1 ing the photoreceptor-specific expression of
nocturnin.
2 cells, in a pattern identical to endogenous
nocturnin.
3 A deletion series of the
nocturnin 5'-flanking sequence driving the green fluores
4 nvolved in such circadian control identified
nocturnin,
a novel gene that displays high-amplitude cir
5 distinct spatial and temporal expression of
nocturnin and PARN suggests that there may be specific m
6 mal triglyceride transfer protein (MTP), and
nocturnin are involved in the circadian regulation of in
7 re we report that the targeted disruption of
Nocturnin (
Ccrn4l) in mice, a gene that encodes a circad
8 /or translational silencing, we propose that
nocturnin deadenylates clock-related transcripts in a no
9 Our data support a pivotal role for
Nocturnin downstream of the circadian clockwork in the p
10 nocturnin promoter, which we designated the
nocturnin element (NE).
11 e 388 amino acid protein that we have named "
nocturnin" (
for night-factor).
12 t the PCE II in the proximal promoter of the
nocturnin gene is sufficient for driving the photorecept
13 is precise spatial expression pattern of the
nocturnin gene.
14 Nocturnin is a clock-regulated deadenylase that controls
15 Nocturnin is a vertebrate circadian clock-regulated gene
16 Substrate preference studies show that
nocturnin is an exonuclease that specifically degrades t
17 ter homolog of the vertebrate circadian gene
nocturnin is expressed in a subset of dorsal neurons and
18 Here we show that
nocturnin is expressed rhythmically in the small intesti
19 The deadenylase and leucine zipper protein
Nocturnin is now shown to play a central role.
20 While
nocturnin is rhythmically expressed in the cytoplasm of
21 The gene
nocturnin is rhythmically transcribed in Xenopus retinal
22 Gene expression data suggest that
Nocturnin knockout mice have deficits in lipid metabolis
23 Our observations suggest that
nocturnin may function through protein-protein interacti
24 Expression of
nocturnin mRNA is confined to the clock-containing photo
25 Nocturnin mRNA levels exhibit a high amplitude circadian
26 Mice lacking
nocturnin (
Noc(-/-) mice) are resistant to diet-induced
27 Nocturnin (
NOC) is a circadian-regulated protein related
28 Nocturnin (
NOC) is a unique deadenylase with robustly rh
29 Nocturnin nuclease activity is magnesium dependent, as t
30 Transcription of
nocturnin peaks in these cells in the middle of the nigh
31 Therefore, we propose that
nocturnin plays an important role in the trafficking of
32 ied a novel protein-binding motif within the
nocturnin promoter, which we designated the nocturnin el
33 Mice lacking
Nocturnin remain lean on high-fat diets, with lower body
34 In these studies, we show that
nocturnin removes the poly(A) tail from a synthetic RNA
35 t P-CREB controls the rhythmic regulation of
nocturnin transcription and perhaps that of other night
36 toreceptors, with a phase similar to that of
nocturnin transcription.