ライフサイエンスコーパス: nogalamycin

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1 iated DNA at the same site in the absence of nogalamycin.

2 noK in the biosynthesis of the anthracycline nogalamycin.

3 rase I-mediated DNA cleavage site induced by nogalamycin.

4 cycline antibiotics such as daunorubicin and nogalamycin.

5 pha are cross-resistant to menogaril but not nogalamycin.

6 The anthracycline drug nogalamycin, a non-covalent intercalator with preference

7 Many DNA binding ligands (e.g., nogalamycin, actinomycin D, terbenzimidazoles, indolocar

8 Nogalamycin, an aromatic polyketide displaying high cyto

9 We found that adriamycin, nogalamycin, and actinomycin D comprise a class of drugs

10 Using nogalamycin as a model, we have studied the mechanism of

11 Substitution of this nogalamycin binding site with a DNA bending sequence (A(

12 T-rich regions are known to be essential for nogalamycin binding.

13 Further, the anthracycline antibiotic nogalamycin binds cleanly to the 5'-TG (5'-CA) site form

14 nerated using the X-ray structure of the DNA-nogalamycin complex.

15 The structure of the 1:1 nogalamycin:d(ATGCAT)2 complex has been determined in so

16 ng property of nogalamycin, suggest that the nogalamycin-DNA complex may provide a DNA structural ben

17 rprisingly, DNase I footprinting analysis of nogalamycin-DNA complexes has revealed a drug-free regio

18 The complex resembles the structure of nogalamycin-DNA complexes with the drug bound at 5'-TG s

19 in > chromomycin A3, and the specificity was nogalamycin > chromomycin A3 > hedamycin.

20 tion was in the following order: hedamycin > nogalamycin > chromomycin A3, and the specificity was no

21 revent TC formation on the SRE in vitro were nogalamycin > Hoechst 33342 > chromomycin.

22 in NIH3T3 cells, however, were chromomycin > nogalamycin > Hoechst 33342.

23 ities, including ethidium, daunorubicin, and nogalamycin, have been used to probe the flexibility of

24 Our results suggest that nogalamycin, in contrast to camptothecin, may stimulate

25 ved in two related X-ray structures in which nogalamycin is bound at terminal 5'-TpG sites.

26 Steric occlusion prevents a second nogalamycin molecule from binding at the symmetry-relate

27 reactions of dithranol, a substrate for the nogalamycin monooxygenase (NMO) from Streptomyces nogala

28 ng of the anthracycline antitumor antibiotic nogalamycin (Ng) to these two heptamers stabilizes the d

29 By contrast, nogalamycin poisons topoisomerase I but not topoisomeras

30 The mechanism by which nogalamycin poisons topoisomerase I has been studied by

31 ition of both EGR1 and TBP, the intercalator nogalamycin prevented EGR1 complex formation, resulting

32 ether with the known DNA bending property of nogalamycin, suggest that the nogalamycin-DNA complex ma

33 NA footprinting analyses that the binding of nogalamycin to an upstream site (from position -6 to -3)

34 Nogalamycin was most effective when the drug was pre-inc

35 s, respectively, and the intercalating agent nogalamycin, which binds G/C-rich sequences in the major

36 We show that the nogalose sugar ring of nogalamycin, which binds to the minor groove of DNA, pla

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