ライフサイエンスコーパス: nociceptive neuron

1 stinct underlying mechanisms within a single nociceptive neuron.

2 brainstem to drive feedforward inhibition of nociceptive neurons.

3 ay enhance the signaling of primary afferent nociceptive neurons.

4 el, Na(v)1.7, which is strongly expressed in nociceptive neurons.

5 ting on the histamine H1 receptor in C-fiber nociceptive neurons.

6 eased in situ to activate TRPV1 receptors on nociceptive neurons.

7 heat germ agglutinin (WGA) to nonpeptidergic nociceptive neurons.

8 d vanilloid receptor 1, a marker for primary nociceptive neurons.

9 s are therefore hypothesized to be polymodal nociceptive neurons.

10 with significantly larger N-type currents in nociceptive neurons.

11 oxious heat and inflammatory hyperalgesia in nociceptive neurons.

12 be the principal heat-responsive channel for nociceptive neurons.

13 ct membrane properties of these two types of nociceptive neurons.

14 he TRPV1 ion channel and selectively ablates nociceptive neurons.

15 important cation channel present on primary nociceptive neurons.

16 nhancing the descending inhibition of spinal nociceptive neurons.

17 tenance of mature dorsal root ganglion (DRG) nociceptive neurons.

18 gulation of opioid excitability functions in nociceptive neurons.

19 led an upregulation of Nav1.3 in dorsal horn nociceptive neurons.

20 the electroresponsive properties of primary nociceptive neurons.

21 during the falling phase, characteristic of nociceptive neurons.

22 ted cation channel acting as key receptor in nociceptive neurons.

23 actions on chemokine receptors expressed by nociceptive neurons.

24 e employed to rapidly and selectively delete nociceptive neurons.

25 expected degree of molecular diversity among nociceptive neurons.

26 d for the proper development of pain-sensing nociceptive neurons.

27 elopment of pain therapies targeted at these nociceptive neurons.

28 by substance P or serotonin, in contrast to nociceptive neurons.

29 l root ganglion (DRG) neurons, which include nociceptive neurons.

30 in the function of C. elegans olfactory and nociceptive neurons.

31 id (NMDA) excited nociceptive as well as non-nociceptive neurons.

32 by action potential activity in a subset of nociceptive neurons.

33 between cranial sensory neurons and the PBL-nociceptive neurons.

34 r mechanisms underlying such interactions in nociceptive neurons.

35 eveal that balboa is also highly enriched in nociceptive neurons.

36 s-sensitization between AITC and acidosis in nociceptive neurons.

37 that Kv7.5 provides the primary M current in nociceptive neurons.

38 , regions that contain functionally distinct nociceptive neurons.

39 tissues but has not been directly studied in nociceptive neurons.

40 ar milieu to control excitability of primary nociceptive neurons.

41 ly, many of these agents activate peripheral nociceptive neurons.

42 ion channels and is expressed in a subset of nociceptive neurons.

43 ceptor TRPV1, a key ion channel expressed in nociceptive neurons.

44 ) family of ion channels and is expressed in nociceptive neurons.

45 tory Gs-coupled opioid receptor signaling in nociceptive neurons.

46 receptor expression in small non-peptidergic nociceptive neurones.

47 These included 10/21 C-fibre nociceptive neurones.

48 ificant), and was similar to that of A-fibre nociceptive neurones.

49 lar single unit recordings were made from 61 nociceptive neurons (23 NS, 38 WDR) in the superficial a

50 ns (23 NS, 38 WDR) in the superficial and 37 nociceptive neurons (3 NS, 34 WDR) in the deeper dorsal

51 edge of the molecular composition of KARs in nociceptive neurons, a key piece in understanding the me

52 We report a signaling pathway of SP in nociceptive neurons: Acting predominantly through NK1 re

53 larly in the enhanced excitability of spinal nociceptive neurons after repeated noxious inputs, are l

54 rMrgD with rMrgE, which occurs in peripheral nociceptive neurons, allowed coimmunoprecipitation of th

55 the nociceptive neurones, was not limited to nociceptive neurones and apart from receptive properties

56 ctly with TRPV1, an ion channel expressed in nociceptive neurones and brain.

57 n pathway for protease-induced activation of nociceptive neurons and an important new target for anti

58 ibits the enhancement of responses of spinal nociceptive neurons and changes in exploratory behavior

59 gulate the physiological properties of other nociceptive neurons and drive central sensitization.

60 sed preferentially in most slowly conducting nociceptive neurons and in sympathetic neurons.

61 nkyrin 1 (TRPA1) ion channel is expressed in nociceptive neurons and its activation causes ongoing pa

62 maintain hyperresponsiveness of spinal cord nociceptive neurons and pain-related behaviors.

63 ales acute noxious mechanical sensitivity in nociceptive neurons and suppresses neuropathic pain tran

64 ce high-frequency action potential firing in nociceptive neurons and that resurgent currents associat

65 The function of Mrgprd in nociceptive neurons and the physiologically relevant som

66 of ecto-5'-nucleotidase (CD73) in trigeminal nociceptive neurons and their axonal fibers, including t

67 identities and spinal terminations of TrkA+ nociceptive neurons and TrkC+ proprioceptive neurons.

68 However, how TrkA regulates the function of nociceptive neurons and whether its activity levels may

69 (Nav1) transmit pain signals from peripheral nociceptive neurons, and blockers of these channels have

70 R) superfamily, is expressed specifically in nociceptive neurons, and is implicated in the modulation

71 aV2.3 calcium channels are both expressed in nociceptive neurons, and mice lacking either protein dis

72 V4) in Xenopus laevis oocytes, HEK cells and nociceptive neurons, and stimulated neuronal hyperexcita

73 onism suppressed PAR(2) signaling to primary nociceptive neurons, and TRPV4 deletion attenuated PAR(2

74 tability of L3-L5 dorsal horn multireceptive nociceptive neurons, and when pain-related behaviors wer

75 Spinal nociceptive neurons are well known to undergo a process

76 um channel Nav1.9 is expressed in peripheral nociceptive neurons, as well as visceral afferents, and

77 Ablation of the nociceptive neurons ASH and ADL transforms social animal

78 e transmembrane protein ODR-4, acting in the nociceptive neurons ASH and ADL.

79 as hyperresponsiveness in lumbar dorsal horn nociceptive neurons associated with the aberrant express

80 In nociceptive neurons, Balboa::GFP proteins distribute uni

81 aled upregulation of Na(v)1.3 in dorsal horn nociceptive neurons but not in astrocytes or microglia,

82 by changes in the excitability of peripheral nociceptive neurons, but the precise mechanisms controll

83 lgesic lipid-derived mediators, which excite nociceptive neurons by activating selective G-protein-co

84 zed of these is the sensitization of primary nociceptive neurons by arachidonic acid metabolites such

85 ectly inhibit peripheral capsaicin-sensitive nociceptive neurons by dephosphorylating and desensitizi

86 modulation of presynaptic TRPV1 channels in nociceptive neurons by descending noradrenergic inputs m

87 PD-1 activation in DRG nociceptive neurons by PD-L1 induced phosphorylation of

88 review how non-neuronal cells interact with nociceptive neurons by secreting neuroactive signaling m

89 G protein-coupled receptors of nociceptive neurons can sensitize transient receptor pot

90 In addition, nociceptive neurons did not exhibit windup in the SP-SAP

91 (e.g., lipopolysaccharides) activate primary nociceptive neurons directly through Toll-like receptors

92 rotrophin family, is crucial for survival of nociceptive neurons during development.

93 and its activator, p35, are up-regulated in nociceptive neurons during peripheral inflammation.

94 PD-L1 also potently suppressed nociceptive neuron excitability in human DRGs.

95 Nociceptive neurons express a unique set of ion channels

96 dy, we tested the hypothesis that trigeminal nociceptive neurons express the TLR4 or CD14 receptors,

97 Most nociceptive neurons express the vanilloid receptor, TRPV

98 ed cytotoxicity and the specific deletion of nociceptive neurons expressing the wild-type vanilloid r

99 nables reversible optical silencing of mouse nociceptive neuron firing without exogenous gene express

100 al, functional and molecular similarities to nociceptive neurons from more complex organisms and can

101 is phenomenon may allow new insight into how nociceptive neuron function in response to a variety of

102 eceptive (LTM) neurons showed Nav1.8-LI, and nociceptive neurons had significantly more intense immun

103 Nociceptive neurons have also been reported in the vicin

104 RG neurons, a process that may contribute to nociceptive neuron hyperexcitability, which is associate

105 f-avoidance of sister dendrites from the PVD nociceptive neuron in Caenorhabditis elegans.

106 he firing of two important classes of spinal nociceptive neurons in a rat model of OA.

107 - and C-fiber-evoked responses of trigeminal nociceptive neurons in anesthetized rats.

108 1), has been shown to be highly expressed by nociceptive neurons in dorsal root and trigeminal gangli

109 as located on peptidergic and nonpeptidergic nociceptive neurons in dorsal root ganglia (DRG) and on

110 P3 receptor at these sites did not sensitize nociceptive neurons in healthy animals.

111 tly related to functional distinctions among nociceptive neurons in maturity.

112 Selective targeting of sensory or nociceptive neurons in peripheral nerves remains a clini

113 Gly potently inhibited heat-evoked firing of nociceptive neurons in rat dorsal horn.

114 pid GM1 ganglioside plays a critical role in nociceptive neurons in regulating opioid receptor excita

115 Recordings were made from 29 nociceptive neurons in the C2 dorsal horn of the rat tha

116 Pirt is expressed in most nociceptive neurons in the dorsal root ganglia (DRG) inc

117 NMDA-evoked responses of nociceptive and non-nociceptive neurons in the medullary dorsal horn.

118 Nociceptive neurons in the peripheral nervous system det

119 exclusively, expressed in smaller trigeminal nociceptive neurons in the rat.

120 tion of MOG results in aberrant sprouting of nociceptive neurons in the spinal cord.

121 ular changes that sensitize the responses of nociceptive neurons in the spinal dorsal horn.

122 the A delta- and C-fiber-evoked responses of nociceptive neurons in the superficial and deeper dorsal

123 the A delta- and C-fiber-evoked responses of nociceptive neurons in the superficial and deeper dorsal

124 dan-1,5-dicarboxylic acid), were examined on nociceptive neurons in the ventroposterolateral (VPL) nu

125 s of the cannabinoid agonist WIN 55,212-2 on nociceptive neurons in the ventroposterolateral (VPL) nu

126 ed receptor 2 was expressed by virtually all nociceptive neurons in thoracic dorsal root ganglia.

127 ration prevented some CFA-induced changes in nociceptive neurons including: the increased fiber follo

128 itatory postsynaptic currents in spinal cord nociceptive neurons, increased CGRP release from sciatic

129 ough which reactive prostanoids may activate nociceptive neurons independent of prostaglandin recepto

130 to more fully understand how the activity in nociceptive neurons individually and collectively is rel

131 Here we show that activation of nociceptive neurons induces shedding of L-selectin from

132 In nociceptive neurons, inhibition tended to be maximal at

133 Nociceptive neurons innervate the skin with complex dend

134 small subpopulations of pruriceptive and/or nociceptive neurons innervating the cheek project to tha

135 Pulpitis and osteitis affected the nociceptive neurons innervating the orofacial region by

136 was observed in a subpopulation of putative nociceptive neurons innervating the site of inflammation

137 ecision required for chemotaxis, whereas ASH nociceptive neurons integrate noxious cues over several

138 lation of TRPV1 channels by noradrenaline in nociceptive neurons is a mechanism whereby noradrenaline

139 s PKD, and the expression of PKD isoforms by nociceptive neurons is poorly characterized.

140 which is constitutively expressed by primary nociceptive neurons, is the link between peripheral infl

141 m synaptic connections with the second-order nociceptive neurons located in the dorsal horn of the sp

142 rated transduction of cells positive for the nociceptive neuron marker vanilloid receptor subtype 1,

143 X in the regulation of [Ca(2+)]i in putative nociceptive neurons may be unique relative to other cell

144 modulation of TRPV1 channels by dopamine in nociceptive neurons may represent a way for dopamine to

145 eport provides a genetic analysis of primary nociceptive neuron mechanisms that promote sensitization

146 In the nociceptive neurons, ODR-3 may interact with OSM-9, a ch

147 potential cation channel V1 expressed in the nociceptive neurons of dorsal root ganglion (DRG).

148 In HEK and KNRK cell lines and in nociceptive neurons of mouse dorsal root ganglia, Cat-S

149 lso known as the vanilloid receptor, VR1) in nociceptive neurons of the dorsal root and trigeminal ga

150 known as NaN) is preferentially expressed in nociceptive neurons of the dorsal root ganglia (DRG) and

151 potential ankyrin 1 (TRPA1) is expressed by nociceptive neurons of the dorsal root ganglia (DRGs) an

152 Although TRPV1 receptors are mainly found in nociceptive neurons of the peripheral nervous system, th

153 Here, we describe how nociceptive neurons of the spinal cord and thalamus proc

154 ivated ionophore preferentially expressed in nociceptive neurons of trigeminal and dorsal root gangli

155 The peripheral terminals of primary nociceptive neurons play an essential role in pain detec

156 opposing sensory inputs: aversive inputs to nociceptive neurons promote social feeding, whereas anta

157 Comparisons of data from nociceptive neurones recorded in CFA treated animals aft

158 ion of the presynaptic terminals of adjacent nociceptive neurons requires different levels of Trim9,

159 the differentiation and survival of sensory nociceptive neurons, requires Brn3a to maintain normal t

160 d predominantly in sensory neurons including nociceptive neurons responding to protons.

161 specifically in the Class IV multidendritic nociceptive neuron, significantly attenuated ultraviolet

162 al nociception by describing a population of nociceptive neurones that receive convergent input from

163 show here that social feeding is induced by nociceptive neurons that detect adverse or stressful con

164 dorsal root ganglia (DRG) neurons, including nociceptive neurons that expressed TRPV1, PAR(2), and ne

165 this cascade in mechanical sensitization of nociceptive neurons that innervate the meninges, a proce

166 tained protease signaling to colonocytes and nociceptive neurons that naturally express PAR2 and medi

167 The neuronal loss is restricted to nociceptive neurons that normally depend on TrkA for neu

168 identify a subpopulation of nonpeptidergic, nociceptive neurons that project exclusively to the skin

169 vous system senses peripheral damage through nociceptive neurons that transmit a pain signal.

170 hyperexcitability and spontaneous firing of nociceptive neurons that underlie pain.

171 n modulate the activity of TRPV1 channels in nociceptive neurons, the effects of dopamine and dopamin

172 sensory transmission in nociceptive and non-nociceptive neurons, thereby contributing to radicular p

173 d and released by peripheral damage-sensing (nociceptive) neurons; these neurons also express SP rece

174 G) E(2) and D(2), respectively, would excite nociceptive neurons through direct activation of TRPA1.

175 tering the sensitivity and/or selectivity of nociceptive neurons to aversive stimuli.

176 i.v.) it did not alter the responses of non-nociceptive neurons to brush stimulation.

177 ansient receptor potential (TRP) channels of nociceptive neurons to induce neurogenic inflammation an

178 asting increases in the responses of central nociceptive neurons to innocuous and noxious stimuli.

179 The responsiveness of spinal cord nociceptive neurons to innocuous mechanical stimuli can

180 d reduced responses of peripheral and spinal nociceptive neurons to noxious stimuli but only when the

181 t that ubiquitination is a mechanism used in nociceptive neurons to regulate TrkA level and function.

182 functional complexes that allow craniofacial nociceptive neurons to respond synergistically to altere

183 its acute pain and alters the sensitivity of nociceptive neurons to subsequent stimuli.

184 somes, convey NGF signals from the target of nociceptive neurons to their cell bodies.

185 Results suggest that nociceptive neurons use the BMP2/4 ligand, along with id

186 ide (iCGRP) release from capsaicin-sensitive nociceptive neurons via in vitro superfusion of bovine d

187 ediator in this condition, can also activate nociceptive neurons via the proteinase-activated recepto

188 TRPV1, a PGE2-regulated channel in nociceptive neurons was also increased in the DRG.

189 ending inhibitory mechanism acting on spinal nociceptive neurons was obtained by monitoring noxious s

190 RP expression was detected in under half the nociceptive neurones, was not limited to nociceptive neu

191 ether SFL is caused by spontaneous firing in nociceptive neurons, we studied the following groups of

192 th nasal or labial receptive fields, whereas nociceptive neurons were found in the adjacent portions

193 matic action potential (AP) configuration in nociceptive neurons were incomplete 24 hr after CFA.

194 Drosophila melanogaster larvae whose primary nociceptive neurons were reduced in levels of specific c

195 m clusters of selectively thermoreceptive or nociceptive neurons were used to guide precise microinje

196 ate immune response, is regulated by primary nociceptive neurons, which are generally considered to h

197 expression of Cdk5 and its activator p35 in nociceptive neurons, which is modulated during a periphe

198 Alkaline pH evokes an inward current in nociceptive neurons, which is primarily mediated by TMC-

199 Inhibition or removal of certain nociceptive neurons, while retaining all other sensory m

200 There was a tendency for nociceptive neurones with slower CVs and/or smaller cell

201 be attributed to a sensitization of central nociceptive neurons with an increased excitability to af

202 e, type C low-threshold mechanosensitive and nociceptive neurons with markedly different molecular an