ライフサイエンスコーパス: non-coding

1 bic behavior, our data provide evidence that non-coding, although functional GLRB gene polymorphisms

2 Corroborating this data, we found that non-coding Alu RNA significantly correlates with tumor p

3 Most of the GWA variants are non-coding and the genes responsible for the association

4 The non-coding ASCC3 isoform counteracts the function of the

5 ther infer the biological functions of those non-coding associated genes based on their co-expressed

6 on effects in the clinical interpretation of non-coding chromosomal rearrangements.

7 resolve the impasse in understanding extreme non-coding conservation.

8 ractions for the analysis of both coding and non-coding disease-associated mutations to obtain mechan

9 e associations are preferentially located in non-coding DNA regions and in particular in tissue-speci

10 -coding RNAs (lincRNAs) are transcribed from non-coding DNA sequences.

11 ciation study (GWAS) risk variants reside in non-coding DNA sequences.

12 Non-coding DNA variants are suspected to account for a s

13 nes, scrambling gene order and replacing all non-coding DNA with synthetic genetic parts.

14 been found, such as novel genes arising from non-coding DNA, chimeric fusions, and lateral gene trans

15 odel of mutational heterogeneity facilitates non-coding driver identification and integrative analysi

16 Statistical detection of non-coding driver regions is challenged by a varying mut

17 Here, we develop a statistically founded non-coding driver-detection method, ncdDetect, which inc

18 ments, collectively referred to as conserved non-coding elements (CNEs), are non-randomly distributed

19 a suggest that mutations affecting conserved non-coding elements of PITX2 may constitute an important

20 Thus, non-coding elements responsive to extracellular cues uni

21 with common human diseases map to enhancers, non-coding elements that shape cell-type-specific transc

22 e of tightly regulated, biochemically active non-coding elements, such as transcription factor-bindin

23 As being the most extensively studied, non-coding, evolutionary conserved, post-transcriptional

24 asible to test for associations in the large non-coding fraction of the genome.

25 studied differentially expressed coding and non-coding genes in relation to systemic sclerosis patho

26 ns in the expression of both coding and long non-coding genes in the sub-chronic and chronic stages o

27 ential for termination of protein-coding and non-coding genes through interaction with S2-phosphoryla

28 Interestingly, 676 deregulated non-coding genes were detected, 257 of which were classi

29 erstand the mechanisms by which variation in non-coding genetic sequences contributes to disease.

30 Linking non-coding genetic variants associated with the risk of

31 d neurons helps functional interpretation of non-coding genetic variants associated with these diseas

32 ill improve the functional interpretation of non-coding genetic variants in the molecular genetic dis

33 s to predict pathogenicity of synonymous and non-coding genetic variants, and provide a web server of

34 re, and extends potential involvement of the non-coding genome in its pathogenesis.

35 as been made in defining essentiality in the non-coding genome.

36 prioritise small indels throughout the whole non-coding genome.

37 milies is caused by tandem duplications in a non-coding genomic region containing an active enhancer

38 e identified sequence variants, localized to non-coding genomic regions, associated with kidney funct

39 anges correlated to phenotypes lie mostly in non-coding genomic regions.

40 A non-coding hexanucleotide repeat expansion in intron 1 o

41 d, TROM, to identify both protein-coding and non-coding indicators.

42 , precursor mRNA (pre-mRNA) splicing removes non-coding intron sequences to produce mature mRNA.

43 NA splicing, whereby the spliceosome removes non-coding introns from pre-mRNAs and joins exons.

44 ased approach identified two long intergenic non-coding(linc)RNAs, lincRNA-Cox2 and lincRNA-AK170409,

45 udy, we intended to explore the role of long non-coding (lnc) RNAs in this transitional stage.

46 hways recurrently subject to MSI and uncover non-coding loci that frequently display MSI.

47 more likely to disrupt coding and regulatory non-coding loci, particularly when truncating constraine

48 ing peripheral axon injury, dysregulation of non-coding microRNAs (miRs) occurs in dorsal root gangli

49 For individual candidates, presence of non-coding mutations associates with altered expression

50 The extent to which non-coding mutations contribute to Mendelian disease is

51 The heavily mutated landscape of coding and non-coding mutations in cutaneous melanoma resolved nove

52 Non-coding mutations may drive cancer development.

53 d identifies regions that potentially harbor non-coding mutations underlying disorders of sexual deve

54 lowed the annotation of more than 13 million non-coding mutations, 18 029 gene fusions, 187 429 genom

55 Non-coding (nc)RNAs known as enhancer-derived RNAs (eRNA

56 association was found between ACQ and single non-coding nucleotide variants of the GLRB gene (rs78726

57 stimating the relative rate parameter of the non-coding partition in a heterochronous dataset, MCMC i

58 Here, the authors show that a non-coding polymorphic regulatory element at 7p14.3 may

59 benign prostate transcriptomes to identify a non-coding polymorphic regulatory element at 7p14.3 that

60 We identified two novel non-coding rare variants associated with LDL cholesterol

61 gene expression analysis revealed that this non-coding region alteration is associated with the sign

62 ession of expanded CCUG repeat RNAs from the non-coding region of the CCHC-type zinc finger nucleic a

63 with high CpG/UpA sequences inserted into a non-coding region were similarly replication defective.

64 eletion of any intergenic or deeply intronic non-coding region, indicating that proximal regulatory s

65 spective nucleotide triplet substitutions in non-coding regions and in 4-fold degenerate sites.

66 o A:T, their distribution between coding and non-coding regions and synonymous-to-non-synonymous muta

67 Similar to coding region transcription, non-coding regions are split at transcriptional sites.

68 The sizes of non-coding regions in the Longidoridae nematodes were ve

69 icant fraction of Pol III transcription from non-coding regions is not subjected to Xist-mediated tra

70 entifying these transcriptional regions from non-coding regions is the first step towards lincRNA rec

71 ur model specifically studies the effects of non-coding regions of DNA (in this case, CpG sites) on m

72 The significance of editing within non-coding regions of RNA is poorly understood.

73 a statistical approach to isolate coding and non-coding regions of the cancer genome that appear enri

74 genes, aberrant enhancer element activity at non-coding regions of the genome is a key driver of tumo

75 For somatic point mutations in coding and non-coding regions of the genome, we propose CScape, an

76 ce, especially chromosomal rearrangements in non-coding regions of the human genome, remains one of t

77 effect, pathogenic or neutral, of indels in non-coding regions of the human genome.

78 the potential pathogenic impact of indels in non-coding regions of the human genome.

79 The non-coding regions of tumour cell genomes harbour a cons

80 ne or two protein-coding genes and conserved non-coding regions putatively involved in replication an

81 genomic regions and also showed that defined non-coding regions, such as first introns of genes and r

82 lanced accuracy in coding regions and 70% in non-coding regions, while even higher accuracy may be ac

83 (ASHCEs) that predominantly (>99%) reside in non-coding regions.

84 80% in coding regions and approaching 90% in non-coding regions.

85 ncing indicating disease-causing variants in non-coding regions.

86 s is known about cancer-causing mutations in non-coding regions.

87 our work provided a better understanding of non-coding regulatory mechanisms of transcriptomics and

88 deleterious genomic variation, especially in non-coding regulatory regions of human genome.

89 Using ncdDetect, we screened non-coding regulatory regions of protein-coding genes ac

90 lopment and disorder, variation that affects non-coding regulatory regions of the genome is likely to

91 d to whole-exome sequencing, and variants in non-coding regulatory regions.

92 tance of 3 prime untranslated region (3'UTR) non-coding regulatory variants across neurodevelopmental

93 rovide a comprehensive catalog of functional non-coding regulatory variants that may be responsible f

94 indings show the importance of investigating non-coding regulatory variants when determining risk fac

95 Non-coding ribonucleic acids (ncRNA) are functional RNA

96 de association studies previously identified non-coding risk variants associated with PCa and melanom

97 on studies have identified a great number of non-coding risk variants for colorectal cancer (CRC).

98 nct messenger RNA (mRNA) and long intergenic non-coding RNA (lincRNA) profiles compared to hepatocell

99 that the mutation and dysregulation of long non-coding RNA (lncRNA) are associated with numerous dis

100 Long non-coding RNA (lncRNA) are emerging as contributors to

101 Here we report that the long non-coding RNA (lncRNA) HOTAIR (for HOX Transcript Antis

102 Long non-coding RNA (lncRNA) is a large class of gene transcr

103 We identified a rodent-specific long non-coding RNA (lncRNA) linc1281, hereafter Ephemeron (E

104 also binds and regulates the levels of long non-coding RNA (lncRNA) Neat1 and together with PABPN1 i

105 We identified a long non-coding RNA (lncRNA) that arises from the antisense s

106 cis-regulatory element demarcated by a long non-coding RNA (lncRNA) that controls the function and l

107 tes with the expression of an antisense long non-coding RNA (lncRNA) that has previously been shown t

108 Clustering by mRNA, long non-coding RNA (lncRNA), and miRNA expression converged

109 characterized non-coding RNAs including long non-coding RNA (lncRNA).

110 The brain cytoplasmic (BC1) RNA is a non-coding RNA (ncRNA) involved in neuronal translationa

111 ly, ZNF750 promoted the expression of a long non-coding RNA (TINCR), which mediated both cancer-inhib

112 Here we identify FILNC1 (FoxO-induced long non-coding RNA 1) as an energy stress-induced long non-c

113 stic link between an activity-dependent long non-coding RNA and epilepsy.

114 ivated as characterized by the appearance of non-coding RNA and histone modifications.

115 Furthermore, a long non-coding RNA antisense to FOXM1 (FOXM1-AS) promotes th

116 ding RNA 1) as an energy stress-induced long non-coding RNA by FoxO transcription factors.

117 nships among RNAs for mutation detection and non-coding RNA classification.

118 ctive specific transcript), a prototype long non-coding RNA essential for establishing X chromosome i

119 ress FoxOs induce the expression of the long non-coding RNA FILNC1, which inhibits survival of RCC by

120 RMRP and NEAT1, two non-coding RNA genes, carry mutations that affect protei

121 , and a recent study indicated that the long non-coding RNA HOX transcript antisense RNA (HOTAIR) is

122 the first time an important role of a long, non-coding RNA in antigenic variation and demonstrated a

123 T and suggest a function for major satellite non-coding RNA in the organization of an RNA-nucleosome

124 In addition, we annotated various classes of non-coding RNA including microRNA, long intergenic RNA,

125 RNA processing machinery to cleave its small non-coding RNA into a 22-nt RNA fragment, Sal-1, which

126 This small non-coding RNA is also highly expressed within the nucle

127 criptional profiling, we found that the long non-coding RNA MIR100HG and two embedded microRNAs, miR-

128 hesis, processing and function of coding and non-coding RNA molecules and their interacting proteins

129 lar signaling, and microRNAs which are small non-coding RNA molecules that function in post-transcrip

130 relocalized the Bcl11b enhancer identified a non-coding RNA named ThymoD (thymocyte differentiation f

131 the tumor suppressor gene PTEN and the long non-coding RNA NEAT1.

132 The long non-coding RNA PARTICLE (Gene PARTICL- 'Promoter of MAT2

133 of differentially expressed genes and their non-coding RNA partners, long noncoding RNAs and microRN

134 s of the complex, underscoring its role as a non-coding RNA processing/degradation unit.

135 eate a chromatin environment that influences non-coding RNA production, DNA methylation, and transcri

136 ed the largest class of over-expressed small non-coding RNA species in tubers.

137 MicroRNAs (miRNAs) are small non-coding RNA species that have been shown to have role

138 e recently emerged as a large class of novel non-coding RNA species.

139 c disorders.Brain cytoplasmic (BC1) RNA is a non-coding RNA that has been implicated in translational

140 N-BLR is a primate-specific long non-coding RNA that modulates the epithelial-to-mesenchy

141 characterization of a novel long intergenic non-coding RNA with MyoD-regulated and skeletal muscle-r

142 role in chromosome silencing induced by the non-coding RNA Xist.

143 f different types of RNA (including mRNA and non-coding RNA) targeted by endogenous RNase H1.

144 ipts, including mRNA, the various classes of non-coding RNA, and small RNA.

145 that satellite DNA, and corresponding small non-coding RNA, helps the dosage compensation machinery

146 Here we show that the long non-coding RNA, NEAT1, directly modulates neuronal excit

147 Here, we describe an unexpected role in non-coding RNA-directed DNA methylation in Arabidopsis t

148 ere, recent advances in our understanding of non-coding RNA-mediated regulation of skin development a

149 into mechanisms of chromatin modification by non-coding RNA.

150 in group 1 ILCs that is demarcated by a long non-coding RNA.

151 s, expresses seven small nuclear uracil-rich non-coding RNAs (called HSURs) in latently infected cell

152 erase III (Pol III) transcribes medium-sized non-coding RNAs (collectively termed Pol III genes).

153 Long intergenic non-coding RNAs (lincRNAs) are transcribed from non-codi

154 Long non-coding RNAs (lncRNAs) are a family of novel genes th

155 In these tumors, expression of long non-coding RNAs (lncRNAs) are deregulated and closely as

156 Long non-coding RNAs (lncRNAs) are expressed in a highly tiss

157 Long non-coding RNAs (lncRNAs) are important regulators of di

158 Long non-coding RNAs (lncRNAs) are largely heterogeneous and

159 Although long non-coding RNAs (lncRNAs) are non-protein-coding transcr

160 To date, Y chromosome-linked long non-coding RNAs (lncRNAs) are poorly characterized and t

161 Long non-coding RNAs (lncRNAs) are prominently associated wit

162 Long non-coding RNAs (lncRNAs) have been implicated in numero

163 Long non-coding RNAs (lncRNAs) have been implicated in the re

164 To date, a large number of long non-coding RNAs (lncRNAs) have been recently discovered

165 For example, although long non-coding RNAs (lncRNAs) have been shown to critically

166 Recently, long non-coding RNAs (lncRNAs) have emerged as an important c

167 Long non-coding RNAs (lncRNAs) have emerged as potential key

168 In particular, the biological roles of long non-coding RNAs (lncRNAs) have never been characterized

169 urther, ethanol-induced upregulation of long non-coding RNAs (lncRNAs) HOTAIR and MALAT1 in endotheli

170 over, through screening hypoxia-related long non-coding RNAs (lncRNAs) in PDK1-positive tissue, we fi

171 the transcription of a wide variety of long non-coding RNAs (lncRNAs) in the genomes of several orga

172 tabases indicated similarity with plant long non-coding RNAs (lncRNAs) involved in splicing regulatio

173 The expression of long non-coding RNAs (lncRNAs) is dysregulated in hepatocellu

174 We hypothesized that circulating long non-coding RNAs (lncRNAs) may act as diagnostic markers

175 New evidence indicates that long non-coding RNAs (lncRNAs) play crucial roles in epigenet

176 Long non-coding RNAs (lncRNAs) play key roles in human diseas

177 Although long non-coding RNAs (lncRNAs) regulate various cellular even

178 Long non-coding RNAs (lncRNAs) regulating gene expression at

179 espite the overwhelming number of human long non-coding RNAs (lncRNAs) reported so far, little is kno

180 rts have vastly expanded the catalog of long non-coding RNAs (lncRNAs) with varying evolutionary cons

181 a cell-type-specific manner, producing long non-coding RNAs (lncRNAs), rather than protein-coding tr

182 h as small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs), undergo trans-splicing and po

183 be translated (mRNAs) from the class of long non-coding RNAs (lncRNAs).

184 s, and a significant subset of them are long non-coding RNAs (lncRNAs).

185 s that regulate gene expression such as long non-coding RNAs (lncRNAs).

186 re disproportionately present in human long, non-coding RNAs (lncRNAs).

187 Non-coding RNAs (ncRNAs) are known to regulate gene expr

188 The discovery of structured non-coding RNAs (ncRNAs) in bacteria can reveal new face

189 sion levels of both protein coding genes and non-coding RNAs (ncRNAs).

190 nery and further serves as a source of short non-coding RNAs (ncRNAs).

191 hereas a subset of gene transcripts and long-non-coding RNAs adjacent to TE insertions are affected b

192 mutations in 20 protein-coding genes, 4 long non-coding RNAs and 10 untranslational regions.

193 eover, we identify multiple neurite-targeted non-coding RNAs and RNA-binding proteins with potential

194 together with coding genes, (antisense) long non-coding RNAs are deregulated in skin tissue of system

195 While a myriad non-coding RNAs are known to be essential in cellular pr

196 s in the folding and regulatory functions of non-coding RNAs but their structure proves difficult to

197 d therapeutic targets against gastric cancer.Non-coding RNAs can modify the expression of proteins in

198 Lastly, long non-coding RNAs can serve well as associated genes to in

199 ions might be attributed to the hypothetical non-coding RNAs embedded within the gene.

200 PIWI-interacting RNAs (piRNAs) are small non-coding RNAs essential for animal germ cell developme

201 In addition, 35 maternally expressed non-coding RNAs exhibited the same allele-specific epige

202 Non-coding RNAs have been drawing increasing attention i

203 Various families of non-coding RNAs have been identified as substrates of th

204 ultraconserved regions (T-UCRs) encode long non-coding RNAs implicated in human carcinogenesis.

205 quencing studies have identified hundreds of non-coding RNAs in bacteria, including regulatory small

206 The roles of long non-coding RNAs in cancer metabolism remain largely unex

207 genes and 991 differentially expressed small non-coding RNAs in cortical tubers compared to autopsy c

208 r abundance, the molecular functions of long non-coding RNAs in mammalian nervous systems remain poor

209 To address the relevance of small non-coding RNAs in SARS-CoV pathology, we deep sequenced

210 samples reveled thousands of uncharacterized non-coding RNAs including long non-coding RNA (lncRNA).

211 machinery to further process bacterial small non-coding RNAs into microRNA-like fragments.

212 Non-coding RNAs may contribute to this regulatory orches

213 snoRNAs and provided the first evidence that non-coding RNAs may play an important role in regulating

214 Our results suggest that non-coding RNAs play important roles in the regulatory n

215 Non-coding RNAs play indispensable roles in regulating t

216 kl mutant are correlated with changes in the non-coding RNAs produced by Pol IV and Pol V.

217 Non-coding RNAs produced from active arrays are complexe

218 As such, non-coding RNAs should be considered as potential biomar

219 Changes in small non-coding RNAs such as micro RNAs (miRNAs) can serve as

220 In trypanosomes, all mRNAs, and non-coding RNAs such as small nucleolar RNAs (snoRNAs) a

221 ed a large set of tissue-specific coding and non-coding RNAs that are bound to active promoters and e

222 MicroRNAs (miRNAs) are small non-coding RNAs that are involved in post-transcriptiona

223 cting RNAs (piRNAs) are a new class of small non-coding RNAs that are known to be associated with RNA

224 Circular RNAs (circRNAs) are a class of non-coding RNAs that are widely expressed in various cel

225 re 26-30-nucleotide germ line-specific small non-coding RNAs that have evolutionarily conserved funct

226 internal RNA modification in both coding and non-coding RNAs that is catalysed by the METTL3-METTL14

227 MicroRNAs (miRNAs) are small, non-coding RNAs that play critical roles in the post-tra

228 also reveals a regulatory mechanism by long non-coding RNAs to control energy metabolism and tumor d

229 ed fragments) are an abundant class of small non-coding RNAs whose biological roles are not well unde

230 MicroRNAs (miRNAs) are small regulatory non-coding RNAs with a diversity of cellular functions,

231 00 protein coding genes (PCGs) and 100 long non-coding RNAs with domestication-associated haplotypes

232 MicroRNAs (miRNAs) are short non-coding RNAs with key roles in cellular regulation.

233 Recently, site-specific small non-coding RNAs, also termed DNA damage response RNAs (D

234 g genes, 508 novel transcribed regions, 5178 non-coding RNAs, and 35 846 small RNA loci that were for

235 mulating articles are presented: one on long non-coding RNAs, another on the ligand-activated transcr

236 es are bound by a large number of coding and non-coding RNAs, but approaches to comprehensively map t

237 Here, we review the roles of long non-coding RNAs, chromosomal organizational structures a

238 Small non-coding RNAs, in particular microRNAs (miRNAs), regul

239 re recently, different classes of regulatory non-coding RNAs, including microRNAs.

240 sRNA interactions were also identified with non-coding RNAs, including sRNAs and tRNAs, demonstratin

241 arily conserved enzyme that generates short, non-coding RNAs, including tRNAs and 5S rRNA.

242 ion of 110 RNA-binding proteins and 137 long non-coding RNAs, most of them previously not linked to s

243 References 1013 MicroRNAs (miRNAs) are small non-coding RNAs, of typically 20-24 nt, that regulate ge

244 The NtcA regulon also included eight non-coding RNAs, of which Ncr1071, Syr6 and NsiR7 were e

245 hat include fusion proteins, novel exons and non-coding RNAs, one-third of which showed allelically i

246 located in the nucleus, is to polyadenylate non-coding RNAs, which undergo trans-splicing and polyad

247 merase III-associated transcription of small non-coding RNAs.

248 ch as transcription factor-binding sites and non-coding RNAs.

249 concealed using microarrays, including four non-coding RNAs.

250 est genome fraction is encoding thousands of non-coding RNAs.

251 NAs even in the absence of a training set of non-coding RNAs.

252 and cytoplasmic RBP functions for coding and non-coding RNAs.

253 referentially to mRNAs, rather than unstable non-coding RNAs.

254 hogenesis with a specific focus on antisense non-coding RNAs.

255 ms for the regulation of imprinted genes and non-coding RNAs.

256 n to bias transcription toward coding versus non-coding RNAs.

257 tor for the quality control of mitochondrial non-coding RNAs.

258 ry of: (i) new leads for gene function, (ii) non-coding RNAs; (iii) genes, pathways and ncRNAs that a

259 Viruses express several classes of non-coding RNAs; the functions and mechanisms by which m

260 bes putative functional roles to a number of non-coding schizophrenia (SCZ) risk variants.

261 hus pinpointing risk factors of disease from non-coding sequence data.

262 ein-coding gene and tRNA overlap with little non-coding sequence in the compact P. rubra genome.

263 ck of ALAS2 expression, indicating that this non-coding sequence is indispensable for ALAS2 expressio

264 We show that non-coding sequence variation at the FRO2 locus leads to

265 did identify the disruption of exon-proximal non-coding sequences (e.g., the promoter) as functionall

266 ylvae and I. pulchra genomes have many long non-coding sequences between genes, likely driving genom

267 delian diseases can be made by exploring the non-coding sequences of the human genome.

268 ancer have largely focused on genes, whereas non-coding sequences remain relatively unexplored.

269 s affected by recurrent mutations disrupting non-coding sequences was similar to that affected by rec

270 ers using the combined effects of coding and non-coding single nucleotide variants, structural varian

271 vior of living cells to be reprogrammed, and non-coding small RNAs (sRNAs) are increasingly being use

272 ogether, these results indicate a functional non-coding SNP in EPHA2 promoter affects PAX2 binding an

273 the interpretation of personal genomes.While non-coding synonymous and intronic variants are often no

274 us, the ASCC3 gene expresses both coding and non-coding transcript isoforms with opposite effects on

275 lopmental progression and tumor suppression, non-coding transcription orchestrates chromatin folding

276 Recent research in the area of the non-coding transcriptome signified the crucial roles for

277 We also monitored the behaviors of X-linked non-coding transcripts before and after XCI.

278 iated haploblocks express novel multi-exonic non-coding transcripts that are tissue-specific and enri

279 pha satellite array produces a unique set of non-coding transcripts, and RNAs present at active centr

280 edicted the potential regulatory function of non-coding transcripts, revealed enriched motifs of tran

281 fy the biologic mechanism by which a common, non-coding variant can distally regulate a gene and cont

282 are key to dissecting the allelic effects of non-coding variants and their contribution to phenotypic

283 L) methods for predicting disease-associated non-coding variants are faced with a chicken and egg pro

284 Ls in the Hutterites suggest that these rare non-coding variants are likely to mediate their effects

285 in two different contexts: the prediction of non-coding variants associated with Mendelian and with c

286 al regulatory functions for 423 of 565 (75%) non-coding variants associated with platelet traits and

287 Rare non-coding variants have been associated with extreme ge

288 ent methods ineffectively capture pathogenic non-coding variants in genic regions, resulting in overl

289 P outperforms leading methods in identifying non-coding variants that are pathogenic and is therefore

290 Recently, non-coding variants upstream of PRDM13 (MCDR1) and a dup

291 contributes to the prediction of functional non-coding variants, including expression quantitative t

292 Among these non-coding variants, somatic insertions are among the le

293 enes, such as BRCA1, and many common, mostly non-coding variants.

294 ng alleles, but no analogous code exists for non-coding variants.

295 models in assessing the pathogenic impact of non-coding variants.

296 tential to elucidate the functional roles of non-coding variants.

297 t in identifying and interpreting regulatory non-coding variants.

298 king, filtering and annotation of coding and non-coding variants.

299 ntifies functional enhancers and reveals how non-coding variation associated with human immune dysfun

300 nce context alterations to reliably identify non-coding variation that causes disease.

301 prehensive assessment of the consequences of non-coding variation.