1 whereas the N-terminal domain is considered
non-catalytic.
2 , each of relative molecular mass 26K, and a
non-catalytic 45K beta-subunit, a homologue of the beta-
3 ed of one catalytic domain associated with a
non-catalytic accessory domain.
4 dney-specific isoform of ATP6N1A, the 116-kD
non-catalytic accessory subunit of the proton pump.
5 ounded-amoeboid cells use both catalytic and
non-catalytic activities of MMPs for invasion.
6 ights an interplay between the catalytic and
non-catalytic activities of TET1 that is essential for n
7 ylating substrates and by means of regulated
non-catalytic activities.
8 Here we demonstrate that this
non-catalytic activity of LepB is to promote the associa
9 Thus, PDE7A1 possesses a
non-catalytic activity that can contribute to the termin
10 In turn,
non-catalytic ADAMTS-4 domains were critical for hydroly
11 unit to form the interface that contains the
non-catalytic adenine nucleotide-binding site.
12 dy identifies a novel inhibitor of PKA and a
non-catalytic affect of a cyclic nucleotide phosphodiest
13 stalk with F1-c10 implies that it binds to a
non-catalytic alpha-beta interface in F1 and its inclina
14 These genes are believed to encode
non-catalytic alpha-type subunits of 26S proteasomes and
15 results show the b dimer to be located at a
non-catalytic alpha/beta cleft, with bI close to subunit
16 MPT51 may in fact represent a new family of
non-catalytic alpha/beta hydrolases.
17 ency for two enzymes that differ by a single
non-catalytic amino acid residue.
18 The
non-catalytic amino terminus of DNMT1 binds to HDAC2 and
19 e interaction motif (KIM) located within the
non-catalytic amino terminus of DUSP2.
20 Catalytic and
non-catalytic antibodies are studied in this context of
21 ve marginally higher active site burial than
non-catalytic antibodies, these values are generally sma
22 We show that both the catalytic and
non-catalytic APC/C-Fzr1/Cdh1-mediated activities of PTE
23 The
non-catalytic beta subunit of glucosidase II (GIIbeta) i
24 ort the cloning of full-length cDNAs for the
non-catalytic beta- and gamma-subunits.
25 A
non-catalytic binding cleft, proximal to the site of the
26 autophosphorylation is promoted by specific
non-catalytic binding proteins.
27 Palphabeta has high affinity, cGMP-specific,
non-catalytic binding sites and that Pgamma stimulates c
28 and dissociation from various catalytic and
non-catalytic binding sites on protein surfaces.
29 ibitory effect of genistein is due to direct
non-catalytic blockade of the channels.
30 in embryonic ectoderm development (EED) is a
non-catalytic but an essential component of PRC2 and its
31 sical and biochemical studies indicates that
non-catalytic but conserved residues directly regulate t
32 variant leucine in a conserved domain of the
non-catalytic C terminus restored viability to cells exp
33 2 FYVE-type domain and the N-terminal kinase
non-catalytic C-lobe domain (KIND) that could not be det
34 to the active site and activated by the Nek9
non-catalytic C-terminal domain (CTD).
35 A conserved
non-catalytic C-terminal domain of WRN was sufficient fo
36 blocks, ATR(Mec1) phosphorylates Chk1 on the
non-catalytic C-terminal domain.
37 proper DNA-binding subsite is located on the
non-catalytic C-terminal domain.
38 phorylation and is markedly inhibited by its
non-catalytic C-terminal region.
39 Its
non-catalytic,
C-terminal half contains several proliner
40 We demonstrate that the
non-catalytic C2 domain of PTEN specifically binds PI(3)
41 the I-CvuI DNA structures in the presence of
non-catalytic (
Ca(2+)) and catalytic ions (Mg(2+)).
42 The C-terminal
non-catalytic carbohydrate binding module could not be o
43 LPMOs can contain
non-catalytic carbohydrate binding modules (CBMs), but t
44 catalytic modules and, frequently, multiple
non-catalytic carbohydrate binding modules (CBMs).
45 cell wall polysaccharides generally contain
non-catalytic,
carbohydrate-binding modules (CBMs) that
46 The molecular basis of how the N-terminal
non-catalytic CD1 regulates the catalytic activity and c
47 and in vivo functional characterization of a
non-catalytic CHI-fold family from plants.
48 mode of non-heme iron binding trapped by the
non-catalytic Co(2+), which, we postulate, may be transi
49 Here we used affinity chromatography with
non-catalytic Coa and vWbp to identify the ligands for t
50 eparate genes encoding the catalytic and the
non-catalytic collagenic tail (ColQ) subunits, respectiv
51 etal muscle and found that the level of this
non-catalytic component by itself was sufficient to chan
52 t cell line lacks expression of IKK gamma, a
non-catalytic component of the IKK complex.
53 in, but does not alter the expression of the
non-catalytic components of the Set1 complexes.
54 ately 450 kDa complex that contains all five
non-catalytic components of the Set1A complex, including
55 ectroscopic methods under potentiometric but
non-catalytic conditions.
56 When the PML/RAR alpha cleaving but not the
non-catalytic control ribozyme is introduced into the NB
57 Introduction of a
non-catalytic,
control ribozyme into NB4 cells caused no
58 the non-catalytic core; contacts between the
non-catalytic core and Rrp44, which inhibit exoribonucle
59 The nuclear RNA exosome includes a 9-subunit
non-catalytic core that binds Rrp44 (Dis3) and Rrp6 subu
60 ed RNA path to Rrp6 that penetrates into the
non-catalytic core; contacts between the non-catalytic c
61 lly how Tolloid activity is regulated by its
non-catalytic CUB domains in the Drosophila embryo.
62 llowing S-nitrosylation of Trx proteins at a
non-catalytic cysteine (Cys) residue.
63 nd UbcM2 form a complex upon alkylation of a
non-catalytic cysteine in UbcM2, Cys-136.
64 -binding pocket and that can be mutated to a
non-catalytic cysteine residue.
65 ellular ligands and possess highly conserved
non-catalytic cytoplasmic domains.
66 of VAV1 catalytic-dependent (MAPK, JNK) and
non-catalytic-
dependent (nuclear factor of activated T c
67 dues, we show that Ero1alpha is regulated by
non-catalytic disulphides.
68 ation modulates the biological activities of
non-catalytic DNA binding proteins.
69 are known to assemble by sequence-divergent
non-catalytic dockerin domains (NCDDs)(4).
70 The kinase-like
non-catalytic domain (KIND) of Spire directly interacts
71 f engineered motors, we demonstrate that the
non-catalytic domain has a key role in the motility mech
72 Our results highlight the role of the
non-catalytic domain in fine-tuning substrate specificit
73 Thus, one role of this
non-catalytic domain may be to prevent transposition in
74 are consistent with a role of the conserved
non-catalytic domain of a human RecQ helicase in DNA rep
75 degradation machinery targets the C-terminal
non-catalytic domain of ACS6, which is sufficient to con
76 In this study, we show that the
non-catalytic domain of GAP is required for its recruitm
77 Here we report that the N-terminal
non-catalytic domain of separase binds to the C-terminal
78 tion motif located within the amino-terminal
non-catalytic domain of the protein.
79 equence containing five PXXP motifs from the
non-catalytic domain of the PTP is sufficient for intera
80 ally significant subdomains within the large
non-catalytic domain of these proteins.
81 An N-terminal
non-catalytic domain of YopH binds p130Cas in a phosphot
82 The amino-terminal,
non-catalytic domain of YopH is bifunctional; it is esse
83 in a large protein complex and requires its
non-catalytic domain to localize to the cell periphery a
84 rmined by sequences within an amino-terminal
non-catalytic domain whereas MAPK binding often leads to
85 We find that a
non-catalytic domain within Cas9, REC3, recognizes targe
86 of two regions of homology in the C-terminal
non-catalytic domain, termed polo-box 1 (PB1) and polo-b
87 g within the region of the mRNA encoding its
non-catalytic domain.
88 talyzes hydrolysis of GTP on ARF1 but also a
non-catalytic domain.
89 However, both the N- and C-terminal
non-catalytic domains from all mammalian tolloids bind c
90 molecular interactions between catalytic and
non-catalytic domains of BAP1, which generate a composit
91 es and the functional role of the C-terminal
non-catalytic domains of Chk1.
92 Having ascribed functions to the Tolloid
non-catalytic domains, we recapitulate embryonic BMP gra
93 Its
non-catalytic donut-shaped core includes 9 subunits that
94 th loss of factor IX-binding exosites on the
non-catalytic factor XI heavy chain.
95 nded RNA binding proteins (DRBs), a group of
non-catalytic factors containing one or more double-stra
96 and stimulates GSK3 enzymatic activity in a
non-catalytic fashion.
97 next generation of BoNT vaccines, utilizing
non-catalytic full-length BoNT or a subunit vaccine comp
98 hile it is widely believed that Rev1 plays a
non-catalytic function in translesion synthesis, the rol
99 the Rev1 dCMP transferase activity from its
non-catalytic function in yeast.
100 However, it is not well understood about the
non-catalytic function of Rev1 in translesion synthesis.
101 In addition to its dCMP transferase, a
non-catalytic function of Rev1 is suspected in cellular
102 those of UV lesions, which only require the
non-catalytic function of Rev1.
103 These findings identify an essential,
non-catalytic function of the C2 domain of Psd2p and rai
104 then closely aligned, which requires XLF, a
non-catalytic function of XRCC4-LIG4, and DNA-PK activit
105 its catalytic function was abolished but its
non-catalytic function remained intact.
106 tion of its deacetylase domain, indicating a
non-catalytic function.
107 Such
non-catalytic functions have been ascribed to many kinas
108 dy we demonstrate that biotin has additional
non-catalytic functions in regulating gene expression in
109 CKIdelta/epsilon and DBT may have divergent
non-catalytic functions in the clockwork as well.
110 mination of endothelial lipase catalytic and
non-catalytic functions in vitro, and from human genetic
111 containing SECIS elements and be adapted for
non-catalytic functions.
112 a, each contain one catalytic domain and two
non-catalytic GAF domains, whereas two small inhibitory
113 Mutational study reveals that several
non-catalytic glycan-interacting residues, structurally
114 Histone chaperones are a
non-catalytic group of proteins that are central to the
115 ke Moesin and engagement of effectors of its
non-catalytic growth-promoting activity.
116 tains the ATPase motor protein SNF2h and the
non-catalytic hACF1 subunit.
117 dies of this class of receptors as well as a
non-catalytic homolog, the clearance receptor.
118 sition state) closely resembles that seen in
non-catalytic hydrogen bonds, with distances and angles
119 lated by the binding of bicarbonate ion to a
non-catalytic (
inhibitory) site that controls the ligati
120 DNA ends for catalysis while another pair of
non-catalytic integrase dimers bridge between the two vi
121 t CAIX augments MCT1 transport activity by a
non-catalytic interaction.
122 fferent positions of the two b subunits at a
non-catalytic interface and imply that each b subunit ha
123 Specifically, in the
non-catalytic interface, the B subunit seems to be incap
124 first molecular insight at the catalytic and
non-catalytic interfaces, which was not possible in the
125 owever, it remains poorly understood how the
non-catalytic ISWI subunits BAZ1A and BAZ1B might contac
126 e three protein domains suggests a potential
non-catalytic ligand-binding role.
127 Dockerin modules located within a
non-catalytic macromolecular scaffold, whose primary rol
128 osed that E.coli RNase III can function in a
non-catalytic manner, by binding RNA without cleaving ph
129 of Numb-TS4D in a non-apoptotic and possibly
non-catalytic manner.
130 ain how OTUB1 inhibits other E2 enzymes in a
non-catalytic manner.
131 cineurin suppresses this futile cycling by a
non-catalytic mechanism involving the masking of nuclear
132 Furthermore, using a
non-catalytic mechanism, MMP-9 promotes rounded-amoeboid
133 on of TRAF6 to cytosolic p62 aggregates by a
non-catalytic mechanism.
134 g that 14-3-3 inhibits the complex through a
non-catalytic mechanism.
135 ere we studied the ancestral role of a model
non-catalytic modulatory subunit.
136 nding of type I cohesin modules located in a
non-catalytic molecular scaffold to type I dockerin modu
137 would lead to the loss or dislocation of two
non-catalytic MuA subunits positioned in the transpososo
138 We show that the
non-catalytic N terminus of Doa4 mediates its recruitmen
139 at complex formation is mediated through the
non-catalytic N-terminal domain of DNA ligase I and the
140 Instead, the
non-catalytic N-terminus of PDK1 mediates the formation
141 The
non-catalytic nine-subunit exosome core (Exo9) features
142 interacting with the thumb subdomain of its
non-catalytic p51 subunit.
143 inhibitor 'bridges' the DNA and a transient
non-catalytic pocket on the two-fold axis at the GyrA di
144 s to reiterated cohesin domains located in a
non-catalytic primary scaffoldin.
145 ts HIV-1 viral replication via catalytic and
non-catalytic processes.
146 ide detailed insights into the catalytic and
non-catalytic processing of small molecules by hCE1, and
147 smooth muscle MLCK (smMLCK), as well as the
non-catalytic product telokin.
148 Recently, a small
non-catalytic protein, PEA-15, has also been demonstrate
149 feature of bacterial cellulosomes is a large
non-catalytic protein, the scaffoldin, which contains mu
150 The
non-catalytic proteins encoded by PUL1,6-beta-glucan tar
151 lysis at moderate and high temperature and a
non-catalytic pyrolysis process are presented.
152 lack the catalytic non-conserved (conserved
non-catalytic/
Ras exchange motif/structurally conserved
153 t on both kinase activity and the C-terminal
non-catalytic RCC1 domain.
154 We have demonstrated that this
non-catalytic receptor can inhibit NT-3 signaling when c
155 rchical activation of downstream pathways in
non-catalytic receptors.
156 ing yeast, Mps1 phosphorylation of a central
non-catalytic region of Bub1 promotes its association wi
157 mutagenesis, we have mapped an exosite to a
non-catalytic region of LF.
158 e results suggest a novel model in which the
non-catalytic region of PKCmu acts as a scaffold for ass
159 tyrosine phosphorylations in the N-terminal
non-catalytic region of the molecule, which contains an
160 -interactive site was mapped to a C-terminal
non-catalytic region that is conserved in the PP1(C)2 is
161 have one or two highly conserved C-terminal
non-catalytic regions, termed polo boxes.
162 ters and contains one degenerate site with a
non-catalytic residue next to the Walker B motif.
163 performed to determine how mutations of this
non-catalytic residue play a role in increasing 50% inhi
164 Substitution of key
non-catalytic residues at the Dnmt3a-Dnmt3L interface or
165 ple effect", whereby mutations in peripheral
non-catalytic residues can cause subtle allosteric chang
166 Expression of the catalytic or
non-catalytic ribozymes in control cells lacking PML/RAR
167 l genomics" annotated proteins and catalytic/
non-catalytic RNAs are studied in this context.
168 These results define a novel
non-catalytic role for Poleta in promoting PCNA monoubiq
169 may bind to the carboxyl terminus to serve a
non-catalytic role in assembly and/or stabilization of a
170 strong support for REV1 playing an important
non-catalytic role in coordinating translesion synthesis
171 een unsuccessful, suggesting that Rtr1 has a
non-catalytic role in CTD dephosphorylation.
172 suggesting that CKIdelta/epsilon may have a
non-catalytic role in stabilizing PER.
173 A consequence of the
non-catalytic role of domain 1 is that its active site r
174 nt cancer cells are primarily dependent on a
non-catalytic role of EZH2 in the stabilization of the P
175 However,
non-catalytic roles for REV1 have been suggested by the
176 TTL14 has a degenerate active site and plays
non-catalytic roles in maintaining complex integrity and
177 A secondary,
non-catalytic,
rubredoxin-like iron site is conserved in
178 The core
non-catalytic scaffoldin subunit, CipA, bears nine type
179 repeated cohesin (Coh) modules located in a
non-catalytic scaffoldin.
180 one of several type I cohesin modules in the
non-catalytic scaffolding protein.
181 family, provide insight into the function of
non-catalytic SDR residues, and illustrate that limited
182 the opportunity to analyze for functions of
non-catalytic SDR residues.
183 ver, how new Sec residues evolve and whether
non-catalytic Sec residues exist in proteins is not know
184 of these instances the domain functions as a
non-catalytic sensor of ligands.
185 rheumatoid fibroblast-like synoviocytes that
non-catalytic signaling is associated with rapid interna
186 to use the canonical ATP-binding motifs for
non-catalytic signaling through allostery.
187 ed for both efficient catalytic activity and
non-catalytic signaling.
188 ved in the binding of bicarbonate ion in the
non-catalytic site and an active-site variant (D44N) tha
189 l molecule compound, 1E7-03, that targeted a
non-catalytic site of PP1 and increased VP30 dephosphory
190 , pyridoxine 5'-phosphate oxidase contains a
non-catalytic site that binds pyridoxal 5'-phosphate tig
191 ormed at the active site may transfer to the
non-catalytic site without passing though the solvent.
192 tic of dual specificity phosphatases or to a
non-catalytic site, respectively.
193 s stabilized by bicarbonate ion binding to a
non-catalytic site.
194 Extent, timing, and role of
non-catalytic-
site movements are unknown.
195 n binding of hydrophobic peptides to several
non-catalytic sites.
196 In heterodimeric GPPSs, a
non-catalytic small subunit (GPPS-SSU) interacts with a
197 supporting in vitro evidence for additional,
non-catalytic Spastin functions.
198 ce of an autophosphorylation site within the
non-catalytic Src homology 3 (SH3) domain.
199 between transcription and translation of the
non-catalytic subunit from its assembly into ColQ-AChE.
200 by the overexpression of an AMPK-activating
non-catalytic subunit mutant (AMPK-gamma1-R70Q) dramatic
201 homologue with 5 WD40 repeats, Trm82, is the
non-catalytic subunit of a tRNA methylase.
202 Here we show that alpha4, a
non-catalytic subunit of the protein phosphatase 2A, pla
203 However, the
non-catalytic subunit, hACF1, altered the remodeling pro
204 Our data suggest roles for
non-catalytic subunits (Nop56 and Nop58) in rRNA binding
205 The
non-catalytic subunits are assumed to be redundant adapt
206 To elucidate the roles of the
non-catalytic subunits in determining the specificity of
207 arguing for specific regulatory roles of the
non-catalytic subunits in the differentiation of PI3Kgam
208 omposed of a catalytic alpha-subunit and two
non-catalytic subunits, beta and gamma.
209 nsists of a catalytic subunit (PP1c) and two
non-catalytic subunits, M130 and M20.
210 alytic p110gamma subunit, which binds to two
non-catalytic subunits, p87 or p101, and controls a plet
211 that the EF-Tu switch I region binds to the
non-catalytic surface of AbDsbA.
212 These data point to the possibility that the
non-catalytic surface of DsbA is a potential substrate o
213 APDH), an important glycolytic enzyme, has a
non-catalytic (
thus a non-canonical) role in inducing mi
214 was superior to Williamson in prediction of
non-catalytic transient complex interfaces.
215 cobacter gastric pathogens utilizes a unique
non-catalytic triad for catalysis, which could be exploi
216 d a BDNF survival response, co-expression of
non-catalytic TrkB substantially reduced this response.
217 ated by the relative levels of catalytic and
non-catalytic TrkB.
218 ic subunits TSEN2 and TSEN34, as well as the
non-catalytic TSEN54 and TSEN15.
219 Modular cellulases contain
non-catalytic type A carbohydrate-binding modules (CBMs)
220 ) of the topo II isoforms and by a conserved
non-catalytic tyrosine, Y640 in topo IIalpha and Y656 in
221 These
non-catalytic tyrosine-phosphorylated receptors (NTRs) s
222 they are found, including both catalytic and
non-catalytic versions.
223 enoyl-coenzyme A (CoA) hydratases, EchA6 is
non-catalytic yet essential and binds long-chain acyl-Co
224 h aspartic acid has been shown to coordinate
non-catalytic zinc in matrix metalloproteinases.
225 ss II aldolase has an active site zinc and a
non-catalytic zinc nearby.
226 lass II aldolase FbaA through binding to the
non-catalytic zinc site.
227 FbaA mutants (D144A and E174A) affecting the
non-catalytic zinc were resistant to nickel inhibition.
228 A
non-catalytic Zn(2+) site in the A. aeolicus GatB stabil