ライフサイエンスコーパス: nodose

1 The nodose A delta neurones adapted rapidly to mechanical st

2 ne also failed to activate stretch-sensitive nodose A-fibres in the lungs.

3 ischarge in nociceptive C-fibers (41/44) and nodose Adelta fibres (29/30) that are rapidly adapting l

4 innervate the intestines, and that the left nodose afferents innervate predominantly the duodenum.

5 In addition, CARTp-IR neurons in the nodose also were stained positively for NADPH-diaphorase

6 eurons, as well as of sensory neurons of the nodose and dorsal root ganglia.

7 d that a population of Fluorogold-containing nodose and dorsal root ganglion cells were also PACAP-po

8 ies demonstrated the presence of PACAP-IR in nodose and dorsal root ganglion cells, but not in neuron

9 The nerve terminals within the lungs of both nodose and jugular C-fibres responded with action potent

10 After 7 d, the nodose and jugular ganglia were removed, sectioned, and

11 autonomic afferent fibre cell bodies in the nodose and jugular ganglia.

12 ely labeled nerve cell bodies located in the nodose and jugular ganglia.

13 th intact afferent vagal pathways, including nodose and jugular ganglia.

14 in the vagal sensory ganglia referred to as nodose and jugular ganglia.

15 patch clamp recording of capsaicin-sensitive nodose and jugular ganglion neurones retrogradely labell

16 Both the nodose and jugular vagal ganglia provide sensory innerva

17 ferent neurons whose somata reside in vagal (nodose and jugular) ganglia.

18 dies reside within two distinct ganglia, the nodose and jugular, and whose properties allow for diffe

19 nt input from BDNF-containing neurons in the nodose and petrosal cranial sensory ganglia.

20 Mature nodose and petrosal ganglia neurons (placodally derived

21 e issues we defined survival requirements of nodose and petrosal neurons for GDNF in vitro and in bdn

22 lation of ganglion cells in the dorsal root, nodose and trigeminal ganglia exhibited moderate-to-stro

23 rdings were made from dissociated guinea-pig nodose and trigeminal ganglion neurons in culture to stu

24 g cardiac ganglia, and sections of stellate, nodose, and dorsal root ganglia (DRG, thoracic levels 1-

25 neuronal populations including sympathetic, nodose, and dorsal root ganglion sensory neurons.

26 Nodose axons also grew selectively toward cocultured net

27 accompanied by action potential discharge in nodose, but not in jugular C-fibres.

28 H 58261 (0.1 microm) partially inhibited the nodose C-fibre activation by adenosine, and the combinat

29 sts, blocked the bronchoconstriction-induced nodose C-fibre discharge.

30 hat, like the nerve terminals, lung specific nodose C-fibre neurones express functional P2X receptors

31 cin and bradykinin application, but only the nodose C-fibre population responded with action potentia

32 that adenosine selectively depolarizes vagal nodose C-fibre terminals in the lungs to action potentia

33 paration to study the electrical activity of nodose C-fibres in response to bronchoconstriction.

34 The nodose C-fibres responded strongly to serotonin and this

35 nosine-induced action potential discharge in nodose C-fibres was mimicked by either the selective A1

36 ction potential discharge in jugular but not nodose C-fibres.

37 pivotal role in the mechanical activation of nodose C-fibres.

38 In patch-clamp studies, nodose, coeliac and superior cervical ganglia (SCG) neur

39 We found that, although the left nodose contained significantly more neurons (7,603), tha

40 articularly significant in the brainstem and nodose cranial sensory ganglia (NGs), structures critica

41 the neurons of the geniculate, petrosal, and nodose cranial sensory ganglia.

42 ly the morphologically distinct, myelinated, nodose-derived mechanoreceptors described in animals are

43 geminal) ectoderm is grafted in place of the nodose (epibranchial) placode, Pax3-expressing cells for

44 branchial placodes (geniculate, petrosal and nodose) form visceral sensory neurons that innervate tas

45 innervated the bladder and colon in both the nodose ganglia (NG) and L6/S1 and L1/L2 dorsal root gang

46 pinal cord potassium channel) contributes to nodose ganglia (NG) malfunction, disrupting gastrointest

47 ed by allergic inflammation were examined in nodose ganglia (NG) removed from guinea pigs immunized t

48 t in a majority of vagal afferent neurons of nodose ganglia (NG), immunoreactivity for other NMDA rec

49 the 5-HT3A subunit in superior cervical and nodose ganglia (NG).

50 ly in both the dorsal root ganglia (DRG) and nodose ganglia (NG).

51 A small percentage of the nAChRs in nodose ganglia also contain alpha2 and alpha4 subunits.

52 60% of the labeled neurons were found in the nodose ganglia and 40% in the jugular ganglia.

53 ose-excited and glucose-inhibited neurons in nodose ganglia and characterize their glucose-sensing pr

54 mn (T1 to L1), ipsilateral and contralateral nodose ganglia and ipsilateral dorsal root ganglia from

55 2, Bmal1, and Nr1d1 mRNA is expressed in the nodose ganglia and levels oscillated over a 24 h period.

56 ors are found in cranial afferent neurons in nodose ganglia and their central terminations within the

57 ound that aortic baroreceptor neurons in the nodose ganglia and their terminals express ASIC2.

58 ent neurons whose cell bodies resided in the nodose ganglia and whose receptive fields were located i

59 findings indicate that the nAChRs in SCG and nodose ganglia are heterogeneous, which suggests that di

60 vagal sensory neurons located in the jugular-nodose ganglia complex (JNC) with identified receptive f

61 that a majority of the nAChRs in the SCG and nodose ganglia contain the alpha3 and beta4 subunits, bu

62 in vagal afferent neurons isolated from rat nodose ganglia demonstrated that 31/118 (26%) neurons we

63 Cardiac afferents from the nodose ganglia differed from CDRGNs in having smaller ac

64 Most vagal afferent neurons in rat nodose ganglia express mRNA coding for the NR1 subunit o

65 Both rat and human nodose ganglia expressed OX-R1 as detected by RT-PCR, an

66 increased neural proliferation within adult nodose ganglia following capsaicin-induced neuronal deat

67 ified in the visceral sensory neurons of the nodose ganglia from rats through immunocytochemical stud

68 Substance P/Neurokinin A positive neurons in nodose ganglia from virus-inoculated guinea pigs at Day

69 Neurites from explanted E14 nodose ganglia grew selectively toward cocultured E14 di

70 These results show that rat nodose ganglia have glucose-excited and glucose-inhibite

71 microinjection of AAV vectors into the vagal nodose ganglia in vivo leads to selective, effective and

72 nous GLP-1, we established a novel bilateral nodose ganglia injection technique to deliver a lentivir

73 etween CCK and serotonin at the level of the nodose ganglia may explain the robust postprandial pancr

74 Two groups of nodose ganglia neurones were identified: group A neurone

75 mp recordings were performed on isolated rat nodose ganglia neurons.

76 carbocyanine methanesulfonate (DiI) into the nodose ganglia of animals with prior supranodose de-effe

77 of Fos-immunoreactive neuronal nuclei in the nodose ganglia of LETO rats, but not in the nodose gangl

78 anscripts encoding DCC were expressed in the nodose ganglia of mice from E12 to adulthood but were de

79 nodose ganglia of LETO rats, but not in the nodose ganglia of OLETF rats.

80 ation of GLP-1R mRNA expression in the vagal nodose ganglia of OP rats.

81 m agglutinin-horseradish peroxidase into the nodose ganglia of rats that had received unilateral vent

82 urons in primary neuronal cell cultures from nodose ganglia of rats.

83 on of TRPV1-expressing pulmonary neurones in nodose ganglia of sensitized rats; this increase in TRPV

84 ceptor alpha and beta (LXRalpha/beta) in the nodose ganglia of the vagus nerve.

85 immunoreactive neurons in the trigeminal and nodose ganglia over this period of development.

86 ivo gene silencing of PI3K and Erk1/2 in the nodose ganglia prevented ghrelin inhibition of leptin- o

87 ve afferent neurones with cell bodies in the nodose ganglia projected to the rostral trachea and lary

88 t Lipofectamine transfection of cultured rat nodose ganglia to determine the effect of these molecule

89 Na(V)1.7 gene expression in nodose ganglia was effectively and selectively reduced w

90 OX-R1 and -R2 expression by rat and human nodose ganglia was examined by reverse-transcriptase pol

91 Nodose ganglia were collected from 8-week-old female C57

92 The nodose ganglia were labeled starting 4 days PI, suggesti

93 Rat aortic baroreceptor neurones in the nodose ganglia were labelled in vivo by applying a fluor

94 MDA subunits expressed in the left and right nodose ganglia were not significantly different.

95 After at least 1 week, the nodose ganglia were removed and the neurons were culture

96 ely from the NA, neurons of the DmnX and the nodose ganglia were surveyed for DiI labeling.

97 mall neurons of dorsal root, trigeminal, and nodose ganglia) and localizes to their sensory terminals

98 ishes a latent infection in sensory ganglia (nodose ganglia) of the tenth cranial nerve.

99 gular ganglia) and placode-derived neurones (nodose ganglia) project C-fibres in the vagus, and that

100 CR analysis, its expression is restricted to nodose ganglia, and not present in cortex, hippocampus,

101 e dorsal vagal complex of the hindbrain, the nodose ganglia, and the ganglia of the myenteric and sub

102 observed scattered 5-HT1D-IR neurons in the nodose ganglia, and there was sparse terminal immunoreac

103 re given injections of dextran biotin in the nodose ganglia, and, after tracer transport, stomach who

104 cluding the petrosal, superior cervical, and nodose ganglia, as well as ganglia in the myenteric plex

105 e in lung C-fibre terminals arising from the nodose ganglia, but failed to evoke action potential dis

106 NOS-IR cells were also present in the nodose ganglia, but only some exhibited CGRP immunoreact

107 The fast-blue-positive neurons in the nodose ganglia, by contrast, were large in diameter (40

108 In nodose ganglia, CAP but not alphabeta-m-ATP evoked inwar

109 transcripts and protein were detected in the nodose ganglia, OT signaling might also affect extrinsic

110 superior cervical, and 12 of 36 and 1 of 36 nodose ganglia, respectively.

111 the superior cervical ganglia (SCG), sensory nodose ganglia, stellate ganglia, and pelvic ganglia.

112 The nodose ganglia, the stomach, the first 8 cm of duodenum,

113 ervating the duodenum were recorded from rat nodose ganglia.

114 polymodal Adelta-fibres that arise from the nodose ganglia.

115 hannels in sensory neurons isolated from rat nodose ganglia.

116 nal populations can be identified within the nodose ganglia.

117 fied as PCR products from mRNA prepared from nodose ganglia.

118 glion and Adelta-fibres from the jugular and nodose ganglia.

119 C6-IR cells were also present in sections of nodose ganglia.

120 rvating the intestine were recorded from rat nodose ganglia.

121 R cells and NOS-IR cells were present in the nodose ganglia.

122 ACAP-IR cells and fibers were present in the nodose ganglia.

123 ion may be carried by the circulation to the nodose ganglia.

124 NOS innervation is probably derived from the nodose ganglia.

125 of a putative sodium channel (NaNG) from dog nodose ganglia.

126 ncluding the petrosal, superior cervical and nodose ganglia.

127 CsA) on cardiac sensory neurons (CSN) of the nodose ganglia.

128 ic plexus were retrogradely labeled from the nodose ganglia.

129 gene expression is prevalent in human adult nodose ganglia.

130 lament-positive pulmonary sensory neurons in nodose ganglia.

131 d larger currents compared to those from the nodose ganglia.

132 arbocyanine perchlorate (DiI) bilaterally to nodose ganglia.

133 ncreatic inflammation, we studied pancreatic nodose ganglion (NG) and dorsal root ganglion (DRG) sens

134 d currents in dorsal root ganglion (DRG) and nodose ganglion (NG) neurons that innervate the stomach

135 e expressed in vagal afferent neurons in the nodose ganglion (NG), we also systematically compared MC

136 m currents are similarly distributed between nodose ganglion A-fibres and C-fibres innervating the lu

137 Those fibres derived from the nodose ganglion adapted rapidly, whereas those derived f

138 for recording of isometric tension while the nodose ganglion and attached vagus nerve were pulled int

139 ylrhodamine and biotin was injected into the nodose ganglion and used to label the terminal arbors of

140 injection of horseradish peroxidase into the nodose ganglion anterogradely labelled axonal boutons we

141 Neurons of the nodose ganglion are derived from the epibranchial placod

142 trast, embryonic day 15 superior cervical or nodose ganglion axons grew heavily into the same age hea

143 three findings: 1) the presence of NADPHd in nodose ganglion cells with morphological features of fir

144 chnique, we identified cultured adult rabbit nodose ganglion cells with slow AHPs in current-clamp mo

145 acutely dissociated vagal afferent neurones (nodose ganglion cells) of the ferret to investigate the

146 acutely dissociated vagal afferent neurones (nodose ganglion cells) of the ferret to investigate the

147 vation of guinea pig airway-specific primary nodose ganglion cells.

148 The nodose ganglion contained the somata of mainly fast-cond

149 om these results we concluded that the vagal nodose ganglion contains neurones that may possess only

150 Dorsal root ganglion and nodose ganglion expressed all isoforms except for CA IX.

151 otinylated dextran amine (BDA) into the left nodose ganglion in rats.

152 Vagal afferents were labeled by nodose ganglion injections of wheat germ agglutinin-hors

153 Animals received nodose ganglion injections of wheat germ agglutinin-hors

154 roxidase (0.5-1.0 mul) was injected into the nodose ganglion ipsilateral to the vagotomized side.

155 Nodose ganglion neurones (NGNs) become less excitable fo

156 tch-clamp recording from acutely dissociated nodose ganglion neurones (NGNs) we have examined the ion

157 e in properties between P2X2/3 receptors and nodose ganglion neurones further supports the conclusion

158 Here we show that OEA directly excited nodose ganglion neurones, the cell bodies of vagal affer

159 ndles and patch clamp recordings of isolated nodose ganglion neurons (NGNs).

160 ganglion neurons, and that the responses of nodose ganglion neurons to ATP show altered kinetics and

161 ilar age-related changes in the responses of nodose ganglion neurons to BDNF were observed in culture

162 n a subpopulation of vagal afferent neurons (nodose ganglion neurons), the pattern of impulse activit

163 Unlike nodose ganglion neurons, both retinal ganglion cells (RG

164 which have only 45% of the normal number of nodose ganglion neurons, exhibit selective losses of the

165 Adult inferior vagal ganglion neurons (nodose ganglion neurons, NGNs) were acutely isolated 4-6

166 ion in the sustained ATP-induced currents in nodose ganglion neurons.

167 GFP expression in approximately one-third of nodose ganglion neurons.

168 toxin B (CT-B) from NTS-X to NADPHd-positive nodose ganglion neurons; and 3) striking reductions of N

169 root ganglion (DRG) and approximately 50% of nodose ganglion neurons] to evoke a depolarizing inward

170 g MTII injection into the NTS ipsilateral to nodose ganglion removal was significantly attenuated, wh

171 Finally, unilateral nodose ganglion removal, resulting in degeneration of va

172 ed synapsin I phosphorylation ipsilateral to nodose ganglion removal.

173 Nodose ganglion sensory neurones exert a significant ref

174 placode marker Pax2 and form neurons in the nodose ganglion that express the epibranchial neuron mar

175 etramethylrhodamine dextran (TMR-D) into the nodose ganglion to label vagal aortic afferents (at 3 an

176 tract that could be anterogradely labeled by nodose ganglion tracer injections was quantitatively ass

177 tracing of vagal afferents arising from the nodose ganglion was achieved with biotinylated dextran a

178 he retrograde transport of [125I]NT-3 to the nodose ganglion was reduced by NT-3 and by NGF, and the

179 main bronchi with the right vagus nerve and nodose ganglion were isolated from guinea-pigs passively

180 d 24 months of age were injected in the left nodose ganglion with 3 microl of either 4% wheat germ ag

181 urons, in developing petrosal ganglion (PG), nodose ganglion, and dorsal root ganglion neurons grown

182 hin-4 (NT-4) to perikarya in the ipsilateral nodose ganglion, and transganglionically transported [12

183 , no such changes were observed in the vagal nodose ganglion, demonstrating that the effect of high o

184 nating from neurogenic placodes, such as the nodose ganglion, failed to express EGFP, suggesting that

185 In the nodose ganglion, NF-immunoreactive neurones accounted fo

186 pathway (the nucleus tractus solitarii, NTS; nodose ganglion, NG).

187 nocortin-4 receptor (MC4R) expression in the nodose ganglion, where the cell bodies of vagal sensory

188 TrkA and TrkC and the absence of TrkB in the nodose ganglion, whereas the profile for NT-4 suggests a

189 ot affect the adaptation of rapidly adapting nodose ganglion-derived nerve endings in response to mec

190 The electrophysiological adaptation of nodose ganglion-derived neurones following prolonged sup

191 nucleus of the solitary tract, the target of nodose ganglion-derived visceral afferents.

192 are reproduced in mice lacking Piezo2 in the nodose ganglion.

193 rs are exclusively A-fibres arising from the nodose ganglion.

194 strema, nucleus tractus solitarius (NTS) and nodose ganglion.

195 strema, nucleus tractus solitarius (NTS) and nodose ganglion.

196 from the medulla oblongata, spinal cord, and nodose ganglion.

197 trols) was injected with WGA-HRP in the left nodose ganglion.

198 horseradish peroxidase (WGA-HRP) in the left nodose ganglion.

199 l after the main period of cell death in the nodose ganglion.

200 gglutinin-horseradish peroxidase in the left nodose ganglion.

201 denum by GFP-positive neurons located in the nodose ganglion.

202 Neither nodose ganglionectomy nor vagotomy altered the CB1 recep

203 This staining disappeared after nodose ganglionectomy, consistent with a presynaptic fun

204 projection fields ipsilateral to unilateral nodose ganglionectomy.

205 By contrast, C-fibres from nodose (inferior) neurones innervate primarily structure

206 and excitation of laryngeal C neurons in the nodose/jugular (N/J) ganglia.

207 an extracellular electrode positioned in the nodose/jugular ganglion.

208 Also, the rapid adaptation of nodose nerve endings in the trachea observed during a me

209 We previously demonstrated that nodose nerve endings supplying the trachea are exquisite

210 roject neurites along central and peripheral nodose neurite pathways and survive until well after the

211 all, approximately 10% of the large-diameter nodose neurofilament-positive neurons projecting fibers

212 of NT4 and caused PNEC hyperinnervation and nodose neuron hyperactivity.

213 n of 5-HT evoked dose-dependent increases in nodose neuronal discharges.

214 These results suggested that the nodose neuronal responses to luminal osmolarity and to t

215 hibitor, abolished luminal factor-stimulated nodose neuronal responses.

216 nist each abolished the luminal 5-HT-induced nodose neuronal responses.

217 granisetron abolished luminal stimuli-evoked nodose neuronal responses.

218 G/PNa was not different for P2X2, P2X2/3 and nodose neurones (0.03) but was significantly higher (0.0

219 PNa was not different among P2X3, P2X2/3 and nodose neurones (1.2-1.5) but was significantly higher (

220 Nodose neurones all showed immunoreactivity for both P2X

221 iological recordings from gastric-projecting nodose neurones assessed the ability of glucose to modul

222 ce P (SP) responsiveness in acutely isolated nodose neurones from adult guinea-pigs was investigated

223 ward current in both control and HFD gastric nodose neurones in vitro, the 5-HT response and receptor

224 Nodose neurones incubated with 5-HT in the presence of n

225 We conclude that MS nodose neurones may be unimodal MS or bimodal MS/CS, and

226 Histologically, nodose neurones projecting lung C-fibres were different

227 A separate group of nodose neurones that possessed high-affinity CCK type A

228 at both the P2X2/3 heteromeric receptor and nodose neurones.

229 oth receptors (P2X2/3) and from cultured rat nodose neurones.

230 otentials (APs) in acutely dissociated adult nodose neurones.

231 ientations into the nuclei of BDNF-dependent nodose neurons and NGF-dependent trigeminal neurons at s

232 er a single action potential, the AHPslow in nodose neurons displays a slow rise time to peak (0.3-0.

233 Double labeling revealed that 30.2% of nodose neurons expressed immunoreactivity to both NR2B a

234 IH was found in all neonatal nodose neurons in vitro, contrary to previous reports wh

235 In sharp contrast, 80% of nodose neurons isolated 24 h after in vivo aerosolized a

236 ion of substance P (SP; 0.1 to 10 microM) to nodose neurons isolated from guinea pigs with normal uni

237 present in 56.7% of neurons; NR2C-expressing nodose neurons made up 49.4% of the total population; NR

238 l RT-PCR, we noted that the vast majority of nodose neurons retrogradely labelled from the lung, expr

239 2A receptor mRNA was expressed in individual nodose neurons retrogradely labelled from the lungs.

240 ed the airway-specific, capsaicin-sensitive, nodose neurons to action potential threshold.

241 otype such that large, capsaicin-insensitive nodose neurons with fast-conducting "Adelta" fibers prov

242 its in dorsal root ganglion, sympathetic and nodose neurons, but not in hindbrain noradrenergic or mi

243 recording, CsCl, which inhibits only I(H) in nodose neurons, hyperpolarized the resting membrane pote

244 ta indicate that the M-current is present in nodose neurons, is activated at resting membrane potenti

245 and HCN4 immunoreactivity was present in all nodose neurons.

246 n marker Phox2a on the same schedule as host nodose neurons.

247 changes in the tachykinin responsiveness of nodose neurons.

248 tes to the resting membrane potential in all nodose neurons.

249 CCK stimulated CARTp release from cultured nodose neurons.

250 ed among gastric- and portal vein-projecting nodose neurons.

251 reactivity colocalized with NR2D in 13.1% of nodose neurons.

252 NMDA NR1 subunit was present in 92.3% of all nodose neurons.

253 unoreactivities were colocalized in 11.5% of nodose neurons.

254 reactivity was observed in just 13.5% of all nodose neurons.

255 in the rostral portion and non-neural crest (nodose) neurons in the more central and caudal portions

256 neurons in vivo, we analyzed development of nodose (NG), petrosal (PG), and vestibular (VG) ganglion

257 ied in dissociated primary culture of either nodose or dorsal root ganglia (DRG).

258 t the majority of neurones within either the nodose or jugular ganglion adapted rapidly to prolonged

259 se in neurons comprising the placode-derived nodose-petrosal complex occurred.

260 Dissociate cultures of nodose-petrosal ganglion cells from newborn rats were gr

261 particularly striking in the cranial sensory nodose-petrosal ganglion complex (NPG), in which loss of

262 The major visceral sensory population, the nodose-petrosal ganglion complex (NPG), requires BDNF an

263 ncreased the number of VIP-ir neurons in the nodose/petrosal ganglia cultures and did not alter the n

264 urons labeled for specific neurochemicals in nodose/petrosal ganglia cultures.

265 Addition of NGF to nodose/petrosal ganglia neuron-enriched cultures signifi

266 to dissociated, enriched, cultures of mature nodose/petrosal ganglia neurons, and the neurons process

267 l of 50% of visceral afferent neurons in the nodose/petrosal sensory ganglion complex, including arte

268 approximately 0.5 m s(-1)), 71% were of the nodose phenotype and 29% of the jugular phenotype.

269 Nodose (placode-derived) nociceptive-like fibres are exc

270 ion of carbohydrates elicited powerful vagal nodose responses.

271 GFRalpha1-deficient dopaminergic and nodose sensory ganglia neurons no longer respond to GDNF

272 e resting membrane potential of neonatal rat nodose sensory neurons were investigated using the whole

273 es of embryonic rat trigeminal, dorsal root, nodose, superior cervical ganglia or retina with a varie

274 y distinct sources: neurones situated in the nodose vagal ganglia and neurones situated in the jugula

275 dy addressed the hypothesis that jugular and nodose vagal ganglia contain the somata of functionally

276 recordings were made from single jugular or nodose vagal ganglion neurons that projected their senso

277 ot ganglia were more similar to jugular than nodose vagal neurons.

278 minals arising from the jugular (rather than nodose) vagal ganglia and the output of the Pa5 is predo

279 Unilateral supra-nodose vagotomy eliminated p55-ir from ipsilateral centr

280 ber of retrogradely labeled afferents in the nodose was very similar to the total number of DRG affer

281 All neurones possessing AHPslow in ferret nodose were C fibre neurones; all AHPslow neurones had c

282 xamined, including the superior cervical and nodose, which are severely affected in both Ret- and GDN