ライフサイエンスコーパス: non-covalent

1 indicating that the dominant interaction is non-covalent.

2 hat the nature of nfGNPs-VLPs interaction is non-covalent.

3 s diverse field with a focus on covalent and non-covalent 2D polymers and frameworks, and self-assemb

4 horesis studies demonstrate the formation of non-covalent adducts with natural plasmids.

5 aptamers using two different approaches: (1) non-covalent adsorption of drop-casted pyrenil-modified

6 gonists, did not affect sensitisation by the non-covalent agonist carvacrol, which activates by bindi

7 action of the agonist, because covalent and non-covalent agonists were equally effective, and is lon

8 Supramolecular copolymers, non-covalent analogues of synthetic copolymers, constitu

9 In particular, this review analyzes various non-covalent and covalent interactions and chemistry app

10 This review is focused on non-covalent and covalent interactions that are employed

11 se processes, it is highly regulated by both non-covalent and covalent mechanisms that are still bein

12 volves the use of reversible chemistry (both non-covalent and covalent) to programme a response that

13 The interaction is non-covalent and extraction with octanol completely remo

14 meditope peptides could be used as specific non-covalent and paratope-independent handles in targete

15 Here, a non-covalent approach was used to conjugate PEG bearing

16 With the non-covalent approach, the sensitivity was higher (1.52

17 The use of ionic self-assembly, a facile non-covalent approach, to access non-conventional block

18 he supramolecular complexation behaviour and non-covalent approaches rather than on the proposed appl

19 e chemically modified, by either covalent or non-covalent approaches, in order to interface them with

20 structural template guides for the specific non-covalent assembly of multi-subunit complexes, equiva

21 By non-covalent association after proteolytic cleavage, the

22 tained in the bacterial envelope through the non-covalent association of proteins with cell wall carb

23 o-ADAMTS9, propeptide fragments maintained a non-covalent association with the catalytic domain.

24 er by a change in complex constitution or by non-covalent association.

25 ng strategies on stiff, glass substrates and non-covalent attachment methods are limiting.

26 , new, and general method for the reversible non-covalent attachment of amphiphilic DNA probes contai

27 -specific chemisorption of MTFP and multiple non-covalent attractive interactions between the carbony

28 petition between electrostatic repulsion and non-covalent attractive interactions.

29 Interestingly, when non-covalent backside ubiquitin binding cannot occur, th

30 caffold for molecular transport based on its non-covalent base pairing to assemble both stationary an

31 ompared to native beta-Lactoglobulin and the non-covalent beta-lactoglobulin/caffeic complex (betaLg/

32 Also, due to the ability of the non-covalent beta-sheet cross-links to reassemble, the h

33 he present paper describes the assessment of non-covalent binding (NCB) between milk proteins and pol

34 nhibit the fibrillation of alpha-Syn, due to non-covalent binding of DOPAC to alpha-Syn monomer.

35 Non-covalent binding of K63-Ubn to 2CARD induces its tet

36 Specific non-covalent binding of metal ions and ligands, such as

37 The biological implications of non-covalent binding of polyphenols to BLG were investig

38 f Smt3p cannot bind concurrently to both the non-covalent binding site and the catalytic cysteine of

39 ing sites for allicin, whereas the number of non-covalent binding sites increased for diallyl disulfi

40 d gas diffusion electrodes (GDEs) by using a non-covalent binding strategy.

41 However, the effect of non-covalent binding to Nedd8 remains unknown.

42 ATP competes with regular DNA for non-covalent binding to the T4 ligase and is found to si

43 1p and E3 components to the E2p core through non-covalent binding.

44 s a consequence of blocking the stimulatory, non-covalent, binding of ubiquitin to the backside of Ub

45 Thus, bPoNAs can serve as tools for both non-covalent bioconjugation and structure-function nucle

46 tibody and the intermediate affinity of this non-covalent bond, fully assembled probes do not aggrega

47 Waals radii) and its ability to form strong non-covalent bonding interactions with pi-electron-rich

48 This tutorial review summarizes non-covalent bonding, reversible reactions and responsiv

49 The non-covalent bonds allow the extrusion of the inks into

50 Non-covalent bonds, more likely salt bridge and ionic in

51 ch as reversible binding through covalent or non-covalent bonds, thermodynamic equilibration and stru

52 We also demonstrate how strong non-covalent bonds, which are versatile for controlled p

53 inked macromolecules connected by transient, non-covalent bonds; they are a fascinating class of soft

54 s has been performed under both covalent and non-covalent catalysis, with diaryl prolinols, imidazoli

55 interactions contribute to the formation of non-covalent chainmail in BPP-1, unlike covalent inter-p

56 The idea I advocate here is that the non-covalent change in protein conformation itself might

57 ry and the emergence of dynamic covalent and non-covalent chemistries, novel perspectives have been o

58 However, the contribution of non-covalent chromatin structure to the poised state is

59 tion in mesostructured soft solids involving non-covalent co-assembly has received little attention.

60 olution on how the monomer structure affects non-covalent COF layer stacking.

61 The straightforward non-covalent combination of MSN and gold-protein cluster

62 we describe the structure determination of a non-covalent complex between human Ubc9 and SUMO-1 at 2.

63 This is one of the longest non-covalent complex half-lives yet reported and, to the

64 The K(d) of this non-covalent complex is 178.0+/-1.5 microm.

65 , the intracellular delivery of avidin, as a non-covalent complex with a biotinylated Tat vector, is

66 ivery capabilities and function by forming a non-covalent complex with cargo, protecting it from nucl

67 m, mature myostatin is found in an inactive, non-covalent complex with its prodomain.

68 hat these proteins form a tightly associated non-covalent complex, the H/L complex, and we identify t

69 and finally dynamic molecular motion within non-covalent complexes as unravelled by hydrogen-deuteri

70 that CB[7]6 is among the tightest monovalent non-covalent complexes ever reported in water with Ka =7

71 The non-covalent complexes formed between the peptide and ca

72 arisons reveal similarities to several other non-covalent complexes in the ubiquitin pathway, suggest

73 irst crystallographic structural analysis of non-covalent complexes of a picornavirus 3C(pro) with pe

74 sociation and formation of covalent bonds in non-covalent complexes through the reactivity in the res

75 Moreover, the non-covalent complexes were optimally detected at wavele

76 heir ability to specifically target and form non-covalent complexes with other proteins.

77 -throughput methodology for analysis of weak non-covalent complexes.

78 The array is fabricated using non-covalent conjugation of an aptamer-anchor polynucleo

79 tunable biohybrid hydrogels by covalent and non-covalent conjugation schemes, including both theory-

80 Here we show that non-covalent contacts between the active molecular compo

81 tructures, we uncover a conserved network of non-covalent contacts that defines the GPCR fold.

82 ic' binding of the metal to weak and labile, non-covalent coordination interactions that allow for re

83 lf-assembling beta-sheet peptides to provide non-covalent cross-linking through beta-sheet assembly,

84 d with a small-amount dynamic CB[8]-mediated non-covalent crosslinking (2.5 mol%), yields extremely s

85 These non-covalent crosslinking moieties are able to undergo a

86 oducing chemical moieties to promote dynamic non-covalent crosslinking of the conjugated polymers.

87 Specific non-covalent crosslinks involving domains/motifs lead to

88 The humanized form (B6-3) was obtained as a non-covalent dimer from secretion in Pichia pastoris (11

89 dal head; physiological oligomers consist of non-covalent dimer-of-dimers.

90 main cysteines, retained the ability to form non-covalent dimers, and all of the BST-2 variants were

91 Together, these data indicate that the non-covalent dissociation is limited by the amount of ch

92 (AH78 TriplatinNC) and 7 (AH78H), are potent non-covalent DNA binding agents where nucleic acid recog

93 There is a wide range of applications for non-covalent DNA binding ligands, and optimization of su

94 chanisms, we have successfully constructed a non-covalent DNA catalysis network that resembles an all

95 n methods have been developed in the form of non-covalent DNA catalytic reactions, in which single-st

96 In the present communication, a non-covalent fenarimol-imprinted polymer was synthesized

97 e interactions by docking, both covalent and non-covalent, for 38 lipases with a large number of stru

98 ecular polymers depending on the cooperative non-covalent forces driving their formation, with partic

99 ulsive steric and stabilizing intermolecular non-covalent forces in the stereodetermining hydride tra

100 of n-->pi* interactions in the inventory of non-covalent forces that contribute to protein stability

101 oups that may interact either by covalent or non-covalent forces with other molecules present in the

102 whereas octanal bound PPIs via covalent and non-covalent forces.

103 The presence of GUG triplets in non-covalent fragments of the ribozyme allow trans-splic

104 nt synthetic approaches for the covalent and non-covalent functionalization and characterization of G

105 her frequently used covalent strategies, our non-covalent functionalization protocol largely retains

106 The non-covalent functionalization through pi-pi stacking in

107 Non-covalent functionalization with phospholipid-polyeth

108 A sensor array containing six non-covalent gold nanoparticle-fluorescent polymer conju

109 into organophilic material via covalent and non-covalent grafting strategies.

110 Contrary to the non-covalent heterogeneous dispersion of pure (unmodifie

111 The resulting non-covalent heterotrimer was exported in a Tat-dependen

112 Heme iron interaction with HrtR is non-covalent, hexacoordinated, and involves two histidin

113 The apple 4 domain (A4; F272-E362) mediates non-covalent homodimer formation even when the cysteine

114 that the molecular self-assembly in water by non-covalent host-guest molecular recognition is suffici

115 successful supramolecular polymerization by non-covalent host-guest molecular recognition was confir

116 thylene glycol interact with heparin to form non-covalent hydrogels.

117 associations are stabilized and mediated by non-covalent hydrogen bonds that arise on the backbone o

118 tion interface was fabricated via simple and non-covalent immobilization of antibody using lectin-med

119 The method of non-covalent immobilization of DNA probes on an uncharge

120 ppropriate bifunctional linker molecules, or non-covalent immobilization via electrostatic interactio

121 enetic or chemical modification, we report a non-covalent infusion technique that facilitates efficie

122 K27 is a potent, non-covalent inhibitor of nucleotide exchange, showing c

123 ailed interactions between first generation, non-covalent inhibitors and GlgE, a variant Streptomyces

124 o generate potent, class-specific, bioactive non-covalent inhibitors for these enzymes are still limi

125 to advance the development of high affinity, non-covalent inhibitors of K-Ras oncogenic mutants.

126 ve cells using either covalent attachment or non-covalent insertion, while maintaining high cell viab

127 lographically observed structural motifs and non-covalent interaction acceptor-donor pairings.

128 We found an unexpected non-covalent interaction between AbDsbA and the highly c

129 ELF domain of FANCL is required to mediate a non-covalent interaction between FANCL and ubiquitin.

130 vity and/or selectivity have been imputed to non-covalent interaction between the reaction partners.

131 ting evidence points to the emerging role of non-covalent interaction between ubiquitin and the targe

132 as been a growing interest in exploring this non-covalent interaction in nanoscale drug delivery syst

133 driver for assembly, the contribution of the non-covalent interaction is to direct the molecular-leve

134 nidine and arginine formed both covalent and non-covalent interaction products.

135 ir targets in a manner other than reversible non-covalent interaction will be required.

136 s occurs via an initial metal ion-dependent, non-covalent, interaction between TSG-6 and HCs that als

137 The pretargeting approach utilises specific non-covalent interactions (e.g. strept(avidin)/biotin) o

138 In natural systems, highly synergistic non-covalent interactions among biomolecular components

139 d crystalline molecules are organized due to non-covalent interactions and due to delicate nature of

140 achieved a predictable control over various non-covalent interactions and have used these weak inter

141 r the rational manipulation of these complex non-covalent interactions and their direct incorporation

142 ly of low-molecular weight compounds by weak non-covalent interactions and thus, they may be easily d

143 Non-covalent interactions are thought to be involved in

144 or two diverse catalytic systems with unique non-covalent interactions at the heart of each process.

145 r identical, indicating similar fractions of non-covalent interactions being formed in the transition

146 the channel protein through a combination of non-covalent interactions between adjacent helices and c

147 vantage of the cumulative effect of multiple non-covalent interactions between adjacent molecules.

148 Non-covalent interactions between beta-lactoglobulin (BL

149 sic feature of this model is the presence of non-covalent interactions between hemicellulose chains a

150 The theoretical analysis of the non-covalent interactions between host and guest confirm

151 s that are loaded onto nanoparticles through non-covalent interactions between polyhistidine tags and

152 In this work, substituent effects tune non-covalent interactions between side-chain fluorinated

153 Our findings indicate that non-covalent interactions between SUMO and BLM are requi

154 s dependent on SUMO binding, indicating that non-covalent interactions between SUMO and target protei

155 hat the amide E:Z equilibrium is affected by non-covalent interactions between the amide oxygen and a

156 of viral capsid self-assembly require weak, non-covalent interactions between the capsid subunits to

157 Non-covalent interactions between the cellulose crystals

158 lling the nucleation of the crystals and the non-covalent interactions between the doped oligomers.

159 Strong non-covalent interactions between the MOF surface and ca

160 be dedicated to catalytic systems for which non-covalent interactions between the partners of the re

161 Non-covalent interactions between ubiquitin (Ub)-modifie

162 standing of the synergy between covalent and non-covalent interactions can form the basis for any pre

163 ssembly of binary systems driven by specific non-covalent interactions can greatly expand the structu

164 ous assembly driven by coordination multiple non-covalent interactions can help explain the well-orde

165 and consolidated by the recruitment of other non-covalent interactions contributed by subsurface moie

166 nt proteins provide striking examples of how non-covalent interactions could be exploited for tuning

167 a cooperative binding model wherein multiple non-covalent interactions create a web of interdependent

168 logy is validated by directly connecting the non-covalent interactions defined through empirical data

169 Stronger non-covalent interactions delayed pepsin and pancreatin

170 The utilization of non-covalent interactions for the design of adhesives wi

171 w molecular weight gelators (LMWGs) based on non-covalent interactions has been proven to be a useful

172 n water by specific, directional and dynamic non-covalent interactions has led to the development of

173 In this way, many types of non-covalent interactions have been characterized, from

174 sed in the light of the role of covalent and non-covalent interactions in controlling the ensemble of

175 re designed to interact with one another via non-covalent interactions in order to create function.

176 ative enzymes and their models, the roles of non-covalent interactions in promoting this activity are

177 al understanding of the roles of long-range, non-covalent interactions in redox processes, but also a

178 s this, the significantly higher strength of non-covalent interactions in the absence of competing so

179 The role of non-covalent interactions in the formation of visco-elas

180 n-biotin interaction is one of the strongest non-covalent interactions in the nature.

181 These results indicate that manipulating non-covalent interactions in zein can alter and in some

182 unfolding interest in integrating unorthodox non-covalent interactions into functional systems.

183 racteristics underlying the most significant non-covalent interactions involved in fibrin polymerizat

184 binding and catalysis are often mediated by non-covalent interactions involving aromatic functional

185 ' in situ conditions where a wide variety of non-covalent interactions may be relevant.

186 plasmon resonance (SPR) phenomenon to study non-covalent interactions not just between plasmonic par

187 In the presence of FIB, substantive non-covalent interactions occurred between rabbit cornea

188 rb on graphitic nanomaterials (GNMs) through non-covalent interactions occurring at their interfaces.

189 Non-covalent interactions of EGCG with proteins contribu

190 tuitive to use it to study the structure and non-covalent interactions of proteins that form in solut

191 pecific, directional, tunable and reversible non-covalent interactions offer unprecedented advantages

192 They can be as labile as non-covalent interactions or as permanent as covalent bo

193 to their dynamic, stimuli-responsive nature, non-covalent interactions represent versatile design ele

194 three-dimensional structures, and uncovering non-covalent interactions that underlie polypeptide fold

195 terplay between polyvalent electrostatic and non-covalent interactions that work in unison to disrupt

196 Supramolecular chemistry uses non-covalent interactions to coax molecules into forming

197 mvent the challenge of programming extensive non-covalent interactions to control protein self-assemb

198 This strategy takes advantage of non-covalent interactions to template a topochemical pho

199 ms make simultaneous use of several types of non-covalent interactions together, one would expect the

200 esidue offset is lucrative, as it leaves the non-covalent interactions unsatisfied at the termini and

201 d subsequently quantify the strengths of the non-covalent interactions using Kohn-Sham density functi

202 By establishing conditions that preserve non-covalent interactions we exploit the surface to capt

203 a viral RNA sensor, RIG-I, both covalent and non-covalent interactions with K63-linked ubiquitin chai

204 olated guest molecules demonstrates that the non-covalent interactions with the host hardly affect th

205 les are assembled into regular structures by non-covalent interactions, attract tremendous interests

206 re the nature of the covalent chemical bond, non-covalent interactions, bond formation, and exotic 3-

207 he risk of false-positive identifications by non-covalent interactions, but also preserves SUMO-subst

208 By using specific, dynamic, and tunable non-covalent interactions, engineered approaches to drug

209 Furthermore, non-covalent interactions, such as electrostatics, pi-st

210 Non-covalent interactions, such as self-interaction and

211 iew, we focus on the role and composition of non-covalent interactions, which are essential when stud

212 dynamic polymeric networks through specific non-covalent interactions, with a particular emphasis on

213 We found that the structure is stabilized by non-covalent interactions, with dominant contributions f

214 ng nanomaterial whose assembly is driven via non-covalent interactions.

215 action partners that can be held together by non-covalent interactions.

216 stic properties of zein arise as a result of non-covalent interactions.

217 dapt to cell behavior as a result of dynamic non-covalent interactions.

218 e excited state by employing confinement and non-covalent interactions.

219 e correlations is introduced for postulating non-covalent interactions.

220 nition phenomena are a direct consequence of non-covalent interactions.

221 Self-assembly occurs via non-covalent interactions.

222 eric structures from small molecules through non-covalent interactions.

223 ersible complex formation, due to prevailing non-covalent interactions.

224 e absorption and luminescence properties via non-covalent interactions.

225 n-2D materials that adhere primarily through non-covalent interactions.

226 ave renewed their interest in water-mediated non-covalent interactions.

227 eine was enclosed within the gel network via non-covalent interactions.

228 ucts and at the same time exhibiting various non-covalent interactions.

229 ing that protein network was mostly based on non-covalent interactions.

230 IP3 R1 remain associated, presumably through non-covalent interactions.

231 show that NEDD8 ultimate buster 1 (NUB1), a non-covalent interactor of the Ubl NEDD8 (neural precurs

232 Here we systematically investigated non-covalent interchain interactions for CH3 domains in

233 Specifically, the weak non-covalent intermolecular interactions induced by the

234 trameric complex exhibits the involvement of non-covalent intermolecular interactions that are locali

235 dually assemble on U3 and U5 ends before the non-covalent juxtaposition of two viral DNA ends, produc

236 l of photo-activation, enabling the study of non-covalent kinetic intermediates and heterogeneous mix

237 es, the activities of which are regulated by non-covalent ligand binding, and that may provide a temp

238 The p75(NTR) DD forms non-covalent, low-affinity symmetric dimers in solution.

239 The kinetic stability of non-covalent macromolecular complexes controls many biol

240 ential benefit of using a serum protein in a non-covalent manner in conjunction with paclitaxel nanoc

241 s can coat the surfaces of Ad particles in a non-covalent manner to modify their transduction propert

242 stabilized by serum protein transferrin in a non-covalent manner.

243 e synthetic biology, nanodisc-technology and non-covalent mass spectrometry provides excellent synerg

244 e not held together by covalent bonds but by non-covalent mechanical interactions.

245 t NAAA in a potent and selective manner by a non-covalent mechanism are described.

246 These data demonstrated that our non-covalent modification was able to alter Ad's interac

247 were immobilized to the graphene surface via non-covalent modification.

248 (CFL) and cephapirin (CFP)), was prepared by non covalent molecular imprinting approach and applied t

249 t the mechanical force applied to pull apart non-covalent molecular bonds (such as receptor-ligand pa

250 actor governing recognition, particularly in non-covalent molecularly imprinted polymers.

251 compound exemplifies a second generation of non-covalent NAAA inhibitors that may be useful in the t

252 of dynamic features as a consequence of the non-covalent nature of their core interactions, but also

253 inically relevant setting, likely due to the non-covalent nature of their interaction with collagen m

254 both Smurf1 and its homologue Smurf2 carry a non-covalent Nedd8-binding site within its catalytic HEC

255 Responsive graphene oxide sheets form non-covalent networks with optimum rheological propertie

256 This is the first demonstration of non-covalent PEGylation of acylated peptides, an importa

257 , phospholipids (dithranol, THAP, HABA), and non-covalent peptide-peptide and protein-peptide complex

258 advance for future structure-based design of non-covalent peptidomimetic inhibitors.

259 Non-covalent pi-pi interactions are central to chemical

260 ustering by enabling reversible, cooperative non-covalent (pi-pi, solvophobic, and hydrogen bonding)

261 MO-interacting motif favors formation of the non covalent PIAS1.SUMO.UBC9 ternary complex.

262 g sites also help explain the selectivity of non-covalent PLpro inhibitors.

263 A non-covalent polymerization reaction between macromolecu

264 In this study, non-covalent polymers from self-assembled boric acid wer

265 Surface coating using non-covalent polymers from self-assembled boric acid wil

266 Non-covalent polymers have remarkable advantages over sy

267 l properties of formally substitution-inert "non-covalent" polynuclear platinum complexes (PPCs).

268 We introduce a non-covalent pore engineering approach to achieve except

269 ut their active response is mediated through non-covalent processes, which may limit the extent to wh

270 uctural proteomics under the assumption that non-covalent protein complexes being transferred into th

271 moieties in these polymeric mimics improves non-covalent protein delivery, providing crucial design

272 Rationally designed non-covalent protein nanocapsules incorporating copper-f

273 DD8 can control protein function through its non-covalent recognition by interacting proteins.

274 In this tutorial review the non-covalent recognition of CWAs is considered from firs

275 shed a mechanism-of-action involving initial non-covalent recognition of inhibitors at the IspD bindi

276 Non-covalent recognition of ubiquitin (Ub) and ubiquitin

277 age structure, as opposed to being formed by non-covalent self-assembly of non-porous sub-units.

278 tion platform might be realized by combining non-covalent self-assembly of porous networks and SAMs,

279 for mediating targeted cell penetration and non-covalent self-assembly with therapeutic cargo, formi

280 SUMO pathway suggests that formation of the non-covalent Smt3p-Ubc9p complex occurs mutually exclusi

281 ierarchical functional nanomaterials through non-covalent soft-chemical routes.

282 , supramolecular structures held together by non-covalent solvophobic and coordination interactions a

283 cond conformational change associated with a non-covalent step not previously reported for Pol beta.

284 The second part introduces various non-covalent strategies for achieving desired doping in

285 exity of the extracellular matrix (ECM) to a non-covalent structure with minimal chemically defined c

286 The overall approach offers an efficient, non-covalent synthesis method for the solution-phase fab

287 ning self-assembled structure in biology and non-covalent synthesis.

288 ce of novel protein ligands by identifying a non-covalent synthetic ligand to the DNA-binding domain

289 her differentiation in terms of covalent and non-covalent systems.

290 Finally, our results also indicate that the non-covalent ternary complex is required for the known t

291 as assembled into a previously unidentified non-covalent ternary complex with SUMO as evidenced by b

292 ecurrent structural motifs to form extensive non-covalent tertiary interactions.

293 This non-covalent three-helix bundle domain is homologous in

294 either covalent arabinogalactan mycolates or non-covalent trehalose mycolates in live mycobacteria.

295 mology domain (THD) of human (h)4-1BBL forms non-covalent trimers, we found that m4-1BBL formed a cov

296 Non-covalent Ub binding to the backside of certain E2s p

297 n the ubiquitin pathway, suggesting that the non-covalent Ubc9-SUMO interface may be important for po

298 nexpected synergism between the covalent and non-covalent ubiquitin interaction modes.

299 The results imply that non-covalent ubiquitin-like protein-E2 complexes are con

300 rand remains annealed to the plasmid through non-covalent Watson-Crick base-pairing; its removal, the