ライフサイエンスコーパス: nociception

1 riggered or exacerbated peripherally induced nociception.

2 istinct pairs of sensory neurons to modulate nociception.

3 ration of autonomic nerves and modulation of nociception.

4 in primary sensory neurons where it mediates nociception.

5 nderstanding evolutionary roots of mammalian nociception.

6 enetic silencing specifically reduced facial nociception.

7 e neural development, complex behaviours and nociception.

8 tors while targeting receptors involved with nociception.

9 n and inhibits nociceptors, thereby reducing nociception.

10 d in drug addiction, movement disorders, and nociception.

11 he tail-withdrawal test, a measure of spinal nociception.

12 naling participates in the process of dental nociception.

13 ting precise spatial and temporal control of nociception.

14 ential physiological processes, most notably nociception.

15 de and TRPV1 suggestive of a role for NMB in nociception.

16 limbic areas involved with interoception and nociception.

17 unds, making it a crucial player in chemical nociception.

18 ity, vascular smooth muscle contraction, and nociception.

19 suppression of neuronal hypersensitivity and nociception.

20 this behavior could be used to measure tooth nociception.

21 of neuromodulation for processing of bladder nociception.

22 he crisis: vaso-occlusion, inflammation, and nociception.

23 ables rapid and selective optical control of nociception.

24 es such as affective regulation, reward, and nociception.

25 g a role of Piezo proteins in mechanosensory nociception.

26 naling pathways that have been linked to pro-nociception.

27 unexpected contribution of ASIC1 channels to nociception.

28 potential vanilloid 1 (TRPV1) and sensitizes nociception.

29 V1 is the principal transduction channel for nociception.

30 which has not previously been implicated in nociception.

31 y relies on neural processes engaged by self-nociception.

32 a brainstem region involved in modulation of nociception.

33 critical for survival and depends on thermal nociception.

34 ive pain-sensing neurons, but sparing normal nociception.

35 aluated these agonists in models relevant to nociception.

36 ion, but they play a minimal role in cardiac nociception.

37 reas to test the effects of CSD on meningeal nociception.

38 tivity of TRPV1 in rats and mice and reduced nociception.

39 areas not previously directly implicated in nociception.

40 irrors the interaction between attention and nociception.

41 ons involved in the facilitation of visceral nociception.

42 ariety of noxious stimuli and is involved in nociception.

43 ull expression of mechanical but not thermal nociception.

44 scular coronary disease and abnormal cardiac nociception.

45 microg/kg while having no effect on thermal nociception.

46 blocks pain behaviors in a formalin model of nociception.

47 tagonist MK-801 into the vPAG did not affect nociception.

48 nd is involved in inflammation, anxiety, and nociception.

49 rations must be primarily driven by enhanced nociception.

50 to be involved in the descending control of nociception.

51 e closely associated with excitotoxicity and nociception.

52 ium channel isoform plays a critical role in nociception.

53 drug discovery in controlling TRPV1-induced nociception.

54 implications in view of the role of TRPV1 in nociception.

55 s) play important roles in the modulation of nociception.

56 portant role in chronic inflammatory thermal nociception.

57 to play a critical role in the modulation of nociception.

58 ys, including thermal and visceral models of nociception.

59 A changes (P<0.05) during subsequent thermal nociception.

60 duced acute and chronic peripherally induced nociception.

61 s via caudal brainstem structures to control nociception.

62 modality- and sex-specific role for PMCA2 in nociception.

63 e diverse processes including blood flow and nociception.

64 and mediate protease-evoked inflammation and nociception.

65 orylation has the opposite effect on thermal nociception.

66 mouse DRG neurons selectively abolished heat nociception.

67 superficial dorsal horn, an area involved in nociception.

68 l the role of the AWC(OFF) neuron in thermal nociception.

69 cted role for TMCs in alkaline sensation and nociception.

70 ene functioning antagonistically to modulate nociception.

71 d thereby contributes to enhanced mechanical nociception.

72 ower of Drosophila for genetic dissection of nociception.

73 g genetic validation of their involvement in nociception.

74 ovel form of sensation that we term auditory nociception.

75 compounds that completely blocked persistent nociception.

76 cal mechanisms that drive distinct stages of nociception.

77 cations for sensory neuron transcription and nociception.

78 We found that, during capsaicin-induced nociception, 5,6-EET levels increased in dorsal root gan

79 in this context, we revisit the concepts for nociception, acute and chronic pain, and negative moods

80 iologic and pathologic conditions, including nociception, addiction, and fragile X syndrome.

81 gn and evaluate therapeutic efficacy of anti-nociception agent Capsaicin (Cap) and anti-TNFalpha siRN

82 ession of many genes known to be involved in nociception, analgesia, and antidepressant drug actions.

83 otrigeminal pathway is a potent modulator of nociception and a potential target for interventions to

84 matically reduced acute peripherally induced nociception and alleviated neuropathic and inflammatory

85 Girk-dependent signaling contributes to nociception and analgesia, reward-related behavior, mood

86 nervous system, where they have key roles in nociception and analgesia.

87 ce of repeated neonatal morphine exposure on nociception and analgesia.

88 ystem that make it attractive for studies of nociception and anesthesiology and plasticity of primary

89 y contribute to cognition, reward, mood, and nociception and are implicated in a range of neurologica

90 c-like conditions may dually regulate muscle nociception and cardiovascular reflexes.

91 , for the first time, the optical control of nociception and central sensitization in behaving mammal

92 , TSP4 antibodies or genetic ablation blocks nociception and changes in synaptic transmission in mice

93 s efficacious in the mouse formalin model of nociception and Chung model of neuropathic pain, without

94 hese two players in a feedback cycle linking nociception and cytoskeletal remodeling.

95 a and the mu-opioid receptors that influence nociception and ethanol consumption, respectively.

96 ately been associated with regulating muscle nociception and exercise pressor reflexes (EPRs), and P2

97 down Dmpiezo in sensory neurons that mediate nociception and express the DEG/ENaC ion channel pickpoc

98 2-AG or AEA inhibit nociception and feeding through a pathway requiring the

99 part of the neural circuitries that mediate nociception and fertility, any deviation from its normal

100 ing postnatal influence of the RVM in spinal nociception and highlight the central role of descending

101 , synaptic, neuropeptide release to modulate nociception and highlight the similarities between the t

102 tinal pathology, thereby modulating visceral nociception and IBS symptomatology, and might provide an

103 In particular, TRPA1 channel is involved in nociception and in sensory perception of many pungent ch

104 TP receptor P2X(3) is strongly implicated in nociception and is more abundant on trigeminal primary a

105 avalpha2delta1 knockdown blocks TSP4 induced nociception and its pathological correlates.

106 Cannabinoids also modulate nociception and locomotion through an NPR-19-independent

107 ptor (MOR)-expressing dorsal horn neurons in nociception and morphine analgesia is incompletely under

108 is a proton-gated ion channel implicated in nociception and neuronal death during ischemia.

109 irect measures of specific brain function of nociception and new insights into preoperative evaluatio

110 re believed to be key signaling molecules in nociception and nociceptive sensitization.

111 the understanding of the neurodevelopment of nociception and of the wide array of factors that may im

112 Sexually dimorphic nociception and opioid antinociception is very pervasive

113 ibility of functional, endogenous MOP-CB1 in nociception and other pharmacologic effects has been rai

114 dorsal root ganglia (DRG) neurons mediating nociception and other sensory modalities express many ty

115 re known to exert powerful control of spinal nociception and pain behaviours in adult mammals.

116 ate the Nav1.1 subtype, the role of which in nociception and pain has not been elucidated.

117 Currently there are no objective measures of nociception and pain in the perioperative period.

118 s point to ZBTB20 as a critical regulator of nociception and pain sensation by modulating TRP channel

119 ecifically in nociceptors showed a defect in nociception and pain sensation in response to thermal, m

120 Thus progress on studies of nociception and pain-like responses in animal models dep

121 e basolateral amygdala of mice with resolved nociception and persisting behavioral effects.

122 ch D1-like receptors (D1LRs) modulate spinal nociception and plasticity by regulating activation of t

123 within the PFC in the modulation of visceral nociception and point to TLR4 as a potential therapeutic

124 OT release from these OT neurons suppresses nociception and promotes analgesia in an animal model of

125 f regulated endogenous nucleotide release in nociception and provide a detailed mechanism of a pain-i

126 ach and duodenum and play a role in visceral nociception and reflexes.

127 ple genes and the environment that influence nociception and regulate the consciousness of pain.

128 found suggestive evidence of involvement of nociception and renin-angiotensin systems in this effect

129 entral and peripheral nerves responsible for nociception and sensitization of the defensive behavior

130 kably, Avil-cre;Sptan1(f/f) mice have intact nociception and small-diameter axons, but severe ataxia

131 y transduction channel that mediates thermal nociception and some aspects of pathological pain.

132 feeding and metabolism, learning and memory, nociception and spinal reflexes, and anxiety and related

133 for PAP in purine nucleotide metabolism and nociception and suggest a novel use for PAP in the treat

134 The reported link between nociception and targets of the anti-inflammatory drug su

135 ning in meal duration is a response to tooth nociception and that this nociception can be measured fo

136 muscle afferents can dually regulate muscle nociception and the exercise pressor reflex.

137 role for Tachykinin signaling in regulating nociception and the power of Drosophila for genetic diss

138 rstanding of the physiological mechanisms of nociception and thermosensation, the molecular mechanics

139 neuronal activity that underlie the onset of nociception and touch discrimination in the preterm infa

140 for reward effects, the tail flick test for nociception, and a measure of locomotor activity for gen

141 ases and ion channels involved in olfaction, nociception, and blood coagulation.

142 ed by a reduction in neutrophil recruitment, nociception, and cartilage degradation.

143 one-trial and multitrial fear conditioning, nociception, and extinction of conditioned taste aversio

144 processes, including synaptic transmission, nociception, and fear.

145 delta-1 is involved in various modalities of nociception, and for the development of behavioral hyper

146 Stress modifies nociception, and humans with post-traumatic stress disor

147 processing affective/pleasure/motivational, nociception, and mating-specific (such as for erection a

148 otective effect of RPCT is initiated by skin nociception, and requires neurogenic signaling involving

149 re likely to have distinct roles in visceral nociception, and that (2) the chronic stress-induced enh

150 aV1.7), a channel reported to be involved in nociception, and thus it might have potential as a pain

151 behavioral changes as shown by anxiety-like, nociception, and touch-sensitivity tests.

152 as unrelated to altered fear conditioning or nociception, and was dissociable from intact appetitive

153 tributes to the regulation of vascular tone, nociception, angiogenesis and the inflammatory response.

154 However, cerebral contributions beyond nociception are not yet well characterized, leading to a

155 the brain creates a painful experience from nociception are still unknown.

156 We redefine nociception as the mechanism protecting the organism fro

157 TRPV1 plays a key role in nociception, as it is activated by heat, low pH, and lig

158 wild-type mice in any model of inflammatory nociception assessed.

159 rojections have an impact on CeA stress- and nociception-associated maladaptive responses, which can

160 Nociception behavior is elicited by the ecologically rel

161 Finally, optogenetically triggered nociception behavior is unaffected by pickpocket RNAi, w

162 The nociception behavior of Drosophila melanagaster larvae i

163 mpairment without causing defects in thermal nociception behavior.

164 e range of physiological processes including nociception, behavior, cognitive function, appetite, met

165 requirement for Balboa and PPK in mechanical nociception behaviors and their specific expression in l

166 e mutant for pickpocket show greatly reduced nociception behaviors in response to harsh mechanical st

167 ogenetics to activate larval nociceptors and nociception behaviors in the third-larval instar.

168 EG/ENaC) subunit, is required for mechanical nociception but not thermal nociception in these sensory

169 ng ion channel 3 (ASIC3) is involved in acid nociception, but its possible role in neurosensory mecha

170 the hypothalamus and has been implicated in nociception, but the circuit mechanisms remain unexplore

171 eceptor (MC4R) ligands are known to modulate nociception, but the site of action of MC4R signaling on

172 nels are important for thermal sensation and nociception, but their gating mechanisms have remained e

173 We demonstrate that rapamycin modulates nociception by acting on subsets of primary afferents an

174 gest that Hsp90 promotes opioid-induced anti-nociception by an ERK mechanism in mouse brain and that

175 ate that the ectonucleotidase NT5E regulates nociception by hydrolyzing AMP to adenosine in nocicepti

176 a high-FODMAP (HFM) diet increases visceral nociception by inducing dysbiosis and that the FODMAP-al

177 response to tooth nociception and that this nociception can be measured for over a week.

178 The evidence that nociception can be regulated at the level of mRNA transl

179 hototransduction, smooth muscle contraction, nociception, cell proliferation and control of neuronal

180 namely on perineural cells, and in line with nociception defects of the JAM-C SC KO animals, on finel

181 ence support the adaptive value of immediate nociception during injury, no direct evidence exists for

182 er gait alterations were related to enhanced nociception, edema, or motor nerve dysfunction.

183 cessary for discrimination between touch and nociception emerge from 35-37 weeks gestation in the hum

184 proton-gated cation channels associated with nociception, fear, depression, seizure, and neuronal deg

185 , our results indicate a critical mechanical nociception function for heteromeric PPK and Balboa chan

186 nce abuse, emesis, inflammatory pain, spinal nociception, gastrointestinal function, and cardiovascul

187 , and how such varying effects may impact on nociception given the role of this channel in sensory ac

188 le of each subtype in modulating anxiety and nociception have been inconsistent.

189 ances in our understanding of the process of nociception have led to insight into gene-based pain the

190 dose-response curve in suppression of acute nociception (i.e., the hot-plate assay) when morphine pr

191 et in nociceptors phenocopies the mechanical nociception impairment without causing defects in therma

192 ice also exhibited attenuation of mechanical nociception in a gene dose-dependent manner.

193 ropathic pain but only slightly blocked anti-nociception in a naive tail-flick model, while enhancing

194 these P2X(7) antagonists effectively reduced nociception in a rat model of neuropathic pain (Chung mo

195 new population of OT neurons that modulates nociception in a two tier process: (1) directly by relea

196 id agonist and NK1R antagonist in inhibiting nociception in an animal model of acute pain while lacki

197 th its ability to attenuate formalin induced nociception in an animal model of pain.

198 during mechanical-, heat-, and cold-induced nociception in anesthetized rats.

199 he tyraminergic/octopaminergic inhibition of nociception in C. elegans and the noradrenergic inhibiti

200 se results demonstrate that opiates modulate nociception in Caenorhabditis elegans through a complex

201 er development or maintenance of neuropathic nociception in either neuropathic pain model.

202 e and neuropeptide signaling acts to inhibit nociception in food-poor environments.

203 elegans and the noradrenergic inhibition of nociception in mammals that also involves inhibitory pep

204 y network to the noradrenergic inhibition of nociception in mammals, where norepinephrine suppresses

205 ed in controlling mechanical and temperature nociception in mice.

206 a2AARs using the tail flick assay of thermal nociception in mice.

207 ition strongly blocked morphine-induced anti-nociception in models of post-surgical and HIV neuropath

208 Both basal mechanical and thermal nociception in neonatal, morphine-exposed rats were sign

209 lower nociceptor excitability and attenuate nociception in peripheral tissues.

210 bose) polymerase-1 inhibitor PJ34 on altered nociception in streptozotocin-induced diabetic rats.

211 n pathway and not associated with changes in nociception in the absence of injury or with changes in

212 nd to be concordant with previous studies of nociception in the anaesthetised rat brain, supporting t

213 l networks that directly influence meningeal nociception in the brainstem trigeminocervical complex (

214 They contribute to sensory function and nociception in the peripheral nervous system, and in the

215 ventromedial medulla (RVM), known to modify nociception in the spinal cord dorsal horn.

216 molecular characteristics that differentiate nociception in the trigeminal system from that in the so

217 d for mechanical nociception but not thermal nociception in these sensory cells.

218 6% acetic acid and the inflammatory phase of nociception induced by 2.5% formalin, indicating that th

219 ver, the ruthenium complexes inhibited overt nociception induced by formalin, acetic acid, capsaicin,

220 could account for all of the changes in anti-nociception induced by Hsp90 inhibition.

221 nvolved in the biologic pathways relevant to nociception, inflammation, and mood.

222 tion during urothelial stretch is central to nociception, inflammation, contractility, and proliferat

223 s in ppk-positive cells, and that mechanical nociception is abolished in the absence of both channels

224 Abnormal cardiac nociception is also a cause for persistent chest pain ca

225 Nociception is an evolutionarily conserved mechanism to

226 Nociception is essential for survival whereas pathologic

227 provide novel support to the view that self-nociception is involved during empathy for pain, and dem

228 The current knowledge about heat nociception is mainly confined to the thermosensors, inc

229 Nociception is protective and prevents tissue damage but

230 sed that central sensitization associated to nociception (maladaptive plasticity) and plasticity rela

231 valuated, using thermal stimulation to evoke nociception, measuring changes in paw withdrawal latenci

232 Functions of ASICs in mammals include nociception, mechanosensation, and modulation of synapti

233 tch) and additionally in a capsaicin-induced nociception model of pain without any confounding effect

234 tal gray (PAG) is a brain region involved in nociception modulation, and an important relay center fo

235 the hot-plate test, a measure of supraspinal nociception, morphine antinociception was increased, and

236 ling pathways that are essential for vision, nociception, motor coordination, and reward processing.

237 Although capsaicin-induced nociception, neuropeptide release, and ionic currents ar

238 hypothesis that cryolipolysis can attenuate nociception of a range of sensory stimuli, including sti

239 psaicin, and has been extensively studied in nociception of sensory neurons.

240 TRPV1 receptors feature prominently in nociception of spinal primary afferents but are also exp

241 ate this, we examined mechanical and thermal nociception on postnatal days 11, 13, 15, 19, 24, 29, 39

242 but is not essential for heat or mechanical nociception or hypersensitivity in the adult mouse.

243 ological processes that indirectly influence nociception, or alleviate pain arising from the overload

244 ivated current (I(h)) has been implicated in nociception/pain, but its expression levels in nocicepto

245 c neuropathy is manifested either by loss of nociception (painless syndrome) or by mechanical hyperal

246 TRP ion channels participate in nociception, presumably via Ca(2+) influx, in most anima

247 e was enhanced in the presence of persistent nociception, producing a phenomenon of analgesia-enhance

248 molecular mechanisms by which mTOR regulates nociception remain unclear.

249 but the site of action of MC4R signaling on nociception remains to be elucidated.

250 heteromers, and, consequently, their role in nociception remains unknown.

251 and is functionally required for mechanical nociception responses.

252 f complex physiological functions, including nociception, reward processing, and motivation.

253 ved in forebrain circuits related to memory, nociception, social fear, and auditory sensory integrati

254 previously validated markers of TMJ pain or nociception (specifically, meal duration and food intake

255 ed into four categories: those that modulate nociception, stabilize or unload painful structures, inf

256 TRPV1-microtubule interaction in transducing nociception stimuli to cells by cytoskeletal rearrangeme

257 of thermosensors only partially impairs heat nociception, suggesting the existence of undiscovered me

258 n diverse physiological processes, including nociception, synaptic plasticity, learning, and memory.

259 ivated by external protons and play roles in nociception, synaptic transmission, and the physiopathol

260 tion), motor activity (activity monitor) and nociception (tailflick, pawlick) measures was compared.

261 uate the effect of blocking TLR4 on visceral nociception, TAK-242, a selective TLR4 antagonist, was a

262 In a tail flick assay of nociception, TAL increased response latency by 65 and 70

263 Neuropathic pain is a form of pathological nociception that occurs in a significant portion of trau

264 Chemical nociception, the detection of tissue-damaging chemicals,

265 Nociception, the sensory mechanism that allows animals t

266 from the brain, and is commonly a result of nociception; the physiological process initiated by acti

267 calcium channels (T-channels) in peripheral nociception; therefore, our goal was to examine the func

268 d cold sensitivity, but no change in thermal nociception threshold.

269 genetic inhibition of mechanical and thermal nociception thresholds.

270 EREG-mediated activation of EGFR enhanced nociception through a mechanism involving the PI3K/AKT/m

271 d producing supraspinal inhibition of spinal nociception through activation of serotonergic and norad

272 esults indicate that feeding state modulates nociception through the interaction of monoamine and neu

273 ons in thermosensation, thermoregulation and nociception, thus significantly extending the concept of

274 diverse physiological processes ranging from nociception to taste.

275 sential pathways for transmission of cardiac nociception to the central nervous system during myocard

276 sensitivity but not those mediating thermal nociception under naive conditions.

277 rons to downstream targets in the context of nociception, using novel transgenic lines, optogenetics,

278 suggest that maternal loss of Ube3a affects nociception via a central, but not peripheral mechanism,

279 indings indicate that S1P evokes significant nociception via G-protein-dependent activation of an exc

280 scular system during heat- and cold-mediated nociception via modulating glutamatergic/GABAergic neuro

281 This reduction in nociception was comparable to an intra-TMJ injection of

282 Nociception was determined by electronic Von Frey test.

283 nd tumor necrosis factor alpha (TNFalpha) in nociception was evaluated through behavioral and enzyme-

284 voltage-gated sodium channel 1.7 (Nav1.7) in nociception was revealed by remarkable human clinical an

285 into the genetic and neural basis of thermal nociception, we developed assays that quantify noxious h

286 the noradrenergic/peptidergic modulation of nociception, we examined the octopaminergic inhibition o

287 ion channel subunits required for mechanical nociception, we identify a gene that we name balboa (als

288 To directly test the importance of PIP(2) in nociception, we intrathecally injected PIP(2) into mice.

289 e monoarthritis as a condition of persistent nociception, we showed that analgesia induced by either

290 nderlying regional differences in processing nociception, we sparsely traced non-peptidergic nocicept

291 mulations, namely, proprioception, touch and nociception were delivered to the limb and the electrone

292 DMSO had no effect on nociception when microinjected into the vlPAG alone, but

293 acterized, leading to a predominant focus on nociception when studying pain and developing interventi

294 teers to characterize perceptual learning in nociception, which has been rarely studied.

295 identify a similar region as fundamental to nociception, which suggests the dpIns is its human homol

296 SC) module produced robust, lateralised anti-nociception while activation of LC(:PFC) produced aversi

297 udy provides a novel molecular mechanism for nociception with possible implications for pain sensitiv

298 , but noradrenergic signalling promotes anti-nociception, with alpha(2)-adrenergic agonists used clin

299 a critical role for scaffolding proteins in nociception, yet few studies have investigated scaffoldi

300 s ligand, lysophosphatidylinositol (LPI), in nociception, yet their role in central pain processing h