetoacetyl-CoA thiolase from inhibitory S-nitrosylation and thereby affects sterol biosynthesis.

53 Moreover, S-nitrosylation and ubiquitination of LKB1 were confirmed

54 hereby promoting the inhibition of PTEN by S-nitrosylation and ubiquitination.

55 Thus, OxyR serves as a master regulator of S-nitrosylation, and alternative posttranslational modific

56 NOs), formed by nitric oxide (NO)-mediated S-nitrosylation, and hydrogen peroxide (H2O2), a prominent

57 oring local NO production, nuclear protein S-nitrosylation, and induction of mitochondrial biogenesis

58 eased the levels of Nos2 expression, protein nitrosylation, and protein nitration, alleviating nitros

59 levated, as were lipid peroxidation, protein nitrosylation, and ROS.

60 xyR resulted in large increases in protein S-nitrosylation, and S-nitrosylation of OxyR induced trans

61 s including the nitrite reductase, reductive nitrosylation, and still controversial nitrite anhydrase

62 at muscle proteins were highly modified by S-nitrosylation, and that oxidative stress-responsive gene

63 ; by the drug CGP3466B, which prevents GAPDH nitrosylation; and by mutating cysteine-150 of GAPDH, it

64 Total cellular levels of protein S-nitrosylation are controlled predominantly by S-nitrosog

65 Recent studies have pointed to protein S-nitrosylation as a critical regulator of cellular redox

66 In summary, this study discloses cysteine S-nitrosylation as a new factor responsible for increasing

67 Our study identifies NO and HDAC2 nitrosylation as part of a signaling pathway that regula

68 scope, a particular emphasis is placed on S-nitrosylation as the emerging physiologic mechanism for

69 ished autonomy, indicating that simultaneous nitrosylation at both sites was required.

70 These agonists stimulate S-nitrosylation at Cys(247) of GAPDH, which fails to inter

71 NO induced S-nitrosylation at Cys-280/289, and mutation of either sit

72 described reduction of CaMKII activity by S-nitrosylation at Cys-6 was also observed here, but only

73 o endothelial cells is identified with TG2 S-nitrosylation at the endothelial cell-blood interface.

74 iew, we explore the functional features of S-nitrosylation at the proteome level and the structural d

75 ammation are normally regulated by protein S-nitrosylation but systemic assessments of nitric oxide b

76 ys-346 (Panx1(C40A/C346A)) prevented Panx1 S-nitrosylation by GSNO as well as the GSNO-mediated inhib

77 00 nM, indicating that Hcr protects Hcp from nitrosylation by its substrate, NO.

78 Finally, inhibition of S-nitrosylation by knockdown of thioredoxin-interacting pr

79 (GSNOR), an enzyme that governs levels of S-nitrosylation by promoting protein denitrosylation, regu

80 Under physiological conditions, S-nitrosylation can be an important modulator of signal tr

81 Although the S-nitrosylation catalysed by haem proteins is well known,

82 that S-nitrosylation and GSNOR1-mediated de-nitrosylation contribute to auxin physiology, and impair

83 Protein post-translational modification by S-nitrosylation conveys a ubiquitous influence of nitric o

84 Panx1 currents; consistent with a role for S-nitrosylation, current inhibition was reversed by the re

85 pecific P2X4R overexpression had increased S-nitrosylation, cyclic GMP, NO formation, and were protec

86 r findings support the notion that dynamic S-nitrosylation/denitrosylation reactions are essential in

87 that LKB1 is degraded by LPS treatment via S-nitrosylation-dependent proteasome pathways, and this ha

88 d as a tool for studying iron-sulfur protein nitrosylation despite the fact that there exists a wealt

89 fective enrichment of proteins modified by S-nitrosylation, disulfide formation, and Cys-sulfenic aci

90 paired beta(2) integrin function and actin S-nitrosylation do not occur in neutrophils from mice lack

91 AR S-nitrosylation does not impact its subcellular distributi

92 Endogenous S-nitrosylation during anaerobic respiration is controlled

93 oxide production is transient due to actin S-nitrosylation during exposure to hyperoxia.

94 duced significant vasodilation and increased nitrosylation during hypoxaemia that could not be revers

95 w, we discuss the mechanisms through which S-nitrosylation exerts its broad pleiotropic influence on

96 se, a denitrosylase that regulates protein S-nitrosylation, exhibited decreased adipogenesis and incr

97 e used isothermal calorimetry to show that S-nitrosylation facilitates the formation of Ca(2+)-loaded

98 Comparative analysis shows that S-nitrosylation fine tunes the overall architecture of S10

99 also indicate that druggable regulators of S-nitrosylation, for example S-nitrosoglutathione (GSNO) r

100 nal class of enzymes that regulate protein S-nitrosylation from yeast to mammals and suggest that SNO

101 in the thiol-based transfer of NO groups (S-nitrosylation) has not been considered.

102 Most PTM events, except S-nitrosylations, have low fractional occupancy.

103 ese single cysteines did not prevent Panx1 S-nitrosylation; however, mutation of either Cys-40 or Cys

104 This post-translational modification, S-nitrosylation, impacts protein function, stability, and

105 approach to understand the broader role of S-nitrosylation in auxin physiology in Arabidopsis.

106 teins is well known, no direct evidence of S-nitrosylation in copper proteins has been reported.

107 s demonstrate that the consensus motifs of S-nitrosylation in cytoplasmically accessible sites are cr

108 identify a metabolic hallmark of aberrant S-nitrosylation in HCC and exploit it for therapeutic gain

109 a specific molecular signature of aberrant S-nitrosylation in HCC, a novel molecular target in SDH, a

110 , and redox regulation exhibited increased S-nitrosylation in NE samples compared with IE plants upon

111 identify mechanisms for reversal of actin S-nitrosylation in neutrophils after exposure to high oxyg

112 rotein is endogenously modified by Cys(85) S-nitrosylation in PC12 cells, which are a well establishe

113 and they highlight the importance of PTEN S-nitrosylation in supporting cell survival and proliferat

114 ivation alone is sufficient to induce PTEN S-nitrosylation in the absence of PARK2 depletion.

115 Thus, through a bird's-eye view of S-nitrosylation in the cardiovascular system, we provide a

116 Here we review mechanisms that regulate S-nitrosylation in the context of its essential role in "s

117 C155S), excluding an essential role of GAPC1 nitrosylation in the mechanism of nuclear relocalization

118 In this study, we investigated the role of S-nitrosylation in the NO regulation of high voltage-activ

119 gest new insight into the role of aberrant S-nitrosylation in the pathogenesis of neurodegeneration.

120 Roussin's Red Ester is also favored on nitrosylation in the presence of the thiolate scavenging

121 sm and further highlight the importance of S-nitrosylation in the regulation of the immune response.

122 Here we describe protein S-nitrosylation in yeast (heretofore unknown) that is medi

123 difications (phosphorylation, oxidation, and nitrosylation) in SH-SY5Y neuroblastoma cells expressing

124 tion, we uncovered major roles for protein S-nitrosylation, in general, and for phospholamban and car

125 d for phospholamban and cardiac troponin C S-nitrosylation, in particular, in betaAR-dependent regula

126 to short filamentous actin in response to S-nitrosylation, including vasodilator-stimulated phosphop

127 The possibility that S-nitrosylation induces cAPX ubiquitination and degradatio

128 ide (NO) signaling is largely conducted by S-nitrosylation, involving >3000 proteins.

129 data indicate that obesity-induced protein S-nitrosylation is a key mechanism compromising the hepati

130 S-Nitrosylation is a post-translational modification of pr

131 S-nitrosylation is a post-translational modification on cy

132 S-Nitrosylation is a redox-mediated posttranslational modi

133 Nitrosylation is a reversible post-translational modific

134 S-nitrosylation is a ubiquitous protein modification emerg

135 We report that protein S-nitrosylation is an obligate concomitant of anaerobic re

136 ide evidence that the mechanism of reductive nitrosylation is gated by a conformational change of the

137 Although protein S-nitrosylation is increasingly recognized as mediating ni

138 S-nitrosylation is therefore revealed here as a nitric oxi

139 S-Nitrosylation is well established as an important post-t

140 PN, and CS resulted in cysteine and tyrosine nitrosylation leading to an altered three-dimensional st

141 Manipulation of the S-nitrosylation level may prove therapeutic in heart failu

142 xygen species (ROS) via the control of the S-nitrosylation level of ROS-metabolizing enzymes, thus mo

143 S-nitrosylation levels, however, were increased in DMD.

144 Post-translational S-nitrosylation may provide functional diversity and speci

145 mammals and suggest that SNO-CoA-mediated S-nitrosylation may subserve metabolic regulation.

146 ide (NEM), indicating that NO acted via an S-nitrosylation mechanism.

147 S-Nitrosylation mediates the feedback regulation of N-type

148 stimulation, global reductions in cellular S-nitrosylation mitigate hypertrophic signaling resulting

149 Protein S-nitrosylation modulates important cellular processes, in

150 The observed fast reductive nitrosylation observed at low NO concentrations may func

151 oglutathione (GSNO), another NO source for S-nitrosylation, occurred in H2O2-treated cells, while a d

152 Nitrosylation of (NEt4)2[Fe2S2(SPh)4] (1) in the presenc

153 The extent of nitrosylation of a given cysteine residue is governed by

154 tric oxide synthase (iNOS) activity causes S-nitrosylation of a key UPR regulator, IRE1alpha, which l

155 that involves AR function inactivation by S-nitrosylation of a single C601 residue present in the DN

156 ric-oxide synthase (NOS-2) and resulted in S-nitrosylation of actin.

157 Here, we describe S-nitrosylation of additional ER pathways that affect the

158 ne and MG), which is most likely caused by S-nitrosylation of aldose reductase.

159 s synthesis of reactive species leading to S-nitrosylation of beta-actin, which causes temporary inhi

160 Mice harboring mutations that prevent S-nitrosylation of betaCys93 had higher rates of morbidity

161 Here, we demonstrate that NO-induced S-nitrosylation of CaMKIIalpha also directly generated aut

162 vivo and in vitro experiments showed that S-nitrosylation of cAPX was responsible for the rapid decr

163 Coincident S-nitrosylation of cardiac troponin C decreases myocardial

164 s GAPDH activity was reversibly inhibited by nitrosylation of catalytic Cys-149 mediated either chemi

165 e-2 (COX-2), increased by atorvastatin via S-nitrosylation of COX-2 and reduced by COX-2 inhibitors.

166 only provide the first direct evidence of S-nitrosylation of Cu(II)-bound cysteine in metalloprotein

167 We find that this depends on the selective S-nitrosylation of Cys(501) in the mitochondrial chaperone

168 Specific nitrosylation of Cys-226 decreases NAB1 activity and cou

169 uctural elements that govern the selective S-nitrosylation of cysteine residues, and the potential ov

170 Exposure of bacteria to NO results in the nitrosylation of cysteine thiols in proteins and low mol

171 Reactive species cause S-nitrosylation of cytosolic actin that enhances actin pol

172 Reactive species cause S-nitrosylation of cytosolic actin that enhances actin pol

173 eNMDAR-mediated increase in NO can produce S-nitrosylation of Drp1 (dynamin-related protein 1) and Cd

174 The reductive nitrosylation of ferric (met)hemoglobin is of considerab

175 In hepatocytes, cholate promoted S-nitrosylation of GAPDH and its translocation to the nucl

176 Thus, we found that nitrosylation of GAPDH is not a step toward formation of

177 S-nitrosylation of GAPDH was assessed using a biotin-switc

178 , inhibition of nNOS resulted in a loss of S-nitrosylation of gephyrin and the formation of larger ge

179 In conclusion, S-nitrosylation of gephyrin is important for homeostatic a

180 Thus, S-nitrosylation of GluA1 at C875 enhances S831 phosphoryla

181 mpal neuroplasticity mediated, in part, by S-nitrosylation of HDAC2 and histone acetylation, such pla

182 f nitrosylated GAPDH reduced cholate-induced nitrosylation of HDAC2 and SIRT1; this effect was accomp

183 d factor, is one of the genes regulated by S-nitrosylation of HDAC2.

184 JCI, Zhang and colleagues demonstrate that S-nitrosylation of hemoglobin at betaCys93 is important fo

185 (NO) as a signaling molecule that mediates S-nitrosylation of histone deacetylase 2 (HDAC2) and epige

186 anslocation to the nucleus, accompanied by S-nitrosylation of histone deacetylase 2 (HDAC2) and Sirtu

187 The S-nitrosylation of HopAI1 restores MAPK signaling and is r

188 The increase in NO results in S-nitrosylation of insulin-degrading enzyme (IDE) and dyna

189 While S-nitrosylation of IRE1alpha inhibited its ribonuclease ac

190 promise UPR function through iNOS-mediated S-nitrosylation of IRE1alpha, which contributes to defecti

191 Furthermore, iNOS was found to cause S-nitrosylation of ITGalpha6 at Cys86 in prostate cancer c

192 In conclusion, S-nitrosylation of ITGalpha6 increased the extent of prost

193 Finally, S-nitrosylation of ITGalpha6 weakened its binding to lamin

194 itric oxide synthase (NOS1) is involved in S-nitrosylation of key sarcoplasmic reticulum (SR) Ca(2+)

195 164) gain of function decreased glomerular S-nitrosylation of laminin in eNOS(-/-) mice.

196 deposition of laminin and collagen IV and de-nitrosylation of laminin.

197 We demonstrate that obesity promotes S-nitrosylation of lysosomal proteins in the liver, thereb

198 nitric oxide (NO) production, NO-dependent S-nitrosylation of matrix metalloprotease 9 (MMP9) as well

199 represses the tumour suppressor gene p53 via nitrosylation of Mdm2.

200 vity of microglial caspase-3 and increased S-nitrosylation of mitochondria-associated caspase-3 throu

201 ation of NO synthase, leading to NO-mediated nitrosylation of Na(V)1.5 and to induction of the late N

202 Targeted S-nitrosylation of NMDARs by NitroMemantine is potentiated

203 S-nitrosylation of nuclear factor kappaB (NF-kappaB) on th

204 increases in protein S-nitrosylation, and S-nitrosylation of OxyR induced transcription from a regul

205 NO accumulation results in the S-nitrosylation of PAL and 4CL required for the synthesis

206 aken together, these results indicate that S-nitrosylation of Panx1 at Cys-40 and Cys-346 inhibits Pa

207 alpha inhibited its ribonuclease activity, S-nitrosylation of PERK activated its kinase activity and

208 For example, S-nitrosylation of peroxiredoxin-2 (Prx2), a peroxidase wi

209 Notably, S-nitrosylation of phospholamban consequent upon betaAR st

210 S-nitrosylation site and demonstrated that S-nitrosylation of PPARgamma inhibits its transcriptional

211 equivalent PPARgamma expression; however, S-nitrosylation of PPARgamma was elevated in S-nitrosoglut

212 Endogenous S-nitrosylation of proteins, a principal mechanism of cell

213 st immunity, are in large part mediated by S-nitrosylation of proteins.

214 d S-nitrosoglutathione readily induced the S-nitrosylation of Prx1, causing structural and functional

215 Importantly, S-nitrosylation of PTEN decreases its phosphatase activity

216 The release of epigenetic repression by nitrosylation of RING1A is critical for effective transd

217 Nitrosylation of RING1A reduced its binding to chromatin

218 Nitrosylation of RING1A reduces its binding to chromatin

219 S-Nitrosylation of S100A1 is present in cells, increases C

220 nel RyR1 can be enhanced by S-oxidation or S-nitrosylation of separate Cys residues, which are allost

221 S-Nitrosylation of SHP-2 inhibited its phosphatase activit

222 the local redox environment and influence S-nitrosylation of surface proteins on platelets and endot

223 nhibition of the sulfur transfer activity, S-nitrosylation of the active site residue Cys63 causes an

224 Deficient S-nitrosylation of the cardiac ryanodine receptor (RyR2) h

225 In particular, we show that S-nitrosylation of the intermediate filament protein desmi

226 elevated NO levels in myocytes and caused S-nitrosylation of the Na(+) channel, Na(v)1.5.

227 ylation reflects in part the regulation by S-nitrosylation of the principal protein post-translationa

228 g increased mitochondrial ROS emission and S-nitrosylation of the RyR, whereas hydrogen peroxide indu

229 sine and arginine residues, acetylation, and nitrosylation of thiol groups and tyrosine residues, hav

230 ed nitrosative/oxidative stress results in S-nitrosylation of transcription factor MEF2C in A53T hNs

231 ductase activity was potentiated following S-nitrosylation of Trx proteins at a non-catalytic cystein

232 ssion and NO were associated with reversible nitrosylation of tuberous sclerosis complex (TSC) 2, and

233 de dismutase (MnSOD) activity by causing the nitrosylation of tyrosine 34, thereby increasing ROS.

234 oso-N-acetylcysteine induced site-specific S-nitrosylation of VLCAD mutants at cysteine residue 237.

235 se from primary afferent terminals through S-nitrosylation of voltage-activated Ca(2+) channels.

236 ocalization of iNOS, and its binding to, and nitrosylation of, the epigenetic modifier ring finger pr

237 translational modification of proteins via S-nitrosylation often impacts enzymatic activities, our da

238 owever, genetic evidence for the effect of S-nitrosylation on auxin physiology has been lacking.

239 implications for understanding the impact of nitrosylation on cellular redox homeostasis.

240 enesis, we find that Cys106 is the site of S-nitrosylation on DJ-1 and that mutation of this site inh

241 We have investigated the effects of S-nitrosylation on the rhodanese domain of the Escherichia

242 NO reacts with cysteine residues (S-nitrosylation) on hyperpolarization-activated and nucleo

243 S-Nitrosylation operates in concert with phosphorylation t

244 ied previously as subject to physiological S-nitrosylation or S-oxidation.

245 atile mechanisms such as nutrient depletion, nitrosylation, or apoptosis.

246 ith N-ethylmaleimide (NEM), which occludes S-nitrosylation, or with 1-(2-trifluromethylphenyl)imidazo

247 to the pathophysiological role of aberrant S-nitrosylation pathways will enhance our understanding of

248 onditions only slight differences in their S-nitrosylation pattern, the in vivo S-nitroso-proteome of

249 sts that loss of the iron-sulfur cluster (by nitrosylation) permits positively charged residues in th

250 nitrosoglutathione Reductase 1 (GSNOR1) by S-nitrosylation, preventing scavenging of S-nitrosoglutath

251 (from meat or vegetables) on the endogenous nitrosylation process was also tested.

252 The nitrosylation products are similar to a pair of dinuclea

253 f NO metabolites (oxidation, nitrosation and nitrosylation products) were measured in plasma and eryt

254 In particular, nitrosylation promoted disulfide formation involving the

255 , Adh6-regulated, SNO-CoA-mediated protein S-nitrosylation provides a regulatory mechanism parallelin

256 The fast, efficient and reversible S-nitrosylation reaction is used to demonstrate its abilit

257 tion and find that sGC undergoes a reductive nitrosylation reaction that is coupled to the S-nitrosat

258 The NsrR nitrosylation reaction was not significantly affected by

259 oxins that generate excessive NO, aberrant S-nitrosylation reactions can occur and affect protein mis

260 The wide functional purview of S-nitrosylation reflects in part the regulation by S-nitro

261 Here, we show that HDAC2 nitrosylation regulates neuronal radial migration during

262 Transfection of cells with a S-nitrosylation-resistant Ras mutant reduced iNOS protein

263 econstitution of IRE1alpha expression with a nitrosylation-resistant variant restored IRE1alpha-media

264 Furthermore, overexpression of S-nitrosylation-resistant variants of lysosomal enzymes en

265 lting from a combination of decreased RyR2 S-nitrosylation (RyR2-SNO) and increased RyR2 oxidation (R

266 trate in this issue of Molecular Cell that S-nitrosylation selectively modulates enzymatic activity o

267 S-palmitoylation, S-glutathionylation, and S-nitrosylation show little correlation with pKa values pr

268 llustrate a paradoxical inhibitory role of S-nitrosylation signaling in MSC vasculogenesis.

269 a mutant form of RING1A (C398A) lacking the nitrosylation site almost abrogated transdifferentiation

270 ther identified Cys 139 of PPARgamma as an S-nitrosylation site and demonstrated that S-nitrosylation

271 .2, and Cys-346 in the Cavbeta3 subunit were nitrosylation sites mediating NO sensitivity of N-type c

272 ifications, including disulfide formation, S-nitrosylation (SNO) and S-glutathionylation (SSG), have

273 Protein S-nitrosylation (SNO) is increased following myocardial IP

274 n modifications (acetylations, methylations, nitrosylations, succinylation, and ubiquitinations), som

275 and 5, which are palmitoylated, as sites of nitrosylation, suggesting a competition between these tw

276 ion of GSNOR results in pathologic protein S-nitrosylation that is implicated in human hepatocellular

277 tem, and we highlight examples of aberrant S-nitrosylation that may lead to altered oxygen homeostasi

278 sulphuraria RuBisCO is inhibited by cysteine nitrosylation that results in trapping of these gaseous

279 immunohistochemical evidence for extensive S-nitrosylation that takes place in the goldfish and mouse

280 evelopment and stress responses is through S-nitrosylation, that is, covalent attachment of NO to cys

281 oute for the transfer of NO bioactivity is S-nitrosylation, the addition of an NO moiety to a protein

282 and SNP significantly increased EC protein S-nitrosylation, the colocalization of S-nitrosothiol (S-N

283 ubunit four-helix bundle is conserved upon S-nitrosylation, the conformation of S100A1 protein is reo

284 S-Nitrosylation, the covalent addition of an nitric oxide

285 oute for the transfer of NO bioactivity is S-nitrosylation, the covalent attachment of an NO moiety t

286 that signals predominantly through protein S-nitrosylation to form S-nitrosothiols (SNOs) in target p

287 ocytes was performed together with protein S-nitrosylation to investigate the effects of CO at the ce

288 eine (C430S) in LKB1 prevented LPS-induced S-nitrosylation, ubiquitination, and degradation.

289 roarginine methyl ester [L-NAME]) or protein nitrosylation (via dithiothreitol) on bile salt homeosta

290 GAPDH nitrosylation was assessed in normal and cholestatic rat

291 Cysteine 237 S-nitrosylation was associated with an 8-17-fold increase

292 Nitrosylation was optimal under mildly acidic conditions

293 itrosylation and glutathionylation, although nitrosylation was widely prominent.

294 a(2+) currents are reduced by NO-activated S-nitrosylation, we tested whether CNs affect membrane cha

295 enic mice to titrate the levels of protein S-nitrosylation, we uncovered major roles for protein S-ni

296 Furthermore, the consensus motifs of S-nitrosylation were much more abundant in Cav2.2 than in

297 hemically with a strong NO donor or by trans-nitrosylation with GSNO.

298 at exocytotic proteins might be targets of S-nitrosylation, with their dysfunction under conditions o

299 reductase (GSNOR), which exhibit enhanced S-nitrosylation, would have improved outcomes in a preclin

300 This work reveals that nitrosylation yields multiple products structurally rela