ライフサイエンスコーパス: non-consensus

1 In the core promoter region both the non-consensus 21 bp spacing and the specific sequence be

2 cing depends on the presence of a suboptimal non-consensus 3' splice site.

3 pothesis that the redundant consensus and/or non-consensus 5' Sp1 binding sites are required to block

4 The SPO22 intron has a non-consensus 5' splice site (5'SS) that dictates its Na

5 ons causing CTP expression and adoption of a non-consensus 5'-UTR/proximal promoter region.

6 The +1123/+1134 region harbored non-consensus activator protein-1 and Ets1 binding sites

7 They also suggest that non-consensus alterations in the NKp80 hemITAM, as commo

8 t the NKp80 hemITAM and demonstrate that two non-consensus amino acids, in particular arginine 6, cri

9 mal expression of aprt , suggesting that the non-consensus and consensus binding sites at the 5' end

10 lps normalize the RPR's rates of cleavage of non-consensus and consensus pre-tRNAs.

11 iting pathogen-specific patterns compared to non-consensus and nonmulti-task clustering approaches.

12 nteractions, particularly when the bases are non-consensus, and that this contributes to setting phys

13 The presence of a non-consensus androgen response element in the promoter

14 f an overlapping SBE and newly characterized non-consensus AP-1 binding sequence that integrates the

15 exhibits differential activity for distinct non-consensus AP-1 sites present in human papillomavirus

16 We have observed oligosaccharides on a non-consensus asparaginyl residue in the C(H)1 constant

17 consensus base-pair T:A at position 6 or the non-consensus base-pair C:G at position 6.

18 The occurrence of non-consensus bases within these domains is responsible

19 f1p works through the PED element which is a non-consensus binding site.

20 ments resulted in the selection of multiple, non-consensus branchpoint sequences.

21 , the first nucleotide binding site contains non-consensus catalytic site residues, including Asp(668

22 e we show that PAP also contains four nearby non-consensus cdk sites that are phosphorylated by MPF.

23 A previous report has identified a non-consensus direct repeat (DR-1) element in the RXRgam

24 of the RXRgamma1 promoter region revealed a non-consensus DR-1 element at -232 bp from the transcrip

25 anscription factor, namely Pdx-1, binds four non-consensus elements in the IGRP promoter.

26 ogenin B1 estrogen responsive unit, with two non-consensus EREs, with higher affinity than one or two

27 motif, and a GATA motif, which overlaps the non-consensus GAS motif.

28 nse element that contains both consensus and non-consensus GAS motifs, two putative Ets binding sites

29 rticoid response unit (GRU) comprised of two non-consensus glucocorticoid receptor (GR) binding sites

30 t further understanding of the phenomenon of non-consensus glycosylation can be used to gain fundamen

31 sequence homology comparison indicates that non-consensus glycosylation occurs on Asn residues in th

32 man IgG1 antibody resulted in an increase in non-consensus glycosylation to 3.15%, a greater than 4-f

33 ivity of wild-type R can be modulated by its non-consensus "head" sequence but this modulation became

34 ing the RAG-SE complex, we hypothesized that non-consensus heptamer sequences might affect PCC stabil

35 We find that certain non-consensus heptamers, including a cryptic heptamer im

36 For PCH2, a long 5' exon and a non-consensus intron branchpoint dictate Nam8-dependence

37 clusters with greater coherence compared to non-consensus methods.

38 results suggested further definition of the non-consensus motifs, and database searches with these u

39 nterestingly, the 577 bp fragment contains a non-consensus nuclear factor kappaB (NF-kappaB)-binding

40 tein makes numerous specific contacts to the non-consensus nucleotides in the loop E motif (S-turn) i

41 , metA and metC, suggests that in vivo, with non-consensus operators, the repressor binds to at least

42 of homology with certain previously reported non-consensus p53 binding sequences.

43 Additional experiments revealed a second non-consensus Pax-6 binding site in the -306/-274 IGRP p

44 Here we identify a non-consensus PBD binding site within Dbf4 and demonstra

45 The HCDCREL-1 gene possesses a non-consensus polyadenylation signal that apparently is

46 exhibit dramatic transcriptional defects on non-consensus promoters.

47 6 degrees ), but is much less sharp with the non-consensus purine-purine steps A6G7 and G6G7 (roll an

48 een the consensus pyrimidine-purine step and non-consensus purine-purine steps at positions 6-7 both

49 onsensus pyrimidine-purine step T6G7 and the non-consensus pyrimidine-purine step C6G7 (roll angles o

50 that CAP discriminates between consensus and non-consensus pyrimidine-purine steps at positions 6-7 s

51 These data suggest that some non-consensus RSS, frequently present at chromosomal tra

52 interactions were stronger on DNA containing non-consensus sequences, like those of typical promoters

53 licing at multiple sites, some of which have non-consensus sequences.

54 utilization of a 5' splice site at -I and a non-consensus site at +1.

55 Ngamma-activation site (GAS) overlapped by a non-consensus site for nuclear factor kappa B (NFkappaB)

56 address whether E2F1 directly bound to this non-consensus site, we demonstrated that the DNA binding

57 E2F1 and a factor that binds adjacent to the non-consensus site.

58 UMO and BLM are required for modification at non-consensus sites and that preferential SUMO-2/3 modif

59 ensus sites were phosphorylated prior to the non-consensus sites at metaphase of meiosis I, and remai

60 remained so throughout maturation, while the non-consensus sites did not become fully phosphorylated

61 U1A binds novel non-consensus sites upstream of the secretory poly(A) si

62 10-fold lower concentration of MPF than the non-consensus sites.

63 s of exons spliced in aberrant order were at non-consensus sites.

64 oribosyltransferase (aprt) gene contains one non-consensus Sp1 binding site at its 5' end followed by

65 eve that we have identified a cross-species, non-consensus Sp1-binding site that binds Sp1 and that a

66 urthermore we have identified the usage of a non-consensus splice donor site in four families with an

67 f a yeast protein involved in recognition of non-consensus splice donor sites.

68 12, splices a class of pre-mRNA introns with non-consensus splice sites.

69 ecific activation segment phosphorylation at non-consensus substrate sites is proposed that is likely

70 vation segment autophosphorylation sites are non-consensus substrate sites.

71 preferred sequences, but allow resolution at non-consensus target sites.

72 sus TATA DNA and complexes between TBP and a non-consensus TATA box were kinetically unstable even at

73 ngle and kinetic stability of complexes on a non-consensus TATA box, making them similar to those on

74 cription, particularly from promoters with a non-consensus TATA box.

75 We also found that TBP bent non-consensus TATA DNA to a lesser degree than consensus

76 ions resulting in increased utilization of a non-consensus TC TATA element of the HIS3 promoter.

77 While non-consensus, this sequence still permits both trans-es

78 We have identified a non-consensus, TRalpha2-specific 5' splice site and cons

79 at any given time, the sequences flanking a non-consensus TRE or even the environment in which the c