ライフサイエンスコーパス: no appreciable

1 No appreciable absorption change was observed for AMTr-A

2 No appreciable absorption in the solar actinic region (l

3 otinic acetylcholine receptors (nAChRs) with no appreciable activation of alpha4beta2 nAChRs, the pre

4 e partial agonists, and RNPA and SNPA caused no appreciable activation.

5 4400 nM against the Y2R were measured, with no appreciable activity against the related NPY-Y1 recep

6 ly to the type 2 CRF receptor (CRF-R2), with no appreciable activity on CRF-R1.

7 11g demonstrated no appreciable adipogenic effect through PPAR gamma agon

8 ibition of phosphatidylinositol 3-kinase had no appreciable affect.

9 0.3 and 2.6+/-0.3 microM, respectively) with no appreciable affinity to nearly 40 other receptors.

10 n nAChRs with an IC(50) value of 110 nM with no appreciable affinity to the alpha7 nAhRs.

11 d growth factor stimulation, suggesting that no appreciable amounts of accessible PIP3 and PI(3,4)P2

12 No appreciable amounts of fatty acid amides (e.g., oleam

13 e untreated tumor cell-based vaccines led to no appreciable antitumor response.

14 PTFOS induced no appreciable artifacts on CT and MR images, and PTFOS

15 No appreciable association of tea drinking was found wit

16 tal volume and hospital-level factors having no appreciable association with adverse events.

17 There was no appreciable association with breast cancer risk overa

18 This study suggests that ALA has no appreciable association with risk of incident MI in e

19 There is no appreciable barrier for the H2 reaction at prepared s

20 y use of 500 mg of vitamin C for 8 years had no appreciable beneficial or harmful effect on risk of i

21 (P < .001) was sustained at 12 months, with no appreciable between-group difference.

22 ecific binding (>95% of total binding), with no appreciable binding in white matter areas with either

23 No appreciable binding of AMP or EDTA/ATP is observed.

24 ins of SAP97, with higher affinity for PDZ2; no appreciable binding to PDZ3 could be measured.

25 Selectivity studies showed no appreciable block by 10-20 mum ML204 of TRPV1, TRPV3,

26 ine in activity occurred within 15 min, with no appreciable change after 2 hr.

27 ell number by increasing proliferation, with no appreciable change in apoptosis.

28 Invasive hemodynamics showed no appreciable change in global function.

29 in growth in human fibroblasts, but there is no appreciable change in IE1 and IE2 transcription.

30 evels of K-ras 4B transcript expression, but no appreciable change in K-ras 4A transcript levels.

31 X2 mutants did not bind p110alpha and showed no appreciable change in p-AKT(Ser473) levels.

32 ive pressure breathing remained hypoxic with no appreciable change in PaO2.

33 There was no appreciable change in PRA for patients receiving a fi

34 In 2 (22%) of 9 subjects, there was no appreciable change in PRA.

35 Mac-l+ cells alone gave no appreciable change in responsive T cells or graft rej

36 cation resulted in decreased specificity but no appreciable change in sensitivity.

37 Moreover, there is no appreciable change in the early/late kinetics of tran

38 In contrast, no appreciable change in the fluorescence and CD spectra

39 f IL-6 were significantly reduced, there was no appreciable change in the level of IL-1beta or other

40 However, there was no appreciable change in the mean transmission rate of t

41 ependence of the unfolding rate, arguing for no appreciable change in the nature of the transition st

42 e of the motor compared with wild type, with no appreciable change in the stroke size, as observed wi

43 ells compared to non-TSH-treated cells, with no appreciable change in TNF-alpha production from CD11b

44 evels of intracellular viral genomic DNA and no appreciable change in viral DNA packaging into capsid

45 No appreciable change is expected for Fe(2+) and Ni(2+).

46 No appreciable change was observed in cell growth, cell

47 ults indicate that these mutant enzymes show no appreciable changes in K(m) for 1-chloro-2,4-dinitrob

48 s for Glu97 which eliminate the charge cause no appreciable changes in the kinetic parameters or mole

49 Although the simulations showed no appreciable changes to the radius of the pore located

50 Unlike the minimal TUT4 TUTase, MEAT1 shows no appreciable conformational change upon UTP binding an

51 hat of wild-type enzyme indicating there are no appreciable conformational changes.

52 either aqueous or nonaqueous solvent causes no appreciable conformational changes.

53 partitioned into the membrane, and there was no appreciable covalent association of [3H]Tam with cell

54 onstants approximately 8 min), and specific (no appreciable cross reactivity with the targets of the

55 No appreciable CYP3A4 stabilization was detected in eith

56 ry HIV-1 isolates in PBMCs, while displaying no appreciable cytotoxicity.

57 swelling were < 20 microns/hour, indicating no appreciable damage to intercellular junctions.

58 L was recycled and reused up to 5 times with no appreciable decrease in the conversions.

59 There were no appreciable defects in nuclear translocation of p65/R

60 over a several-month period, indicating that no appreciable degradation of the stationary phase had t

61 y embryonic lethality, Cdc25A(+/-) mice show no appreciable developmental defect.

62 We also found that there is no appreciable difference between the mid-frequency S(2)

63 There was no appreciable difference in cdk9 levels, suggesting tha

64 No appreciable difference in either toxicity or efficacy

65 No appreciable difference in inhibition was found betwee

66 he corresponding I forms, the study revealed no appreciable difference in the backbone dynamics of ei

67 onducted approximately a decade apart showed no appreciable difference in the distribution of 10-year

68 No appreciable difference in the platelet inhibition pro

69 pre-TCR and alpha beta TCR complexes exhibit no appreciable difference in their association with lipi

70 No appreciable difference was observed between simplex a

71 s, whereas the lipid bilayer thickness shows no appreciable differences and only a slight increase up

72 No appreciable differences between imidazol-2-ylidene an

73 The great majority of SNPs showed no appreciable differences in allele frequency among pop

74 Here, we show that there are no appreciable differences in disease progression, hemat

75 In healthy women, no appreciable differences in plasma concentrations of t

76 er than in the control group, and there were no appreciable differences in ST-segment shift during th

77 There were no appreciable differences in the course of the primary

78 Although no appreciable differences in type A and type B' mRNA cy

79 iperin(-/-) macrophages and dendritic cells, no appreciable differences were detected in deficient em

80 In the carotenoid fraction no appreciable differences were found between both proce

81 No appreciable differences were found in the distributio

82 t area; whereas, the VNS-treated rats showed no appreciable diminution of GAD cells rostral to the co

83 n serum at 37 degrees C for 24 hr, there was no appreciable dissociation of 99mTc.

84 AbrB23 (R25S) had no appreciable DNA binding activity but retained a hexam

85 bly, the C. parapsilosis Est3 alone exhibits no appreciable DNA-binding activity, but can be crosslin

86 induction of apoptosis in PCa cells but had no appreciable effect in normal PrEC cells.

87 gical responses to warmer temperatures (with no appreciable effect of changing rainfall).

88 No appreciable effect of substituting W for Y on the sec

89 tamination and incomplete DNA hydrolysis had no appreciable effect on 5-methyl-2'-deoxycytidine quant

90 ghly active antiretroviral therapy, we found no appreciable effect on alpha1 circle numbers in those

91 its affinity for low-affinity sites but with no appreciable effect on antagonist ([3H]mesulergine) bi

92 t, as early as 2 h after administration, had no appreciable effect on antigen-specific T- and B-cell

93 OTUD7B deficiency in mice has no appreciable effect on canonical NF-kappaB activation

94 vity of Cdc2/Cyclin B1 complex, while it had no appreciable effect on Cdk2/ Cyclin E activity even at

95 We report that CD98hc invalidation has no appreciable effect on cell adhesion, clearly showing

96 e CaP cells to chemotoxic drugs while having no appreciable effect on cell growth in the absence of t

97 2 in both glioma and breast cancer cells had no appreciable effect on cellular or secreted S1P levels

98 placebo-controlled randomized trials showed no appreciable effect on CKD or mortality months later,

99 retreatment of Caco-2 cells with MbetaCD had no appreciable effect on CPE-induced cytotoxicity.

100 oxicam, a COX-1-specific inhibitor, displays no appreciable effect on either cancer cell line even af

101 This treatment had no appreciable effect on FRAT levels in two other RA-sen

102 1017 at concentrations up to 80 mu M, showed no appreciable effect on GABA currents, whereas U-97775

103 ence into ICL3 amino or carboxyl termini had no appreciable effect on Gi coupling.

104 tion of the consensus guidelines in 2011 had no appreciable effect on HCQ dosing and that transitioni

105 The introduction of the guidelines had no appreciable effect on HCQ dosing.

106 l proliferation induced by IL-2 in G(1) with no appreciable effect on IL-2 receptor expression in a m

107 U-0126, a specific inhibitor of Mek1,2, had no appreciable effect on ionomycin-induced calpain activ

108 BH3 peptide and a mutant Bax BH3 peptide had no appreciable effect on Jurkat cells.

109 , noncanonical multiubiquitin chains but has no appreciable effect on steady-state levels or half-lif

110 First, some mutations had no appreciable effect on the ability of CaM to activate

111 the obex, and the parabrachial nucleus, had no appreciable effect on the amplitude of either vestibu

112 e addition of the substrate, fosfomycin, has no appreciable effect on the association kinetics of enz

113 pulations, we found that CCR7 deficiency had no appreciable effect on the exit of CD4 T cells from in

114 mu- or kappa-opioid receptor antagonists had no appreciable effect on the glutamate-induced injury.

115 Correcting automated errors had no appreciable effect on the interpretation of results f

116 ro invasion assays revealed that hypoxia has no appreciable effect on the invasive ability of these c

117 ility of L-serine to inhibit the enzyme have no appreciable effect on the Km or kcat of the enzyme.

118 Multivariable adjustment had no appreciable effect on the ORs for CP or MR, but the C

119 We found that removal of MGs had no appreciable effect on the stability of newly formed c

120 mitochondria of control cells and there was no appreciable effect on the steady-state level of the r

121 cantly delayed tumor rejection, while having no appreciable effect on tumor growth.

122 stivirus of the family Flaviviridae, but has no appreciable effect on vesicular stomatitis virus (VSV

123 ediate early or early viral antigens and had no appreciable effect on viral DNA synthesis.

124 s, induction of phosphatase-dead PTEN showed no appreciable effect.

125 esponse, low levels of endogenous IL-10 have no appreciable effect; exogenous rhIL-10 has a limited e

126 3A- and GluN3B-containing NMDA receptors and no appreciable effects at AMPA receptors.

127 However, anti-C5aR Abs alone had no appreciable effects on AP-1.

128 dent downregulation effected by CD8* but had no appreciable effects on high dose SEB-dependent killin

129 Replacements of TMV produced no appreciable effects on the affinities of 14 test liga

130 vector were detected after transplantation, no appreciable expansion in their numbers occurred.

131 nly assumed in evolutionary models, we found no appreciable F(1)fitness reduction and only slight F(2

132 er conditions employed herein (200 mM NaCl), no appreciable Fpg affinity for the carba-8-oxo-dG subst

133 Surprisingly, SCY4 showed no appreciable growth defect.

134 cial and invasive fungal infections, and has no appreciable hepatotoxicity.

135 tream of the homeobox; otherwise, they share no appreciable homology.

136 selectively remove deISGylase activity with no appreciable impact on its other deubiquitinase and pe

137 model, modulation of beta-catenin levels had no appreciable impact on tumor onset in an ErbB2-driven

138 There were no appreciable improvements in other bronchoalveolar lav

139 with activities in the nanomolar range with no appreciable in vitro toxicity to human cells were ide

140 rstitial macrophages and T lymphocytes, with no appreciable increase in B lymphocytes.

141 increase in NF-kappaB2/p100 expression with no appreciable increase in p52, its cleavage product.

142 e ERT use), even for 25 years or longer, had no appreciable increase in risk of breast cancer, althou

143 n a reversal of prior trends, there has been no appreciable increase in the prevalence of stage 3 and

144 up and increased from months 18 to 24, while no appreciable increase in treatment response occurred i

145 ed in the extracellular domain of LFA-1 with no appreciable influence on integrin function and confor

146 cts of medication and comorbid illnesses had no appreciable influence on the findings.

147 No appreciable inhibition was observed.

148 ATM has no appreciable inhibitory effect on other PB1-PB1 domain

149 egrity of the NCp7 protein, and (4) there is no appreciable interaction between a nonreactive isoster

150 d in other tissues examined, indicating that no appreciable intestinal absorption occurred.

151 Concurrently, no appreciable isomerization (cis to trans epoxide) was

152 to MRL-lpr/lpr mice, BALB-lpr/lpr mice show no appreciable kidney pathology.

153 We found no appreciable left ventricular intramural gradients in

154 CSD analysis revealed no appreciable local generator contribution to the visua

155 he nla4, nla6, nla18, and nla28 mutants have no appreciable loss in motility, but they fail to aggreg

156 If washed sporozoites have no appreciable loss of infectivity, they likely do not h

157 with soluble CD4 at 37 degrees C resulted in no appreciable loss of SU from either SIV or HIV-1.

158 cture with a Tm of 76.0 +/- 0.2 degreesC and no appreciable loss of the secondary structure up to 85

159 Within dairy products, no appreciable lysine was detected in yogurts.

160 in Cx50 with a cysteine resulted in small or no appreciable membrane currents.

161 ngs support the consensus view that there is no appreciable mixing of Golgi-resident enzymes with ER

162 No appreciable modification of risk by diet was detected

163 Electron microscopy revealed no appreciable morphological difference in anther cells

164 The spherical volume of the lens showed no appreciable net increase, but the axial length of the

165 seconds, with minimal background signal and no appreciable nonspecific binding, opening the possibil

166 No appreciable peak broadening and no detectable memory

167 primates, occurred at doses where there was no appreciable penetration into deep structures of the b

168 While single crf mutations have no appreciable phenotypes, disruption of multiple CRFs r

169 a DA-D2 antagonist, whereas D-Govadine shows no appreciable physiological effects at this receptor.

170 er, with mice receiving 1 and 2.5 mg showing no appreciable plasma DNA levels.

171 n of the fabricated area shows that there is no appreciable plastic deformation under a 4 nm groove,

172 No appreciable pseudoenhancement was observed with exoph

173 Recent research indicates they have no appreciable psychopathology and are as educated and e

174 r 24 h, as determined by circular dichroism; no appreciable racemization was observed in low-molecula

175 s in the prostate and pancreatic tumors with no appreciable radioactive accumulation (</= 0.1% ID) in

176 nce of pyridine, little ester is formed, and no appreciable reaction takes place with beta-oxygenated

177 omparable reactivity with glyceraldehyde and no appreciable reactivity with galactose or glucose.

178 There was no appreciable relationship between change in PAWP and c

179 No appreciable renal clearance of (64)Cu-DOTA-VEGF(121)

180 No appreciable renal toxicity was observed at any dose l

181 sitive transformed and tumorigenic cells; 3) no appreciable response of 4F2/CD98 heavy chain to argin

182 There is no appreciable role for SKPT-1 in the degradation of CDT

183 vement (Tub3, Dhc1, and Mlp2) appear to play no appreciable role in homolog juxtaposition, unlike the

184 We found no appreciable role of the ACE gene in influencing left

185 ons, while the Srs2 helicase appears to play no appreciable role.

186 No appreciable shift in the position of the catalytic tr

187 mporal profile of the transfer function with no appreciable shift in time or change in shape.

188 e D1 sequence in the critical regions showed no appreciable specific binding for several radioactive

189 To our surprise, we find no appreciable statistical dependence between the many p

190 ld type enzymes are similar; thus, there are no appreciable structural changes.

191 0 and 58 against L. major and T. cruzi, with no appreciable toxicity to human osteoblasts, resulting

192 progenitor, and stem AML cells while causing no appreciable toxicity to normal hematopoietic cells.

193 the BBB by a minor diffusional process with no appreciable transport via saturable processes.

194 Despite the increased tracer retention, no appreciable washout of tracer was observed in the pro

195 4)] site with no iron and a diiron site with no appreciable zinc in ZnS(4)Rbr were confirmed by analy