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1 d signaling at low concentrations of zygotic Nodal.
2 tants only when co-expressed with endogenous Nodal.
3 ted, processed and active in the presence of Nodal.
4 t Gdf3 functions at the same pathway step as Nodal.
5 ry behaviors in cells that have not received Nodal.
6 nd ubiquitous Vg1, and zygotic and localized Nodal.
15 troduce versatility, V, as a novel metric of nodal affiliation: V approximately 0 means that a node i
22 ntestinalis Previous studies have implicated Nodal and FGF signals in the specification of lateral an
23 clarified the role of two signaling factors, Nodal and Gdf3, during the early stages of development.
24 ng topology of the DMN, we investigated both nodal and global dynamic DMN-topology metrics across dif
26 mmunohistochemistry) early breast cancer any nodal and human epidermal growth factor receptor 2 statu
29 upporting the involvement of the specialised nodal and perinodal domains (the paranode and juxtaparan
30 detection of autoantibodies directed against nodal and perinodal targets is likely to be of increasin
31 ent on LR patterning genes, including Foxj1, Nodal and Pitx2 Our findings have implications for how L
33 nitors, GATA factors directly regulate BMP4, Nodal and Wnt signaling components that promote embryoni
34 cells further from the margin, which receive Nodal and/or Fgf signaling, are specified as mesoderm.
35 resides in the endoplasmic reticulum without Nodal, and is only secreted, processed and active in the
37 ngly non-Fermi liquid behavior, including a "nodal-antinodal dichotomy" reminiscent of that seen in s
38 propose that disruption of the cytoskeleton, nodal architecture, and other components of axon infrast
40 node formation; however, its precise role in nodal assembly, stability, and maintenance is still not
42 e and human disialosyl antibodies target the nodal axolemma, induce acute axonal degeneration in the
43 s in clipped nodes reflect the status of the nodal basin and if targeted axillary dissection (TAD), w
48 of preoperative imaging in defining axillary nodal burden, deselection of patients for sentinel lymph
50 ward flow generated by asymmetric beating of nodal cilia, which eventually induces asymmetric Nodal/L
53 ng-term stabilization of the newly assembled nodal complex, and that loss of AnkG after nodal stabili
56 hand, late ablation of AnkG from established nodal complexes leads to slow but progressive nodal dest
57 re no longer juxtaposed, and single detached nodal complexes replace the symmetrical heminodes found
58 id nodal disassembly but to loss of specific nodal components in a time-dependent manner.SIGNIFICANCE
61 increase in heart rate and atrioventricular nodal conduction properties and might be critical for va
63 ent of loss of cell-cell contact and Activin/Nodal-dependent pluripotency and a peptide is described
65 een successfully retrieved at surgery, while nodal deposits of any size continue to mandate completio
66 odal complexes leads to slow but progressive nodal destabilization over 10 months, primarily affectin
67 anocolloid activity of 150 MBq to facilitate nodal detection against the gamma-probe background signa
68 r nodal stabilization does not lead to rapid nodal disassembly but to loss of specific nodal componen
70 inoma of the head and neck who have advanced nodal disease (stage N2 or N3) and who have received che
73 r risk of death among patients with residual nodal disease [overall cohort, HR 0.63 (0.48-0.84); aden
74 ility of finding N2 or N3 (prN2/3) malignant nodal disease on endobronchial ultrasound-guided transbr
77 first empirically based estimates of occult nodal disease risk in patients after surgery for papilla
82 d to identify patients who underwent upfront nodal dissection for mucosal head and neck squamous cell
85 as used to show that left-right signaling of Nodal, downstream of symmetry breaking, may be an ancest
86 tonic coupling, and stochastic pacing on the nodal dynamics of spatially discordant alternans, we pro
87 zed beta = 0.21, P = 0.010) and time-varying nodal efficiency (standardized beta = 0.17, P = 0.024).
88 ns of the bilateral precuneus showed reduced nodal efficiency, and the reduction of efficiency was si
92 We show that the expression status of these nodal factors can be altered by inducing the OsMADS1-GR
93 ional tumor controls (ie, including isolated nodal failure) were 82% (95% CI, 62%-92%) and 62% (95% C
96 ell fate allocation, we now demonstrate that Nodal functions in an incoherent feedforward loop, toget
97 between the axon and myelinating glia at the nodal gap (i.e., NF186) and the paranodal junction (i.e.
104 S-glycosylation site of GmCLV1A causes stem nodal identity alterations as well as flower and pod abn
105 Introduction of a single mutant allele of Nodal in the Tet mutant background partially restored pa
109 e risk of distant recurrence was 13% with no nodal involvement (T1N0), 20% with one to three nodes in
110 ted adenocarcinoma appears to have decreased nodal involvement at the time of resection and increased
111 rbidity, receipt of neoadjuvant therapy, and nodal involvement, a longer survival was associated with
112 weighted derived tumor diameter, para-aortic nodal involvement, advanced stage, ADC90 and ADC95, nADC
113 extension beyond the prostatic capsule), no nodal involvement, and a detectable PSA level of 0.2 to
114 Given the patient's age, tumor size, lack of nodal involvement, and clear surgical margins, she met r
116 have further assessed the impact of regional nodal irradiation in women with either high-risk node-ne
118 ments of ventral neural progenitors, whereas Nodal is essential for the characteristic stacking behav
120 ion; "sculpting" of a terminal hook from the nodal joint; and often additional adjustments, such as l
121 l cilia, which eventually induces asymmetric Nodal/Lefty/Pitx2 expression on the left side of the lat
123 We examined the diffusion coefficient of Nodal ligands and Lefty inhibitors in live zebrafish emb
125 attenuates the activity of a point source of Nodal ligands Squint and Cyclops in a non-cell autonomou
126 eport the discovery of two-dimensional Dirac nodal line fermions in monolayer Cu2Si based on combined
128 toemission spectroscopy (ARPES) with a Dirac nodal line near the Fermi level identified using scannin
132 imetals (TSMs) including Weyl semimetals and nodal-line semimetals are expected to open the next fron
133 ero-dimensional points, the band crossing of nodal-line semimetals forms a one-dimensional closed loo
134 aracterization, the existence of topological nodal-line states in the non-centrosymmetric compound Pb
138 ation that preserves translational symmetry, nodal lines require protection by additional crystalline
144 vealed that NG2 cell processes contacted the nodal membrane at discrete points, while astrocytes had
145 e, revealing that IQCJ-SCHIP1 contributes to nodal membrane-associated cytoskeleton organization, lik
146 e variants (SSNVs) identified in synchronous nodal metastases and metachronous recurrent tumors, resp
147 odes in the proximal field, and 8 months for nodal metastases in both truncal and the proximal field.
149 PSMA) PET/CT is a new method to detect early nodal metastases in patients with biochemical relapse of
151 breast pCR had a relative risk for positive nodal metastases of 7.4 (95% CI, 3.7-14.8; P < .001) com
153 tive study of patients with biopsy-confirmed nodal metastases with a clip placed in the sampled node
154 l status after NCT, and the risk for missing nodal metastases without axillary surgery in this cohort
155 patients with pathologically proven axillary nodal metastases, (18)F-fluciclovine-avid axillary nodes
156 ee survival was 170 months in the absence of nodal metastases, 35 months for metastases limited to lo
157 he study cohort (n = 8772), 333 patients had nodal metastases, for an overall positivity rate of 3.8%
161 a disease-related outcome (local recurrence, nodal metastasis, distant metastasis, or disease-specifi
162 blished p-EMT as an independent predictor of nodal metastasis, grade, and adverse pathologic features
164 lated significantly with patients presenting nodal metastatic melanoma, suggesting that targeting thi
165 Patients with axillary node-negative or nodal micrometastases, estrogen receptor-positive, and h
168 erved in spleen (n = 14), liver (n = 3), and nodal (n = 8) lesions and corresponded to foci FDG uptak
169 e show that paranode-dependent clustering of nodal Na(+) channels requires axonal betaII spectrin whi
171 lymph-node dissection (dissection group) or nodal observation with ultrasonography (observation grou
172 gene more frequently (P = 0.02) compared to nodal or extranodal cases, alluding to distinct immunopa
174 d as to whether AnkG functions as an initial nodal organizer or whether it functions as a nodal stabi
177 eages can check proliferative potential, but nodal pathways that can limit tumor growth are obscure.
178 flow, resulting in a signaling cascade - the Nodal-Pitx2 pathway - being robustly established within
179 eaking of embryonic L-R symmetry and how the Nodal-Pitx2 pathway controls lateralized cell differenti
180 rect attention to the anteroventral BST as a nodal point in a stress-modulatory network for coordinat
181 ote, the sarcomeric z-disc also represents a nodal point in cardiomyocyte function and signaling.
182 esults illuminate how MCPIP1 serves as a key nodal point in coordinating tumor growth, angiogenesis,
185 sic balancing mechanism involving AKT as the nodal point of PI3K, mTORC1/2 and GSK3beta that coordina
190 hat IQCJ-SCHIP1 interacts with several major nodal proteins, and we suggest that it contributes to a
192 From 7 European centers, 140 patients with nodal PTCL who underwent baseline PET/CT were selected.
195 mine rates of axillary dissection (ALND) and nodal recurrence in patients eligible for ACOSOG Z0011.
196 ollow-up >/=12 months, the 5-year cumulative nodal recurrence rate was 1% and did not differ signific
198 revalence, data on atypical atrioventricular nodal reentrant tachycardia (AVNRT) are scarce, and the
200 n patients with CHD who had atrioventricular nodal reentrant tachycardia and were treated with cathet
204 timulation, [Ca(2+)] elevations localized to nodal regions occurred in mouse motor axons from ventral
205 asic understanding of the highly specialised nodal regions of peripheral nerves serves to strengthen
206 ively compromised in T2DM, whereas the other nodal regions of the DMN, including the medial prefronta
208 er, these results demonstrate that CCN3 is a nodal regulator in AAA biology and identify CCN3 as a po
212 d with gluconeogenesis, entailing a critical nodal role of PEPCKmt in linking catabolism of glucose a
213 rmal development (crown roots on cereals and nodal roots on strawberry [Fragaria spp.]) and in respon
214 operative axillary imaging or routine use of nodal RT, ALND can be avoided in a large majority of Z00
216 that zebrafish lefty mutants exhibit excess Nodal signaling and increased specification of mesendode
217 ates mesodermal cell migration downstream of Nodal signaling and indirectly affects endodermal cell m
218 AEL can be used to resolve multiple roles of Nodal signaling at different stages of embryonic develop
219 ta indicate that gdf3 is critical for robust Nodal signaling at multiple stages in zebrafish embryoni
220 strate that Gdf3 is an essential cofactor of Nodal signaling during establishment of the embryonic ax
221 ification of the three germ layers by graded Nodal signaling has long been seen as a paradigm for pat
223 s are less tolerant of mild perturbations to Nodal signaling levels than wild type embryos, they can
224 ' postulates that Toddler signaling enhances Nodal signaling to properly specify endoderm, whereas th
227 d to elevated DNA methylation, as both Lefty-Nodal signalling and normal morphogenesis are largely re
228 xidation of 5-methylcytosine modulates Lefty-Nodal signalling by promoting demethylation in oppositio
229 ored patterning, suggesting that hyperactive Nodal signalling contributes to the gastrulation failure
231 hat TGFss superfamily members, antagonist of Nodal signalling LEFTY1 and CER1, are paracrine determin
232 ed interactions between Wnt/beta-catenin and Nodal signalling, whereas BMP signalling is dispensable.
234 insensitive and nonspecific because both use nodal size criteria, which is notoriously inaccurate.
235 and survival, adjusting for factors such as nodal size, laterality, extranodal extension, margin sta
236 etwork that integrates essential Wnt-Tcf and nodal-Smad inputs in a selective and interdependent way
239 d nodal complex, and that loss of AnkG after nodal stabilization does not lead to rapid nodal disasse
240 nodal organizer or whether it functions as a nodal stabilizer after the nodal complex has been assemb
241 ters, as well as novel concepts of metabolic nodal stage (mN) and metabolic nodal response (mNR).
242 for the tumor stage in 20 subjects, for the nodal stage in 22 patients, and for extrathoracic metast
243 aim to systematically evaluate the impact of nodal stage migration on survival in SCCA and address a
249 ptor-positive vs hormone receptor-negative), nodal status (0 vs 1-3 vs or >/=4 positive nodes), and t
250 (HR, 1.75; 95% CI, 1.16-2.64; P = .008), and nodal status (HR, 1.45; 95% CI, 1.12-1.87; P = .05) were
251 1.78; 95% CI, 1.00-3.17; P = .05), positive nodal status (HR, 5.89; 95% CI, 2.05-16.87; P = .001), a
253 ffs for tumor size (<2.2 cm, >/=4.8 cm,) and nodal status (no positive nodes, 1 to 3 positive nodes,
254 ssess the associations of tumor diameter and nodal status (TN), tumor grade, and other factors with p
257 and traditional prognostic variables such as nodal status and stage indicated that the computer extra
258 ic resonance (MR) imaging in determining the nodal status of non-small cell lung cancer (NSCLC) with
259 view of the declining influence of axillary nodal status on adjuvant therapy decision-making, ongoin
261 1 studies with 5-year survival stratified by nodal status, and 20 studies with hazard ratios in our a
262 n tumor characteristics (tumor stage, grade, nodal status, and comorbidity) rather than differences i
263 cation by country, age, radiotherapy intent, nodal status, and oestrogen receptor and HER-2 status.
264 ficant association with metastasis, positive nodal status, and poor survival of colon cancer patients
265 a definite indication for chemotherapy, any nodal status, any hormone receptor status, Eastern Coope
266 ination, grade, hormone receptor status, and nodal status, between the screening-detected invasive ca
267 stic factors for disease-free survival; only nodal status, both central and local grade, and RS were
269 -sided log-rank test stratified according to nodal status, prior adjuvant chemotherapy, the interval
270 multivariable analysis that was adjusted for nodal status, prior use of hormone replacement therapy,
272 termined from a Cox model incorporating age, nodal status, tumor size and grade, and estrogen recepto
279 y-p-phenylene wires (i.e., PHEn) changes the nodal structure of HOMO that leads to length-invariant o
280 havior and proximity to metallic states with nodal superconductivity mark this d-band system as uncon
281 ed inconsistent inferences, both in terms of nodal support and topology, with smaller subsets of the
282 ted with NCT followed by standard breast and nodal surgery from January 1, 2010, through December 31,
284 d volume (including metabolic tumor volume), nodal SUVmax, and our new concepts of mN stage and mNR.
286 maternal transcription factor that mediates Nodal/TGF-beta signaling, with cis-regulatory modules (C
287 nhibits the funny current (If) in sinoatrial nodal tissue, resulting in a decrease in the rate of dia
288 ether the ability of the mesendoderm inducer Nodal to activate its inhibitor Lefty is required for de
289 revealed divergent dynamic reorganization in nodal topological characteristics between groups, in the
292 linical response (the absence of primary and nodal tumour by clinical examination), in addition to ov
297 of grid stress, a prediction of the largest nodal voltage deviation, and an estimate of the distance
298 result in voltage collapse blackouts, where nodal voltages slowly decline before precipitously falli
299 1, highlighting p62 and redox homeostasis as nodal vulnerabilities for therapeutic targeting in these
300 with BMP-4 in addition to its known partner Nodal, whereas Cryptic interacts only with Activin B.
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