ライフサイエンスコーパス: nitroxyl

1 of nitric oxide as opposed to its redox form nitroxyl.

2 is to enable nNOS to generate NO instead of nitroxyl.

3 ONNOH), the adducts of nitric oxide (NO) and nitroxyl (3NO- and 1HNO), are revised.

4 rification pathway, including isolation of a nitroxyl adduct similar to that proposed in the P450nor

5 readily enable the continuous generation of nitroxyl, an antithrombotic species, from physiologicall

6 uction from the ferric catalase oxidation of nitroxyl and identify a catalase-mediated pathway as a p

7 nd related reactive nitrogen species such as nitroxyl and peroxynitrite, after up-regulation of expre

8 ydrolysis of this nitroso species to produce nitroxyl, and reductive nitrosylation of the ferric heme

9 ts a prompt turn-on response when exposed to nitroxyl, and this emission response is specific to HNO

10 de (NO) to its one-electron reduced species, nitroxyl anion (3NO-) has been determined by a combinati

11 Nitroxyl anion (HNONO(-)), the one-electron reduced form

12 Nitroxyl anion (NO(-)) is the one-electron reduction pro

13 dence indicates that the NO-related species, nitroxyl anion (NO), is produced in physiological system

14 the NADPH/O2 reaction is proposed to be the nitroxyl anion (NO-) based on the formation of a ferrous

15 The nitroxyl anion (NO-) formed from HNO (pKa 4.5) was trapp

16 The nitroxyl anion (NO-) is a highly reactive molecule that

17 In the absence of oxygen, nitroxyl anion (NO-) is liberated in a reaction producin

18 does not synthesize NO, but rather generates nitroxyl anion (NO-) that is subsequently converted to N

19 aNonoate], an S-nitrosothiol [GSNO], and the nitroxyl anion donor, Angelis salt).

20 2)(-), Angeli's anion) is used to generate a nitroxyl anion in its excited singlet state ((1)NO(-)).

21 The singlet state of nitroxyl anion, 1NO-, is physiologically inaccessible.

22 d (c) oxidized forms of nitrogen such as the nitroxyl anion, the nitric oxide free radical, and S-nit

23 on NO disappearance from heme groups to form nitroxyl anions or S-nitrosated Hb at low ratios of NO t

24 sults for evaluating the biological roles of nitroxyl are discussed.

25 cially noteworthy at high pH, where bicyclic nitroxyls are inhibited by formation of an oxoammonium h

26 le formation of a hydroxylamine N-oxide when nitroxyls are oxidized in alkaline media.

27 iven reactions, consistent with formation of nitroxyl as an immediate product.

28 intermediates, which upon hydrolysis release nitroxyl (azanone, HNO) in excellent yields.

29 with one nitroxyl bearing 15N and the other nitroxyl bearing 14N (14N-X-15N), were employed as probe

30 lly asymmetric nitroxyl biradicals, with one nitroxyl bearing 15N and the other nitroxyl bearing 14N

31 interaction of r# with the asymmetric ortho-nitroxyl biradical (14N-O-15N), which exists in a condit

32 The para-nitroxyl biradical (14N-P-15N) exists in weak spin excha

33 Both isotopically symmetric nitroxyl biradicals (14N-X-14N) and isotopically asymmet

34 cals (14N-X-14N) and isotopically asymmetric nitroxyl biradicals, with one nitroxyl bearing 15N and t

35 and chemical interactions between r and the nitroxyl biradicals.

36 Cu/nitroxyl catalysts have been identified that promote hig

37 may be tuned by changing the identity of the nitroxyl cocatalyst.

38 roscopically by the sorption of paramagnetic nitroxyl compounds (spin probes) of different polarity,

39 The species resembles a nitroxyl coordinated to a highly distorted disulfide, an

40 useful synthetic intermediates and potential nitroxyl delivery agents.

41 Bicyclic nitroxyl derivatives, such as 2-azaadamantane N-oxyl (AZ

42 is the best choice for determination of iron-nitroxyl distances in the range of 15-30 A.

43 d that is consistent with the formation of a nitroxyl disulfide in the gas phase.

44 requirements and charge stabilization of the nitroxyl disulfide reaction intermediate are discussed.

45 Addition of Angeli's salt, a nitroxyl donor, to ferric catalase also produces the fer

46 The formation of a heme-bound nitroxyl equivalent and its subsequent oxidation is a no

47 Thus, nitroxyl exists almost exclusively in its protonated for

48 etermination is the first for a nonheme iron nitroxyl {FeNO}(8) and has allowed to identify structura

49 d to determine the distance between iron and nitroxyl for spin-labeled metmyoglobin variants in low-s

50 rmal steric effect), while for the noncyclic nitroxyl fragment (except for one case), a leveled steri

51 r interest to the chemical activation of the nitroxyl fragment by oxidation/reduction of selected fun

52 nd colleagues showed that protonation of the nitroxyl fragment deactivated the alkoxyamine C-ON bond.

53 rmal steric effect also applies to noncyclic nitroxyl fragments and that for one case an enhanced ste

54 For all cyclic nitroxyl fragments, the steric effect is described as th

55 ydrogen bond (IHB) between the alkyl and the nitroxyl fragments, which leads to an 8-fold decrease in

56 The nitroxyl free radicals used were TEMPO, TEMPAMINE, and T

57 A series of stable nitroxyl free radicals, which are characterized by diffe

58 Nitroxyl, generated from Angeli's salt, reacts with ferr

59 rations between the unpaired electron of the nitroxyl group and isotopically identified nuclei.

60 an hydrogen bond with the oxygen atom of the nitroxyl group of Tempo, and that a single water molecul

61 distances from the unpaired electron of the nitroxyl group of the spin-label to the methylene and me

62 xidation reactions of five different organic nitroxyls have been performed across a wide pH range (0-

63 was shown previously to mimic the effect of nitroxyl (HN=O), the putative active metabolite of cyana

64 The thermodynamic properties of aqueous nitroxyl (HNO) and its anion (NO(-)) have been revised t

65 The redox siblings nitroxyl (HNO) and nitric oxide (NO) have often been ass

66 Angeli's salt produces both nitroxyl (HNO) and nitric oxide (NO), depending upon the

67 rosothiols can react with thiols to generate nitroxyl (HNO) and the corresponding disulfide.

68 Despite its negative redox potential, nitroxyl (HNO) can trigger reactions of oxidation.

69 Nitroxyl (HNO) donated by Angeli's salt activates uptake

70 The nitroxyl (HNO) donor, Angeli's salt, exerts positive ino

71 acene derivative was prepared as a potential nitroxyl (HNO) donor.

72 Nitroxyl (HNO) exerts inotropic and lusitropic effects i

73 he biological and pharmacological effects of nitroxyl (HNO) from its oxidized/deprotonated product ni

74 Nitroxyl (HNO) is a redox sibling of nitric oxide (NO) t

75 date the factors that impart selectivity for nitroxyl (HNO) over nitric oxide (NO), thiols, and H2S i

76 Despite the mechanisms for endogenous nitroxyl (HNO) production and action being incompletely

77 Nitroxyl (HNO) reacts with thiols, and this reactivity r

78 The fact that nitroxyl (HNO) reduces platelet aggregation, preconditio

79 gel chemistry were used to fabricate optical nitroxyl (HNO) sensors [corrected] Selective detection o

80 NOate Angeli's salt (Na(2)N(2)O(3)) releases nitroxyl (HNO) under physiological conditions and exhibi

81 cts the hydrolysis of the latter compound to nitroxyl (HNO) which dimerizes to cis-hyponitrous acid (

82 ic and mechanistic data for the reactions of nitroxyl (HNO) with biomolecules (k approximately 10(3)

83 enzene (PhNO) serves as a stable analogue of nitroxyl (HNO), a biologically relevant, redox-active ni

84 The formation of nitroxyl (HNO), a product of the reaction of 5 with diet

85 Nitroxyl (HNO), a redox congener of nitric oxide (NO.),

86 Due to its inherent reactivity, nitroxyl (HNO), must be generated in situ through the us

87 A potential alternative is nitroxyl (HNO), the 1-electron reduction product of nitr

88 orescent turn-on sensor for the detection of nitroxyl (HNO), the one-electron reduced form of nitric

89 reduced state with concomitant generation of nitroxyl (HNO), the one-electron reduction product of NO

90 Nitroxyl (HNO), the one-electron-reduced form of nitric

91 Nitroxyl (HNO), the protonated one-electron reduction pr

92 Donors of nitroxyl (HNO), the reduced congener of nitric oxide (NO

93 Detection of nitroxyl (HNO), the transient one-electron reduced form

94 occur upon exposure of cysteine residues to nitroxyl (HNO), which has received recent attention as a

95 Selective detection of nitroxyl (HNO), which has recently been identified as a

96 and H2S can be ascribed to the generation of nitroxyl (HNO), which is a direct product of the reactio

97 discussed and may involve the intermediate, nitroxyl (HNO).

98 quely advantageous prodrug form of bioactive nitroxyl (HNO).

99 ms of the bioeffectors nitric oxide (NO) and nitroxyl (HNO).

100 one-electron reduced analogue of NO, namely nitroxyl (HNO/NO(-)), has revealed distinguishing proper

101 Nitroxyl (HNO/NO(-)), the reduced form of nitric oxide,

102 Azanone (nitroxyl, HNO) is a highly reactive compound whose biolo

103 entical potentials and lifetimes for ferrous nitroxyl intermediate (Fe(II)-NO(-)) in CYP119 and Mb.

104 Iron-nitroxyl interspin distances in the range of 17-30 A wer

105 d herein show that the catalytic activity of nitroxyls is more strongly affected by the nitroxyl/oxoa

106 Azanone (HNO, nitroxyl) is a highly reactive and short-lived compound

107 d trapping experiments demonstrate that HNO (nitroxyl) is formed, at least when tppts is the reductan

108 Nitrosyl hydride, HNO, also commonly termed nitroxyl, is a transient species that has been implicate

109 Nitrosyl hydride, HNO or nitroxyl, is the one-electron reduced and protonated for

110 nd exhibits a nu(NO) vibration indicative of nitroxyl-like character.

111 alysis reveals the nitroso groups possess a "nitroxyl-like" bent configuration.

112 Metal-nitroxyl (M-HNO/M-NO(-)) coordination units are found in

113 ich suggests that the biological activity of nitroxyl may be mediated by its reactivity with ferrous

114 ia/reperfusion and suggest that formation of nitroxyl may contribute to postischemic myocardial injur

115 e mimicked by Angeli's salt, arguing against nitroxyl mediation.

116 ion of a hydroxyl group located close to the nitroxyl moiety successively into aldehyde, then acid, a

117 nd aqueous thermochemistry and reactivity of nitroxyl (nitrosyl hydride, HNO) were elucidated with mu

118 role of two reactive nitrogen oxide species, nitroxyl (NO(-)) and nitric oxide (NO(.)), in myocardial

119 Nitroxyl (NO(-)) may be produced by nitric-oxide synthas

120 The dihedral angle between the beta-H and nitroxyl O bonds is smaller in phosphorylated nitrones,

121 ntrol the binding and release of coordinated nitroxyl or its anion at these biological metal sites, w

122 Nitroxyl, or nitrosyl hydride, (HNO) is a pharmacologica

123 ise mechanism taking place through a side-on nitroxyl Os(VI) intermediate, OsO2 (eta(2) -NO)(-) .

124 itions was used to vary the potential of the nitroxyl/oxoammonium redox couple by 0.95 V.

125 f nitroxyls is more strongly affected by the nitroxyl/oxoammonium redox potential than by steric effe

126 Nitroxyl permeability in sensor films deposited in round

127 nown classes of "oxygen mimetic" agents: the nitroxyl radical 2,2,6, 6-tetramethylpiperidin-N-oxyl (4

128 is (1) fluorescent, (2) stable as opposed to nitroxyl radical adducts, (3) biologically relevant, and

129 activity of a diverse range of water-soluble nitroxyl radical compounds.

130 al and catalytic activity of a wide range of nitroxyl radical derivatives.

131 to modified bases in DNA containing oxidized nitroxyl radical EPR probes.

132 -methoxypiperidine-N-oxyl) were conducted by nitroxyl radical exchange experiments.

133 en-atom-transfer from a Cu(II)-alkoxide to a nitroxyl radical is higher in energy than hydrogen trans

134 spin-label mimetic of PI(3)P that contains a nitroxyl radical near the threitol group of the lipid.

135 strate oxidation" mediated by Cu(II) and the nitroxyl radical of TEMPO via a Cu(II)-alkoxide intermed

136 This stable nitroxyl radical reacts rapidly with reducing radicals a

137 cally hindered aniline/anilide complexes and nitroxyl radical species.

138 ssion results in the formation of the stable nitroxyl radical TEMPO(.) as well as a reactive carbocat

139 low-energy pathway involving addition of the nitroxyl radical to the double bond followed by H-atom a

140 tained by the reaction of 2 molar equiv of a nitroxyl radical with an unactivated alkene.

141 nsisting of an acridinium photooxidant and a nitroxyl radical, promotes site-selective amination of a

142 of the unmodified compounds with the stable nitroxyl radical, TEMPO (2,2,6,6-tetramethylpiperidin-1-

143 Stable nitroxyl radical-containing compounds, such as 2,2,6,6-t

144 om the intermediate by another equivalent of nitroxyl radical.

145 generate the transient Cp2Ti(III)Cl and the nitroxyl radical.

146 g of the epoxide followed by trapping by the nitroxyl radical.

147 achloroperoxybenzoic acid in the presence of nitroxyl radicals and detected with the use of rapid-mix

148 Titanium-oxygen bonds derived from stable nitroxyl radicals are remarkably weak and can be homolyz

149 tic resonance (EPR) imaging utilizing stable nitroxyl radicals is a promising technique for measuring

150 The nitroxyl radicals served as selective reductants of APO-

151 The decay of water-soluble nitroxyl radicals showed radicals are formed in the aque

152 The reaction of nitroxyl radicals TEMPO (2,2',6,6'-tetramethylpiperidiny

153 The reaction of stable sterically hindered nitroxyl radicals with benzylic and allylic substrates w

154 fer an electron and a proton to phenoxyl and nitroxyl radicals, indicating that e(-) and H(+) are cou

155 n atom transfer (HAT) from hydroxylamines to nitroxyl radicals, using the stable radicals TEMPO(*) (2

156 , using the different optical spectra of the nitroxyl radicals.

157 iological and cardiovascular implications of nitroxyl reactions are discussed.

158 Nitroxyl reduction was confirmed using EPR and triphenyl

159 sfer from a Cu(II)-alkoxide to a coordinated nitroxyl species.

160 on the spin-lattice relaxation rates of the nitroxyl spin label using the modified Bloembergen equat

161 overy measurements of the enhancement of the nitroxyl spin lattice relaxation rates between approxima

162 with the fatty acid spin-label, [15N,2H12]-5-nitroxyl stearate, have been obtained at the two sample

163 activity observed between TEMPO and bicyclic nitroxyls, such as ABNO (ABNO = 9-azabicyclo[3.3.1]nonan

164 n this reaction, which provides evidence for nitroxyl, the one-electron reduced form of nitric oxide.

165 n of 17 produces nitrous oxide, evidence for nitroxyl, the one-electron-reduced form of nitric oxide.

166 leading to the ultimate liberation of NB or nitroxyl, thereby inhibiting AlDH.

167 rseradish peroxidase is capable of oxidizing nitroxyl to nitric oxide.

168 rosylation of the ferric heme of catalase by nitroxyl to yield the ferrous-NO catalase complex.

169 Similarly, pro-prodrug forms of nitroxyl were prepared by derivatization of the hydroxyl