ライフサイエンスコーパス: non-canonical

1 The exception was the non-canonical 3' A:oxoG configuration, which EcoLigA acc

2 In contrast, a non-canonical 5' splice site blocks the second transeste

3 levates acetylation of histone H3K14 and the non-canonical acetylation of H3K23 in etiolated seedling

4 ER) of AML and play an important role in the non-canonical activation of signal transducer and activa

5 and interferes with the caspase-11-induced, non-canonical activation of the inflammasome.

6 Moreover, these MR-dependent GRK2 and GRK5 non-canonical activities appear to involve cross-talk wi

7 ted that overexpression of Nog disrupted BMP non-canonical activity, which led to a dramatic reductio

8 Here, we describe a non-canonical, AGGF1-mediated regulatory system for endo

9 ons near active transcriptional start sites; non-canonical AID (nc-AID), leading to genome-wide non-c

10 ociated with channel gating, the fluorescent non-canonical amino acid coumarin-tyrosine was genetical

11 d in nonfunctional proteins, we used in vivo non-canonical amino acid mutagenesis to determine the sp

12 anoSIMS) and fluorescence-based biorthogonal non-canonical amino acid tagging (BONCAT) - for studying

13 r in a cell type of interest and providing a non-canonical amino acid with a chemical handle, we sele

14 and tRNA, aminoacylation of the tRNA with a non-canonical amino acid, and efficient participation of

15 specific genetic encoding of cyanine dyes as non-canonical amino acids (Cy-ncAAs) into proteins.

16 The diversity of non-canonical amino acids (ncAAs) endows proteins with n

17 To overcome this hurdle, we utilized non-canonical amino acids and bio-orthogonal chemistry t

18 We show these non-canonical amino acids are incorporated into various

19 This successful demonstration that non-canonical amino acids can be directly administered i

20 lade of likely proton-pumping rhodopsin with non-canonical amino acids in the spectral tuning and pro

21 y to incorporate multiple copies of multiple non-canonical amino acids into a protein of interest.

22 he site-specific incorporation of natural or non-canonical amino acids into superfolder green fluores

23 specific labeling of nascent proteins with a non-canonical amino-acid and click chemistry.

24 ells, as well as mechanisms generating other non-canonical antigenic epitopes targeted by the T cell

25 concerns about earlier studies that invoked non-canonical arginylation specificities of Ate1.

26 endent upregulation of Cyclin B1, a putative non-canonical arm of the Hh pathway.

27 8 from Thermotoga maritima, which contains a non-canonical ATP binding site, revealed that in the pre

28 Here, we characterize a non-canonical ATP-binding cassette (ABC) transporter in

29 Neurons along this non-canonical auditory pathway responded selectively to

30 but not on ATG13, suggesting ARE belong to a non-canonical autophagy pathway.

31 ciated phagocytosis (LAP) is a novel form of non-canonical autophagy where LC3 (microtubule-associate

32 exhibit effective mechanisms to remove such non-canonical base analogs from DNA precursor pools.

33 Non-canonical base pairing within guanine-rich DNA and R

34 Software to predict non-canonical base pairs and pairing probabilities is no

35 of complex RNA motifs, including ubiquitous non-canonical base pairs and pseudoknots, remains a chal

36 Movement originates from pivoting at stacked non-canonical base pairs in a Family A three-way junctio

37 eta-catenin-dependent signaling activity and non-canonical beta-catenin-independent Ror2-mediated Wnt

38 Our results reveal the orchestration of non-canonical BMP and Wnt/beta-catenin signaling pathway

39 Thus, both canonical and non-canonical BMP signaling establish the precise spatio

40 otein with no known physiological role, as a non-canonical cargo receptor that directly binds to core

41 However, the mechanisms for non-canonical caspase substrate recognition and proteoly

42 of IL-1beta (interleukin-1beta) through the non-canonical caspase-11 inflammasome.

43 pDCs development and led to the expansion of non-canonical CD8(+) cDCs.

44 w CENP-N and CENP-C decode and stabilize the non-canonical CENP-A nucleosome to enforce epigenetic ce

45 However, roles of non-canonical central nervous system signalling mechanis

46 circadian oscillator (WICO) are generated by non-canonical circadian clocks.

47 Notably, we found that this non-canonical cleavage at Ala-470-Asn-471 is instrumenta

48 Moreover, HLA-DQ2.5 preferentially binds the non-canonical CLIP2 over the canonical CLIP1.

49 Like SecYEG, the non-canonical complex activates the ATPase activity of t

50 Ribonucleotides are the most abundant non-canonical component of yeast genomic DNA and their p

51 Collectively, these results illustrate how non-canonical computations improve motion estimation wit

52 of metabolism and lack of information about non-canonical connections between metabolites limits the

53 We establish the existence of a non-canonical cortical NOTCH1 signalling pathway that re

54 In this report, we show that the non-canonical CTD of T. brucei RNA pol II is important f

55 kness, deploys an RNA pol II that contains a non-canonical CTD to accomplish an unusual transcription

56 TD devoid of repeats, appropriately called a non-canonical CTD, which performs completely unknown fun

57 eine protease superfamily, and all possess a non-canonical Cys-His-Ser catalytic triad.

58 We conclude that non-canonical DDR1 signaling enables breast cancer cells

59 This examination of both canonical and non-canonical dehydration mechanisms reveals hidden cata

60 fish embodies a time window characterized by non-canonical DNA methylation-enhancer relationships, in

61 nine-rich DNA strands can fold in vitro into non-canonical DNA structures called G-quadruplexes.

62 G-triplexes are non-canonical DNA structures formed by G-rich sequences

63 on of extended RNA:DNA hybrids or R-loops or non-canonical DNA structures including G-quadruplexes ha

64 UBA5 is a non-canonical E1 activating enzyme that possesses an ade

65 provides a first view of protocadherin-15's non-canonical EC linkers and suggests how they may funct

66 ence suggests they might also utilize other, non-canonical effector pathways.

67 These findings highlight a non-canonical Egfr signalling mechanism, centered on Arf

68 ion of EGFR-Met and EGFR-ErbB3 associations; non-canonical EGFR-Met interactions are implicated in re

69 lling, only GLI inhibitors would act against non-canonical EMT-induced GLI activation.

70 L1 cell adhesion molecule LAD-2 acting as a non-canonical ephrin receptor to EFN-4 to promote axon g

71 We recently described a non-canonical ER quality control mechanism for folding o

72 ifically in fibroblasts, in which they drive non-canonical, ERK-dependent autocrine signalling that i

73 DNA motif, but others appeared dependent on non-canonical factors.

74 ed in the stimulation of macroautophagy in a non-canonical fashion, independent of mTOR and ULK1, but

75 including better tRNA functional prediction, non-canonical features, predicted structural impacts fro

76 l and optogenetic studies indicate that this non-canonical feedback is region specific: it is most pr

77 ERGalt uses a non-canonical first exon whose transcription was initiat

78 ding elements in canonical Type 1 IRESs, and non-canonical flanking domains (d8, d9 and d12).

79 itated by weakened Watson-Crick and reversed non-canonical flanking pairs.

80 We find that this type of non-canonical fork convergence in fission yeast is prone

81 Recent investigations have identified a "non-canonical" form of RdDM dependent on RNA polymerase

82 tructurally diverse, including canonical and non-canonical forms, whereas in land plants, phytochrome

83 iculum (ER)-associated ribosomes, exerting a non-canonical function as an RNA-binding protein in the

84 ot observed with MMC treatment, suggesting a non-canonical function for the FA pathway in response to

85 Our data also highlights the non-canonical function of L. donovani tyrosyl-tRNA synth

86 by smoothened (SMO) inhibition, suggesting a non-canonical function of PTCH1.

87 To characterize this non-canonical function, we created a panel of ALT cells

88 eads to a switch from canonical silencing to non-canonical functions during blood stem cell specifica

89 Periodically, new non-canonical functions have been ascribed to RNA, such

90 inoacylation activity, several aaRSs perform non-canonical functions in diverse biological processes.

91 membrane sector, Vo, has been implicated in non-canonical functions including membrane fusion and ne

92 Our findings highlight novel non-canonical functions of PLK1 as a key regulator of EM

93 ary motor neuropathy and alter canonical and non-canonical functions of TrpRS.

94 The 'non-canonical' functions of many of these upregulated tR

95 The results indicate Rad and Rem are non-canonical G-proteins with respect to the regulatory

96 the folds of guanine-rich oligonucleotides, non-canonical G-quadruplex structures are based on G-qua

97 h sequence and demonstrates the existence of non-canonical G4s in cells, thus broadening the definiti

98 ase-expressing neurons impairs mesoaccumbal, non-canonical GABA co-release and enhances reward-seekin

99 Furthermore, the BAZ1A bromodomain has a non-canonical gatekeeper residue and binds relatively we

100 eceptor either via canonical (Gs-coupled) or non-canonical (Gi-coupled) pathways underpins most forms

101 ty, we determined the crystal structure of a non-canonical GIL-specific TCR (F50) expressing the TRAV

102 liant on a number of adaptations including a non-canonical glutamine (Gln) metabolic pathway and that

103 LC pathogenesis, and reveal a novel role for non-canonical Hh signaling through the induction of chro

104 on by balancing between canonical Hh-Gli and non-canonical Hh-Galphai-RhoA pathways and highlight IFT

105 pting Smo ciliary localization, but elevates non-canonical Hh-Galphai-RhoA-stress fibre signalling by

106 iation of IFT80-deficient OPCs by inhibiting non-canonical Hh-RhoA-Cofilin/MLC2 signalling.

107 Here, we determine that non-canonical histone signature acetylated H3 lysine 23

108 hage priming by inhibiting the activation of non-canonical IkappaB kinase varepsilon and IkappaBalpha

109 man macrophages, TcpB attenuated LPS-induced non-canonical inflammasome activation and suppressed pyr

110 domain was essential for TcpB to subvert the non-canonical inflammasome activation as a TcpB(G158A) m

111 Non-canonical inflammasome activation is mediated by cas

112 y review the burgeoning caspase-11-dependent non-canonical inflammasome field, focusing mainly on the

113 erial lipopolysaccharides in the case of the non-canonical inflammasome.

114 tain mRNAs continues via the eIF2D-dependent non-canonical initiation pathway.

115 , that genes related to a recently described non-canonical integrin beta3 pathway, were significantly

116 not client, in vitro Rather, we found that a non-canonical interaction between Bag1/3 and the Hsc70 S

117 when bound to Galphai3, indicating that the non-canonical interaction of RGS2 with Galphaq is due to

118 e of RGS2 in complex with Galphaq revealed a non-canonical interaction that could be due to interfaci

119 We found that UIS3 binds host LC3 through a non-canonical interaction with a specialized surface on

120 n interphase breast cancer cells, exhibiting non-canonical interaction with ER-alpha via its DNA-bind

121 pairing probabilities for both canonical and non-canonical interactions.

122 contain active NOTCH receptors and mediate a non-canonical intercellular NOTCH signaling.

123 e to recognize the Cdc7 phosphopeptide and a non-canonical interface to bind Dbf4.

124 xamers, through a previously uncharacterized non-canonical interface.

125 y conserved genes indicate a high density of non-canonical introns, lacking conventional GT-AG splice

126 The activation of this response is non-canonical, involving a regulatory mechanism requirin

127 more frequent than U2-type and prevalent in non-canonical junctions reported by RSF.

128 ubiquitin-conjugating enzyme responsible for non-canonical K63-linked polyubiquitination of TNF recep

129 with a highly unusual architecture featuring non-canonical lactone as well as lactam rings.

130 l residue that dictates the preference for a non-canonical LAXTG recognition motif over LPXTG.

131 s adjust the structures to accommodate these non-canonical linkages (Proc.

132 pathway in neurons whereby ApoE activates a non-canonical MAP kinase cascade that enhances APP trans

133 We propose that eEFSec employs a non-canonical mechanism involving the distinct C-termina

134 LTPpre induction involves a non-canonical mechanism of retrograde nitric oxide signa

135 This non-canonical mechanism of signaling induces the express

136 Otx2 and Gsc utilizes a novel, flexible and non-canonical mechanism of transcription that does not r

137 his less understood endocytosis represents a non-canonical mechanism regulated by lipids such as chol

138 ATP-independent endocytosis represents a non-canonical mechanism that can efficiently retrieve me

139 Surprisingly, this modification occurs via a non-canonical mechanism that uses nicotinamide adenine d

140 on of the complement system by canonical and non-canonical mechanisms results in the generation of mu

141 cellular models to investigate canonical and non-canonical mechanisms underlying excessive OCL activa

142 'three-pronged' combination of canonical and non-canonical mechanisms.

143 This model provides a simple explanation for non-canonical methylation patterns at some loci or in ce

144 between miRNA and target mRNAs, but rather a non-canonical miRNA targeting activity outside the seed

145 alled miRBShunter, to identify canonical and non-canonical miRNA-binding sites based on de novo motif

146 ew unbiased method to identify canonical and non-canonical miRNA-binding sites from peaks identified

147 At molecular level we provide evidence for non-canonical mode of action of Wnt5a and its regulation

148 usly and two novel types, one of which has a non-canonical morphology and position.

149 ormational states are proposed to be rich in non-canonical motifs and to play roles in the folding an

150 form by reshuffling base pairs in and around non-canonical motifs.

151 '-OH ends inflicted during tRNA splicing and non-canonical mRNA splicing in the fungal unfolded prote

152 these genes are thought to assemble into two non-canonical multisubunit RNAPs - a virion RNAP (vRNAP)

153 Ate1 R-transferase toward previously invoked non-canonical N-terminal or internal amino acid residues

154 suggested (i) that Ate1 can also arginylate non-canonical N-terminal residues; (ii) that Ate1 is cap

155 discrimination against off-target sites with non-canonical NAG and NGA PAMs and/or mismatched spacers

156 MyD88 regulates non-canonical NF-kappaB and canonical Wnt signaling duri

157 canonical pathway without impacting the many non-canonical NF-kappaB functions.

158 sponsible for the preferential activation of non-canonical NF-kappaB pathway in LPS-conditioned DCs.

159 B kinase proteins from Aiptasia suggest that non-canonical NF-kappaB processing is an evolutionarily

160 on required for the control of NIK-regulated non-canonical NF-kappaB signaling pathway.

161 hr377Ile mutant in T cells leads to enhanced non-canonical NF-kappaB signaling that is sensitive to t

162 ry TNF receptor family members that activate non-canonical NF-kappaB via accumulation of NF-kappaB in

163 c endothelial cells; dependent on VCAM-1 and non-canonical NFkappaB signalling via LTbetaR.

164 ella Typhimurium and flagellin, canonical or non-canonical NLRP3 activators LPS and ATP, Escherichia

165 ligands for sensing by both the AIM2 and the non-canonical NLRP3 inflammasomes.

166 ub1, a second key enzyme was identified, the non-canonical non-ribosomal peptide synthetase Fub8.

167 central to the control of the fate through a non-canonical Notch mechanism.

168 -dependent, but gamma-secretase-independent, non-canonical Notch signaling involved in presynaptic pr

169 The G-quadruplex (G4) is a non-canonical nucleic acid structure which regulates imp

170 evidence has gathered suggesting that these non-canonical nucleic acid structures form in vivo and p

171 principle, such analysis can be extended to non-canonical nucleic acid structures, but this approach

172 in classes of these compounds: canonical and non-canonical nucleobases.

173 In conclusion, our findings indicate a non-canonical (nutrient- and energy-independent) mechani

174 Analysis of mutant mice shows that these non-canonical p53 activities contribute to embryonic dev

175 indicated the presence of numerous putative non-canonical p53 binding motifs in the CerS6 promoter.

176 Here, we have identified non-canonical p53-binding sites within the human subtelo

177 to be least accurate in loop regions, where non-canonical pairs are important for determining the de

178 Non-canonical pairs can be predicted using a knowledge-b

179 ndary structure, allow accurate inference of non-canonical pairs, an important step towards accurate

180 age at all DNA sites with both canonical and non-canonical PAMs.

181 eage-restricted IL-21-induced IL-1beta via a non-canonical pathway and provide evidence for its impor

182 ng but is likely to regulate brain size in a non-canonical pathway independently of beta-catenin-1 an

183 y, surprisingly, it regulates Hmx3 through a non-canonical pathway involving both an increase in cAMP

184 Recently, a non-canonical pathway of PKGIalpha activation has been p

185 is locally trafficked in dendrites through a non-canonical pathway remains a fundamental question.

186 The identification of the non-canonical pathway suggests an intersection point bet

187 ized to have a downstream role in the Wnt-5a non-canonical pathway, is a common cause of DRS.

188 Among other non-canonical pathways, WNT5A activates planar cell pola

189 Both genetically encodable and non-canonical peptides are exceptionally stable to therm

190 domain of the ISWI subunit BAZ1B and for the non-canonical PHD and bromodomain modules of the paralog

191 ese results we conclude that the non-genomic/non-canonical physiological functions of glucocorticoids

192 Thus, non-canonical PI3K-antagonism by Itpkb restricts pre-TCR

193 GLD4 is one of the non-canonical poly(A) polymerases that regulates cytopla

194 epressing the expression and function of the non-canonical polycomb complex 1 (PRC1) subunit RYBP.

195 ted carrageenan-induced regulon, including a non-canonical polysaccharide utilization locus (PUL) and

196 Unexpectedly, helix VIII was found in a non-canonical position, stabilizing the active-like stat

197 ssociated to both canonical PRC1 (cPRC1) and non-canonical PRC1 (ncPRC1) complexes.

198 Cell, Beguelin et al. report a mechanism of non-canonical PRC1 recruitment by BCL6 in collaboration

199 nscriptional repressor and the presence of a non-canonical PRC1-BCOR-CBX8 complex.

200 Dysfunction in this non-canonical proteasome degradation pathway may contrib

201 SPATA2 interacts with CYLD through its non-canonical PUB domain, which binds the catalytic CYLD

202 of this unprecedented enzymatic approach to non-canonical purine-containing RNAs is explored via the

203 fforts on the genetic code expansion using a non-canonical quadruplet reading frame.

204 hes to expand the RBP repertoire to discover non-canonical RBPs are currently needed.

205 s Review aims to illustrate the diversity of non-canonical RdDM mechanisms described to date, recogni

206 termined that there are several alternative 'non-canonical RdDM' pathways that function through disti

207 The non-canonical receptive field properties of the OND RGC-

208 for an Hsp70-client interaction and involved non-canonical regions of the chaperone.

209 e, a new study discovers a high incidence of non-canonical 'reverse meiosis' and a new form of meioti

210 onal framework for bypassing, highlighting a non-canonical ribosomal state to allow for mRNA structur

211 y regulated by ADAR1 and ADAR2 through their non-canonical RNA editing and dsRNA binding-independent

212 wed by mass spectrometry identified numerous non-canonical RNA-binding proteins that stabilize ribozy

213 d from the scaffolding function and how this non-canonical role could contribute to/alter the outcome

214 of Immunity, Calippe et al. (2017) uncover a non-canonical role for CFH in the inhibition of mononucl

215 o acids by S. cerevisiae PheRS and support a non-canonical role for SccytoPheRS post-transfer editing

216 Our novel findings support a non-canonical role of class IIa HDACs in the scaffolding

217 This non-canonical role of the kinetochore in defining a chro

218 ycolytic enzyme, has a non-catalytic (thus a non-canonical) role in inducing mitochondrial eliminatio

219 echanisms of regulation, as well as emerging non-canonical roles and how our knowledge of ATM, ATR, a

220 Ultimately we focus on two non-canonical roles for caveolin - membrane repair and r

221 ecent studies have also uncovered additional non-canonical roles for snoRNAs.

222 translation, transfer RNAs (tRNAs) play many non-canonical roles in various biological pathways and e

223 ed to as heterochromatin, suggesting further non-canonical roles of the proteasome in gene expression

224 Here we provide an overview of the non-canonical roles of tRNAs and their mimics in bacteri

225 anonical signalling, Nodal signals through a non-canonical route to maintain Shh.

226 Our results reveal the presence of non-canonical secreted peptides in EVs, which can subseq

227 ey of alternative 3UTR isoforms implicates a non-canonical seedless site in cooperative miRNA-mediate

228 Activation by a DRD1 agonist produced non-canonical signal transduction via Galphaq-PLC-IP3-Ca

229 oth canonical Wnt signaling and NFAT and Akt non-canonical signaling.

230 Binding at this non-canonical site induces an unprecedented conformation

231 Although proteases that cleave PAR(2) at non-canonical sites can trigger distinct signaling casca

232 hylogenetic analyses revealed that ISE2 is a non-canonical Ski2-like RNA helicase that represents a s

233 Despite this, we identify canonical and non-canonical skin pigmentation loci, including near SLC

234 Minigene assays were performed for two non-canonical splice site variants and revealed missplic

235 thods were developed to identify genome-wide non-canonical spliced regions including special events o

236 hm, "Read-Split-Fly" (RSF), which can detect non-canonical spliced regions with higher sensitivity an

237 We explain how non-canonical splicing can lead to aberrant transcripts

238 These non-canonical splicing events are a major source of newl

239 is generally thought that most canonical or non-canonical splicing events involving U2- and U12 spli

240 rocessing, revealing many previously unknown non-canonical splicing events.

241 uclear canonical (PAPalpha and PAPgamma) and non-canonical (Star-PAP) PAPs play diverse roles in PAS

242 Translation initiation from non-canonical start codons may contribute to the synthes

243 Translation from non-canonical start codons ranged from 0.007 to 3% relat

244 , BoNT/X is the only toxin that also cleaves non-canonical substrates VAMP4, VAMP5 and Ykt6.

245 These non-canonical subtelomeric p53-binding sites conferred t

246 Here we targeted the non-canonical synaptic vesicle SNAREs Vps10p-tail-intera

247 e duplex SVM model enables the prediction of non-canonical target sites and more accurately resolves

248 Here, we report on a non-canonical TBP family-insensitive (TFI) mechanism of

249 ide variety of other TRAV/TRBV combinations (non-canonical TCRs).

250 Moreover, a subclass of weak non-canonical terminators was identified that completely

251 function by suppressing the pro-inflammatory non-canonical TGF-beta pathway and by activating the ERK

252 previously unknown regulator that restricts non-canonical TGF-beta signaling in NK cells.

253 Mechanistically, SMAD4 restrained non-canonical TGF-beta signaling mediated by the cytokin

254 f AA as a PPARalpha agonist that inactivates non-canonical TGF-beta signaling.

255 suggesting a link between p190-B-RhoGAP and non-canonical TGF-beta signalling in HSPC differentiatio

256 AP3K7) is a key mediator of inflammation and non-canonical TGF-beta signalling.

257 ling was markedly altered when expression of non-canonical TGF-beta-driven target genes was impaired.

258 This study provides insight into a non-canonical TGFbeta signaling cascade that is responsi

259 Our findings reveal a non-canonical (that is, YAP/TAZ-independent) effect of L

260 of our experimental validation, we propose a non-canonical topology of the IL-23.IL-23R.IL-12Rbeta1 c

261 By forming non-canonical toxin pairs, we identify that the F-compon

262 tors, and our results thus substantiate that non-canonical trafficking mechanisms are a common featur

263 egulates vascular barrier function through a non-canonical, transcription-independent signalling mech

264 Non-canonical transforming growth factor beta (TGFbeta)

265 slation system and thus represents the first non-canonical translation enhancing factor to be found i

266 Aberrant proteins generated by non-canonical translation initiation may be a factor in

267 Non-canonical translation of this repeat gives rise to s

268 These results provide evidence for a non-canonical tRNA methyltransferase mechanism that char

269 cal Type A dsRBDs interact with dsRNA, while non-canonical Type B dsRBDs lack RNA-binding residues an

270 Integration is mediated by a non-canonical tyrosine integrase (Int) lacking an N-term

271 standard and immunoproteasome is governed by non-canonical ubiquitination on non-lysine sites.

272 cellular localization and phosphorylation by non-canonical upstream kinases.

273 Here, we define WNT5A, a non-canonical Wnt ligand implicated in epithelial differ

274 WNT5a, a traditionally non-canonical WNT ligand regulates Ser-89 phosphorylatio

275 WNT5A, a non-canonical WNT ligand, has been shown to promote adip

276 h, channeling the signal input for different non-canonical Wnt pathways during vertebrate gastrulatio

277 ata suggest the involvement of canonical and non-canonical WNT pathways in glioblastoma promoting key

278 a dual strategy affecting both canonical and non-canonical WNT pathways.

279 urther provide evidence that sFRP2 redirects non-canonical Wnt signaling from Frizzled 7 (Fz7) to the

280 entify a novel intersection of canonical and non-canonical Wnt signaling in adult progenitor cell dif

281 nt signaling in proliferating adult NSCs and non-canonical Wnt signaling in differentiating neuroblas

282 nts of the planar cell polarity (PCP) arm of non-canonical Wnt signaling including VANGL1, VANGL2 and

283 Our analysis delineates that non-canonical Wnt signaling is required for cell interca

284 gastrulation require a balanced activity of non-canonical Wnt signaling pathways, but the factors re

285 uppressing effects mediated by canonical and non-canonical WNT signaling.

286 D5 receptor, antagonizing both canonical and non-canonical WNT signaling.

287 regulates Wnt stimulated JNK activity in the non-canonical Wnt signaling.

288 ) transduces the signal during canonical and non-canonical Wnt signaling.

289 Here we show that endothelial non-canonical Wnt signalling regulates endothelial sensi

290 Collectively our data suggest that non-canonical Wnt signalling stabilizes forming vascular

291 g in this pathway parallels that seen in the non-canonical Wnt-dependent regulation of planar cell po

292 t oncogenic K-Ras, but not H-Ras, suppresses non-canonical Wnt/Ca(2+) signaling, an effect that contr

293 The non-canonical Wnt/planar cell polarity (Wnt/PCP) pathway

294 as well as precise molecular control via the non-canonical Wnt/planar cell polarity pathway, Shh/BMP

295 CCN1 induces the expression of the non-canonical Wnt5a in pericyte but not in EC cultures.

296 ncordantly, treatment of mice with TNP470, a non-canonical Wnt5a inhibitor, reestablishes endothelial

297 In conclusion, elevated non-canonical WNT5A signaling in VAT contributes to the

298 ely, these data demonstrate a FOXC1-elicited non-canonical WNT5A signaling mechanism comprising NF-ka

299 y investigated the potential contribution of non-canonical WNT5A/PCP signaling to visceral adipose ti

300 show that mouse and human germ cells exhibit non-canonical X dosage states that differ from the soma