ライフサイエンスコーパス: nocardicin

コーパス検索結果 (１語後でソート)

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1 m-containing penicillins, cephalosporins and nocardicins.

2 lactam structures related to monobactams and nocardicins.

3 S-Adenosylmethionine:nocardicin 3-amino-3-carboxypropyltransferase catalyzes

4 While the nocK mutant still produced nocardicin A at levels near that seen for wild-type N. u

5 ielded mutants that maintained production of nocardicin A at levels similar to the wild-type strain.

6 c pathway, coordinating the initial steps of nocardicin A biosynthesis to the production of its pHPG

7 ules pointing to a pentapeptide precursor in nocardicin A biosynthesis, unless module skipping or oth

8 was the only N-oxidizing enzyme required for nocardicin A biosynthesis.

9 The nocardicin A biosynthetic gene cluster was recently iden

10 ence of mRNA transcripts for the early-stage nocardicin A biosynthetic genes.

11 a positive transcriptional regulator of the nocardicin A biosynthetic pathway, coordinating the init

12 escribed and its role in the biosynthesis of nocardicin A discussed.

13 Paradoxically, the nocardicin A gene cluster encodes two non-ribosomal pept

14 Like isopenicillin N, nocardicin A has a tripeptide core of non-ribosomal orig

15 rans was sufficient to restore production of nocardicin A in the disruption mutant.

16 Nocardicin A is a monocyclic beta-lactam isolated from t

17 Nocardicin A is a monocyclic beta-lactam isolated from t

18 Nocardicin A is the most potent of a series of monocycli

19 ne that did not produce detectable levels of nocardicin A or the early precursor p-hydroxybenzoyl for

20 The biosynthetic gene cluster for the nocardicin A producer Nocardia uniformis subsp. tsuyaman

21 Nocardicin A production was restored in the nocL mutant

22 and found to encode proteins in keeping with nocardicin A production, including the nocardicin N-oxyg

23 Insertional mutagenesis of nocJ abolished nocardicin A production, while the l-homoseryl isomer, i

24 the nocardicin homoseryl side chain in both nocardicin A with isonocardicin A, and nocardicin C with

25 ep is likely involved in the biosynthesis of nocardicin A, a rare but precedented editing event in th

26 The most potent of this series is nocardicin A, containing a syn-configured oxime moiety,

27 n of the 2'-amine of nocardicin C to provide nocardicin A, it was uncertain whether NocL was the only

28 Within the biosynthetic gene cluster of nocardicin A, nocR encodes a 583-amino-acid protein with

29 e S-adenosylmethionine, and a second column, nocardicin A-agarose, specifically bound the desired tra

30 me-forming enzyme required for production of nocardicin A.

31 sis of the monocyclic beta-lactam antibiotic nocardicin A.

32 The nocardicins are a family of monocyclic beta-lactam antib

33 tases NocA and NocB that lie at the heart of nocardicin biosynthesis, a family of monocyclic beta-lac

34 formis, and therefore has no obvious role in nocardicin biosynthesis, the nocL disruptant failed to g

35 Notably present in the nocardicin biosynthetic gene cluster is nocJ, encoding a

36 shown to effect oxidation of the 2'-amine of nocardicin C to provide nocardicin A, it was uncertain w

37 both nocardicin A with isonocardicin A, and nocardicin C with isonocardicin C.

38 nt accumulated the biosynthetic intermediate nocardicin C, confirming its role as the sole oxime-form

39 onfirmation of its role as the PLP-dependent nocardicin C-9' epimerase responsible for interconversio

40 phenolic site in the beta-lactam substrates nocardicin E, F, and G, a late step of the biosynthesis

41 tion to the critical beta-lactam ring of the nocardicin family of antibiotics.

42 through an unusual ether linkage to the core nocardicin framework.

43 erase responsible for interconversion of the nocardicin homoseryl side chain in both nocardicin A wit

44 with nocardicin A production, including the nocardicin N-oxygenase, NocL, in addition to genes of un

45 To further detail the role of NocL in nocardicin production in N. uniformis, and to examine th

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