ライフサイエンスコーパス: non-coding region

1 several of the introns and in the downstream non-coding region.

2 with all except one having mutations in the non-coding region.

3 ral gene, but by alterations in the upstream non-coding region.

4 o the group of coding exons and the group of non-coding regions.

5 y low specificity due to the large amount of non-coding regions.

6 h the coding regions being "whiter" than the non-coding regions.

7 sts a tight control over length expansion of non-coding regions.

8 d genetic markers including those located in non-coding regions.

9 nd non-specific genes are long in coding and non-coding regions.

10 as 14,919 bp in its entirety with few, short non-coding regions.

11 (ASHCEs) that predominantly (>99%) reside in non-coding regions.

12 or synergistic epistasis in the evolution of non-coding regions.

13 istent with very weak selection in conserved non-coding regions.

14 Parallel evolution was also identified in non-coding regions.

15 usly unnoticed, subtle functional signals in non-coding regions.

16 mic locations and between protein-coding and non-coding regions.

17 ' regions, with partial sharing of 5' and 3' non-coding regions.

18 80% in coding regions and approaching 90% in non-coding regions.

19 n the gene number and the characteristics of non-coding regions.

20 PIT elements appear to occur exclusively in non-coding regions.

21 ncing indicating disease-causing variants in non-coding regions.

22 bserved at all codon positions as well as in non-coding regions.

23 s is known about cancer-causing mutations in non-coding regions.

24 icated because most GWAS SNPs are located in non-coding regions.

25 dispersed throughout approximately 40 kb of non-coding regions.

26 ritization of genomic variants in coding and non-coding regions.

27 challenging due to a lack of annotations in non-coding regions.

28 of other SNPs, most of which are located in non-coding regions.

29 fic statistical models of protein-coding and non-coding regions.

30 rs they may be used to chart and explore the non-coding regions.

31 on compared to both non-synonymous sites and non-coding regions.

32 removing 26% of predicted genes that are in non-coding regions.

33 al protein coding regions in these putative 'non-coding' regions.

34 The A+U-rich element (ARE) in the 3' non-coding region (3' NCR) of short-lived cytokine mRNAs

35 The 220 nucleotide 5'non-coding region (5'NCR) of the human immunoglobulin he

36 of sequence conservation revealed over 5,000 non-coding regions actively conserved across all three s

37 gene expression analysis revealed that this non-coding region alteration is associated with the sign

38 A majority of these variants reside in non-coding regions and are co-inherited with hundreds of

39 in humans, which fall almost exclusively in non-coding regions and are enriched near genes involved

40 he human genome is significantly higher than non-coding regions and chromosomes.

41 Sequence analysis of the non-coding regions and enzymatic characterization of the

42 spective nucleotide triplet substitutions in non-coding regions and in 4-fold degenerate sites.

43 between the bending potential of coding and non-coding regions and its impact on the translational p

44 ed by combining models of protein-coding and non-coding regions and models of regulatory sites near g

45 wide association study (GWAS) signals map to non-coding regions and potentially point to non-coding v

46 o A:T, their distribution between coding and non-coding regions and synonymous-to-non-synonymous muta

47 Thus, the non-coding regions and the gene sets in prokaryotes seem

48 k.hmm, heuristic Markov models of coding and non-coding regions and the Gibbs sampling multiple align

49 minantly inherited ataxias with mutations in non-coding regions, and dominantly inherited ataxias wit

50 regions, such as coding exons and conserved non-coding regions, and use it to guide cross-species co

51 rotein-coding regions, which is not found in non-coding regions, and used them to distinguish protein

52 The evolution of non-coding regions appears to be determined primarily by

53 The variants are located in a non-coding region approximately 300 kb upstream from the

54 at a large proportion of sites in conserved non-coding regions are associated with very small fitnes

55 and more evidence to suggest that conserved non-coding regions are biologically significant since th

56 ated lineage-specific substitution rates for non-coding regions are considered classic signatures of

57 of genomic sequence labeling into coding and non-coding regions are followed by the rounds of model p

58 ocated on separate linkage groups, but their non-coding regions are highly similar, consistent with a

59 gene sequences show that both the coding and non-coding regions are non-random.

60 that most individual mutations in conserved non-coding regions are only slightly deleterious but are

61 Similar to coding region transcription, non-coding regions are split at transcriptional sites.

62 Although non-coding regions are sprinkled with short (<200 bp) is

63 ing because indels caused by a single cut in non-coding regions are unlikely to produce a functional

64 the use of these tools to identify conserved non-coding regions between the human and mouse genomes,

65 quences require models of protein coding and non-coding regions derived either from experimentally va

66 In addition to modifications in non-coding regions, editing contributes to diversificati

67 tively uniform and intra- and inter-operonic non-coding regions evolve congruently.

68 Some non-coding regions exhibited high mutation frequencies,

69 ntation conditions confirmed that coding and non-coding regions explained aspartic and glutamic acid

70 sequence, the remaining rare variants in the non-coding region have no apparent impact on risk.

71 hat accompany the calculated curves indicate non-coding regions have a significantly lower (G+C) comp

72 man and mouse genomes has revealed that many non-coding regions have levels of sequence conservation

73 bout the effect mutations in these conserved non-coding regions have on fitness and how many of them

74 Conserved non-coding regions identify potentially functional DNA t

75 by two different methods, (i) comparison of non-coding regions in conserved operons, and (ii) neural

76 ered, such example adds to the importance of non-coding regions in human pathology.

77 edict functional variants in both coding and non-coding regions in order to understand phenotype and

78 guide sequences that target both coding and non-coding regions in spCas9 CRISPR system across human,

79 we show that a class of conserved, primarily non-coding regions in tetrapods originated from a previo

80 ation can shed light on how polymorphisms in non-coding regions in the human genome might underlie ph

81 The sizes of non-coding regions in the Longidoridae nematodes were ve

82 perties and differentiate between coding and non-coding regions in the nucleotide chain.

83 ces not only from coding exons but also from non-coding region including core promoters generated by

84 sequences can identify coding and conserved non-coding regions, including regulatory elements, and p

85 e also identify novel recurrent mutations in non-coding regions, including the 3' region of NOTCH1, w

86 eletion of any intergenic or deeply intronic non-coding region, indicating that proximal regulatory s

87 eared anomalous, occurring within coding and non-coding regions, indicating pervasive transcription i

88 genes showed signs of purifying selection in non-coding regions, indicating that adolescence-active g

89 te that sequences corresponding to the mtDNA non-coding region interact with the inner membrane in a

90 We found that rs11187065, located in the non-coding region (intron 1) of insulin-degrading enzyme

91 of a gene caused by a small deletion in the non-coding region is a novel mechanism, which to the bes

92 As such, examining non-coding regions is important for understanding tyrosi

93 icant fraction of Pol III transcription from non-coding regions is not subjected to Xist-mediated tra

94 entifying these transcriptional regions from non-coding regions is the first step towards lincRNA rec

95 ms (SNPs) (including imputed ones) fall into non-coding regions, making it difficult to associate sta

96 point mutations within stem-loop V of the 5'-non-coding region (NCR) reduce neurovirulence and cell-s

97 s-acting sequences within the genomic RNA 3' non-coding region (NCR).

98 mately 700 additional termination signals in non-coding regions (NCR) far away from the nearest annot

99 We investigated the role of the 3' non-coding region of a mouse voltage-gated potassium cha

100 n of the GGGGCC hexanucleotide repeat in the non-coding region of chromosome 9 open reading frame 72

101 caused by a triplet repeat expansion in the non-coding region of either the DMPK (DM1) or CNBP (DM2)

102 ribed and amplified with primers from the 5' non-coding region of HCV and HGV by a nested polymerase

103 toxin-encoding dsRNA segments in that the 3' non-coding region of its plus strand has no sequence hom

104 ts that polymorphic genetic variation in the non-coding region of mitochondrial DNA (the 16184-16193

105 Because so much of the non-coding region of pag-3 was conserved, the control of

106 expanded GGGGCC hexanucleotide repeat in the non-coding region of the C9orf72 gene on chromosome 9p21

107 ession of expanded CCUG repeat RNAs from the non-coding region of the CCHC-type zinc finger nucleic a

108 Phylogenetic inference using the non-coding region of the chloroplast psbA gene resolves

109 n of the GGGGCC hexanucleotide repeat in the non-coding region of the Chromosome 9 open-reading frame

110 S (cold sensitive), has a mutation in the 5' non-coding region of the fur gene while the two other mu

111 sites in a relatively small region of the 5' non-coding region of the gene.

112 Sequences of the non-coding region of the plastid psbA minicircle (psbA(n

113 12) is caused by CAG repeat expansion in the non-coding region of the PPP2R2B gene.

114 nslocations and/or point mutations in the 5' non-coding region of the putative oncogene BCL-6, that a

115 ms were due to alternative splicing but in a non-coding region of the transcript such that only one t

116 We report that the non-coding region of this virus, HPV type 77, contains a

117 on of RITOLS replication occurs in the major non-coding region of vertebrate mtDNA and is effectively

118 Many of the eQTLs in the non-coding regions of a gene, or linked to nearby genes,

119 ns contain varying lengths of the coding and non-coding regions of beta - HYDROXYISOBUTYRYL-CoA HYDRO

120 the function of polymorphisms in coding and non-coding regions of class IB alcohol dehydrogenase (AD

121 entification of gene-specific probes from 3' non-coding regions of different members can assist in th

122 hnique for selective amplification of the 3' non-coding regions of different wheat HSP16.9 genes by r

123 ur model specifically studies the effects of non-coding regions of DNA (in this case, CpG sites) on m

124 dentification of regulatory sequences within non-coding regions of DNA is an essential step towards e

125 dentify potential regulatory elements in the non-coding regions of genes.

126 Ligand binding to structural elements in the non-coding regions of messenger RNA modulates gene expre

127 ent (IRE) is a 30nt RNA motif located in the non-coding regions of mRNAs of proteins involved in iron

128 ingle nucleotide polymorphisms (SNPs) in the non-coding regions of PEA15, including three frequent va

129 The significance of editing within non-coding regions of RNA is poorly understood.

130 Sequence homologies to the non-coding regions of several cereal genes were also exp

131 The 5'-non-coding regions of six mRNAs were shown to contain in

132 Hexanucleotide expansions, GGGGCC, in the non-coding regions of the C9orf72 gene were found in maj

133 a statistical approach to isolate coding and non-coding regions of the cancer genome that appear enri

134 ate eye enhancers in intron eight and the 3' non-coding regions of the dac locus defined by clusters

135 The leader and trailer non-coding regions of the EBOV genome likely regulate it

136 Mutations in PIGY can occur in coding and non-coding regions of the gene and cause variable phenot

137 tric illness and the frequent implication of non-coding regions of the gene by association analysis f

138 ion frequency repeats have been found in the non-coding regions of the gene.

139 osable element (TE) that are abundant in the non-coding regions of the genes of many plant and animal

140 Recent work annotating the non-coding regions of the genome has contributed to post

141 ics and genotype imputation, we annotate the non-coding regions of the genome in breast cancer cells

142 genes, aberrant enhancer element activity at non-coding regions of the genome is a key driver of tumo

143 available functional information relevant to non-coding regions of the genome, and, importantly, led

144 rtion of tagSNPs have been identified within non-coding regions of the genome, distinguishing functio

145 e vast majority of these SNPs are located in non-coding regions of the genome, the mechanisms by whic

146 For somatic point mutations in coding and non-coding regions of the genome, we propose CScape, an

147 variants that are likely to be causal are in non-coding regions of the genome.

148 e association study (GWAS) risk loci fall in non-coding regions of the genome.

149 en identified, the vast majority residing in non-coding regions of the genome.

150 sed by unstable microsatellite expansions in non-coding regions of the genome.

151 associated with human disease are located in non-coding regions of the genome.

152 Coding and 5' and 3' non-coding regions of the GP VI gene were analyzed by po

153 NVs) and copy number variants (CNVs), in the non-coding regions of the human genome can play an impor

154 ce, especially chromosomal rearrangements in non-coding regions of the human genome, remains one of t

155 f human structural variants, particularly in non-coding regions of the human genome.

156 effect, pathogenic or neutral, of indels in non-coding regions of the human genome.

157 the potential pathogenic impact of indels in non-coding regions of the human genome.

158 is a silent substitution, and four occur in non-coding regions of the leptin receptor.

159 promoters and exon 7s primarily affects the non-coding regions of the message.

160 of 709 examples each, taken from coding and non-coding regions of the same genome.

161 clinically relevant sites in both coding and non-coding regions of the transcriptome.

162 Most splicing variants lie in non-coding regions of the transcripts.

163 eases are caused by repeat expansions in the non-coding regions of their resident genes.

164 The non-coding regions of tumour cell genomes harbour a cons

165 of gene containing transcripts, possess long non-coding regions (often >45 kb) and remain chromatin b

166 a genome-wide significant 62 kilo base (kb) non-coding region on chromosome 7p14.1 where de novo del

167 mutations affecting RNA-binding proteins and non-coding regions on RNAs, highlighting the importance

168 Two non-coding regions, one in each paralog, appear to be un

169 is limited because many associations are in non-coding regions or difficult to target genes.

170 By treating phylogenetically footprinted non-coding regions (PFRs) as proxies for CRMs, we endeav

171 In addition to wide-spread editing in non-coding regions protein recoding by RNA editing allow

172 ne or two protein-coding genes and conserved non-coding regions putatively involved in replication an

173 human CBFA1 gene, therefore, contains the 5' non-coding region rather than a human OSF2 homolog.

174 ied out in Xenopus oocytes, we found that 3' non-coding region sequences of mKv1.4 mRNAs did not sign

175 p, which consists of both human and mouse 5' non-coding regions, served as a case study.

176 Their impact on retrotransposons in non-coding regions shed light on important aspects of ma

177 Two other non-coding regions showed nine changes, all associated w

178 Highly conserved non-coding regions showing rapid sequence changes along

179 more sequence is under natural selection in non-coding regions [such as transcription-factor binding

180 genomic regions and also showed that defined non-coding regions, such as first introns of genes and r

181 de association studies (GWAS), >90% occur in non-coding regions, suggesting a strong regulatory compo

182 elaxation is much more profound in conserved non-coding regions than in protein-coding regions, and t

183 repeats (Di-SSRs) in the genomes, coding and non-coding regions than non Vampire Pathogens (N_VP).

184 r the presence of cis mutations in the major non-coding region that might influence their origins or

185 Our success can be attributed to shorter 3' non-coding regions that are typical of higher-plant gene

186 dozens of allele-specific binding events in non-coding regions that could distinguish between diseas

187 tifies 37 candidate sequences (in coding and non-coding regions) that fold to the target aptamer stru

188 54 and, except for two differences in the 3'-non-coding region, the remainder of the sequence is iden

189 thin MCSs (approximately 70%) resides within non-coding regions; thus, the majority of sequences cons

190 al impact of sequence variation in conserved non-coding regions to impact complex cis-element structu

191 Moreover, two independent insertions in a non-coding region upstream of the pilE gene suggest that

192 nsive sequence conservation was found in the non-coding regions upstream of the pag-3 exons, in sever

193 from the polyprotein coding region to the 3' non-coding region we have further developed a cell-based

194 with high CpG/UpA sequences inserted into a non-coding region were similarly replication defective.

195 While most indels at non-coding regions were a single base pair, 3 base pair

196 lanced accuracy in coding regions and 70% in non-coding regions, while even higher accuracy may be ac

197 of these members appeared distinct in the 3' non-coding region with only 48% identity.

198 gh degree of identity in both the coding and non-coding regions with both the murine G-CSF (85%) and